EXPRESSION OF c-erbB-2, p53, p16 IN SQUAMOUS CELL CARCINOMA OF ANTERIOR TONGUE IN CHINA POPULATION

• Published in: Chinese journal of cancer research Vol. 16; no. 1; pp. 24 - 30
• Main Author: 张宗敏 徐震纲 唐平章 李爱东 王争 赵清正
• Format: Journal Article
• Language: English
• Published: Department of Head and Neck Surgery,Cancer Hospital,Chinese Acdemy of Medical Sciences (CAMS),Peking Union Medical College (PUMC),Beijing 100021%Department of Pathology,Cancer Hospital,Chinese Acdemy of Medical Sciences (CAMS),Peking Union Medical College (PUMC),Beijing 100021%Department of Radio-biology,Institute of Cancer Research,Chinese Acdemy of Medical Sciences (CAMS),Peking Union Medical College (PUMC),Beijing 100021 01.03.2004
• Subjects: c-erbB-2基因; p16基因; p53基因; 中国人群; 免疫组织化学; 过度表达; 鳞状细胞癌; Squamous cell carcinoma; cerbB-2; Prognosis; p16; Anterior tongue; p53
• ISSN: 1000-9604; 1993-0631
• DOI: 10.1007/BF02974862

Objective: Aberrant expression of c-erbB-2, p53, p16 has been found in oral squamous cell carcinoma. We therefore examined expression of these proteins in squamous cell carcinoma of the anterior tongue and compared their relationship with clinical stages and prognosis. Methods: Seventy-six patients with squamous cell carcinoma of the anterior tongue never treated before were obtained from Cancer Hospital, CAMS. Archive tissues of carcinoma and paracarcinoma were examined for c-erbB-2, p53 and p16 expression by immunohistochemistry.Results: The rates of immunopositive staining of c-erbB-2, p53 and p16 were 64.5%, 61.8% and 23.7% respectively; the positive rates in paracarcinoma mucosa were 19.7%, 22.6% and 55.3% respectively. Overexpression of c-erbB-2 was significantly correlated with short overall survival, metastasis and staging. Overexpression of paracarcinoma p53 was significantly correlated with local recurrence.Conclusion. c-erbB-2 may be used as a prognosis marker for the patients with squamous cell carcinoma of the anterior tongue and p53 as a recurrence marker.