Evaluation of the microenvironment formed by interferon-β
Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenviron...
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| Published in | Frontiers in chemical biology Vol. 3 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
21.01.2025
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| ISSN | 2813-530X 2813-530X |
| DOI | 10.3389/fchbi.2024.1425571 |
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| Abstract | Heterogeneity in the cellular microenvironment
in vivo
affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenvironment is also featured by cytokines released from cells, significantly regulating immune cell function. However, the overall understanding, at single-cell resolution, of how cytokines shape the microenvironment and promote paracrine signaling remains unclear. In this manuscript, we propose a methodology that addresses both the microenvironment itself and the response to the microenvironment to comprehend microenvironment behavior at the single-cell level. Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression. |
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| AbstractList | Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenvironment is also featured by cytokines released from cells, significantly regulating immune cell function. However, the overall understanding, at single-cell resolution, of how cytokines shape the microenvironment and promote paracrine signaling remains unclear. In this manuscript, we propose a methodology that addresses both the microenvironment itself and the response to the microenvironment to comprehend microenvironment behavior at the single-cell level. Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression. Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenvironment is also featured by cytokines released from cells, significantly regulating immune cell function. However, the overall understanding, at single-cell resolution, of how cytokines shape the microenvironment and promote paracrine signaling remains unclear. In this manuscript, we propose a methodology that addresses both the microenvironment itself and the response to the microenvironment to comprehend microenvironment behavior at the single-cell level. Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression. |
| Author | Harada, Yoshie Hori, Yutaka Peng, Yu Suzuki, Nobutake Shirasaki, Yoshitaka Yamagishi, Mai Ohara, Osamu Funatsu, Takashi |
| Author_xml | – sequence: 1 givenname: Mai surname: Yamagishi fullname: Yamagishi, Mai – sequence: 2 givenname: Yutaka surname: Hori fullname: Hori, Yutaka – sequence: 3 givenname: Nobutake surname: Suzuki fullname: Suzuki, Nobutake – sequence: 4 givenname: Yu surname: Peng fullname: Peng, Yu – sequence: 5 givenname: Yoshie surname: Harada fullname: Harada, Yoshie – sequence: 6 givenname: Takashi surname: Funatsu fullname: Funatsu, Takashi – sequence: 7 givenname: Osamu surname: Ohara fullname: Ohara, Osamu – sequence: 8 givenname: Yoshitaka surname: Shirasaki fullname: Shirasaki, Yoshitaka |
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in vivo
affects the variability of reactivity among immune cells. Individual-specific microenvironmental... Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental... |
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| Title | Evaluation of the microenvironment formed by interferon-β |
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