Indian clinical practice consensus guidelines for the management of oropharyngeal cancer: Update 2022
The aim of oropharyngeal cancer treatment should be to treat the disease while preserving speech and swallowing abilities. Early-stage disease is generally treated with surgery/radiotherapy (RT). A combination of chemotherapy and RT should be considered instead of RT alone for patients with locally...
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| Published in | Cancer research, statistics, and treatment (Online) Vol. 7; no. Suppl 1; pp. S12 - S16 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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India
Wolters Kluwer - Medknow
01.01.2024
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| Edition | 2 |
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| Online Access | Get full text |
| ISSN | 2590-3233 2590-3225 |
| DOI | 10.4103/crst.crst_120_23 |
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| Abstract | The aim of oropharyngeal cancer treatment should be to treat the disease while preserving speech and swallowing abilities. Early-stage disease is generally treated with surgery/radiotherapy (RT). A combination of chemotherapy and RT should be considered instead of RT alone for patients with locally advanced disease. Patients with locally advanced resectable disease can be treated with transoral or open resection of the primary + ipsilateral/bilateral neck dissection ± adjuvant chemoradiotherapy (CTRT)/adjuvant RT. In unresectable locally advanced disease, sequential induction chemotherapy (TPF [docetaxel, cisplatin, fluorouracil]) followed by locoregional treatment with RT or CTRT can be considered. Adding targeted therapies like nimotuzumab to cisplatin-based CTRT in locally advanced head-and-neck squamous cell carcinoma improves the progression-free survival, locoregional control, and disease-free survival without negatively impacting the quality of life. |
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| AbstractList | The aim of oropharyngeal cancer treatment should be to treat the disease while preserving speech and swallowing abilities. Early-stage disease is generally treated with surgery/radiotherapy (RT). A combination of chemotherapy and RT should be considered instead of RT alone for patients with locally advanced disease. Patients with locally advanced resectable disease can be treated with transoral or open resection of the primary + ipsilateral/bilateral neck dissection ± adjuvant chemoradiotherapy (CTRT)/adjuvant RT. In unresectable locally advanced disease, sequential induction chemotherapy (TPF [docetaxel, cisplatin, fluorouracil]) followed by locoregional treatment with RT or CTRT can be considered. Adding targeted therapies like nimotuzumab to cisplatin-based CTRT in locally advanced head-and-neck squamous cell carcinoma improves the progression-free survival, locoregional control, and disease-free survival without negatively impacting the quality of life. |
| Author | Goyal, Sumit Noronha, Vanita John, Subashini Ramachandra, Prakash Birur, Praveen Anand, Anil K Syiemlieh, Judita Chaturvedi, Pankaj Mahajan, Abhishek Roshan, Vikas Babu, K Govind Patil, Vijay M Gairola, Munish Prabhash, Kumar Singhal, Manish Kaushal, Ashish Rath, G.K. Kuriakose, Moni Nayyar, Rohit Rao, Vishal |
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| Cites_doi | 10.3389/fonc.2019.00815 10.4161/cbt.9.5.10981 10.1016/j.oraloncology.2015.11.019 10.4103/sajc.sajc_96_17 10.3390/cancers14215385 10.18632/oncotarget.8934 10.1016/j.oraloncology.2016.01.002 10.1002/cncr.32179 10.1200/JCO.22.00980 10.1002/hed.23865 10.1016/j.oraloncology.2021.105517 10.1007/s00066-019-01511-z 10.1200/JCO.2022.40.16_suppl.6004 10.1016/j.radonc.2021.01.013 10.3389/fonc.2019.00464 10.1097/PAS.0000000000000666 10.1200/JCO.21.01293 10.1200/JCO.2017.74.9457 10.18632/oncotarget.27443 10.1007/s40487-023-00226-7 10.1002/cncr.29938 10.1200/JCO.2015.62.3157 10.1016/j.otc.2012.04.006 10.1016/S1470-2045(10)70279-5 10.1016/j.oraloncology.2013.11.008 10.4143/crt.2015.359 10.5858/arpa.2017-0286-CP 10.1016/j.ijrobp.2009.04.011 |
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