Dermatophagoides farinae upregulates the effector functions of eosinophils through αMβ2 integrin and PAR-2

Rationale Even in subjects who are not sensitized to house-dust mite (HDM), allergic symptoms can be aggravated by exposure to dust, suggesting that innate immune responses may be involved in these processes. Since eosinophils express pathogen recognition receptors such as pattern recognition recept...

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Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB111
Main Authors Ueda, Yutaka, Tokuyama, Kennichi, Nakagome, Kazuyuki, Kobayashi, Takehito, Nagata, Makoto
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Immune response
Innate immunity
Leukocytes (eosinophilic)
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ISSN0091-6749
1097-6825
DOI10.1016/j.jaci.2017.12.354

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Summary:Rationale Even in subjects who are not sensitized to house-dust mite (HDM), allergic symptoms can be aggravated by exposure to dust, suggesting that innate immune responses may be involved in these processes. Since eosinophils express pathogen recognition receptors such as pattern recognition receptors (PRRs), HDM may directly upregulate eosinophil functions through these receptors. Methods Eosinophils isolated from the blood of healthy donors or allergic patients were stimulated with Df or Der f 1, and their adhesion to recombinant human-intercellular adhesion molecule (ICAM)-1 was measured using eosinophil peroxidase assays.
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.354