Importance of ventricle-to-brain ratio (VBR) and volume of CSF drainage in the treatment of very low pressure hydrocephalus

• Published in: Canadian journal of neurological sciences Vol. 42; no. S1; p. S43
• Main Authors: Houlden, D, Li, M, Portman, S
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.05.2015
• Subjects: Coma; Hydrocephalus; Poster Presentations
• ISSN: 0317-1671; 2057-0155; 2057-0155
• DOI: 10.1017/cjn.2015.194

Introduction: Low pressure hydrocephalus is a known complication of prolonged hydrocephalus sometimes treatable with continued low-pressure drainage at subatmospheric pressures. Clarke et. al. and Filipidis et. al. have reported poor outcomes when treating very low pressure hydrocephalus (VLPH). We present 4 cases of very low pressure hydrocephalus (VLPH) following transnasal endoscopic resection of suprasellar lesions and hypothesize that poor prognostic cases can be identified thereby avoiding prolonged futile treatments. Methods: We performed a retrospective chart review of 4 cases of VLPH and tried to identify metrics contributing to successful treatment. We examined the Pearson correlations between Glasgow Coma Scale and ventricle-to-brain ratio (VBR); volume of CSF drained; net fluids; and serum sodium, urea, and creatinine. Results: Our investigation reveals that Glasgow Coma Score is positively correlated with increased CSF drainage and negatively correlated with increased ventricle-to-brain ratio. The most important determinant of good outcome is brain compliance as measured by the brain’s ability to maintain a good GCS score in the face of wide ranges in ventricle-to-brain ratio (VBR). Conclusion: We propose that futile prolonged subatmospheric drainage be avoided by declining treatment in patients who have ventriculitis and patients who have a narrow range of ventricle-to-brain ratio (VBR) concurrent with a good neurological examination.