Conquering Overtreatment of DCIS: Lessons from PRECISION

As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to un...

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Published inCancer discovery Vol. 15; no. 1; pp. 28 - 33
Main Authors Bhattacharjee, Proteeti, Lips, Esther H., Sawyer, Elinor J., Hwang, E. Shelley, Thompson, Alastair M., Wesseling, Jelle, Behbod, Fariba, Collyar, Deborah, Davies, Helen, Futreal, Andrew, Jonkers, Jos, Navin, Nicholas, Nik-Zainal, Serena, Pinto, Donna, Rea, Daniel, Schmidt, Marjanka, Stobart, Hilary, Thompson, Alastair, van Oirsouw, Marja, van Rheenen, Jacco, Verschuur, Ellen, Wessels, Lodewyk F.A.
Format Journal Article
LanguageEnglish
Published United States 13.01.2025
Subjects
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Carcinoma, Intraductal, Noninfiltrating - diagnosis
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - therapy
Female
Humans
Medical Overuse - prevention & control
Overtreatment
Precision Medicine
Online AccessGet full text
ISSN2159-8274
2159-8290
2159-8290
DOI10.1158/2159-8290.CD-24-1201

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Abstract As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Goodwin et al., p. 34
AbstractList As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Goodwin et al., p. 34
As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Goodwin et al., p. 34.
As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Goodwin et al., p. 34.As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Goodwin et al., p. 34.
Author Thompson, Alastair M.
Futreal, Andrew
Stobart, Hilary
Bhattacharjee, Proteeti
Schmidt, Marjanka
Collyar, Deborah
Davies, Helen
van Rheenen, Jacco
Wesseling, Jelle
Verschuur, Ellen
Pinto, Donna
Behbod, Fariba
Jonkers, Jos
Navin, Nicholas
Wessels, Lodewyk F.A.
van Oirsouw, Marja
Rea, Daniel
Hwang, E. Shelley
Lips, Esther H.
Thompson, Alastair
Sawyer, Elinor J.
Nik-Zainal, Serena
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SubjectTerms Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Carcinoma, Intraductal, Noninfiltrating - diagnosis
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - therapy
Female
Humans
Medical Overuse - prevention & control
Overtreatment
Precision Medicine
Title Conquering Overtreatment of DCIS: Lessons from PRECISION
URI https://www.ncbi.nlm.nih.gov/pubmed/39801240
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