Autoantibodies in sera of patients with hepatocellular carcinoma
Autoantibodies including antinuclear antibody, antismooth-muscle antibody, antimitochondrial antibody, rheumatoid factor, lupus erythematosus factor, antimicrosomal antibody and antithyroglobulin antibody were assayed in 70 sera of hepatocellular carcinoma, 31 sera of liver cirrhosis, 32 sera of chr...
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| Published in | Kanzo Vol. 27; no. 11; pp. 1539 - 1545 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
1986
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| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.27.1539 |
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| Abstract | Autoantibodies including antinuclear antibody, antismooth-muscle antibody, antimitochondrial antibody, rheumatoid factor, lupus erythematosus factor, antimicrosomal antibody and antithyroglobulin antibody were assayed in 70 sera of hepatocellular carcinoma, 31 sera of liver cirrhosis, 32 sera of chronic hepatitis, 60 sera of non-hepatic tumors and 145 normal subjects. A significantly high prevalence of antinuclear antibody was found in patients with hepatocellular carcinoma (24.3%) and with non-hepatic tumors (23.3%). Antinuclear antibody in sera of hepatoma patients was not correlated with other autoantibodies and also with hepatitis B surface antigen, sex and age. Serial assays of antinuclear antibody in sera of different stages from precancerous stage to cancerous stage and/or after resection of hepatic tumor were done in 10 patients with hepatocellular carcinoma whose sera were positive for antinuclear antibody. Antinuclear antibody became positive with the evolution of hepatoma in 2 patients, and disappearance of antinuclear antibody was observed in one patient after resection of hepatic tumor. The contribute significance of antinuclear antibody in serum of hepatoma is not clear, but in some patients with hepatocellular carcinoma, antinuclear antibody can behave like tumor-marker. |
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| AbstractList | Autoantibodies including antinuclear antibody, antismooth-muscle antibody, antimitochondrial antibody, rheumatoid factor, lupus erythematosus factor, antimicrosomal antibody and antithyroglobulin antibody were assayed in 70 sera of hepatocellular carcinoma, 31 sera of liver cirrhosis, 32 sera of chronic hepatitis, 60 sera of non-hepatic tumors and 145 normal subjects. A significantly high prevalence of antinuclear antibody was found in patients with hepatocellular carcinoma (24.3%) and with non-hepatic tumors (23.3%). Antinuclear antibody in sera of hepatoma patients was not correlated with other autoantibodies and also with hepatitis B surface antigen, sex and age. Serial assays of antinuclear antibody in sera of different stages from precancerous stage to cancerous stage and/or after resection of hepatic tumor were done in 10 patients with hepatocellular carcinoma whose sera were positive for antinuclear antibody. Antinuclear antibody became positive with the evolution of hepatoma in 2 patients, and disappearance of antinuclear antibody was observed in one patient after resection of hepatic tumor. The contribute significance of antinuclear antibody in serum of hepatoma is not clear, but in some patients with hepatocellular carcinoma, antinuclear antibody can behave like tumor-marker. |
| Author | IMAI, Haruhiko FURUTA, Seiichi KAMEKO, Mitsuaki KIYOSAWA, Kendo KUMAGAI, Toshiko KANAI, Masamitsu |
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| References | 12) 岸本進,藤井隆:加齢・性差と免疫応答.日本臨床(春季増刊号)510号:882-889, 1984 6) Ablin RJ: Serum antibody in patients with prostatic cancer. Br J Urology 48: 355-361, 1976 17) Miyachi K, Fritzler MJ, Tan EM: Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121: 2228-2234, 1978 20) Takasaki Y, Robinson WA, Tan EM: Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J National Cancer Inst 73: 655-661, 1984 1) Thomas PJ, Kaur JS, Tan EM,: Antinuclear, antinucleolar and anticytoplasmic antibodies in patients with malignant melanoma. Cancer Research 43: 1372-1380, 1983 4) Wasserman J, Glas U, Blomgren H: Autoantibodies in patients with carcinoma of the breast. Clin Exp Immunol 19: 417-422, 1975 19) Takasaki Y, Fishwild D, Tan EM: Characterization of proliferating cell nuclear antigen recongnized by autoantibodies in lupus sera. J Exp Med 159: 981-992, 1984 11) Kozin F, Fowler M, Koethe SM: A comparison of the sensitivities and specificities of different substrates for the fluorescent antinuclear antibody test. Am J Clin Pathol 74: 785-790, 1980 16) Hannestad K, Stollar BD: Certain rheumatoid factors react with nucleosomes. Nature 275: 671-673, 1978 9) Okayasu I, Mizutani H, Yanagisawa F: Cancer in collagen disease. A statistical analysis by reviewing the annual of pathological autopsy cases (Nippon Boken Shuho) in Japan. Cancer 54: 1841-1844, 1984 2) Steiner M, Klein E, Klein G: Antinuclear reactivity of sera in patients with leukemia and other neoplastic diseases. Clin Immunol Immunopathol 4: 374-381, 1975 7) Whitehouse JMA, Holborow EJ: Smooth muscle antibody in malignant disease. Br Med J 4: 511-513, 1971 13) Gray ES, McLay ALC, Home CHW: Non-organ specific autoantibodies in malignant diseases. Scot Med J 20: 203-208, 1975 15) Hurri L, Perttala Y: Observations on nonspecific Waaler-Rose and latex reactions in cancer patients. Ann Med Int Fenn 54: 181-183, 1965 14) Giuliano AE, Irie R, Morton DL: Rheumatoid factor in melanoma patients. Alterations of humoral tumor immunity in vitro. Cancer 43: 1624-1629, 1979 5) Turnbull AR, Turner TL, Wright R: Autoantibodies in early breast cancer. A stagerelated phenomenon?. Br J Cancer 38: 461-463, 1978 10) Doniach D: Autoimmunity in liver disease. In: Progress in Clinical Immunology Vol. 1, Grune and Stratton New York, 1972, p45 3) Hodson ME, Turner-Warwick M: Autoantibodies in patients with bronchial carcinoma. Thorax 30: 367-370, 1975 8) Burnham TK: Antinuclear antibodies in patients with malignancies. Lancet 2: 436-437, 1972 18) Takasaki Y, Deng JS, Tan EM: A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronized cells. J Exp Med 154: 1899-1909, 1981 |
| References_xml | – reference: 15) Hurri L, Perttala Y: Observations on nonspecific Waaler-Rose and latex reactions in cancer patients. Ann Med Int Fenn 54: 181-183, 1965 – reference: 13) Gray ES, McLay ALC, Home CHW: Non-organ specific autoantibodies in malignant diseases. Scot Med J 20: 203-208, 1975 – reference: 9) Okayasu I, Mizutani H, Yanagisawa F: Cancer in collagen disease. A statistical analysis by reviewing the annual of pathological autopsy cases (Nippon Boken Shuho) in Japan. Cancer 54: 1841-1844, 1984 – reference: 5) Turnbull AR, Turner TL, Wright R: Autoantibodies in early breast cancer. A stagerelated phenomenon?. Br J Cancer 38: 461-463, 1978 – reference: 4) Wasserman J, Glas U, Blomgren H: Autoantibodies in patients with carcinoma of the breast. Clin Exp Immunol 19: 417-422, 1975 – reference: 8) Burnham TK: Antinuclear antibodies in patients with malignancies. Lancet 2: 436-437, 1972 – reference: 20) Takasaki Y, Robinson WA, Tan EM: Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J National Cancer Inst 73: 655-661, 1984 – reference: 1) Thomas PJ, Kaur JS, Tan EM,: Antinuclear, antinucleolar and anticytoplasmic antibodies in patients with malignant melanoma. Cancer Research 43: 1372-1380, 1983 – reference: 6) Ablin RJ: Serum antibody in patients with prostatic cancer. Br J Urology 48: 355-361, 1976 – reference: 11) Kozin F, Fowler M, Koethe SM: A comparison of the sensitivities and specificities of different substrates for the fluorescent antinuclear antibody test. Am J Clin Pathol 74: 785-790, 1980 – reference: 7) Whitehouse JMA, Holborow EJ: Smooth muscle antibody in malignant disease. Br Med J 4: 511-513, 1971 – reference: 19) Takasaki Y, Fishwild D, Tan EM: Characterization of proliferating cell nuclear antigen recongnized by autoantibodies in lupus sera. J Exp Med 159: 981-992, 1984 – reference: 14) Giuliano AE, Irie R, Morton DL: Rheumatoid factor in melanoma patients. Alterations of humoral tumor immunity in vitro. Cancer 43: 1624-1629, 1979 – reference: 18) Takasaki Y, Deng JS, Tan EM: A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronized cells. J Exp Med 154: 1899-1909, 1981 – reference: 3) Hodson ME, Turner-Warwick M: Autoantibodies in patients with bronchial carcinoma. Thorax 30: 367-370, 1975 – reference: 12) 岸本進,藤井隆:加齢・性差と免疫応答.日本臨床(春季増刊号)510号:882-889, 1984 – reference: 17) Miyachi K, Fritzler MJ, Tan EM: Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121: 2228-2234, 1978 – reference: 2) Steiner M, Klein E, Klein G: Antinuclear reactivity of sera in patients with leukemia and other neoplastic diseases. Clin Immunol Immunopathol 4: 374-381, 1975 – reference: 16) Hannestad K, Stollar BD: Certain rheumatoid factors react with nucleosomes. Nature 275: 671-673, 1978 – reference: 10) Doniach D: Autoimmunity in liver disease. In: Progress in Clinical Immunology Vol. 1, Grune and Stratton New York, 1972, p45 |
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