Effect of transforming growth factor- β1 on interleukin-6 secretion in human myoblasts
Transforming growth factor- β (TGF- β) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts se...
Saved in:
| Published in | Journal of neuroimmunology Vol. 87; no. 1; pp. 185 - 188 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.07.1998
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0165-5728 1872-8421 |
| DOI | 10.1016/S0165-5728(98)00110-6 |
Cover
| Abstract | Transforming growth factor-
β (TGF-
β) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1
β (IL-1
β) or tumor necrosis factor
α. In the present report, we show that TGF-
β1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF-
β1 increases IL-1
β effect, while a longer incubation inhibits its action. |
|---|---|
| AbstractList | Transforming growth factor-
β (TGF-
β) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1
β (IL-1
β) or tumor necrosis factor
α. In the present report, we show that TGF-
β1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF-
β1 increases IL-1
β effect, while a longer incubation inhibits its action. |
| Author | Scuderi, Flavia Mistretta, Guido Provenzano, Carlo Mazzarelli, Paola Bartoccioni, Emanuela |
| Author_xml | – sequence: 1 givenname: Paola surname: Mazzarelli fullname: Mazzarelli, Paola – sequence: 2 givenname: Flavia surname: Scuderi fullname: Scuderi, Flavia – sequence: 3 givenname: Guido surname: Mistretta fullname: Mistretta, Guido – sequence: 4 givenname: Carlo surname: Provenzano fullname: Provenzano, Carlo – sequence: 5 givenname: Emanuela surname: Bartoccioni fullname: Bartoccioni, Emanuela |
| BookMark | eNqFkM1KAzEUhYNUsFYfQchSF6NJ5i_BhUipP1BwoeIyZDI3bXSaSJIqfS0fxGdy2ooLN93cC5dzDvd8h2jgvAOETig5p4RWF4_9KLOyZvxU8DNCKCVZtYeGlNcs4wWjAzT8kxygwxhfe1GZF2KIXibGgE7YG5yCctH4sLBuhmfBf6Y5NkonHzL8_UWxd9i6BKGD5Zt1WYUj6ADJbu54vlwohxcr33QqpniE9o3qIhz_7hF6vpk8je-y6cPt_fh6mmnGWMpYy1ujSV3TXGuj61I0UFHOtACjVKkK0E3_qGGEN2XBGyOqgkMhdK4bEKrOR-hym6uDjzGAkdomtX6qr2M7SYlcM5IbRnINQAouN4xk1bvLf-73YBcqrHb6rrY-6Kt9WAgyagtOQ2tDT1O23u5I-AHbyIMT |
| CitedBy_id | crossref_primary_10_1016_j_cyto_2006_05_009 crossref_primary_10_1152_ajpendo_00560_2003 crossref_primary_10_3390_ijms241411656 crossref_primary_10_1016_S0165_5728_02_00399_5 crossref_primary_10_1016_j_jneuroim_2006_03_026 crossref_primary_10_1093_ndt_gfq036 crossref_primary_10_1152_ajpregu_00164_2003 crossref_primary_10_1038_gt_2010_124 crossref_primary_10_1038_sj_onc_1206478 crossref_primary_10_1186_s11658_023_00429_w crossref_primary_10_1074_jbc_274_18_12933 crossref_primary_10_1016_S0165_5728_01_00287_9 crossref_primary_10_1016_j_neulet_2010_01_054 crossref_primary_10_1016_S1043_4666_03_00253_9 |
| Cites_doi | 10.4049/jimmunol.153.11.5210 10.1084/jem.171.1.231 10.4049/jimmunol.158.6.2704 10.1038/334260a0 10.1159/000236328 10.1073/pnas.78.9.5623 10.1002/art.1780400514 10.1182/blood.V87.5.1928.1928 10.1172/JCI118779 10.1016/0167-5699(94)90006-X 10.1016/S1074-7613(00)80334-9 10.1002/eji.1830241242 10.1016/0165-2478(94)90076-0 10.1006/cyto.1995.0008 10.1097/00005072-199705000-00003 10.1016/S0165-5728(97)00049-0 10.1016/S0167-5699(97)01103-1 10.1093/intimm/10.3.267 10.1016/0165-5728(95)00136-0 |
| ContentType | Journal Article |
| Copyright | 1998 Elsevier Science B.V. |
| Copyright_xml | – notice: 1998 Elsevier Science B.V. |
| DBID | AAYXX CITATION |
| DOI | 10.1016/S0165-5728(98)00110-6 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-8421 |
| EndPage | 188 |
| ExternalDocumentID | 10_1016_S0165_5728_98_00110_6 S0165572898001106 |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 4.4 457 4CK 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXLA AAXUO ABBQC ABCQJ ABFNM ABFRF ABIVO ABJNI ABLVK ABMAC ABMZM ABTEW ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFKWA AFRHN AFTJW AFXIZ AGEKW AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK AKRLJ ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CJTIS CNWQP CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDW HMG HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LCYCR LUGTX LX8 M29 M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SIN SNS SPCBC SSH SSI SSN SSZ T5K UNMZH WUQ XJT Z5R ZA5 ZGI ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACIEU ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD |
| ID | FETCH-LOGICAL-c222t-2d8dfc07713ccfc759be6182c9efaa5a4ecb534f208b548bf9648e49c3cbe9a73 |
| IEDL.DBID | AIKHN |
| ISSN | 0165-5728 |
| IngestDate | Thu Apr 24 23:02:34 EDT 2025 Wed Oct 29 07:45:02 EDT 2025 Fri Feb 23 02:22:48 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Inflammatory myopathies Interleukin-1 β (IL-1 β) Interleukin-6 (IL-6) Gene therapy Transforming growth factor beta (TGF- β) Myoblasts |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c222t-2d8dfc07713ccfc759be6182c9efaa5a4ecb534f208b548bf9648e49c3cbe9a73 |
| PageCount | 4 |
| ParticipantIDs | crossref_citationtrail_10_1016_S0165_5728_98_00110_6 crossref_primary_10_1016_S0165_5728_98_00110_6 elsevier_sciencedirect_doi_10_1016_S0165_5728_98_00110_6 |
| PublicationCentury | 1900 |
| PublicationDate | 1998-07-01 |
| PublicationDateYYYYMMDD | 1998-07-01 |
| PublicationDate_xml | – month: 07 year: 1998 text: 1998-07-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationTitle | Journal of neuroimmunology |
| PublicationYear | 1998 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Lundberg, Ulfgren, Nyberg, Andersson, Klareskog (BIB12) 1997; 40 Chen, Manning (BIB5) 1996; 8 Allen, Manthey, Hand, Ohura, Ellingsworth, Wahl (BIB1) 1990; 171 Benveniste, Kwon, Chung, Sampson, Pandya, Ping Tang (BIB3) 1994; 153 Wang, He, Qiao, Link (BIB20) 1995; 63 Romano, Sironi, Toniatti, Polentarutti, Fruscella, Ghezzi, Faggioni, Luini, van Hinsbergh, Sozzani, Bussolino, Poli, Ciliberto, Mantovani (BIB15) 1997; 6 Urashima, Ogata, Chauhan, Hatziyanni, Vidriales, Dedera, Schlossman, Anderson (BIB19) 1996; 87 Tilg, Dinarello, Mier (BIB17) 1997; 18 Bartoccioni, Michaelis, Hohlfeld (BIB2) 1994; 42 Hohlfeld, Engel (BIB10) 1994; 15 Confalonieri, Bernasconi, Cornelio, Mantegazza (BIB6) 1997; 56 Fukaura, Kent, Pietrusewicz, Khoury, Weiner, Hafler (BIB8) 1996; 98 Fontana, Constam, Frei, Malipiero, Pfister (BIB7) 1992; 99 Gallucci, Provenzano, Mazzarelli, Scuderi, Bartoccioni (BIB9) 1998; 10 Michaelis, Goebels, Hohlfeld (BIB13) 1993; 143 Wyss-Coray, Borrow, Brooker, Mucke (BIB21) 1997; 77 Kuppner, McKillop-Smith, Forrester (BIB11) 1995; 84 Tsunawaki, Sporn, Ding, Nathan (BIB18) 1988; 334 Schluns, Cook, Le (BIB16) 1997; 158 Blau, Webster (BIB4) 1981; 78 Muzio, Sironi, Polentarutti, Mantovani, Colotta (BIB14) 1994; 24 Wyss-Coray (10.1016/S0165-5728(98)00110-6_BIB21) 1997; 77 Lundberg (10.1016/S0165-5728(98)00110-6_BIB12) 1997; 40 Schluns (10.1016/S0165-5728(98)00110-6_BIB16) 1997; 158 Gallucci (10.1016/S0165-5728(98)00110-6_BIB9) 1998; 10 Tsunawaki (10.1016/S0165-5728(98)00110-6_BIB18) 1988; 334 Hohlfeld (10.1016/S0165-5728(98)00110-6_BIB10) 1994; 15 Michaelis (10.1016/S0165-5728(98)00110-6_BIB13) 1993; 143 Wang (10.1016/S0165-5728(98)00110-6_BIB20) 1995; 63 Blau (10.1016/S0165-5728(98)00110-6_BIB4) 1981; 78 Allen (10.1016/S0165-5728(98)00110-6_BIB1) 1990; 171 Benveniste (10.1016/S0165-5728(98)00110-6_BIB3) 1994; 153 Kuppner (10.1016/S0165-5728(98)00110-6_BIB11) 1995; 84 Urashima (10.1016/S0165-5728(98)00110-6_BIB19) 1996; 87 Muzio (10.1016/S0165-5728(98)00110-6_BIB14) 1994; 24 Confalonieri (10.1016/S0165-5728(98)00110-6_BIB6) 1997; 56 Chen (10.1016/S0165-5728(98)00110-6_BIB5) 1996; 8 Bartoccioni (10.1016/S0165-5728(98)00110-6_BIB2) 1994; 42 Romano (10.1016/S0165-5728(98)00110-6_BIB15) 1997; 6 Fontana (10.1016/S0165-5728(98)00110-6_BIB7) 1992; 99 Tilg (10.1016/S0165-5728(98)00110-6_BIB17) 1997; 18 Fukaura (10.1016/S0165-5728(98)00110-6_BIB8) 1996; 98 |
| References_xml | – volume: 143 start-page: 1142 year: 1993 end-page: 1149 ident: BIB13 article-title: Constitutive and cytokine-induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes publication-title: Am. J. Pathol. – volume: 10 start-page: 267 year: 1998 end-page: 273 ident: BIB9 article-title: Myoblasts produce interleukin-6 in response to inflammatory stimuli publication-title: Int. Immunol. – volume: 42 start-page: 135 year: 1994 end-page: 138 ident: BIB2 article-title: Constitutive and cytokine-induced production of interleukin-6 by human myoblasts publication-title: Immunol. Lett. – volume: 8 start-page: 58 year: 1996 end-page: 65 ident: BIB5 article-title: TGF-beta 1, IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells publication-title: Cytokine – volume: 63 start-page: 79 year: 1995 end-page: 86 ident: BIB20 article-title: Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: double tolerance publication-title: J. Neuroimmunol. – volume: 77 start-page: 45 year: 1997 end-page: 50 ident: BIB21 article-title: Astroglial overproduction of TGF- publication-title: J. Neuroimmunol. – volume: 18 start-page: 428 year: 1997 end-page: 432 ident: BIB17 article-title: IL-6 and APPs: anti-inflammatory and immunosuppressive mediators publication-title: Immunol. Today – volume: 40 start-page: 865 year: 1997 end-page: 874 ident: BIB12 article-title: Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies publication-title: Arthritis Rheum. – volume: 87 start-page: 1928 year: 1996 end-page: 1938 ident: BIB19 article-title: Transforming growth factor- publication-title: Blood – volume: 6 start-page: 315 year: 1997 end-page: 325 ident: BIB15 article-title: Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment publication-title: Immunity – volume: 56 start-page: 479 year: 1997 end-page: 484 ident: BIB6 article-title: Transforming growth factor- publication-title: J. Neuropathol. Exp. Neurol. – volume: 158 start-page: 2704 year: 1997 end-page: 2712 ident: BIB16 article-title: TGF- publication-title: J. Immunol. – volume: 84 start-page: 265 year: 1995 end-page: 271 ident: BIB11 article-title: TGF-beta and IL-1 publication-title: Immunology – volume: 171 start-page: 231 year: 1990 end-page: 247 ident: BIB1 article-title: Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor publication-title: J. Exp. Med. – volume: 24 start-page: 3194 year: 1994 end-page: 3198 ident: BIB14 article-title: Induction by transforming growth factor- publication-title: Eur. J. Immunol. – volume: 78 start-page: 5623 year: 1981 end-page: 5627 ident: BIB4 article-title: Isolation and characterization of human muscle cells publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 98 start-page: 70 year: 1996 end-page: 77 ident: BIB8 article-title: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor- publication-title: J. Clin. Invest. – volume: 153 start-page: 5210 year: 1994 end-page: 5220 ident: BIB3 article-title: Differential modulation of astrocyte cytokine gene expression by TGF- publication-title: J. Immunol. – volume: 334 start-page: 260 year: 1988 end-page: 263 ident: BIB18 article-title: The activation of macrophages by transforming growth factor- publication-title: Nature – volume: 99 start-page: 1 year: 1992 end-page: 7 ident: BIB7 article-title: Modulation of the immune response by transforming growth factor- publication-title: Int. Arch. Allergy Immunol. – volume: 15 start-page: 269 year: 1994 end-page: 274 ident: BIB10 article-title: The immunobiology of muscle publication-title: Immunol. Today – volume: 153 start-page: 5210 year: 1994 ident: 10.1016/S0165-5728(98)00110-6_BIB3 article-title: Differential modulation of astrocyte cytokine gene expression by TGF-β publication-title: J. Immunol. doi: 10.4049/jimmunol.153.11.5210 – volume: 171 start-page: 231 year: 1990 ident: 10.1016/S0165-5728(98)00110-6_BIB1 article-title: Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor β publication-title: J. Exp. Med. doi: 10.1084/jem.171.1.231 – volume: 158 start-page: 2704 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB16 article-title: TGF-β differentially modulates epidermal growth factor-mediated increases in leukemia-inhibitory factor, IL-6, IL-1α and IL-1β in human thymic epithelial cells publication-title: J. Immunol. doi: 10.4049/jimmunol.158.6.2704 – volume: 334 start-page: 260 year: 1988 ident: 10.1016/S0165-5728(98)00110-6_BIB18 article-title: The activation of macrophages by transforming growth factor-β publication-title: Nature doi: 10.1038/334260a0 – volume: 99 start-page: 1 year: 1992 ident: 10.1016/S0165-5728(98)00110-6_BIB7 article-title: Modulation of the immune response by transforming growth factor-β publication-title: Int. Arch. Allergy Immunol. doi: 10.1159/000236328 – volume: 78 start-page: 5623 year: 1981 ident: 10.1016/S0165-5728(98)00110-6_BIB4 article-title: Isolation and characterization of human muscle cells publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.78.9.5623 – volume: 40 start-page: 865 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB12 article-title: Cytokine production in muscle tissue of patients with idiopathic inflammatory myopathies publication-title: Arthritis Rheum. doi: 10.1002/art.1780400514 – volume: 87 start-page: 1928 year: 1996 ident: 10.1016/S0165-5728(98)00110-6_BIB19 article-title: Transforming growth factor-β1: differential effects on multiple myeloma versus normal B cells publication-title: Blood doi: 10.1182/blood.V87.5.1928.1928 – volume: 98 start-page: 70 year: 1996 ident: 10.1016/S0165-5728(98)00110-6_BIB8 article-title: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients publication-title: J. Clin. Invest. doi: 10.1172/JCI118779 – volume: 15 start-page: 269 year: 1994 ident: 10.1016/S0165-5728(98)00110-6_BIB10 article-title: The immunobiology of muscle publication-title: Immunol. Today doi: 10.1016/0167-5699(94)90006-X – volume: 6 start-page: 315 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB15 article-title: Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment publication-title: Immunity doi: 10.1016/S1074-7613(00)80334-9 – volume: 24 start-page: 3194 year: 1994 ident: 10.1016/S0165-5728(98)00110-6_BIB14 article-title: Induction by transforming growth factor-β1 of the interleukin-1 receptor antagonist and of its intracellular form in human polymorphonuclear cells publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830241242 – volume: 84 start-page: 265 year: 1995 ident: 10.1016/S0165-5728(98)00110-6_BIB11 article-title: TGF-beta and IL-1β act in synergy to enhance IL-6 and IL-8 mRNA levels and IL-6 production by human retinal pigment epithelial cells publication-title: Immunology – volume: 42 start-page: 135 year: 1994 ident: 10.1016/S0165-5728(98)00110-6_BIB2 article-title: Constitutive and cytokine-induced production of interleukin-6 by human myoblasts publication-title: Immunol. Lett. doi: 10.1016/0165-2478(94)90076-0 – volume: 8 start-page: 58 year: 1996 ident: 10.1016/S0165-5728(98)00110-6_BIB5 article-title: TGF-beta 1, IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells publication-title: Cytokine doi: 10.1006/cyto.1995.0008 – volume: 56 start-page: 479 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB6 article-title: Transforming growth factor-β1 in polymyositis and dermatomyositis correlates with fibrosis but not with mononuclear cell infiltrate publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/00005072-199705000-00003 – volume: 77 start-page: 45 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB21 article-title: Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(97)00049-0 – volume: 18 start-page: 428 year: 1997 ident: 10.1016/S0165-5728(98)00110-6_BIB17 article-title: IL-6 and APPs: anti-inflammatory and immunosuppressive mediators publication-title: Immunol. Today doi: 10.1016/S0167-5699(97)01103-1 – volume: 10 start-page: 267 year: 1998 ident: 10.1016/S0165-5728(98)00110-6_BIB9 article-title: Myoblasts produce interleukin-6 in response to inflammatory stimuli publication-title: Int. Immunol. doi: 10.1093/intimm/10.3.267 – volume: 63 start-page: 79 year: 1995 ident: 10.1016/S0165-5728(98)00110-6_BIB20 article-title: Suppression of experimental autoimmune myasthenia gravis and experimental allergic encephalomyelitis by oral administration of acetylcholine receptor and myelin basic protein: double tolerance publication-title: J. Neuroimmunol. doi: 10.1016/0165-5728(95)00136-0 – volume: 143 start-page: 1142 year: 1993 ident: 10.1016/S0165-5728(98)00110-6_BIB13 article-title: Constitutive and cytokine-induced expression of human leukocyte antigens and cell adhesion molecules by human myotubes publication-title: Am. J. Pathol. |
| SSID | ssj0015349 |
| Score | 1.6190298 |
| Snippet | Transforming growth factor-
β (TGF-
β) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be... |
| SourceID | crossref elsevier |
| SourceType | Enrichment Source Index Database Publisher |
| StartPage | 185 |
| SubjectTerms | Gene therapy Inflammatory myopathies Interleukin-1 β (IL-1 β) Interleukin-6 (IL-6) Myoblasts Transforming growth factor beta (TGF- β) |
| Title | Effect of transforming growth factor- β1 on interleukin-6 secretion in human myoblasts |
| URI | https://dx.doi.org/10.1016/S0165-5728(98)00110-6 |
| Volume | 87 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1872-8421 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0015349 issn: 0165-5728 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1872-8421 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0015349 issn: 0165-5728 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection Journals customDbUrl: eissn: 1872-8421 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0015349 issn: 0165-5728 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1872-8421 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0015349 issn: 0165-5728 databaseCode: AKRWK dateStart: 19810301 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEB5qBfEiPvHNHkT0sG2aZDe7xyJKtejBB_YWsttdLda0tOnBiz_KH-JvcjZJtYIoeAoMmSXMLjPzZWe-AThggWFWh5YmTPo0FH5IlREeNYiZrW-09TzXKHx5xVt34UWHdSpwMu2FcWWVpe8vfHrurUtJvbRmfdjr1W9cIw6LEDCInPiMz8E8xh8hqjDfPG-3rj4vE1hQZMH4PnUKX408xSK58EiK43wdyn8OUTNh52wZlsp8kTSLT1qBiklXYa2ZIlZ-fiGHJK_gzH-Nr8LCZXlRvgb3BSsxGViSTVNTDFLkAVF39kiKKTuUvL81yCAljjNi1DeTp15KORm7TNLtF8pJPsOPPL8MFKbZ2Xgd7s5Ob09atJyhQDVG_oz6XdG12osQi2ptdcSkMhwxhZbGJglLQqMV2sf6nlAIXpSVPBQmlDrQysgkCjagmg5SswlECRMlkWwox3FnhEaoFUje0IZFUdIVcgvCqdliXRKMuzkX_Ximkoyz2Fk7liKvpvNivgW1T7VhwbDxl4KY7kn87ajEGAV-V93-v-oOLBbtiK5Sdxeq2Whi9jAfydQ-zNVeG_vlqXPP9vV9-wNmxNu8 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxEB4BlYBL1fJQA334gBAcTDYbP48IFaUt4QIIbqu1Y0PUZBMlmwMXflR_CL-JsXdDQUIgcR15rNXYOzPf7jczADu87bi3zNOc65QylTJqnEqoQ8zsU2d9koRC4e6p6Fyw31f8agGO5rUwgVZZ-_7Kp0dvXUuatTWb436_eRYKcbhEwKBi4zOxCB8YT2VAYAd3jzwPfKOrHBhX07D8fxlPtUUU7mm1H3eh4uUA9SToHH-Cj3W2SA6rB_oMC65Yg_XDApHy8JbsksjfjB_G12C5W_8mX4fLqicxGXlSzhNTDFHkGjF3eUOqGTuU3P9rkVFBQseIycDN_vYLKsg05JHhtFBO4gQ_MrwdGUyyy-kGXBz_PD_q0HqCArUY90ua9lTP20QiErXWW8m1cQIRhdXO5znPmbMG7ePTRBmELsZrwZRj2ratcTqX7U1YKkaF-wLEKCdzqVsmdLhzyiLQamvRso5LmfeUbgCbmy2zdXvxMOVikD3hkQmeBWtnWkUuXZKJBhw8qo2r_hpvKaj5mWTPLkqGMeB11a33q_6Alc559yQ7-XX6ZxtWq8LEwNn9CkvlZOa-YWZSmu_x5j0AUxPa4Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+transforming+growth+factor-+%CE%B21+on+interleukin-6+secretion+in+human+myoblasts&rft.jtitle=Journal+of+neuroimmunology&rft.au=Mazzarelli%2C+Paola&rft.au=Scuderi%2C+Flavia&rft.au=Mistretta%2C+Guido&rft.au=Provenzano%2C+Carlo&rft.date=1998-07-01&rft.pub=Elsevier+B.V&rft.issn=0165-5728&rft.eissn=1872-8421&rft.volume=87&rft.issue=1&rft.spage=185&rft.epage=188&rft_id=info:doi/10.1016%2FS0165-5728%2898%2900110-6&rft.externalDocID=S0165572898001106 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0165-5728&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0165-5728&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0165-5728&client=summon |