In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field
The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through...
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| Published in | Chinese physics letters Vol. 31; no. 2; pp. 78 - 82 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
01.02.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0256-307X 1741-3540 |
| DOI | 10.1088/0256-307X/31/2/024701 |
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| Summary: | The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity. |
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| Bibliography: | 11-1959/O4 The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity. LI Xiao-qiang, ZHENG Lu, WANG Xu-Fei（1 Institute of Modern Physics, Pudan University, Shanghai 200433 2Department of Physics, Fudan University, Shanghai 200433 a Applied Ion Beam Physics Laboratory, Fudan University, Shanghai 200433） ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0256-307X 1741-3540 |
| DOI: | 10.1088/0256-307X/31/2/024701 |