In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field

• Published in: Chinese physics letters Vol. 31; no. 2; pp. 78 - 82
• Main Author: 李晓强 郑路 王旭飞
• Format: Journal Article
• Language: English
• Published: 01.02.2014
• Subjects: Blood; Ferromagnetism; Interstitials; Modelling; Seeds; Surgical implants; Torso; 体内; 均匀场; 定位; 梯度场; 磁化; 离体; 种子; 间质
• ISSN: 0256-307X; 1741-3540
• DOI: 10.1088/0256-307X/31/2/024701

The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferro- magnetic implants, magnetized in an ex vivo uniform field, is evaluated by a modelling analysis. A simplified 3D model analogous to a torso size, with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow, is used to evaluate the magnetic particle capturing efficiency by the seed, which is magnetized in a uniform field. The initial modelling results indicate that for 1-10μm iron oxide particles transporting with a blood flow of 0.5-5 mm/s, the seeds of tungsten steel, magnet steel and cast cobalt all present an effective particle capturing efficiency, which shows a fast initial increase and a slow saturation with the increasing magnetic field, a quasilinear increase with the increasing particle size, and a nonlinear decrease with the increasing blood velocity.