Effect of Body Weight Change on Blood Pressure in a Japanese General Population with a Body Mass Index ≥ 22 kg/m2 A Community-Based Cohort Study

The association between changes in body weight and blood pressure (BP) in overweight people in the general population still remains unclear. We sought to clarify the effect of body weight change on BP using a community-based cohort. We studied 1,170 overweight subjects with a body mass index (BMI) ≥...

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Published inInternational Heart Journal Vol. 60; no. 6; pp. 1381 - 1386
Main Authors Kaneko, Hidehiro, Daimon, Masao, Morita, Hiroyuki, Nakanishi, Koki, Itoh, Hidetaka, Kiriyama, Hiroyuki, Mizuno, Yoshiko, Yamamichi, Nobutake, Komuro, Issei
Format Journal Article
LanguageEnglish
Published Tokyo International Heart Journal Association 30.11.2019
Japan Science and Technology Agency
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Online AccessGet full text
ISSN1349-2365
1349-3299
DOI10.1536/ihj.19-314

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Abstract The association between changes in body weight and blood pressure (BP) in overweight people in the general population still remains unclear. We sought to clarify the effect of body weight change on BP using a community-based cohort. We studied 1,170 overweight subjects with a body mass index (BMI) ≥ 22 kg/m2 who underwent health check-ups. Among the study subjects, 175 (15%) were categorized in the weight loss group (weight loss ≥ 5%), 869 (74%) in the weight stable group, and 126 (11%) in the weight gain group (weight gain ≥ 5%). There were no significant differences in baseline BP between the 3 groups. In the weight loss group, systolic and diastolic BP, and the rates of stage 2 (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) and stage 1 hypertension (130 mmHg≤ systolic BP < 140 mmHg or 80 mmHg≤ diastolic BP < 90 mmHg) decreased. In contrast, in the weight gain group, systolic and diastolic BP and the rate of stage 2 hypertension increased. Subgroup analysis showed that the correlation between change in body weight and BP was seen in each subgroup according to age, sex, and BMI. The results of the present study suggest the significance of body weight control for BP control in subjects with BMI ≥ 22 kg/m2.
AbstractList The association between changes in body weight and blood pressure (BP) in overweight people in the general population still remains unclear. We sought to clarify the effect of body weight change on BP using a community-based cohort. We studied 1,170 overweight subjects with a body mass index (BMI) ≥ 22 kg/m2 who underwent health check-ups. Among the study subjects, 175 (15%) were categorized in the weight loss group (weight loss ≥ 5%), 869 (74%) in the weight stable group, and 126 (11%) in the weight gain group (weight gain ≥ 5%). There were no significant differences in baseline BP between the 3 groups. In the weight loss group, systolic and diastolic BP, and the rates of stage 2 (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) and stage 1 hypertension (130 mmHg≤ systolic BP < 140 mmHg or 80 mmHg≤ diastolic BP < 90 mmHg) decreased. In contrast, in the weight gain group, systolic and diastolic BP and the rate of stage 2 hypertension increased. Subgroup analysis showed that the correlation between change in body weight and BP was seen in each subgroup according to age, sex, and BMI. The results of the present study suggest the significance of body weight control for BP control in subjects with BMI ≥ 22 kg/m2.
Author Mizuno, Yoshiko
Kiriyama, Hiroyuki
Kaneko, Hidehiro
Itoh, Hidetaka
Morita, Hiroyuki
Yamamichi, Nobutake
Nakanishi, Koki
Daimon, Masao
Komuro, Issei
Author_xml – sequence: 1
  fullname: Kaneko, Hidehiro
  organization: Department of Advanced Cardiology, Graduate School of Medicine, The University of Tokyo
– sequence: 1
  fullname: Daimon, Masao
  organization: Department of Clinical Laboratory, The University of Tokyo Hospital
– sequence: 1
  fullname: Morita, Hiroyuki
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
– sequence: 1
  fullname: Nakanishi, Koki
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
– sequence: 1
  fullname: Itoh, Hidetaka
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
– sequence: 1
  fullname: Kiriyama, Hiroyuki
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
– sequence: 1
  fullname: Mizuno, Yoshiko
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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  fullname: Yamamichi, Nobutake
  organization: Center for Epidemiology and Preventive Medicine, The University of Tokyo Hospital
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  fullname: Komuro, Issei
  organization: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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32. Cooper JN, Fried L, Tepper P, et al. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults. Hypertens Res 2013; 36: 895-901.
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26. Ahmed SB, Fisher ND, Stevanovic R, et al. Body mass index and angiotensin-dependent control of the renal circulation in healthy humans. Hypertension 2005; 46: 1316-20.
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References_xml – reference: 25. Rahmouni K, Correia ML, Haynes WG, et al. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005; 45: 9-14.
– reference: 4. Hales CM, Fryar CD, Carroll MD, et al. Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007-2008 to 2015-2016. JAMA 2018; 319: 1723-5.
– reference: 32. Cooper JN, Fried L, Tepper P, et al. Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults. Hypertens Res 2013; 36: 895-901.
– reference: 5. GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, et al. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med 2017; 377: 13-27.
– reference: 22. Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019 (in press).
– reference: 26. Ahmed SB, Fisher ND, Stevanovic R, et al. Body mass index and angiotensin-dependent control of the renal circulation in healthy humans. Hypertension 2005; 46: 1316-20.
– reference: 2. Olshansky SJ, Passaro DJ, Hershow RC, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 2005; 352: 1138-45.
– reference: 3. Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235-41.
– reference: 17. Semlitsch T, Jeitler K, Berghold A, et al. Long-term effects of weight-reducing diets in people with hypertension. Cochrane Database Syst Rev 2016; 3: CD008274.
– reference: 31. Rahmouni K. Obesity, sympathetic overdrive, and hypertension: the leptin connection. Hypertension 2010; 55: 844-5.
– reference: 13. Stevens VJ, Corrigan SA, Obarzanek E, et al. Weight loss intervention in phase 1 of the Trials of Hypertension Prevention. The TOHP Collaborative Research Group. Arch Intern Med 1993; 153: 849-58.
– reference: 19. Shiwaku K, Anuurad E, Enkhmaa B, et al. Overweight Japanese with body mass indexes of 23.0-24.9 have higher risks for obesity-associated disorders: a comparison of Japanese and Mongolians. Int J Obes Relat Metab Disord 2004; 28: 152-8.
– reference: 11. Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation 2014; 129: S102-38.
– reference: 18. Anuurad E, Shiwaku K, Nogi A, et al. The new BMI criteria for asians by the regional office for the western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers. J Occup Health 2003; 45: 335-43.
– reference: 29. Greenfield JR, Miller JW, Keogh JM, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 2009; 360: 44-52.
– reference: 33. Sharma AM, Golay A. Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension. J Hypertens 2002; 20: 1873-8.
– reference: 27. Sarzani R, Salvi F, Dessi-Fulgheri P, et al. Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans. J Hypertens 2008; 26: 831-43.
– reference: 8. Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 2016; 387: 957-67.
– reference: 1. Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011; 377: 557-67.
– reference: 23. Japan Society for the Study of Obesity Guidelines for the management of obesity disease 2016. Available at: http://www.jasso.or.jp/data/magazine/pdf/chart_A.pdf. Accessed August 1, 2019.
– reference: 30. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996; 334: 374-81.
– reference: 14. Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. The Trials of Hypertension Prevention Collaborative Research Group. Arch Intern Med 1997; 157: 657-67.
– reference: 21. LeBlanc ES, Patnode CD, Webber EM, et al. Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA 2018; 320: 1172-91.
– reference: 9. Klein S, Burke LE, Bray GA, et al. Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation 2004; 110: 2952-67.
– reference: 15. Blumenthal JA, Babyak MA, Hinderliter A, et al. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Arch Intern Med 2010; 170: 126-35.
– reference: 28. Hall JE, do Carmo JM, da Silva AA, et al. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res 2015; 116: 991-1006.
– reference: 16. Horvath K, Jeitler K, Siering U, et al. Long-term effects of weight-reducing interventions in hypertensive patients: systematic review and meta-analysis. Arch Intern Med 2008; 168: 571-80.
– reference: 7. Huang Z, Willett WC, Manson JE, et al. Body weight, weight change, and risk for hypertension in women. Ann Intern Med 1998; 128: 81-8.
– reference: 6. Ministry of Health, Labor and Welfare Health Service Bureau. National Health and Nutrition Survey. Available at: https://www.mhlw.go.jp/content/000451755.pdf. Accessed August 1, 2019.
– reference: 10. Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: executive summary: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation 2012; 126: 3097-137.
– reference: 20. Fogari R, Zoppi A, Corradi L, et al. Effect of body weight loss and normalization on blood pressure in overweight non-obese patients with stage 1 hypertension. Hypertens Res 2010; 33: 236-42.
– reference: 24. Schmieder RE, Messerli FH. Does obesity influence early target organ damage in hypertensive patients? Circulation 1993; 87: 1482-8.
– reference: 12. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2018; 138: e484-594.
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Snippet The association between changes in body weight and blood pressure (BP) in overweight people in the general population still remains unclear. We sought to...
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SubjectTerms Blood pressure
Body mass index
Body weight
Body weight gain
Body weight loss
Hypertension
Lifestyle modification
Obesity
Overweight
Weight control
Subtitle A Community-Based Cohort Study
Title Effect of Body Weight Change on Blood Pressure in a Japanese General Population with a Body Mass Index ≥ 22 kg/m2
URI https://www.jstage.jst.go.jp/article/ihj/60/6/60_19-314/_article/-char/en
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Volume 60
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