Measuring disability progression in multiple sclerosis
The management of patients with relapsing-remitting multiple sclerosis is difficult for the treating physician due to the extremely variable clinical course of the disease, with widely differing rates of progression of disability observed between patients. The determinants of this variability are un...
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| Published in | Journal of neurology Vol. 253; no. S6; pp. vi31 - vi36 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Springer Nature B.V
01.11.2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0340-5354 1432-1459 |
| DOI | 10.1007/s00415-006-6006-7 |
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| Abstract | The management of patients with relapsing-remitting multiple sclerosis is difficult for the treating physician due to the extremely variable clinical course of the disease, with widely differing rates of progression of disability observed between patients. The determinants of this variability are unknown. Life table analysis provides a method to classify patients on the basis of initial disability scores into percentiles that define their probability of disease progression over a 10-year period. Using this method, a series of standardised disease progression curves have been generated by analysis of disability data in over one thousand subjects with multiple sclerosis, obtained from Sheba Medical Center, Tel-Hashomer, Israel, database. These curves show acceptable validity for predicting disease progression in individual patients. The comparison of individual patient data against these standardised disability progression curves provides a useful method to assess the risk of progression in individual patients and enables practising neurologists to use a valuable tool for making treatment decisions. |
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| AbstractList | The management of patients with relapsing-remitting multiple sclerosis is difficult for the treating physician due to the extremely variable clinical course of the disease, with widely differing rates of progression of disability observed between patients. The determinants of this variability are unknown. Life table analysis provides a method to classify patients on the basis of initial disability scores into percentiles that define their probability of disease progression over a 10-year period. Using this method, a series of standardised disease progression curves have been generated by analysis of disability data in over one thousand subjects with multiple sclerosis, obtained from Sheba Medical Center, Tel-Hashomer, Israel, database. These curves show acceptable validity for predicting disease progression in individual patients. The comparison of individual patient data against these standardised disability progression curves provides a useful method to assess the risk of progression in individual patients and enables practising neurologists to use a valuable tool for making treatment decisions. |
| Author | Achiron, Anat |
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| Cites_doi | 10.1097/00019052-200006000-00004 10.1191/1352458503ms945oa 10.1191/135248506ms1244oa 10.1212/WNL.56.10.1324 10.1016/S0140-6736(98)03053-0 10.1016/j.jns.2005.07.016 10.1212/WNL.40.6.971 10.1093/brain/122.5.871 10.1001/archneur.1993.00540030065016 10.1212/WNL.33.11.1444 10.1093/brain/112.1.133 10.1016/j.clineuro.2005.11.018 10.1016/S1474-4422(05)70166-6 10.1007/s00415-004-1510-0 |
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