Die Physiologie des Implantationsprozesses
Zusammenfassung Die Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein müssen. Die Implantation des menschlichen Embryos lässt sich aus ethischen Gründen in vivo kaum untersuchen. Erkenntnisse aus Tiermodellen sind...
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| Published in | Gynäkologische Endokrinologie Vol. 22; no. 2; pp. 95 - 101 |
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| Main Authors | , |
| Format | Journal Article |
| Language | German |
| Published |
Heidelberg
Springer Medizin
01.05.2024
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1610-2894 1610-2908 |
| DOI | 10.1007/s10304-024-00563-4 |
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| Abstract | Zusammenfassung
Die Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein müssen. Die Implantation des menschlichen Embryos lässt sich aus ethischen Gründen in vivo kaum untersuchen. Erkenntnisse aus Tiermodellen sind aufgrund deutlicher speziesbezogener Unterschiede nur sehr eingeschränkt übertragbar. Aus diesen Gründen werden zunehmend 3‑dimensionale Modelle entwickelt, in denen Trophoblastsphäroide oder embryoide Strukturen mit einer deziduaähnlichen Matrix konfrontiert werden. Im vorliegenden Beitrag werden die aktuell bekannten Faktoren und Interaktionen mit Bedeutung für die Implantation zusammengefasst, sowohl auf zellulärer als auch auf molekularer Ebene. Zunächst werden vorbereitende Prozesse im Menstruationszyklus beschrieben. Daran schließt sich eine Beschreibung relevanter Komponenten des Immunsystems an, wobei ausführlich auf die Eigenschaften und Funktionen uteriner natürlicher Killerzellen eingegangen wird. Im Weiteren wird die Rolle verschiedener molekularer Faktoren in der Implantation diskutiert (Zytokine, Wachstumsfaktoren, Zelladhäsionsmoleküle, Hormone). Perspektivisch ist damit zu rechnen, dass Studien an den oben erwähnten 3‑dimensionalen Modellen trotz aller Limitationen neue Erkenntnisse zur Embryoimplantation beim Menschen liefern werden. Dies könnte sich letztlich positiv auf die reproduktionsmedizinische Praxis auswirken. |
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| AbstractList | Zusammenfassung
Die Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein müssen. Die Implantation des menschlichen Embryos lässt sich aus ethischen Gründen in vivo kaum untersuchen. Erkenntnisse aus Tiermodellen sind aufgrund deutlicher speziesbezogener Unterschiede nur sehr eingeschränkt übertragbar. Aus diesen Gründen werden zunehmend 3‑dimensionale Modelle entwickelt, in denen Trophoblastsphäroide oder embryoide Strukturen mit einer deziduaähnlichen Matrix konfrontiert werden. Im vorliegenden Beitrag werden die aktuell bekannten Faktoren und Interaktionen mit Bedeutung für die Implantation zusammengefasst, sowohl auf zellulärer als auch auf molekularer Ebene. Zunächst werden vorbereitende Prozesse im Menstruationszyklus beschrieben. Daran schließt sich eine Beschreibung relevanter Komponenten des Immunsystems an, wobei ausführlich auf die Eigenschaften und Funktionen uteriner natürlicher Killerzellen eingegangen wird. Im Weiteren wird die Rolle verschiedener molekularer Faktoren in der Implantation diskutiert (Zytokine, Wachstumsfaktoren, Zelladhäsionsmoleküle, Hormone). Perspektivisch ist damit zu rechnen, dass Studien an den oben erwähnten 3‑dimensionalen Modellen trotz aller Limitationen neue Erkenntnisse zur Embryoimplantation beim Menschen liefern werden. Dies könnte sich letztlich positiv auf die reproduktionsmedizinische Praxis auswirken. ZusammenfassungDie Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein müssen. Die Implantation des menschlichen Embryos lässt sich aus ethischen Gründen in vivo kaum untersuchen. Erkenntnisse aus Tiermodellen sind aufgrund deutlicher speziesbezogener Unterschiede nur sehr eingeschränkt übertragbar. Aus diesen Gründen werden zunehmend 3‑dimensionale Modelle entwickelt, in denen Trophoblastsphäroide oder embryoide Strukturen mit einer deziduaähnlichen Matrix konfrontiert werden. Im vorliegenden Beitrag werden die aktuell bekannten Faktoren und Interaktionen mit Bedeutung für die Implantation zusammengefasst, sowohl auf zellulärer als auch auf molekularer Ebene. Zunächst werden vorbereitende Prozesse im Menstruationszyklus beschrieben. Daran schließt sich eine Beschreibung relevanter Komponenten des Immunsystems an, wobei ausführlich auf die Eigenschaften und Funktionen uteriner natürlicher Killerzellen eingegangen wird. Im Weiteren wird die Rolle verschiedener molekularer Faktoren in der Implantation diskutiert (Zytokine, Wachstumsfaktoren, Zelladhäsionsmoleküle, Hormone). Perspektivisch ist damit zu rechnen, dass Studien an den oben erwähnten 3‑dimensionalen Modellen trotz aller Limitationen neue Erkenntnisse zur Embryoimplantation beim Menschen liefern werden. Dies könnte sich letztlich positiv auf die reproduktionsmedizinische Praxis auswirken. |
| Author | Huber, Maria T. Markert, Udo R. |
| Author_xml | – sequence: 1 givenname: Maria T. surname: Huber fullname: Huber, Maria T. organization: Klinik für Geburtsmedizin, Placenta-Labor, Forschungszentrum Lobeda, Universitätsklinikum Jena – sequence: 2 givenname: Udo R. surname: Markert fullname: Markert, Udo R. email: markert@med.uni-jena.de organization: Klinik für Geburtsmedizin, Placenta-Labor, Forschungszentrum Lobeda, Universitätsklinikum Jena |
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| Cites_doi | 10.1097/PAT.0b013e328361429b 10.1083/jcb.103.6.2649 10.1111/aji.12450 10.1093/HUMREP/10.6.1579 10.1007/s10815-018-1300-8 10.1111/aji.13024 10.1016/j.ydbio.2020.04.003 10.1055/s-0028-1108011 10.4049/jimmunol.1401536 10.1006/smim.2000.0319 10.1111/j.1600-0897.2006.00420.x 10.1146/annurev.immunol.18.1.767 10.1530/rep.0.1260149 10.1159/000087913 10.1093/humupd/dmi023 10.1016/j.humimm.2018.07.003 10.1093/humrep/10.suppl_2.30 10.1038/nri886 10.1016/0167-5699(93)90235-D 10.3390/diagnostics10090650 10.1210/jcem.87.6.8563 10.1038/nm.3012 10.1002/jcb.26088 10.1016/j.jri.2010.07.001 10.3892/mmr.2014.2626 10.1111/j.1600-0897.2006.00429.x 10.1016/S1521-6934(02)00130-X 10.1586/eci.11.60 10.1111/aji.12721 10.1038/ni0902-807 10.1210/en.2008-1538 10.1073/pnas.93.7.3115 10.1016/j.placenta.2020.10.011 10.1016/j.molimm.2004.07.035 10.1093/humupd/dmn010 10.1016/S1472-6483(10)61717-8 10.4049/jimmunol.136.12.4480 10.1093/humrep/den348 10.1046/j.1365-2249.2003.02092.x 10.1095/biolreprod49.4.850 10.1016/0028-2243(91)90058-S 10.1210/en.2017-00032 10.1210/er.2003-0021 10.1155/2014/968141 10.1172/jci.insight.137926 10.2353/ajpath.2009.080995 10.1016/j.semcdb.2022.07.003 10.1387/ijdb.082763jb 10.1016/S1043-2760(03)00084-5 10.1016/S0165-0378(01)00139-5 10.1016/j.imbio.2004.04.009 10.1530/ror.0.0020084 10.1111/j.1600-0897.2005.00269.x 10.1111/cei.13142 10.1093/biolre/ioab001 10.1016/j.placenta.2021.02.022 |
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| Keywords | Zytokine Uterus Cytokines Menstrual cycle Natural killer cells Endometrium Menstruationszyklus Natürliche Killerzellen |
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Die Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein... ZusammenfassungDie Implantation der Blastozyste ist ein komplexer Prozess, auf den der Embryo und das Endometrium zum korrekten Zeitpunkt vorbereitet sein... |
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| SubjectTerms | Embryos Endocrinology Endometrium Gynecology Leitthema Medicine Medicine & Public Health Reproductive Medicine |
| Title | Die Physiologie des Implantationsprozesses |
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