Estimation et caractérisation de l’insuffisance rénale chronique en France

L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L...

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Published inAnnales de cardiologie et d'angéiologie Vol. 61; no. 4; pp. 239 - 244
Main Authors Bongard, V., Dallongeville, J., Arveiler, D., Ruidavets, J.-B., Cottel, D., Wagner, A., Ferrières, J.
Format Journal Article
LanguageFrench
Published Paris Elsevier SAS 01.08.2012
Elsevier
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Online AccessGet full text
ISSN0003-3928
DOI10.1016/j.ancard.2012.03.003

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Abstract L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L’IRC a été définie comme des sujets ayant un débit de filtration glomérulaire (DFG) selon la formule MDRD inférieur à 60mL/min/1,73m2. La prévalence obtenue dans l’échantillon a été extrapolée à la population française. Une analyse logistique multivariée a été réalisée afin d’isoler les facteurs indépendamment associés à la prévalence d’une IRC. La prévalence de l’IRC en France a été évaluée à 8,2 % (intervalle de confiance à 95 % : 7,4–8,9 %) soit 2454548 (intervalle de confiance à 95 % : 2215080–2664082) sujets âgés de 35 à 74,9ans. Les facteurs significativement associés à l’IRC sont l’âge, l’hypertension artérielle et les dyslipidémies. En conclusion, l’étude MONA LISA estime pour la première fois en France la prévalence de l’IRC chez des sujets âgés de 35 à 74,9ans. Cette prévalence est probablement une sous-estimation de la prévalence réelle en raison des biais de sélection propres aux enquêtes épidémiologiques représentatives. Chronic kidney disease (CKD) is a major public health issue. In France, few studies have evaluated CKD prevalence. The objective of the MONA LISA study was to estimate and to characterize CKD in three representative cross-sectional surveys in subjects aged 35–74.9years. CKD was defined as subjects having MDRD glomerular filtration rate lower than 60mL/min/1.73m2. Prevalence of CKD in MONA LISA was standardized according to the French population. A multiple logistic regression analysis was performed in order to find independent factors associated to CKD. The French estimate of CKD prevalence was 8.2% (95% confidence interval: 7.4–8.9%), that is 2,454,548 (95% confidence interval: 2,215,080–2,664,082) subjects aged 35–74.9years. Factors significantly and independently associated to CKD were older age, hypertension and dyslipidemias. In conclusion, the MONA LISA study evaluated for the first time in France CKD prevalence in subjects aged 35–74.9years. This prevalence probably underestimates the real CKD size due to selection bias present in every representative cross-sectional survey.
AbstractList L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L’IRC a été définie comme des sujets ayant un débit de filtration glomérulaire (DFG) selon la formule MDRD inférieur à 60mL/min/1,73m2. La prévalence obtenue dans l’échantillon a été extrapolée à la population française. Une analyse logistique multivariée a été réalisée afin d’isoler les facteurs indépendamment associés à la prévalence d’une IRC. La prévalence de l’IRC en France a été évaluée à 8,2 % (intervalle de confiance à 95 % : 7,4–8,9 %) soit 2454548 (intervalle de confiance à 95 % : 2215080–2664082) sujets âgés de 35 à 74,9ans. Les facteurs significativement associés à l’IRC sont l’âge, l’hypertension artérielle et les dyslipidémies. En conclusion, l’étude MONA LISA estime pour la première fois en France la prévalence de l’IRC chez des sujets âgés de 35 à 74,9ans. Cette prévalence est probablement une sous-estimation de la prévalence réelle en raison des biais de sélection propres aux enquêtes épidémiologiques représentatives. Chronic kidney disease (CKD) is a major public health issue. In France, few studies have evaluated CKD prevalence. The objective of the MONA LISA study was to estimate and to characterize CKD in three representative cross-sectional surveys in subjects aged 35–74.9years. CKD was defined as subjects having MDRD glomerular filtration rate lower than 60mL/min/1.73m2. Prevalence of CKD in MONA LISA was standardized according to the French population. A multiple logistic regression analysis was performed in order to find independent factors associated to CKD. The French estimate of CKD prevalence was 8.2% (95% confidence interval: 7.4–8.9%), that is 2,454,548 (95% confidence interval: 2,215,080–2,664,082) subjects aged 35–74.9years. Factors significantly and independently associated to CKD were older age, hypertension and dyslipidemias. In conclusion, the MONA LISA study evaluated for the first time in France CKD prevalence in subjects aged 35–74.9years. This prevalence probably underestimates the real CKD size due to selection bias present in every representative cross-sectional survey.
Author Bongard, V.
Wagner, A.
Arveiler, D.
Ruidavets, J.-B.
Ferrières, J.
Cottel, D.
Dallongeville, J.
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  organization: Inserm UMR1027, service de cardiologie B et département d’épidémiologie, économie de la santé et santé publique, CHU Rangueil, TSA 50032, 31059 Toulouse cedex 9, France
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Issue 4
Keywords Prévalence
Prevalence
Representative survey
Étude populationnelle
Insuffisance rénale chronique
Chronic kidney disease
Risk factors
Facteurs de risque
Pathologie de l'appareil circulatoire
Pathologie du rein
Estimation
Pathologie de l'appareil urinaire
Insuffisance rénale
Caractéristiques
Cardiologie
Appareil circulatoire
Caractérisation
Néphropathie chronique
Insuffisance rénale chronique: Prévalence
Epidémiologie
Facteur risque
Caractéristique
Language French
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Snippet L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de...
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SubjectTerms Appareil urinaire et pathologie générale. Divers
Cardiologie. Appareil circulatoire
Chronic kidney disease
Facteurs de risque
Insuffisance rénale
Insuffisance rénale chronique
Maladies vasculaires des membres. Pathologie de la veine cave. Maladies vasculaires diverses
Nephrologie. Maladies des voies urinaires
Néphropathies. Pathologie vasculaire rénale. Insuffisance rénale
Prevalence
Prévalence
Reins
Representative survey
Risk factors
Sciences biologiques et medicales
Sciences medicales
Vaisseaux sanguins et lymphatiques
Étude populationnelle
Title Estimation et caractérisation de l’insuffisance rénale chronique en France
URI https://dx.doi.org/10.1016/j.ancard.2012.03.003
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