Effect of Periodontal Associated Bacteria on the Peri-implant Tissue of Osseointegrated Implants

The aim of this study was to investigate the effect of periodontal associated bacteria in plaques adhering to peri-implant tissue of osseointegrated implants. 24 implant sites in 21 subjects placed with IMZ® implants, were selected for this study. Plaques adhering to implants were examined by immuno...

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Published inNihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 35; no. 1; pp. 192 - 201
Main Authors IKEDA, Katsumi, MOTOMURA, Youichi, SHIN, Kitetsu, ARAKI, Hisao, HANAZAWA, Shigemasa, OZAKI, Ken, MIYATA, Takashi, SUGIMOTO, Hironobu, KITANO, Shigeo
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY OF PERIODONTOLOGY 1993
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ISSN0385-0110
1880-408X
1880-408X
DOI10.2329/perio.35.192

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Abstract The aim of this study was to investigate the effect of periodontal associated bacteria in plaques adhering to peri-implant tissue of osseointegrated implants. 24 implant sites in 21 subjects placed with IMZ® implants, were selected for this study. Plaques adhering to implants were examined by immunoslot blot and immunoblot assay with monoclonal antibodies that specifically recognized Porphyromonas gingivalis, Prevotella intermedia serotypes I, II, Prevotella melaninogenica and Actinobacillus actinomycetemcomitans serotype b. We also investigated the relationship between the organisms and clinical parameters. According to the result of this examination, periodontal associated bacteria were detected in 11 patients and 13 patients had undetectable. Correlation between the detected periodnotal associated bacteria and clincal parameters in the positive group were observed in probing depth and bleeding on probing.
AbstractList The aim of this study was to investigate the effect of periodontal associated bacteria in plaques adhering to peri-implant tissue of osseointegrated implants. 24 implant sites in 21 subjects placed with IMZ® implants, were selected for this study. Plaques adhering to implants were examined by immunoslot blot and immunoblot assay with monoclonal antibodies that specifically recognized Porphyromonas gingivalis, Prevotella intermedia serotypes I, II, Prevotella melaninogenica and Actinobacillus actinomycetemcomitans serotype b. We also investigated the relationship between the organisms and clinical parameters. According to the result of this examination, periodontal associated bacteria were detected in 11 patients and 13 patients had undetectable. Correlation between the detected periodnotal associated bacteria and clincal parameters in the positive group were observed in probing depth and bleeding on probing.
Author HANAZAWA, Shigemasa
MOTOMURA, Youichi
SUGIMOTO, Hironobu
KITANO, Shigeo
ARAKI, Hisao
OZAKI, Ken
IKEDA, Katsumi
MIYATA, Takashi
SHIN, Kitetsu
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  fullname: KITANO, Shigeo
  organization: Department of Oral Microbiology, School of Dentistry, Meikai University
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References 6) Van Poperin, N. and Lopatin, D. E.: Slot immunoblot assay for detection and quantitation of periodontal disease-associated microorganisms in dental plaque. J. Clin. Microbiol, , 29: 2554-2558, 1991.
26) 岡本莫, 白川正治: 歯周病の臨床病態の疫学的把握, 青野正男 (監修), 歯周治療の科学, 医歯薬出版, 東京, 1991, 11-14.
2) Ericsson, I., Lekholm, U., Branemark, P. -I., Lindhe, J., Giants, P. -O. and Nyman, S.: A clinical evaluation of fixed-bridge restorations supported by the combination of teeth and osseointegrated titanium implants. J. Clin. Periodontol., 13: 307-312, 1986.
5) Hanazawa, S., Sagiya, T., Kitami, H., Ohta, K., Nishikawa, H. and Kitano, S.: Monoclonal antibody against Porphyromonas (Bacteroides) endodontalis lipopolysaccharide and application of the antibody for direct identification of the species. J. Clin. Microbiol., 29: 2550-2553, 1991.
22) Becker, W., Becker, B. E., Newman, M. G., Nyman, S. and Odont.: Clinical and microbiologic findings that may contribute to dental implant failure. Int. J. Oral Maxillofac. Implants, 5: 31-38, 1990.
25) Lekholm, U., Adell, R., Lindhe, J., Branemark, P. -I ., Eriksson, B., Rockler, B., Lindvall, A. -M. and Yoneyama, T. : Marginal tissue reactions at osseointegrated titanium fixtures. Int. J. Oral Maxillofac. Surg., 15: 53-61, 1986.
12) Gmiir, R., Strub, J.R. and Guggenheim, B.: Prevalence of Bacteroides forsythus and Bacteroides gingivalis in subgingival plaque of prosthodontically treated patients on short recall. J. Periodont. Res., 24: 113-120, 1989.
9) 渡辺文彦, 畑好昭 (共著) : IMZインプラントの臨床, 1版, クインテッセンス出版, 東京, 1991, 5-24.
23) Newman, M. G. and Flemmig, T. F.: Periodontal considerations of implants and implant associated microbiota. J. Dent. education, 52: 737-744, 1988.
21) Apse, P., Ellen, R. P., Overall, C. M. and Zarb G. A.: Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: A comparison of sites in edentulous and partially edentulous patients. J. Periodont. Res., 24: 96-105, 1989.
24) Ong, E. S. -M., Newman, H. N., Wilson, M. and Bulman, J.S.: The occurrence of preiodontitisrelated microoraganisms in relation to titanium implants. J. Periodontol., 63: 200-205, 1992.
8) O'Leary, T. J., Drake, R.B. and Naylor, J. E.: The Plaque Control Record. J. Periodontol., 43: 38, 1972.
13) Listgarten, M. A., Lai, C. H. and Evian, C. I.: Comparative antibody titers to Actinobacillus actinomycetemcomitans in juvenile periodontitis, chronic periodontitis and periodontally healthy subjects. J. Clin. Periodontol, , 8: 155-164, 1981.
20) Mombelli, A., Van Oosten, M. A. C., Schiirch, E. and Lang, N. P.: The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol. Immunol., 2: 145-151, 1987.
16) Slots, J., Hafstrom, C., Rosling, B. and Dahlen, G.: Detection of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis in subgingival smears by the indirect fluorescent-antibody technique. J. Periodont. Res., 20: 613-620, 1985.
11) Ebersole, W. J., Taubman, M. A., Smith, D. J., Genco, R. J. and Frey, D. E.: Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans. Clin. Exp. Immunol., 47: 43-52, 1982.
4) Hanazawa, S., Tanaka, S., Kin, M., Amano, S., Nakada, K., Masuda, T. and Kitano, S.: Application of monoclonal antibodies to the detection of black-pigmented Bacteroides spp. in subgingival plaques by immunoslot blot assay. J. Clin. Microbiol., 28: 2248-2252, 1990.
17) Slots, J., Reynolds, H.S. and Genco, R.J.: Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect. Immun., 29: 1013-1020, 1980.
10) Ainamo, J. and Bay, I. : Problems and proposal for recording gingivitis
19) Mashimo, P.A. and Ellison S.A.: Diffusate media for cultivation of oral anaerobic bacteria. J. Dent. Health., 22: 38-45, 1972.
7) Levine, M. and Miller, F. C.: Use of monoclonal antibodies with neutralizing effects on toxic antigens from human bacterial plaque to detect specific bacteria by colony blotting. J. Clin. Microbiol., 29: 2809-2816, 1991.
15) Mouton, C., Hammond, P.G., Slots, J. and Genco R.J.: Serum antibodies to oral Bacterodies asaccharolyticus (Bacteroides gingivalis) : relationship to age and periodontal disease. Infect. Immun., 31: 182-192, 1981.
3) Hansson, H. -A., Albrektsson, T. and Branemark, P. -I.: Structural aspects of the interface between tissue and titanium implants. J. Prosthet. Dent., 50: 108-113, 1983.
1) Ade11, R., Lekholm, U., Rockler, B. and Branemark, P. -I. : A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg., 10: 387-416, 1981.
14) Miyoshi, T., Hanazawa, S., Hirose, K., Saitoh, K., Amano, S., Ohmori, Y. and Kitano S.: Humoral antibody response against Bacteroides gingivalisspecific antigen recognized by monoconal antibody in adult periodontal patients. Infect. Immun., 53: 366-371, 1986.
18) Hanazawa, S., Saitoh, K., Ohmori, Y., Nishara, H., Fujiwara, S. and Kitano, S.: Production of monoclonal antibodies that recognize specific and cross-reactive antigens of Bacteroides gingivalis. Infect. Immun., 46: 285-287, 1984.
References_xml – reference: 15) Mouton, C., Hammond, P.G., Slots, J. and Genco R.J.: Serum antibodies to oral Bacterodies asaccharolyticus (Bacteroides gingivalis) : relationship to age and periodontal disease. Infect. Immun., 31: 182-192, 1981.
– reference: 7) Levine, M. and Miller, F. C.: Use of monoclonal antibodies with neutralizing effects on toxic antigens from human bacterial plaque to detect specific bacteria by colony blotting. J. Clin. Microbiol., 29: 2809-2816, 1991.
– reference: 14) Miyoshi, T., Hanazawa, S., Hirose, K., Saitoh, K., Amano, S., Ohmori, Y. and Kitano S.: Humoral antibody response against Bacteroides gingivalisspecific antigen recognized by monoconal antibody in adult periodontal patients. Infect. Immun., 53: 366-371, 1986.
– reference: 12) Gmiir, R., Strub, J.R. and Guggenheim, B.: Prevalence of Bacteroides forsythus and Bacteroides gingivalis in subgingival plaque of prosthodontically treated patients on short recall. J. Periodont. Res., 24: 113-120, 1989.
– reference: 8) O'Leary, T. J., Drake, R.B. and Naylor, J. E.: The Plaque Control Record. J. Periodontol., 43: 38, 1972.
– reference: 1) Ade11, R., Lekholm, U., Rockler, B. and Branemark, P. -I. : A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg., 10: 387-416, 1981.
– reference: 19) Mashimo, P.A. and Ellison S.A.: Diffusate media for cultivation of oral anaerobic bacteria. J. Dent. Health., 22: 38-45, 1972.
– reference: 11) Ebersole, W. J., Taubman, M. A., Smith, D. J., Genco, R. J. and Frey, D. E.: Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans. Clin. Exp. Immunol., 47: 43-52, 1982.
– reference: 22) Becker, W., Becker, B. E., Newman, M. G., Nyman, S. and Odont.: Clinical and microbiologic findings that may contribute to dental implant failure. Int. J. Oral Maxillofac. Implants, 5: 31-38, 1990.
– reference: 6) Van Poperin, N. and Lopatin, D. E.: Slot immunoblot assay for detection and quantitation of periodontal disease-associated microorganisms in dental plaque. J. Clin. Microbiol, , 29: 2554-2558, 1991.
– reference: 25) Lekholm, U., Adell, R., Lindhe, J., Branemark, P. -I ., Eriksson, B., Rockler, B., Lindvall, A. -M. and Yoneyama, T. : Marginal tissue reactions at osseointegrated titanium fixtures. Int. J. Oral Maxillofac. Surg., 15: 53-61, 1986.
– reference: 24) Ong, E. S. -M., Newman, H. N., Wilson, M. and Bulman, J.S.: The occurrence of preiodontitisrelated microoraganisms in relation to titanium implants. J. Periodontol., 63: 200-205, 1992.
– reference: 2) Ericsson, I., Lekholm, U., Branemark, P. -I., Lindhe, J., Giants, P. -O. and Nyman, S.: A clinical evaluation of fixed-bridge restorations supported by the combination of teeth and osseointegrated titanium implants. J. Clin. Periodontol., 13: 307-312, 1986.
– reference: 4) Hanazawa, S., Tanaka, S., Kin, M., Amano, S., Nakada, K., Masuda, T. and Kitano, S.: Application of monoclonal antibodies to the detection of black-pigmented Bacteroides spp. in subgingival plaques by immunoslot blot assay. J. Clin. Microbiol., 28: 2248-2252, 1990.
– reference: 23) Newman, M. G. and Flemmig, T. F.: Periodontal considerations of implants and implant associated microbiota. J. Dent. education, 52: 737-744, 1988.
– reference: 16) Slots, J., Hafstrom, C., Rosling, B. and Dahlen, G.: Detection of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis in subgingival smears by the indirect fluorescent-antibody technique. J. Periodont. Res., 20: 613-620, 1985.
– reference: 18) Hanazawa, S., Saitoh, K., Ohmori, Y., Nishara, H., Fujiwara, S. and Kitano, S.: Production of monoclonal antibodies that recognize specific and cross-reactive antigens of Bacteroides gingivalis. Infect. Immun., 46: 285-287, 1984.
– reference: 3) Hansson, H. -A., Albrektsson, T. and Branemark, P. -I.: Structural aspects of the interface between tissue and titanium implants. J. Prosthet. Dent., 50: 108-113, 1983.
– reference: 26) 岡本莫, 白川正治: 歯周病の臨床病態の疫学的把握, 青野正男 (監修), 歯周治療の科学, 医歯薬出版, 東京, 1991, 11-14.
– reference: 17) Slots, J., Reynolds, H.S. and Genco, R.J.: Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect. Immun., 29: 1013-1020, 1980.
– reference: 5) Hanazawa, S., Sagiya, T., Kitami, H., Ohta, K., Nishikawa, H. and Kitano, S.: Monoclonal antibody against Porphyromonas (Bacteroides) endodontalis lipopolysaccharide and application of the antibody for direct identification of the species. J. Clin. Microbiol., 29: 2550-2553, 1991.
– reference: 21) Apse, P., Ellen, R. P., Overall, C. M. and Zarb G. A.: Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: A comparison of sites in edentulous and partially edentulous patients. J. Periodont. Res., 24: 96-105, 1989.
– reference: 20) Mombelli, A., Van Oosten, M. A. C., Schiirch, E. and Lang, N. P.: The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol. Immunol., 2: 145-151, 1987.
– reference: 10) Ainamo, J. and Bay, I. : Problems and proposal for recording gingivitis
– reference: 9) 渡辺文彦, 畑好昭 (共著) : IMZインプラントの臨床, 1版, クインテッセンス出版, 東京, 1991, 5-24.
– reference: 13) Listgarten, M. A., Lai, C. H. and Evian, C. I.: Comparative antibody titers to Actinobacillus actinomycetemcomitans in juvenile periodontitis, chronic periodontitis and periodontally healthy subjects. J. Clin. Periodontol, , 8: 155-164, 1981.
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SubjectTerms Immunoblot assay
Immunoslot blot assay
Osseointegrated implant
Peri-implantitis
Periodontal associated bacteria
Title Effect of Periodontal Associated Bacteria on the Peri-implant Tissue of Osseointegrated Implants
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