Clinical Studies on the Relation between Nonspecific Immunological Parameters and Pre-and Post-operative Immunological Activity in Colorectal Cancer Patients
Peripheral blood lymphocytes, T cell subsets (percentages of OKT 3 cells, OKT4 cells, OKT 8 cells and IgG-Fc receptor positive T (FcR(+)T) cells), OKT 4/OKT 8 ratio, PHA and Con A-induced lymphoblastogenesis (stimulation index) and PPD skin test were examined at the pre-and post-operative stage (PO...
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| Published in | Nippon Daicho Komonbyo Gakkai Zasshi Vol. 41; no. 3; pp. 258 - 266 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
The Japan Society of Coloproctology
1988
|
| Online Access | Get full text |
| ISSN | 0047-1801 1882-9619 1882-9619 |
| DOI | 10.3862/jcoloproctology.41.258 |
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| Abstract | Peripheral blood lymphocytes, T cell subsets (percentages of OKT 3 cells, OKT4 cells, OKT 8 cells and IgG-Fc receptor positive T (FcR(+)T) cells), OKT 4/OKT 8 ratio, PHA and Con A-induced lymphoblastogenesis (stimulation index) and PPD skin test were examined at the pre-and post-operative stage (PO 2W, 1M, 3M, 6M) in 51 colorectal cancer patients and were analyzed according to the various stages of cancer. On the basis of correlations among these parameters, pre-and post-operative nonspecific immunological activity was discussed. In the pre-operative period in more advanced cases, increase of OKT 8 and reduction of OKT 4/OKT 8 ratio, PHA and Con A-induced lymphoblastogenesis and PPD skin test were observed in comparison with the other cases. In patients given curative resection for rectal cancer, decrease of lymphocytes and reduction of PHA and Con A-induced lymphoblastogenesis and PPD skin test were observed at PO 2 W, and these recovered 3 M later. On the other hand, in patients with non curative resection, these parameters were reduced at PO 3 M and 6 M. It is suggested from these results that the above parameters are useful for the assessment of immunological activity in colorectal cancer patients. |
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| AbstractList | Peripheral blood lymphocytes, T cell subsets (percentages of OKT 3 cells, OKT4 cells, OKT 8 cells and IgG-Fc receptor positive T (FcR(+)T) cells), OKT 4/OKT 8 ratio, PHA and Con A-induced lymphoblastogenesis (stimulation index) and PPD skin test were examined at the pre-and post-operative stage (PO 2W, 1M, 3M, 6M) in 51 colorectal cancer patients and were analyzed according to the various stages of cancer. On the basis of correlations among these parameters, pre-and post-operative nonspecific immunological activity was discussed. In the pre-operative period in more advanced cases, increase of OKT 8 and reduction of OKT 4/OKT 8 ratio, PHA and Con A-induced lymphoblastogenesis and PPD skin test were observed in comparison with the other cases. In patients given curative resection for rectal cancer, decrease of lymphocytes and reduction of PHA and Con A-induced lymphoblastogenesis and PPD skin test were observed at PO 2 W, and these recovered 3 M later. On the other hand, in patients with non curative resection, these parameters were reduced at PO 3 M and 6 M. It is suggested from these results that the above parameters are useful for the assessment of immunological activity in colorectal cancer patients. |
| Author | Kobayashi, K. Yasushi, T. Kuwabara, T. Watanabe, M. Yanagita, K. Honda, R. Nagasawa, N. Yoshio, T. |
| Author_xml | – sequence: 1 fullname: Yanagita, K. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Nagasawa, N. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Yasushi, T. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Yoshio, T. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Kuwabara, T. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Honda, R. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Kobayashi, K. organization: The First Department of Surgery, School of Medicine, Toho University – sequence: 1 fullname: Watanabe, M. organization: The First Department of Surgery, School of Medicine, Toho University |
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| References | 13) 横田美登志,原田大,渡部誠一郎ほか:胃癌患者末梢血および所属リンパ節リンパ球がはたす抗腫瘍的役割.臨免疫18:953-962, 1986 12) 黒須康彦,萩野教幸,天野定雄ほか:消化器癌における末梢血および癌所属リンパ節リンパ球の癌選択的幼若化能について.日消外会誌19:872-875, 1986 2) 平良朝秀:胃がん患者における各種非特異的免疫学的パラメーターの総合的検討.日臨外医会誌 45:689-705, 1984 7) 渡会伸治,西山潔,国松尚一ほか:胃癌患者末稍血中のT-cell亜群. 日本臨床免疫会誌 8:329-335, 1985 29) Reinherz EL, Moretta L, Roper M et al.: Human T lynphocyte subpopulations defined by, Fc receptors and monoclonal antibodies. J Exp Med 151: 969-974, 1980 26) Currie GA, Basham C: Serum mediated inhibition of the patient to his own tumor : A possible role for circulating antigen. Br J Cancer 26 : 427-437, 1972 27) 花上 仁,野本信之助,吉崎總:癌免疫療法における免疫学的パラメーターと予後について.日消外会誌 16:1374-1379, 1983 24) Unger SW, Bernhard MI, Pace RC et al: Monocyte dysfunction in human cancer. Cancer 51: 669-674, 1983 25) Tsakraklides V, Wanebo HJ, Sternberg SS, et al. : Prognostic evaluation of regional lymph node morphology in colorectal cancer. Am J Surg 129: 174-180, 1975 1) 大屋正章:胃がん患者の各種皮膚反応に関する臨床的研究.第2編胃がん患者におりる皮膚反応とその他の免疫学的パラメーターの相関関係. 日外会誌 79:554-564, 1978 15) 小川智子,小川健治,矢川裕一ほか: 胃癌患者におけるSu-Ps皮膚反応,Su-PR皮膚反応について.日臨外医会誌48: 766-770, 1987 5) 江里口直文,内藤寿則,友清明ほか:胃癌症例におけるリンパ球Subpopulationの分析.日消外会誌 18:36-42,1985 20) 藤本秀江,遠藤栄子,安田広康ほか: フローサイトメーターによる健常人リンパ球サブポピュレーションの検討. 臨病理 33:1377-1385, 1985 16) 竹下正昭,大和田進,中村正治:胃癌患者の免疫能―特にリンパ球サブセットとインターロィキン2からの検討―.日外会誌 88:947-954, 1987 37) 峠啓哉,山田博文,世戸芳博ほか:OK-432経口投与による大腸癌所属リンパ節の免疫活性の賦活.日本臨床免疫会誌 10:19-23, 1987 14) 秀島輝,神代龍之介,蒲池寿ほか:末梢血リンパ球サブセットの変動からみた胃癌手術における脾臓合併切除の生体免疫機能に与える影響.癌と化療 14(PertI):1268-1273, 1987 11) 野本亀久雄,鶴純明,栗根康行ほか:胃癌術後免疫化学療法に伴う血清非特異的抑制因子の推移.癌と化療13 (Part I): 458-463, 1986 21) 新保敏和,矢田純一,中川俊郎ほか:ヒト IgG・Fc receptor陽性リンパ球の検出法と各種疾患における変動.臨免疫 9:141-145, 1977 23) Robinson JC : Assays of immunocompetence in the staging and prognosis of cancer. Surg Gynecol Obstet 153 : 909-921, 1981 35) 今井浩三,小林壮光,谷内昭:悪性腫瘍の免疫療法.臨免疫18:407-413, 1986 4) 竹腰知治,佐治薫豊,木田恒ほか:胃癌患者における各種非特異的免疫パラメーター術前値と手術根治性および遠隔成績との関係.日外会誌 85:1528-1536, 1984 6) 江里口直文,内藤寿則,鍬先清一郎ほか:胃癌患者における免疫学的指標の検討.日消外会誌 18:918-921,1985 34) 山内晶司,津荷龍生,市橋秀仁ほか:胃癌非治癒切除例における術後免疫能の低下と対策.消外 9:1895-1899, 1986 30) 棚田 稔:がん患者における免疫抑制機序に関する臨床的研究. 日外会誌 86:514-526, 1985 38) 春日正己,咲田雅一,土井正樹ほか:OK-432に対する宿主反応性とその効果について, SU-PS反応を用いた検討―日消外会誌 17:1587-1594, 1984 3) 小川泰史:胃癌患者における非特異的免疫能に関する臨床的研究―リンパ球幼若化反応の評価と意義―.日臨外医会誌 45:1016-1033,1984 10) 板垣衛治:胃がん患者におけるIgG-Fcレセプター陽性T細胞の意義に関する基礎的並びに臨床的研究. 日外会誌 86:1405-1416, 1985 31) Constantian MB, Menzoian JO, Nimberg RB et al.: Association of a circulatin im munosuppressive polypeptide with operative and accidental trauma. Ann Surg 185: 73-79, 1977 22) Burnet FM : The evolution of bodily defence. Med J Aust 2: 817-821, 1963 36) 木村良子,土岐博信,岡部健一ほか:OK-432投与方法別免疫賦活能の検討―リンパ球幼若化反応による比較検討―癌と化療13:95-100, 1986 32) 菊地 秀:がん患者血清中の免疫抑制蛋白(IAP)に関する臨床的研究. 日外会誌85:283-299, 1984 33) 山内晶司,寺部啓介,殿村邦彦ほか:悪性腫瘍摘出あるいは放射線治療後,短期間で再発転移のみられた症例について.外科 42:473-476, 1980 19) 横山三男,大久保慶二:モノクローナル抗体によるリンパ球膜マーカーの検査とその臨床的意義. 日臨 43(秋季臨時増刊号):356-366, 1985 8) 佐藤元通, 酒井堅,青野幸治ほか:胃癌患者のリンパ球subsetsの検討. 日消外会誌 18:1645-1649, 1985 17) 寺島雅典,貝塚広史,佐藤雅夫ほか:胃癌切除症例の各種免疫学的指標の推移および免疫療法による変動.日消外会誌 20:2305-2312, 1987 28) Setcavage TM, Kim YB : Inhibition of the immune response by Fc receptor bound specific antibody on T lymphcytes. J Immunol 124:553-556, 1980 9) 品川長夫, 由良二郎, 宮池英夫ほか:手術侵襲による液性および細胞性免疫能の変動と術後感染症. 日外会誌86:1096-1098, 1985 18) 神保聖一,木原正明,高橋善和ほか:モノクローナル抗体を使用したリンパ球サブセット測定法(フローサイトメトリー)の基礎的検討.免疫と疾患 7:365-375, 1984 |
| References_xml | – reference: 7) 渡会伸治,西山潔,国松尚一ほか:胃癌患者末稍血中のT-cell亜群. 日本臨床免疫会誌 8:329-335, 1985 – reference: 20) 藤本秀江,遠藤栄子,安田広康ほか: フローサイトメーターによる健常人リンパ球サブポピュレーションの検討. 臨病理 33:1377-1385, 1985 – reference: 21) 新保敏和,矢田純一,中川俊郎ほか:ヒト IgG・Fc receptor陽性リンパ球の検出法と各種疾患における変動.臨免疫 9:141-145, 1977 – reference: 10) 板垣衛治:胃がん患者におけるIgG-Fcレセプター陽性T細胞の意義に関する基礎的並びに臨床的研究. 日外会誌 86:1405-1416, 1985 – reference: 31) Constantian MB, Menzoian JO, Nimberg RB et al.: Association of a circulatin im munosuppressive polypeptide with operative and accidental trauma. Ann Surg 185: 73-79, 1977 – reference: 3) 小川泰史:胃癌患者における非特異的免疫能に関する臨床的研究―リンパ球幼若化反応の評価と意義―.日臨外医会誌 45:1016-1033,1984 – reference: 36) 木村良子,土岐博信,岡部健一ほか:OK-432投与方法別免疫賦活能の検討―リンパ球幼若化反応による比較検討―癌と化療13:95-100, 1986 – reference: 25) Tsakraklides V, Wanebo HJ, Sternberg SS, et al. : Prognostic evaluation of regional lymph node morphology in colorectal cancer. Am J Surg 129: 174-180, 1975 – reference: 27) 花上 仁,野本信之助,吉崎總:癌免疫療法における免疫学的パラメーターと予後について.日消外会誌 16:1374-1379, 1983 – reference: 38) 春日正己,咲田雅一,土井正樹ほか:OK-432に対する宿主反応性とその効果について, SU-PS反応を用いた検討―日消外会誌 17:1587-1594, 1984 – reference: 12) 黒須康彦,萩野教幸,天野定雄ほか:消化器癌における末梢血および癌所属リンパ節リンパ球の癌選択的幼若化能について.日消外会誌19:872-875, 1986 – reference: 34) 山内晶司,津荷龍生,市橋秀仁ほか:胃癌非治癒切除例における術後免疫能の低下と対策.消外 9:1895-1899, 1986 – reference: 1) 大屋正章:胃がん患者の各種皮膚反応に関する臨床的研究.第2編胃がん患者におりる皮膚反応とその他の免疫学的パラメーターの相関関係. 日外会誌 79:554-564, 1978 – reference: 4) 竹腰知治,佐治薫豊,木田恒ほか:胃癌患者における各種非特異的免疫パラメーター術前値と手術根治性および遠隔成績との関係.日外会誌 85:1528-1536, 1984 – reference: 11) 野本亀久雄,鶴純明,栗根康行ほか:胃癌術後免疫化学療法に伴う血清非特異的抑制因子の推移.癌と化療13 (Part I): 458-463, 1986 – reference: 14) 秀島輝,神代龍之介,蒲池寿ほか:末梢血リンパ球サブセットの変動からみた胃癌手術における脾臓合併切除の生体免疫機能に与える影響.癌と化療 14(PertI):1268-1273, 1987 – reference: 5) 江里口直文,内藤寿則,友清明ほか:胃癌症例におけるリンパ球Subpopulationの分析.日消外会誌 18:36-42,1985 – reference: 16) 竹下正昭,大和田進,中村正治:胃癌患者の免疫能―特にリンパ球サブセットとインターロィキン2からの検討―.日外会誌 88:947-954, 1987 – reference: 29) Reinherz EL, Moretta L, Roper M et al.: Human T lynphocyte subpopulations defined by, Fc receptors and monoclonal antibodies. J Exp Med 151: 969-974, 1980 – reference: 33) 山内晶司,寺部啓介,殿村邦彦ほか:悪性腫瘍摘出あるいは放射線治療後,短期間で再発転移のみられた症例について.外科 42:473-476, 1980 – reference: 9) 品川長夫, 由良二郎, 宮池英夫ほか:手術侵襲による液性および細胞性免疫能の変動と術後感染症. 日外会誌86:1096-1098, 1985 – reference: 8) 佐藤元通, 酒井堅,青野幸治ほか:胃癌患者のリンパ球subsetsの検討. 日消外会誌 18:1645-1649, 1985 – reference: 17) 寺島雅典,貝塚広史,佐藤雅夫ほか:胃癌切除症例の各種免疫学的指標の推移および免疫療法による変動.日消外会誌 20:2305-2312, 1987 – reference: 35) 今井浩三,小林壮光,谷内昭:悪性腫瘍の免疫療法.臨免疫18:407-413, 1986 – reference: 18) 神保聖一,木原正明,高橋善和ほか:モノクローナル抗体を使用したリンパ球サブセット測定法(フローサイトメトリー)の基礎的検討.免疫と疾患 7:365-375, 1984 – reference: 19) 横山三男,大久保慶二:モノクローナル抗体によるリンパ球膜マーカーの検査とその臨床的意義. 日臨 43(秋季臨時増刊号):356-366, 1985 – reference: 13) 横田美登志,原田大,渡部誠一郎ほか:胃癌患者末梢血および所属リンパ節リンパ球がはたす抗腫瘍的役割.臨免疫18:953-962, 1986 – reference: 24) Unger SW, Bernhard MI, Pace RC et al: Monocyte dysfunction in human cancer. Cancer 51: 669-674, 1983 – reference: 32) 菊地 秀:がん患者血清中の免疫抑制蛋白(IAP)に関する臨床的研究. 日外会誌85:283-299, 1984 – reference: 15) 小川智子,小川健治,矢川裕一ほか: 胃癌患者におけるSu-Ps皮膚反応,Su-PR皮膚反応について.日臨外医会誌48: 766-770, 1987 – reference: 37) 峠啓哉,山田博文,世戸芳博ほか:OK-432経口投与による大腸癌所属リンパ節の免疫活性の賦活.日本臨床免疫会誌 10:19-23, 1987 – reference: 6) 江里口直文,内藤寿則,鍬先清一郎ほか:胃癌患者における免疫学的指標の検討.日消外会誌 18:918-921,1985 – reference: 26) Currie GA, Basham C: Serum mediated inhibition of the patient to his own tumor : A possible role for circulating antigen. Br J Cancer 26 : 427-437, 1972 – reference: 2) 平良朝秀:胃がん患者における各種非特異的免疫学的パラメーターの総合的検討.日臨外医会誌 45:689-705, 1984 – reference: 28) Setcavage TM, Kim YB : Inhibition of the immune response by Fc receptor bound specific antibody on T lymphcytes. J Immunol 124:553-556, 1980 – reference: 30) 棚田 稔:がん患者における免疫抑制機序に関する臨床的研究. 日外会誌 86:514-526, 1985 – reference: 22) Burnet FM : The evolution of bodily defence. Med J Aust 2: 817-821, 1963 – reference: 23) Robinson JC : Assays of immunocompetence in the staging and prognosis of cancer. Surg Gynecol Obstet 153 : 909-921, 1981 |
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| Title | Clinical Studies on the Relation between Nonspecific Immunological Parameters and Pre-and Post-operative Immunological Activity in Colorectal Cancer Patients |
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| ispartofPNX | Nippon Daicho Komonbyo Gakkai Zasshi, 1988, Vol.41(3), pp.258-266 |
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