Development of Apoptotic Cell Mimetic Anti-inflammatory Polymers

• Published in: Drug Delivery System Vol. 37; no. 2; pp. 149 - 158
• Main Authors: Tasaki, Akari, Ebara, Mitsuhiro
• Format: Journal Article
• Language: Japanese
• Published: Kawasaki THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 25.03.2022; Japan Science and Technology Agency
• Subjects: anti-inflammatory; Apoptosis; apoptotic cells; Biocompatibility; Biological activity; Biomaterials; Biomedical materials; Cell membranes; Immune system; Immunomodulation; Inflammation; MPS; Polymers; Surgical implants
• ISSN: 0913-5006; 1881-2732; 1881-2732
• DOI: 10.2745/dds.37.149

The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called “immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials：（1）immuno-inert biomaterials, （2）immuno-activating biomaterials, and （3）immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their performance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane inspired polymer and its post-inflammatory effects on immune cells in this article.