Efficacy of Preoperative Dipyridamole-loaded ECG in the Assessment of Coronary Artery Disease in Arteriosclerosis Obliterans
To assess coronary artery disease in arteriosclerosis obliterans (ASO), the efficacy of a dipyridamole-loaded ECG was evaluated. Subjects consisted of 35 patients who underwent surgery for ASO between November 1988 and December 1989. A dose of 0.568mg/kg of dipyridamole was intravenously infused for...
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| Published in | Japanese Journal of Cardiovascular Surgery Vol. 20; no. 9; pp. 1465 - 1469 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society for Cardiovascular Surgery
1991
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| Online Access | Get full text |
| ISSN | 0285-1474 1883-4108 1883-4108 |
| DOI | 10.4326/jjcvs.20.1465 |
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| Abstract | To assess coronary artery disease in arteriosclerosis obliterans (ASO), the efficacy of a dipyridamole-loaded ECG was evaluated. Subjects consisted of 35 patients who underwent surgery for ASO between November 1988 and December 1989. A dose of 0.568mg/kg of dipyridamole was intravenously infused for over 4min. Changes of systemic blood pressure, heart rate and standard 12-lead ECG were accumulated. In eleven cases loaded ECG was considered to be positive and coronary arteriographies were performed. Stenotic lesions of 75% or over were observed in 10 cases, among them CABG was performed in one symptomatic case. In another positive but asymptomatic cases, only the existing ASO lesions were surgically treated. No intraoperative or postoperative ECG abnormality was observed and postoperative courses were uneventful. Negative cases (24 cases) underwent complete revascularization. These findings indicate that a dipyridamole-loaded ECG is a non-invasive preoperative means detecting coronary artery disease preoperatively is useful to decide operative procedure. |
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| AbstractList | To assess coronary artery disease in arteriosclerosis obliterans (ASO), the efficacy of a dipyridamole-loaded ECG was evaluated. Subjects consisted of 35 patients who underwent surgery for ASO between November 1988 and December 1989. A dose of 0.568mg/kg of dipyridamole was intravenously infused for over 4min. Changes of systemic blood pressure, heart rate and standard 12-lead ECG were accumulated. In eleven cases loaded ECG was considered to be positive and coronary arteriographies were performed. Stenotic lesions of 75% or over were observed in 10 cases, among them CABG was performed in one symptomatic case. In another positive but asymptomatic cases, only the existing ASO lesions were surgically treated. No intraoperative or postoperative ECG abnormality was observed and postoperative courses were uneventful. Negative cases (24 cases) underwent complete revascularization. These findings indicate that a dipyridamole-loaded ECG is a non-invasive preoperative means detecting coronary artery disease preoperatively is useful to decide operative procedure. |
| Author | YAMAZAKI, Tohru HAKOSHIMA, Akira ISHIKAWA, Mikio ISHIMARU, Shin FURUKAWA, Kin-ichi |
| Author_xml | – sequence: 1 fullname: HAKOSHIMA, Akira organization: The 2nd Department of Surgery, Tokyo Medical College – sequence: 1 fullname: ISHIKAWA, Mikio organization: The 2nd Department of Surgery, Tokyo Medical College – sequence: 1 fullname: YAMAZAKI, Tohru organization: The 2nd Department of Surgery, Tokyo Medical College – sequence: 1 fullname: FURUKAWA, Kin-ichi organization: The 2nd Department of Surgery, Tokyo Medical College – sequence: 1 fullname: ISHIMARU, Shin organization: The 2nd Department of Surgery, Tokyo Medical College |
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| References | 4) Becker, L.C.: Conditions for vasodilator induced coronary steal in experimental myocardial ischemia. Circulation 57: 1103-1110, 1978. 7) Beller, G.A., Holzgrefe, H.H. and Watson, D.D.: Intrinsic washout rates of thallium-201 in normal and ischemic myocardium after dipyridamole induced vaso-dilation. Circulation 71: 378-386, 1985. 5) Gross, G.J. and Warltier, D.C.: Coronary steal in four models of single or multiple vessel obstruction in dogs. Am. J. Cardiol. 48: 84-92, 1981. 6) Feldman, R.L., Nichols, W.W., Pepine, C.J. et al.: Acute effect of intravenous dipyridamole on regional coronary hemodynamics and metabolism. Circulation 64: 333-344, 1981. 8) Beller, G.A., Holzgrefe, H.H. and Watson, D.D.: Effects of dipyridamole induced vasodilation on myocardial uptake and clearance kinetics of thallium-201. Circulation 68: 1328-1338, 1983. 3) Ando, J., Yasuda, H., Kobayashi, T. et al.: Conditions for “coronary steal” caused by coronary vasodilation in man. Jpn. Heart J. 23: 79-96, 1982. 1) Albro, P.C., Gould, K.L., Wescott, R.J. et al.: Noninvasive assessment of coronary stenosis by myocardial perfusion imaging during pharmacologic coronary vasodilation. Clinical trial. Am. J. Cardiol. 42: 751-760, 1978. 2) Kitamura, K., Jorgensen, C.R., Gobel, F.L. et al.: Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J. Appl. Physiol. 32: 516-522, 1972. 10) Terada, Y., Sugimoto, T., Uraoka, T. et al.: Significance of dipyridamole loading test in ischemic heart disease. Heart 15: 2-15, 1983. 9) Brown, B.G., Josephson, M.A., Petersen, R.B. et al.: Intravenous dipyridamole combined with isometic handgrip for near maximal acute increase in coronary artery disease. Am. J. Cardiol. 48: 1077-1085, 1981. |
| References_xml | – reference: 5) Gross, G.J. and Warltier, D.C.: Coronary steal in four models of single or multiple vessel obstruction in dogs. Am. J. Cardiol. 48: 84-92, 1981. – reference: 6) Feldman, R.L., Nichols, W.W., Pepine, C.J. et al.: Acute effect of intravenous dipyridamole on regional coronary hemodynamics and metabolism. Circulation 64: 333-344, 1981. – reference: 8) Beller, G.A., Holzgrefe, H.H. and Watson, D.D.: Effects of dipyridamole induced vasodilation on myocardial uptake and clearance kinetics of thallium-201. Circulation 68: 1328-1338, 1983. – reference: 4) Becker, L.C.: Conditions for vasodilator induced coronary steal in experimental myocardial ischemia. Circulation 57: 1103-1110, 1978. – reference: 7) Beller, G.A., Holzgrefe, H.H. and Watson, D.D.: Intrinsic washout rates of thallium-201 in normal and ischemic myocardium after dipyridamole induced vaso-dilation. Circulation 71: 378-386, 1985. – reference: 10) Terada, Y., Sugimoto, T., Uraoka, T. et al.: Significance of dipyridamole loading test in ischemic heart disease. Heart 15: 2-15, 1983. – reference: 3) Ando, J., Yasuda, H., Kobayashi, T. et al.: Conditions for “coronary steal” caused by coronary vasodilation in man. Jpn. Heart J. 23: 79-96, 1982. – reference: 2) Kitamura, K., Jorgensen, C.R., Gobel, F.L. et al.: Hemodynamic correlates of myocardial oxygen consumption during upright exercise. J. Appl. Physiol. 32: 516-522, 1972. – reference: 1) Albro, P.C., Gould, K.L., Wescott, R.J. et al.: Noninvasive assessment of coronary stenosis by myocardial perfusion imaging during pharmacologic coronary vasodilation. Clinical trial. Am. J. Cardiol. 42: 751-760, 1978. – reference: 9) Brown, B.G., Josephson, M.A., Petersen, R.B. et al.: Intravenous dipyridamole combined with isometic handgrip for near maximal acute increase in coronary artery disease. Am. J. Cardiol. 48: 1077-1085, 1981. |
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| Title | Efficacy of Preoperative Dipyridamole-loaded ECG in the Assessment of Coronary Artery Disease in Arteriosclerosis Obliterans |
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