An Unusual Case of Acquired AGK-BRAF Gene Fusion in Metastatic EGFR-mutant Lung Adenocarcinoma: A Case Report

Abstract This case report describes a 60-year-old male patient initially diagnosed with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 21 L858R mutation who subsequently developed a rare acquired AGK-BRAF fusion during the course of treatment. This case high...

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Published inJournal of cancer research and practice Vol. 12; no. 1; pp. 20 - 23
Main Authors Chang, Ching-Cheng, Hsieh, Min-Shu, Hsu, Wei-Hsun
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow 2025
Medknow Publications and Media Pvt. Ltd
Edition2
Subjects
Adenocarcinoma
Antimitotic agents
Antineoplastic agents
Case Report
Epidermal growth factor
Genetic aspects
Health aspects
Medical colleges
Taiwan
nonsmall cell lung cancer
epidermal growth factor receptor-mutant
AGK-BRAF fusion
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ISSN2589-0425
2311-3006
2311-3006
DOI10.4103/ejcrp.eJCRP-D-24-00023

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Summary:Abstract This case report describes a 60-year-old male patient initially diagnosed with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 21 L858R mutation who subsequently developed a rare acquired AGK-BRAF fusion during the course of treatment. This case highlights the complexity of managing EGFR-mutant lung cancer with additional acquired genetic alterations, the potential role of these alterations in treatment resistance, and the importance of comprehensive genomic profiling in guiding personalized treatment strategies.
ISSN:2589-0425
2311-3006
2311-3006
DOI:10.4103/ejcrp.eJCRP-D-24-00023