Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies - YAMAZAKI, Hiroshi; KUNIKANE, Eriko; CHIBA, Koji; NISHIYAMA, Sayako; MURAYAMA, Norie; IKEDA, Toshihiko; SUGIYAMA, Yuichi; SHIMIZU, Makiko (RADIOISOTOPES, 2015)
Keywords: allometric scaling; PBPK modeling; percent kg/g method; species difference