Ketogenic Diet Modulates Gut Microbiota–Brain Metabolite Axis in a Sex‐ and Genotype‐Specific Manner in APOE4 Mice - Ivanich, Kira; Yackzan, Andrew; Flemister, Abeoseh; Chang, Ya‐Hsuan; Xing, Xin; Chen, Anna; Yanckello, Lucille M.; Sun, McKenna; Aware, Chetan; Govindarajan, Maalavika; Kramer, Skyler; Ericsson, Aaron; et al. (Journal of neurochemistry, 2025)
Keywords: Alzheimer's disease; Animals; Apolipoprotein E3 - genetics; Apolipoprotein E4; Apolipoprotein E4 - genetics; apolipoprotein ε4; Asymptomatic; Biomarkers; Brain; Brain - metabolism; Diet; Diet, Ketogenic - methods; Female; Females; Gastrointestinal Microbiome - physiology; Genotype; Genotypes; gut microbiome; Gut microbiota; High fat diet; Homeostasis; Intestinal microflora; Ketogenesis; ketogenic diet; key brain metabolite levels; Lipid metabolism; Lipids; Low carbohydrate diet; Male; Metabolic response; Metabolism; Metabolites; Metabolomics; Metagenomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbiomes; Microbiota; Microorganisms; Neurodegenerative diseases; Neuromodulation; Neuroprotection; precision nutrition; Risk factors; Sex; Sex Characteristics; gut microbiome; ketogenic diet; Alzheimer's disease; key brain metabolite levels; precision nutrition; apolipoprotein ε4