A Five-Year Longitudinal Study of Bone Mineral Density in the Lumbar Spine of Menopausal Japanese Women
A five-year longitudinal study was conducted to clarify the pattern of menopause-related vertebral bone loss in healthy women. The subjects were 357 Japanese women aged 40-60 years, who were divided into 7 groups according to their menstrual status. Lumbar spine bone mineral density (BMD) was measur...
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| Published in | Nihon Eiyō, Shokuryō Gakkai shi Vol. 52; no. 1; pp. 13 - 19 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan Society of Nutrition and Food Science
1999
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0287-3516 1883-2849 1883-2849 |
| DOI | 10.4327/jsnfs.52.13 |
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| Abstract | A five-year longitudinal study was conducted to clarify the pattern of menopause-related vertebral bone loss in healthy women. The subjects were 357 Japanese women aged 40-60 years, who were divided into 7 groups according to their menstrual status. Lumbar spine bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) at the baseline and at the end of the 5-year period. Urinary free deoxypyridinoline parameters related to bone metabolism at the end of the 5-year period and the incidence of ‘low BMD’ based on the diagnostic criteria for osteoporosis were also evaluated. These longitudinal data indicated that vertebral bone loss commences before the menopause, and continues for over 10 years after the menopause. Also, the rate of bone loss accelerates sharply during the perimenopausal period and then declines exponentially with time after the menopause. |
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| AbstractList | A five-year longitudinal study was conducted to clarify the pattern of menopause-related vertebral bone loss in healthy women. The subjects were 357 Japanese women aged 40-60 years, who were divided into 7 groups according to their menstrual status. Lumbar spine bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) at the baseline and at the end of the 5-year period. Urinary free deoxypyridinoline parameters related to bone metabolism at the end of the 5-year period and the incidence of ‘low BMD’ based on the diagnostic criteria for osteoporosis were also evaluated. These longitudinal data indicated that vertebral bone loss commences before the menopause, and continues for over 10 years after the menopause. Also, the rate of bone loss accelerates sharply during the perimenopausal period and then declines exponentially with time after the menopause. |
| Author | Koitaya, Noriko Ezawa, Ikuko Tsukahara, Noriko |
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| References | 20) Drinka PJ, Desmet A, Bauwens SF, Rogot A (1992) The effect of overlying calcification on lumbar bone densitometry. Calcif Tissue Int 50: 507-10. 15) Christiansen C, Riis BJ, Rødbro P (1987) Prediction of rapid bone loss in postmenopausal women. Lancet i: 1105-8. 11) Harris S, Dawson-Hughes B (1992) Rates of change in bone mineral density of the spine, heel, femoral neck and radius in healthy postmenopausal women. Bone Miner 17: 87-95. 17) 福永仁夫, 大塚信昭, 曽根照喜 (1995) 骨代謝マーカーからの治療適応の決定. Clin Calcium 5: 30-4. 6) Iki M, Kajita E, Dohi Y, Nishino H, Kusaka Y, Tsuchida C, Yamamoto K, Ishii Y (1996) Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women. Maturitas 25: 59-67. 13) Yoshimura N (1996) Incidence of fast bone losers and factors affecting changes in bone mineral density: a cohort study in a rural Japanese community. J Bone Miner Metab 14: 171-7. 14) 日本骨代謝学会骨粗鬆症診断基準検討委員会 (1996) 原発性骨粗鬆症の診断基準 (1996年改訂版). Osteoporosis Japan 4, 643-52. 16) Tsunenari T, Yamada S, Kawakatsu M, Negishi H, Tsutsumi M (1995) Menopause-related changes in bone mineral density in Japanese women: a longitudinal study on lumbar spine and proximal femur. Calcif Tissue Int 56: 5-10. 7) Okano H, Mizunuma H, Soda M, Kagami I, Miyamoto S, Ohsawa M, Ibuki Y, Shiraki M, Suzuki T, Shibata H (1998) The long-term effect of menopause on postmenopausal bone loss in Japanese women: results from a prospective study. J Bone Miner Res 13: 303-9. 2) Recker RR, Lappe JM, Davies KM, Kimmel DB (1992) Change in bone mass immediately before menopause. J Bone Miner Res 7: 857-62. 12) Hansen MA, Overgaad K, Christiansen C (1995) Spontaneous postmenopausal bone loss in different skeletal areas-followed up for 15 years. J Bone Miner Res 10: 205-10. 19) Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD (1991) Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab 72: 367-73. 10) Young R, May H, Murphy S, Grey C, Compston JE (1996) Rates of bone loss in peri- and postmenopausal women: a 4 year, prospective, population-based study. Clin Sci 91: 307-12. 3) Cosman F, Nieves J, Wilkinson C, Schnering D, Shen V, Lindsay R (1996) Bone density change and biochemical indices of skeletal turnover. Calcif Tissue Int 58: 236-43. 18) Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ (1994) Direct, enzyme- linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 9: 1643-9. 1) 岩槻明彦, 小栗啓義, 板東尚, 前田長正, 相良祐祐輔 (1997) 閉経周辺期の内分泌変化と骨代謝. Clinical Calcium 7, 904-10. 5) Kin K, Kushida K, Yamazaki K, Okamoto S, Inoue T (1991) Bone mineral density of the spine in normal Japanese subjects using dual-energy X-ray absorptiometry: effect of obesity and menopausal status. Calcif Tissue Int 49: 101-6. 21) 鈴木隆雄, 永井晴美, 吉田英世, 楠本彩乃, 天野秀紀, 熊谷修, 渡辺修一郎, 柴田博, 安村誠司, 芳賀博 (1995) 地域高齢者を対象とした骨密度検診におけるDXA法の有用性と限界-腰椎X線所見との比較について-. 日本公衆衛生学雑誌42, 385-97. 4) Riggs BL, Wahner HW, Melton III LJ, Richelson LS, Judd HL, O'Fallon WM (1987) Dietary calcium intake and rates of bone loss in women. J Clin Invest 80: 979-82. 8) Pouilles JM, Tremollieres F, Ribot C (1993) The effects of menopause on longitudinal bone loss from the spine. Calcif Tissue Int 52: 340-3. 9) Elders PJM, Netelenbos JC, Lips P, van Ginkel FC, Khoe E, Leeuwenkamp OR, Hackeng WHL, Van Der Stelt PF (1991) Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J Clin Endocrinol Metab 73: 533-40. |
| References_xml | – reference: 11) Harris S, Dawson-Hughes B (1992) Rates of change in bone mineral density of the spine, heel, femoral neck and radius in healthy postmenopausal women. Bone Miner 17: 87-95. – reference: 15) Christiansen C, Riis BJ, Rødbro P (1987) Prediction of rapid bone loss in postmenopausal women. Lancet i: 1105-8. – reference: 17) 福永仁夫, 大塚信昭, 曽根照喜 (1995) 骨代謝マーカーからの治療適応の決定. Clin Calcium 5: 30-4. – reference: 16) Tsunenari T, Yamada S, Kawakatsu M, Negishi H, Tsutsumi M (1995) Menopause-related changes in bone mineral density in Japanese women: a longitudinal study on lumbar spine and proximal femur. Calcif Tissue Int 56: 5-10. – reference: 14) 日本骨代謝学会骨粗鬆症診断基準検討委員会 (1996) 原発性骨粗鬆症の診断基準 (1996年改訂版). Osteoporosis Japan 4, 643-52. – reference: 8) Pouilles JM, Tremollieres F, Ribot C (1993) The effects of menopause on longitudinal bone loss from the spine. Calcif Tissue Int 52: 340-3. – reference: 1) 岩槻明彦, 小栗啓義, 板東尚, 前田長正, 相良祐祐輔 (1997) 閉経周辺期の内分泌変化と骨代謝. Clinical Calcium 7, 904-10. – reference: 18) Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ (1994) Direct, enzyme- linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 9: 1643-9. – reference: 9) Elders PJM, Netelenbos JC, Lips P, van Ginkel FC, Khoe E, Leeuwenkamp OR, Hackeng WHL, Van Der Stelt PF (1991) Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J Clin Endocrinol Metab 73: 533-40. – reference: 19) Uebelhart D, Schlemmer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD (1991) Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. J Clin Endocrinol Metab 72: 367-73. – reference: 10) Young R, May H, Murphy S, Grey C, Compston JE (1996) Rates of bone loss in peri- and postmenopausal women: a 4 year, prospective, population-based study. Clin Sci 91: 307-12. – reference: 21) 鈴木隆雄, 永井晴美, 吉田英世, 楠本彩乃, 天野秀紀, 熊谷修, 渡辺修一郎, 柴田博, 安村誠司, 芳賀博 (1995) 地域高齢者を対象とした骨密度検診におけるDXA法の有用性と限界-腰椎X線所見との比較について-. 日本公衆衛生学雑誌42, 385-97. – reference: 2) Recker RR, Lappe JM, Davies KM, Kimmel DB (1992) Change in bone mass immediately before menopause. J Bone Miner Res 7: 857-62. – reference: 5) Kin K, Kushida K, Yamazaki K, Okamoto S, Inoue T (1991) Bone mineral density of the spine in normal Japanese subjects using dual-energy X-ray absorptiometry: effect of obesity and menopausal status. Calcif Tissue Int 49: 101-6. – reference: 13) Yoshimura N (1996) Incidence of fast bone losers and factors affecting changes in bone mineral density: a cohort study in a rural Japanese community. J Bone Miner Metab 14: 171-7. – reference: 12) Hansen MA, Overgaad K, Christiansen C (1995) Spontaneous postmenopausal bone loss in different skeletal areas-followed up for 15 years. J Bone Miner Res 10: 205-10. – reference: 4) Riggs BL, Wahner HW, Melton III LJ, Richelson LS, Judd HL, O'Fallon WM (1987) Dietary calcium intake and rates of bone loss in women. J Clin Invest 80: 979-82. – reference: 7) Okano H, Mizunuma H, Soda M, Kagami I, Miyamoto S, Ohsawa M, Ibuki Y, Shiraki M, Suzuki T, Shibata H (1998) The long-term effect of menopause on postmenopausal bone loss in Japanese women: results from a prospective study. J Bone Miner Res 13: 303-9. – reference: 6) Iki M, Kajita E, Dohi Y, Nishino H, Kusaka Y, Tsuchida C, Yamamoto K, Ishii Y (1996) Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women. Maturitas 25: 59-67. – reference: 20) Drinka PJ, Desmet A, Bauwens SF, Rogot A (1992) The effect of overlying calcification on lumbar bone densitometry. Calcif Tissue Int 50: 507-10. – reference: 3) Cosman F, Nieves J, Wilkinson C, Schnering D, Shen V, Lindsay R (1996) Bone density change and biochemical indices of skeletal turnover. Calcif Tissue Int 58: 236-43. |
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| SubjectTerms | bone loss bone mineral density in the lumbar spine Dual-energy X-ray Absorptiometry (DXA) five-year longitudinal study healthy menopausal women |
| Title | A Five-Year Longitudinal Study of Bone Mineral Density in the Lumbar Spine of Menopausal Japanese Women |
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