Utilizing cell-free DNA to validate targeted disruption of MYO7A in rhesus macaque pre-implantation embryos

Direct injection of CRISPR/Cas9 into zygotes enables the production of genetically modified nonhuman primates (NHPs) essential for modeling specific human diseases, such as Usher syndrome, and for developing novel therapeutic strategies. Usher syndrome is a rare genetic disease that causes loss of h...

Full description

Saved in:
Bibliographic Details
Published inJournal of animal reproduction & biotechnology (Online) Vol. 37; no. 4; pp. 292 - 297
Main Authors Ryu, Junghyun, Burch, Fernanda C., Mishler, Emily, Neuringer, Martha, Hennebold, Jon D., Hanna, Carol
Format Journal Article
LanguageEnglish
Published 한국동물생명공학회(구 한국수정란이식학회) 31.12.2022
The Korean Society of Animal Reproduction and Biotechnology
Subjects
cell-free dna
crispr/cas9
knockout
myo7a
usher syndrome
knockout
Cell-free DNA
Myo7A
CRISPR/Cas9
Usher syndrome
Online AccessGet full text
ISSN2671-4639
2671-4663
DOI10.12750/JARB.37.4.292

Cover

Table of Contents:
  • ABSTRACT INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION REFERENCES