Estimation et caractérisation de l’insuffisance rénale chronique en France
L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L...
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Published in | Annales de cardiologie et d'angéiologie Vol. 61; no. 4; pp. 239 - 244 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | French |
Published |
Paris
Elsevier SAS
01.08.2012
Elsevier |
Subjects | |
Online Access | Get full text |
ISSN | 0003-3928 |
DOI | 10.1016/j.ancard.2012.03.003 |
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Abstract | L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L’IRC a été définie comme des sujets ayant un débit de filtration glomérulaire (DFG) selon la formule MDRD inférieur à 60mL/min/1,73m2. La prévalence obtenue dans l’échantillon a été extrapolée à la population française. Une analyse logistique multivariée a été réalisée afin d’isoler les facteurs indépendamment associés à la prévalence d’une IRC. La prévalence de l’IRC en France a été évaluée à 8,2 % (intervalle de confiance à 95 % : 7,4–8,9 %) soit 2454548 (intervalle de confiance à 95 % : 2215080–2664082) sujets âgés de 35 à 74,9ans. Les facteurs significativement associés à l’IRC sont l’âge, l’hypertension artérielle et les dyslipidémies. En conclusion, l’étude MONA LISA estime pour la première fois en France la prévalence de l’IRC chez des sujets âgés de 35 à 74,9ans. Cette prévalence est probablement une sous-estimation de la prévalence réelle en raison des biais de sélection propres aux enquêtes épidémiologiques représentatives.
Chronic kidney disease (CKD) is a major public health issue. In France, few studies have evaluated CKD prevalence. The objective of the MONA LISA study was to estimate and to characterize CKD in three representative cross-sectional surveys in subjects aged 35–74.9years. CKD was defined as subjects having MDRD glomerular filtration rate lower than 60mL/min/1.73m2. Prevalence of CKD in MONA LISA was standardized according to the French population. A multiple logistic regression analysis was performed in order to find independent factors associated to CKD. The French estimate of CKD prevalence was 8.2% (95% confidence interval: 7.4–8.9%), that is 2,454,548 (95% confidence interval: 2,215,080–2,664,082) subjects aged 35–74.9years. Factors significantly and independently associated to CKD were older age, hypertension and dyslipidemias. In conclusion, the MONA LISA study evaluated for the first time in France CKD prevalence in subjects aged 35–74.9years. This prevalence probably underestimates the real CKD size due to selection bias present in every representative cross-sectional survey. |
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AbstractList | L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de l’étude MONA LISA a été d’évaluer et de caractériser l’IRC dans trois échantillons représentatifs français de la population âgée de 35 à 74,9ans. L’IRC a été définie comme des sujets ayant un débit de filtration glomérulaire (DFG) selon la formule MDRD inférieur à 60mL/min/1,73m2. La prévalence obtenue dans l’échantillon a été extrapolée à la population française. Une analyse logistique multivariée a été réalisée afin d’isoler les facteurs indépendamment associés à la prévalence d’une IRC. La prévalence de l’IRC en France a été évaluée à 8,2 % (intervalle de confiance à 95 % : 7,4–8,9 %) soit 2454548 (intervalle de confiance à 95 % : 2215080–2664082) sujets âgés de 35 à 74,9ans. Les facteurs significativement associés à l’IRC sont l’âge, l’hypertension artérielle et les dyslipidémies. En conclusion, l’étude MONA LISA estime pour la première fois en France la prévalence de l’IRC chez des sujets âgés de 35 à 74,9ans. Cette prévalence est probablement une sous-estimation de la prévalence réelle en raison des biais de sélection propres aux enquêtes épidémiologiques représentatives.
Chronic kidney disease (CKD) is a major public health issue. In France, few studies have evaluated CKD prevalence. The objective of the MONA LISA study was to estimate and to characterize CKD in three representative cross-sectional surveys in subjects aged 35–74.9years. CKD was defined as subjects having MDRD glomerular filtration rate lower than 60mL/min/1.73m2. Prevalence of CKD in MONA LISA was standardized according to the French population. A multiple logistic regression analysis was performed in order to find independent factors associated to CKD. The French estimate of CKD prevalence was 8.2% (95% confidence interval: 7.4–8.9%), that is 2,454,548 (95% confidence interval: 2,215,080–2,664,082) subjects aged 35–74.9years. Factors significantly and independently associated to CKD were older age, hypertension and dyslipidemias. In conclusion, the MONA LISA study evaluated for the first time in France CKD prevalence in subjects aged 35–74.9years. This prevalence probably underestimates the real CKD size due to selection bias present in every representative cross-sectional survey. |
Author | Bongard, V. Wagner, A. Arveiler, D. Ruidavets, J.-B. Ferrières, J. Cottel, D. Dallongeville, J. |
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Keywords | Prévalence Prevalence Representative survey Étude populationnelle Insuffisance rénale chronique Chronic kidney disease Risk factors Facteurs de risque Pathologie de l'appareil circulatoire Pathologie du rein Estimation Pathologie de l'appareil urinaire Insuffisance rénale Caractéristiques Cardiologie Appareil circulatoire Caractérisation Néphropathie chronique Insuffisance rénale chronique: Prévalence Epidémiologie Facteur risque Caractéristique |
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Snippet | L’insuffisance rénale chronique (IRC) est un problème majeur de santé publique. En France, peu d’études ont évalué la prévalence de l’IRC. L’objectif de... |
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SubjectTerms | Appareil urinaire et pathologie générale. Divers Cardiologie. Appareil circulatoire Chronic kidney disease Facteurs de risque Insuffisance rénale Insuffisance rénale chronique Maladies vasculaires des membres. Pathologie de la veine cave. Maladies vasculaires diverses Nephrologie. Maladies des voies urinaires Néphropathies. Pathologie vasculaire rénale. Insuffisance rénale Prevalence Prévalence Reins Representative survey Risk factors Sciences biologiques et medicales Sciences medicales Vaisseaux sanguins et lymphatiques Étude populationnelle |
Title | Estimation et caractérisation de l’insuffisance rénale chronique en France |
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