Effect of Electroacupuncture on Reperfusion Ventricular Arrhythmia in Rat

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 26; no. 3; pp. 269 - 271
• Main Author: 曾青 李熳 欧阳兴飚 农艺 刘晓春 施静 关新民
• Format: Journal Article
• Language: English
• Published: China Department of Neurobiology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030 2006
• Subjects: Acupuncture Points; Animals; Electroacupuncture; Female; Male; Myocardial Ischemia - complications; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - therapy; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular - etiology; Tachycardia, Ventricular - therapy; Treatment Outcome; Ventricular Fibrillation - etiology; Ventricular Fibrillation - therapy; 心室疾病; 心律不齐; 灌注治疗; 电针治疗; acute myocardial ischemia; ventricular arrhythmia; electroacupuncture; β-adrenoceptors; M-cholinergic receptor
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/bf02829547

Protective effect and mechanism of electroacupuncture （EA） on acute reperfusion ventricular arrhthmia was investigated. Ventricular arrhythmia was induced by occlusion of the proximal left anterior descend （LAD） branch of coronary artery for 5 min and followed with 15 min reperfusion . EA on acupoint ＂Neiguan＂, ＂Jianshi＂ was performed at 30 min before ligation and continued another 5 min during ischemia. Isoprenaline （20, 30 and 50 μg/kg） or atropine （1 mg/ kg） was intravenously injected at 5min before ischemia. The results showed that EA significantly decreased the incidence of ischemia/reperfusion （I/R） induced ventricular tachycardia （VT）, ventricular fibrillation （VF） and mortality as compared to I/R group. Atropine partially suppressed the EA＇s effect of antiarrhythmia; Isoprenaline increased the incidence and severity of reperfusion arrhythmia, which was inhibited by EA, but this inhibition of EA was blocked with increasing dose of isoprenaline. The results indicated that EA treatment could prevent the occurrence of reperfusion ventricular arrhythmia in rats with myocardial ischemia, and its mechanism might be related to the regulation of EA on the β-adrenoceptors and M-cholinergic receptor activation in myocardium.