Current Opportunities and Future Prospects of Neuroprotective Therapy in Glaucoma. Literature Review. Part 2

This literature review is devoted to one of the most challenging problems of ophthalmology — neuroprotective and neuroregenerative treatment of glaucoma and consists of two parts. The second part of the review deals with the role of glia, inflammation and autoimmunization in the pathogenesis of neur...

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Published inOftalmologii͡a Vol. 22; no. 2; pp. 251 - 264
Main Authors Kurysheva, N. I., Korneeva, A. V., Ponomareva, S. I., Plieva, H. M., Kim, V. E., Kim, I. D., Chebotareva, M. V.
Format Journal Article
LanguageEnglish
Russian
Published Ophthalmology Publishing Group 27.06.2025
Subjects
apoptosis
glaucoma
glaucomatous optic neuropathy
neurodegeneration
neuroprotection
retinal ganglion cells
Online AccessGet full text
ISSN1816-5095
2500-0845
DOI10.18008/1816-5095-2025-2-251-264

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Abstract This literature review is devoted to one of the most challenging problems of ophthalmology — neuroprotective and neuroregenerative treatment of glaucoma and consists of two parts. The second part of the review deals with the role of glia, inflammation and autoimmunization in the pathogenesis of neuroretinal degeneration in glaucoma optic neuropathy (GON), new treatment strategies based on modern achievements of gene and immunotherapy. Special attention is paid to promising therapeutic approaches based on artificial intelligence application, usage of peptide bioregulators, immunomodulators and mixed-action drugs. Alternative methods of axonal regeneration, including gene therapy and stem cell therapy, are discussed.
AbstractList This literature review is devoted to one of the most challenging problems of ophthalmology — neuroprotective and neuroregenerative treatment of glaucoma and consists of two parts. The second part of the review deals with the role of glia, inflammation and autoimmunization in the pathogenesis of neuroretinal degeneration in glaucoma optic neuropathy (GON), new treatment strategies based on modern achievements of gene and immunotherapy. Special attention is paid to promising therapeutic approaches based on artificial intelligence application, usage of peptide bioregulators, immunomodulators and mixed-action drugs. Alternative methods of axonal regeneration, including gene therapy and stem cell therapy, are discussed.
Author Korneeva, A. V.
Plieva, H. M.
Ponomareva, S. I.
Kurysheva, N. I.
Chebotareva, M. V.
Kim, V. E.
Kim, I. D.
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SubjectTerms apoptosis
glaucoma
glaucomatous optic neuropathy
neurodegeneration
neuroprotection
retinal ganglion cells
Title Current Opportunities and Future Prospects of Neuroprotective Therapy in Glaucoma. Literature Review. Part 2
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