Exploration of efficacy and bleeding with combined phosphoinositide 3‐kinase β inhibition and aspirin in man - Nylander, S.; Wågberg, F.; Andersson, M.; Skärby, T.; Gustafsson, D. (Journal of thrombosis and haemostasis, 2015)
Keywords: acetylsalicylic acid; Adenosine - administration & dosage; Adenosine - adverse effects; Adenosine - analogs & derivatives; Adult; Animals; antiplatelet agents; Aspirin - administration & dosage; Aspirin - adverse effects; bleeding; Blood Platelets - drug effects; Blood Platelets - enzymology; Cross-Over Studies; Cyclooxygenase 1 - blood; Cyclooxygenase Inhibitors - administration & dosage; Cyclooxygenase Inhibitors - adverse effects; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hemorrhage - chemically induced; Humans; Male; Models, Animal; ortho-Aminobenzoates - administration & dosage; ortho-Aminobenzoates - adverse effects; ortho-Aminobenzoates - pharmacokinetics; P2Y12 receptor antagonists; Phosphatidylinositol 3-Kinase - antagonists & inhibitors; Phosphatidylinositol 3-Kinase - blood; PI 3‐kinase; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Function Tests; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - adverse effects; Protein Kinase Inhibitors - pharmacokinetics; Purinergic P2Y Receptor Antagonists - administration & dosage; Purinergic P2Y Receptor Antagonists - adverse effects; Pyrimidinones - administration & dosage; Pyrimidinones - adverse effects; Pyrimidinones - pharmacokinetics; Receptors, Purinergic P2Y12 - blood; Receptors, Purinergic P2Y12 - drug effects; Sweden; Young Adult; Sweden; PI 3-kinase; antiplatelet agents; P2Y12 receptor antagonists; bleeding; acetylsalicylic acid