18 F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis

The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in atherosclerotic disease, and may give insight into plaque stability. The aim of this...

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Published in	European journal of vascular and endovascular surgery Vol. 56; no. 2; pp. 172 - 179
Main Authors	Chowdhury, Mohammed M., Tarkin, Jason M., Evans, Nicholas R., Le, Elizabeth, Warburton, Elizabeth A., Hayes, Paul D., Rudd, James H.F., Coughlin, Patrick A.
Format	Journal Article
Language	English
Published	England 01.08.2018
Subjects	Aged Asymptomatic Diseases Carotid Arteries - diagnostic imaging Carotid Artery Diseases - complications Carotid Artery Diseases - diagnostic imaging Chi-Square Distribution Female Fluorodeoxyglucose F18 - administration & dosage Humans Male Plaque, Atherosclerotic Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Radiopharmaceuticals - administration & dosage Peripheral arterial disease Microcalcification Inflammation Positron emission tomography
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ISSN	1078-5884 1532-2165
DOI	10.1016/j.ejvs.2018.03.028

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Abstract	The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in atherosclerotic disease, and may give insight into plaque stability. The aim of this review was to perform a meta-analysis of PET/CT with F-FDG (fluorodeoxyglucose) uptake in symptomatic and asymptomatic carotid artery disease. This was a systematic review, following PRISMA guidelines, which interrogated the MEDLINE database from January 2001 to May 2017. The search combined the terms, "inflammation", "FDG", and "stroke". The search criteria included all types of studies, with a primary outcome of the degree of arterial vascular inflammation determined by F-FDG uptake. Analysis involved an inverse weighted variance estimate of pooled data, using a random effects model. A total of 14 articles (539 patients) were included in the meta-analysis. Comparing carotid artery F-FDG uptake in symptomatic versus asymptomatic disease yielded a standard mean difference of 0.94 (95% CI 0.58-1.130; p < .0001; I = 65%). PET/CT using F-FDG can demonstrate carotid plaque inflammation, and is a marker of symptomatic disease. Further studies are required to understand the clinical implication of PET/CT as a risk prediction tool.
AbstractList	The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in atherosclerotic disease, and may give insight into plaque stability. The aim of this review was to perform a meta-analysis of PET/CT with F-FDG (fluorodeoxyglucose) uptake in symptomatic and asymptomatic carotid artery disease. This was a systematic review, following PRISMA guidelines, which interrogated the MEDLINE database from January 2001 to May 2017. The search combined the terms, "inflammation", "FDG", and "stroke". The search criteria included all types of studies, with a primary outcome of the degree of arterial vascular inflammation determined by F-FDG uptake. Analysis involved an inverse weighted variance estimate of pooled data, using a random effects model. A total of 14 articles (539 patients) were included in the meta-analysis. Comparing carotid artery F-FDG uptake in symptomatic versus asymptomatic disease yielded a standard mean difference of 0.94 (95% CI 0.58-1.130; p < .0001; I = 65%). PET/CT using F-FDG can demonstrate carotid plaque inflammation, and is a marker of symptomatic disease. Further studies are required to understand the clinical implication of PET/CT as a risk prediction tool.
Author	Tarkin, Jason M. Rudd, James H.F. Coughlin, Patrick A. Evans, Nicholas R. Hayes, Paul D. Warburton, Elizabeth A. Chowdhury, Mohammed M. Le, Elizabeth
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Keywords	Peripheral arterial disease Microcalcification Inflammation Positron emission tomography
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Snippet	The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can...
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SubjectTerms	Aged Asymptomatic Diseases Carotid Arteries - diagnostic imaging Carotid Artery Diseases - complications Carotid Artery Diseases - diagnostic imaging Chi-Square Distribution Female Fluorodeoxyglucose F18 - administration & dosage Humans Male Plaque, Atherosclerotic Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Radiopharmaceuticals - administration & dosage
Title	18 F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis
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