Serum level of procollagen-I-peptide in patients on maintenance hemodialysis
The serum level of C-terminal procollagen-I-peptide was measured in 49 patients with chronic renal failure on maintenance hemodialysis, and we consider here the clinical importance of this peptide in the diagnosis of renal osteodystrophy associated with chronic renal failure. The serum level of proc...
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| Published in | Journal of Japanese Society for Dialysis Therapy Vol. 25; no. 9; pp. 1025 - 1028 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society for Dialysis Therapy
1992
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0911-5889 1884-6211 1884-6211 |
| DOI | 10.4009/jsdt1985.25.1025 |
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| Abstract | The serum level of C-terminal procollagen-I-peptide was measured in 49 patients with chronic renal failure on maintenance hemodialysis, and we consider here the clinical importance of this peptide in the diagnosis of renal osteodystrophy associated with chronic renal failure. The serum level of procollagen-I-peptide was 644.9±244.5ng/ml in male patients (n=27), and 697.7±279.7ng/ml in female patients (n=22), both levels being significantly higher than the 390.7±130.4ng/ml (n=24) in our sample of healthy subjects. A comparative study between two patient subgroups, one with a short history of hemodialysis (less than 36 months) and the other with a long history of hemodialysis (longer than 60 months) showed an apparently higher level of procollagen-I-peptide in the latter group. Based upon these results, we conclude that in patients with chronic renal failure on maintenance hemodialysis, the serum level of procollagen-I-peptide may be clinically useful in the diagnosis of ranal osteodystrophy, just as conventional protein-containing markers such as alkaline phosphatase and bone γ-carboxyglutamic acid are. |
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| AbstractList | The serum level of C-terminal procollagen-I-peptide was measured in 49 patients with chronic renal failure on maintenance hemodialysis, and we consider here the clinical importance of this peptide in the diagnosis of renal osteodystrophy associated with chronic renal failure. The serum level of procollagen-I-peptide was 644.9±244.5ng/ml in male patients (n=27), and 697.7±279.7ng/ml in female patients (n=22), both levels being significantly higher than the 390.7±130.4ng/ml (n=24) in our sample of healthy subjects. A comparative study between two patient subgroups, one with a short history of hemodialysis (less than 36 months) and the other with a long history of hemodialysis (longer than 60 months) showed an apparently higher level of procollagen-I-peptide in the latter group. Based upon these results, we conclude that in patients with chronic renal failure on maintenance hemodialysis, the serum level of procollagen-I-peptide may be clinically useful in the diagnosis of ranal osteodystrophy, just as conventional protein-containing markers such as alkaline phosphatase and bone γ-carboxyglutamic acid are. |
| Author | Okajima, Eigoro Uji, Yoshinori Okabe, Hiroaki Motomiya, Yoshihiro |
| Author_xml | – sequence: 1 fullname: Uji, Yoshinori organization: Department of Laboratory Medicine, Kumamoto University Medical School – sequence: 1 fullname: Motomiya, Yoshihiro organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Okabe, Hiroaki organization: Department of Laboratory Medicine, Kumamoto University Medical School – sequence: 1 fullname: Okajima, Eigoro organization: Department of Urology, Nara Medical University |
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| References | 8) 羽毛田慈之: in vitroにおける骨芽細胞の機能. 日骨代謝誌 7: 7-15, 1989 3) Chazan JA, Libbey NP, London MR, Pono L, Abuelo JG: The clinical spectrum of renal osteodystrophy in 57 chronic hemodialysis patients: A correlation between biochemical parameters and bone pathology findings. Clin Nephrol 35: 78-85, 1991 6) Eriksen EF, Melkko J, Charles P, Hasling C, Mosekilde L, Risteli J: Carboxyterminal propeptide of human procollagen type I as a serum marker in metabolic bone disease. JBMM 5 (s): 167, 1990 9) 山口 朗: 培養骨芽細胞の多様性. 日骨代謝誌 7: 16-20, 1989 14) Kaneko Y, Maruyama Y, Tunemi K, Hirata N, Nakatsuji F, Moriya A, Yoshida K, Motomiya Y, Ozono S, Hirao Y, Okajima E: Studies of serum bone Al-P isoenzyme and serum osteocalcin in patients on maintenance hemodialysis. Jpn J Nephrol 32: 345-351, 1990 10) 五関正江, 大井田新一郎, 佐々木哲: 骨のアルカリホスファターゼの構造と生理的機能. 日骨代謝誌 8: 9-19, 1990 11) 佐藤昭夫, 林 泰史, 白木正孝: 骨のミネラル・基質, 骨の加齢 -基礎から臨床まで-, p21-27, 藤田企画出版, 埼玉, 1988 13) Miki T, Nakatsuka K, Tabata T, Nishizawa Y, Morii H: Serum BGP levels in patients with chronic hemodialysis. JBMM 9: 58-59, 1991 12) 岡島英五郎, 金子佳照, 本宮善恢, 守屋 昭, 吉田克法, 佐々木憲二, 丸山良夫, 大園誠一朗, 平尾佳彦, 白木正孝: 維持透析患者の血漿遊離γ-carboxyglutamic acidの検討 腎性骨異栄養症との関連性について. 日腎誌 32: 1203-1210, 1990 4) Mazzaferro S, Coen G, Ballanti P, Bondatti F, Bonucci E, Pasquali M, Sardella D, Tomei E, Taggi F: Qsteocalcin, iPTH, alkaline phosphatase and hand X-Ray scores as predictive indices of histomorphometric parameters in renal osteodystrophy. Nephron 56: 261-266, 1990 5) 岩元則幸, 川瀬義夫, 山崎 悟, 近藤守寛, 平竹康祐, 山本則之, 福田豊史, 小野利彦: 二次性副甲状腺機能亢進症の現況. 腎と骨代謝 4: 293-299, 1991 7) 小澤英吉: 骨芽細胞と破骨細胞のCell-Cell, Cell-Matrix Interactionの形態学的知見. 日骨代謝誌 9: 18-25, 1991 1) 乗松尋道: 骨代謝における骨芽細胞の役割. 日骨代謝誌 7: 2-6, 1989 2) Tanimoto H, Miura T: Bone changes during hemodialysis-relationship between bone X-ray findings and history or biochemical data. JBMM 9: 8-18, 1991 |
| References_xml | – reference: 9) 山口 朗: 培養骨芽細胞の多様性. 日骨代謝誌 7: 16-20, 1989 – reference: 6) Eriksen EF, Melkko J, Charles P, Hasling C, Mosekilde L, Risteli J: Carboxyterminal propeptide of human procollagen type I as a serum marker in metabolic bone disease. JBMM 5 (s): 167, 1990 – reference: 12) 岡島英五郎, 金子佳照, 本宮善恢, 守屋 昭, 吉田克法, 佐々木憲二, 丸山良夫, 大園誠一朗, 平尾佳彦, 白木正孝: 維持透析患者の血漿遊離γ-carboxyglutamic acidの検討 腎性骨異栄養症との関連性について. 日腎誌 32: 1203-1210, 1990 – reference: 5) 岩元則幸, 川瀬義夫, 山崎 悟, 近藤守寛, 平竹康祐, 山本則之, 福田豊史, 小野利彦: 二次性副甲状腺機能亢進症の現況. 腎と骨代謝 4: 293-299, 1991 – reference: 14) Kaneko Y, Maruyama Y, Tunemi K, Hirata N, Nakatsuji F, Moriya A, Yoshida K, Motomiya Y, Ozono S, Hirao Y, Okajima E: Studies of serum bone Al-P isoenzyme and serum osteocalcin in patients on maintenance hemodialysis. Jpn J Nephrol 32: 345-351, 1990 – reference: 10) 五関正江, 大井田新一郎, 佐々木哲: 骨のアルカリホスファターゼの構造と生理的機能. 日骨代謝誌 8: 9-19, 1990 – reference: 13) Miki T, Nakatsuka K, Tabata T, Nishizawa Y, Morii H: Serum BGP levels in patients with chronic hemodialysis. JBMM 9: 58-59, 1991 – reference: 3) Chazan JA, Libbey NP, London MR, Pono L, Abuelo JG: The clinical spectrum of renal osteodystrophy in 57 chronic hemodialysis patients: A correlation between biochemical parameters and bone pathology findings. Clin Nephrol 35: 78-85, 1991 – reference: 4) Mazzaferro S, Coen G, Ballanti P, Bondatti F, Bonucci E, Pasquali M, Sardella D, Tomei E, Taggi F: Qsteocalcin, iPTH, alkaline phosphatase and hand X-Ray scores as predictive indices of histomorphometric parameters in renal osteodystrophy. Nephron 56: 261-266, 1990 – reference: 7) 小澤英吉: 骨芽細胞と破骨細胞のCell-Cell, Cell-Matrix Interactionの形態学的知見. 日骨代謝誌 9: 18-25, 1991 – reference: 2) Tanimoto H, Miura T: Bone changes during hemodialysis-relationship between bone X-ray findings and history or biochemical data. JBMM 9: 8-18, 1991 – reference: 11) 佐藤昭夫, 林 泰史, 白木正孝: 骨のミネラル・基質, 骨の加齢 -基礎から臨床まで-, p21-27, 藤田企画出版, 埼玉, 1988 – reference: 8) 羽毛田慈之: in vitroにおける骨芽細胞の機能. 日骨代謝誌 7: 7-15, 1989 – reference: 1) 乗松尋道: 骨代謝における骨芽細胞の役割. 日骨代謝誌 7: 2-6, 1989 |
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| Title | Serum level of procollagen-I-peptide in patients on maintenance hemodialysis |
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