Integrated Thermogravimetric and Spectroscopic Evaluation of Azo Dye and Its Polymers: Focused Analytical Characterization of the Dye and Broad Assessment of Antibacterial Activity

• Published in: Annales de chimie (Paris. 1914) Vol. 49; no. 2; pp. 145 - 156
• Main Authors: Mankhi, Zainab H., Ali, Hanan M., Hussain, Mahmoud Sh
• Format: Journal Article
• Language: English
• Published: Edmonton International Information and Engineering Technology Association (IIETA) 01.04.2025
• Subjects: Ampicillin; Antibiotics; Antimicrobial agents; Azo compounds; Biodegradation; Biomedical materials; Cancer therapies; Chemicals; Crosslinking; Drug delivery systems; Drug resistance; Dyes; E coli; Fourier transforms; Infrared analysis; Infrared spectroscopy; Investigations; Medical electronics; Microscopy; NMR; Nuclear magnetic resonance; Polymerization; Polymers; Scientists; Solvents; Thermal stability; Thermodynamic properties; Thermogravimetric analysis; Tissue engineering; Wound healing
• ISSN: 0151-9107; 1958-5934; 1958-5934
• DOI: 10.18280/acsm.490205

A study investigates the creation of azo-derived polymers alongside their characterization and biological evaluation with emphasis on antibacterial properties and thermal properties of these materials. This research aims to synthesize ZA1 azo substance as well as ZP3 and ZP4 polymeric derivatives and evaluate their biomedical potential. The research utilized both diazotization and coupling processes for azo compounds synthesis and incorporated phthalic acid as the crosslinking agent in the polymerization reaction. The examination of produced substances used two testing methods which included Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric Analysis (TGA). Antibacterial assessment of Escherichia coli and Staphylococcus aureus occurred by disk diffusion technique against standard medications ampicillin and ciprofloxacin. Laboratory research confirmed that polymerization technologies strengthened the antibacterial strength of azo compounds where ZP4 demonstrated superior outcomes compared to conventional antibiotic treatments. Thermal stability examination by TGA analysis confirmed the appropriate use of produced polymers in biomedical applications. This research is proven that polymers derived from azo compounds show strong potential as antibacterial agents to support medical functions including wound dressings, antimicrobial coatings and medication delivery methods. The discoveries enable to make alternative methods which resist antibiotic-resistant bacterial strains. The research reveals possibility of azo-based polymers adapting into healthcare materials through advanced production understanding which leads to enhanced antimicrobial performance. The research discloses which modifications improve antibacterial agent stability and effectiveness.