Relationship　between　the　Expression　of　CD44v6　and　Development,Progress,　Invasion　and　Metastasis　of　Laryngeal　Carcinoma

• Published in: Current medical science Vol. 25; no. 3; pp. 351 - 353
• Main Author: 刘邦华 孔维佳 龚树生 杨成章 汪广平 朱立新
• Format: Journal Article
• Language: English
• Published: China Department of Otorhinolaryngology Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2005
• Subjects: Adult; Aged; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; CD44v6; Female; Glycoproteins - biosynthesis; Glycoproteins - genetics; Humans; Hyaluronan Receptors - biosynthesis; Hyaluronan Receptors - genetics; Laryngeal Neoplasms - metabolism; Laryngeal Neoplasms - pathology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; 喉肿瘤; 基因表达; 肿瘤转移; precancerous lesion; CD44v6; metastasis; laryngeal carcinoma
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/BF02828165

The expression of CD44v6 and its relationship with the development, progress, invasion and metastasis of laryngeal carcinoma was investigated. The expression and content of CD44v6 mRNA in tissuess were detected by both RT-PCR and FCM which were respectivelyextracted from normal laryngeal mucosa, leukoplakia of larynx, laryngeal papilloma, polyp of vocal cord, tissues of laryngeal carcinoma, metastatic and nonmetastatic lymph nodes of neck, and tissues close to carcinoma. The outcome of RT PCR indicated that the expression rate of CD44v6 mRNA involved in tissues of laryngeal carcinoma and metastatic lymph nodes of neck was the highest (90 %- 100%) compared with that of leukoplakia of larynx, laryngeal papilloma, tissues close to carcinoma by 0.5cm (55.56%--60.00%) and that of normal laryngeal mucosa, polyp of vocal cord, nonmetastatic lymph nodes and tissues close to carcinoma by 1.0 cm was the lowest (13.33%--20%). The result from FCM was highly consistent with that from RT-PCR. It was suggested that CD44v6 was closely related with the development, progress, invasion and metastasis of laryngeal carcinoma. The outcome from the tissues close to carcinoma by different distance could do help to the determination of incisal edge in surgery abstractly.