Hormone Replacement Therapy and Breast Cancer
Evaluation of the role of estrogen and progesterone in hormone replacement therapy (HRT) as a cause and promoter of breast cancer should begin with a study of the effect of these hormones on normal breast tissue. Cyclic alterations in the histologic changes of the breast in relation to menstruation...
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| Published in | Journal of Japan Association of Breast Cancer Screening Vol. 7; no. 3; pp. 237 - 246 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan Association of Breast Cancer Screening
1998
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-0729 1882-6873 1882-6873 |
| DOI | 10.3804/jjabcs.7.237 |
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| Abstract | Evaluation of the role of estrogen and progesterone in hormone replacement therapy (HRT) as a cause and promoter of breast cancer should begin with a study of the effect of these hormones on normal breast tissue. Cyclic alterations in the histologic changes of the breast in relation to menstruation have been confirmed in some studies. However, the histological influence on the breast of exogenous estrogen and progestin in postmenopausal women remains a very controversial subject, and there has been little consistency regarding the relative risk of HRT and breast cancer across many epidemiological studies. However, the Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed about 90% of the worldwide epidemiological evidence on the relationship between breast cancer risk and the use of HRT. These analyses have revealed that the risk of breast cancer in HRT users is significantly increased. However, whether HRT affects mortality from breast cancer is not known. |
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| AbstractList | Evaluation of the role of estrogen and progesterone in hormone replacement therapy (HRT) as a cause and promoter of breast cancer should begin with a study of the effect of these hormones on normal breast tissue. Cyclic alterations in the histologic changes of the breast in relation to menstruation have been confirmed in some studies. However, the histological influence on the breast of exogenous estrogen and progestin in postmenopausal women remains a very controversial subject, and there has been little consistency regarding the relative risk of HRT and breast cancer across many epidemiological studies. However, the Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed about 90% of the worldwide epidemiological evidence on the relationship between breast cancer risk and the use of HRT. These analyses have revealed that the risk of breast cancer in HRT users is significantly increased. However, whether HRT affects mortality from breast cancer is not known. |
| Author | Dobashi, Kazuyoshi |
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| References | 9) Grodstein F, Stampfer MJ, Colditz GA, Willett WC, Manson JE, Joffe M, Rosner B, Fuchs C, Hankinson S, Hunter DJ, Hennekens CH, Speizer FE : Postmenopausal hormone therapy and mortality. N Engl J Med, 336 : 1769-1775, 1997 6) Jick SS, Walker AM, Jick H : Estrogens, progesterone, and endometrial cancer. Epidemiology, 4 : 20-24, 1993 16) Longacre TA, Bartow SA : A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol, 10 : 382-393, 1986 15) Daly E, Vessey MP, Hawkins MM, Carson JL, Gough P, Marsh S : Risk of venous thromboembolism in users of hormone replacement therapy. Lancet, 348 : 977-980, 1996 22) Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE, Stampfer MJ, Hennekens C, Rosner B, Speizner FE : The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med, 332 : 1589-1593, 1995 4) 研修ノート;産婦人科外来の薬物療法;日本母性産婦人科医会編;50, 平成6年10月, 103-105 5) The Writing Group for the PEPI Trial : Effects of hormone replacement therapy on endometrial histology in postmenopausal women. JAMA, 275 : 370-375, 1996 1) Collaborative Group on Hormonal Factors in Breast Cancer (Beral V, et al) : Breast cancer and hormone replacement therapy : collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. Lancet, 350 : 1047-1059, 1997 7) The Writing Group for the PEPI Trial : Effects of estrogen or estrogen/progestagen regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestagen Trial. JAMA, 273 : 199-208, 1995 3) Breckwoldt M, Keck C, Karck U : Benefits and risks of hormone replacement therapy (HRT).J Steroid Biochem Molec Biol, 53 : 205-208, 1995 14) Bilezekian JP : Major issues regarding estrogen replacement therapy in postmenopausal women. J Women Health, 3 : 273-282, 1994 17) Ferguson DJP, Anderson TJ : Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast. Br J Cancer, 44 : 177-181, 1981 21) Mills PK, Beeson WL, Phillips RL, Fraser GE : Prospective study of exogenous hormone use and breast cancer in Seventh-Day Adventists. Cancer, 64 : 591-597, 1989 23) Tavani A, Braga C, Vecchia CL, Negri E, Franceschi S : Hormone replacement treatment and breast cancer risk : An age-specific analysis. Cancer Epidem, Biomarkers & Prevention, 6 : 11-14, 1997 18) Key TJA, Pike MC : The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol, 24 : 29-43, 1988 11) Gould E, Woolley CS, Frankfurt M, McEwen BS : Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci, 46 : 1286-1291, 1990 20) 坂元吾偉 : 悪性疾患の病理学的解釈.産婦人科の世界, 49 : 22-30, 1997 13) Kawaa C, Resnick S, Morrison A, Broolmeyer R, Corrada M, Zonderman A, Bacal C, Lingle DD, Metter E : A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease. The Baltimore Longitudinal Study of Aging. Am Acad Neurology, 48 : 1517-1521, 1997 24) Draper MW, Flowers DE, Huster WJ, Neild JA, Harper KD, Arnaud C : A controlled trial of raloxifene (LY 139481) HC1 : impact on bone turnover and serum lipid profile in healthy postmenopausal women. J Bone Miner Res, 11 : 835-842, 1996 2) 小山嵩夫 : わが国でどの位の女性がホルモン補充療法を受けているか.日更年医誌, 3 : 256, 1966 19) Grant ECG, Antony HM, Myhill S, Price EH, Steel CM : Breast cancer and hormone exposure. Lancet, 348 : 682-1996 12) Tang M, Jacobs D, Stern Y, et al : Effect of oestrogen during menopause on risk and age at on-set of Alzheimaer's disease. Lancet, 348 : 429432, 1996 10) Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Joffe M, Rosner B, Speizer FE, Hennekens CH : Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med, 335 : 453-461, 1996 8) Beresford SAA, Weiss NS, Voigt LF, McKnight B : Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet, 349 : 458-461, 1997 25) Yang NN, Venugopalan M, Hardikar S, Glasebrook A : Identification of an estrogen responseelement activated by metabolites of 17β-estradiol and raloxifene. Science, 273 : 1222-1225, 1996 |
| References_xml | – reference: 2) 小山嵩夫 : わが国でどの位の女性がホルモン補充療法を受けているか.日更年医誌, 3 : 256, 1966 – reference: 5) The Writing Group for the PEPI Trial : Effects of hormone replacement therapy on endometrial histology in postmenopausal women. JAMA, 275 : 370-375, 1996 – reference: 9) Grodstein F, Stampfer MJ, Colditz GA, Willett WC, Manson JE, Joffe M, Rosner B, Fuchs C, Hankinson S, Hunter DJ, Hennekens CH, Speizer FE : Postmenopausal hormone therapy and mortality. N Engl J Med, 336 : 1769-1775, 1997 – reference: 13) Kawaa C, Resnick S, Morrison A, Broolmeyer R, Corrada M, Zonderman A, Bacal C, Lingle DD, Metter E : A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease. The Baltimore Longitudinal Study of Aging. Am Acad Neurology, 48 : 1517-1521, 1997 – reference: 16) Longacre TA, Bartow SA : A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol, 10 : 382-393, 1986 – reference: 17) Ferguson DJP, Anderson TJ : Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast. Br J Cancer, 44 : 177-181, 1981 – reference: 1) Collaborative Group on Hormonal Factors in Breast Cancer (Beral V, et al) : Breast cancer and hormone replacement therapy : collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. Lancet, 350 : 1047-1059, 1997 – reference: 25) Yang NN, Venugopalan M, Hardikar S, Glasebrook A : Identification of an estrogen responseelement activated by metabolites of 17β-estradiol and raloxifene. Science, 273 : 1222-1225, 1996 – reference: 19) Grant ECG, Antony HM, Myhill S, Price EH, Steel CM : Breast cancer and hormone exposure. Lancet, 348 : 682-1996 – reference: 15) Daly E, Vessey MP, Hawkins MM, Carson JL, Gough P, Marsh S : Risk of venous thromboembolism in users of hormone replacement therapy. Lancet, 348 : 977-980, 1996 – reference: 14) Bilezekian JP : Major issues regarding estrogen replacement therapy in postmenopausal women. J Women Health, 3 : 273-282, 1994 – reference: 11) Gould E, Woolley CS, Frankfurt M, McEwen BS : Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci, 46 : 1286-1291, 1990 – reference: 24) Draper MW, Flowers DE, Huster WJ, Neild JA, Harper KD, Arnaud C : A controlled trial of raloxifene (LY 139481) HC1 : impact on bone turnover and serum lipid profile in healthy postmenopausal women. J Bone Miner Res, 11 : 835-842, 1996 – reference: 4) 研修ノート;産婦人科外来の薬物療法;日本母性産婦人科医会編;50, 平成6年10月, 103-105 – reference: 7) The Writing Group for the PEPI Trial : Effects of estrogen or estrogen/progestagen regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestagen Trial. JAMA, 273 : 199-208, 1995 – reference: 21) Mills PK, Beeson WL, Phillips RL, Fraser GE : Prospective study of exogenous hormone use and breast cancer in Seventh-Day Adventists. Cancer, 64 : 591-597, 1989 – reference: 22) Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE, Stampfer MJ, Hennekens C, Rosner B, Speizner FE : The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med, 332 : 1589-1593, 1995 – reference: 23) Tavani A, Braga C, Vecchia CL, Negri E, Franceschi S : Hormone replacement treatment and breast cancer risk : An age-specific analysis. Cancer Epidem, Biomarkers & Prevention, 6 : 11-14, 1997 – reference: 20) 坂元吾偉 : 悪性疾患の病理学的解釈.産婦人科の世界, 49 : 22-30, 1997 – reference: 6) Jick SS, Walker AM, Jick H : Estrogens, progesterone, and endometrial cancer. Epidemiology, 4 : 20-24, 1993 – reference: 3) Breckwoldt M, Keck C, Karck U : Benefits and risks of hormone replacement therapy (HRT).J Steroid Biochem Molec Biol, 53 : 205-208, 1995 – reference: 12) Tang M, Jacobs D, Stern Y, et al : Effect of oestrogen during menopause on risk and age at on-set of Alzheimaer's disease. Lancet, 348 : 429432, 1996 – reference: 18) Key TJA, Pike MC : The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol, 24 : 29-43, 1988 – reference: 8) Beresford SAA, Weiss NS, Voigt LF, McKnight B : Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet, 349 : 458-461, 1997 – reference: 10) Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Joffe M, Rosner B, Speizer FE, Hennekens CH : Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med, 335 : 453-461, 1996 |
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