Microsurgical free flaps for skull base reconstruction following tumor resection: Available techniques and complications

Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexit...

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Published inNeurocirugía (Barcelona. Internet. English ed.) Vol. 34; no. 1; pp. 22 - 31
Main Authors Plou, Pedro, Boccalatte, Luis, Padilla-Lichtenberger, Fernando, Figari, Marcelo, Ajler, Pablo, Larrañaga, Juan
Format Journal Article
LanguageEnglish
Published Spain Elsevier España, S.L.U 01.01.2023
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Online AccessGet full text
ISSN2529-8496
2529-8496
DOI10.1016/j.neucie.2022.11.005

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Abstract Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexity of the defects requiring reconstruction and the potential complications that can occur, represent a true challenge for the surgical team. The goal of this study is to describe the microsurgical reconstructive techniques available, their usefulness and postoperative complications, in patients with malignant tumors involving the skull base. This observational, retrospective study, included all patients who underwent surgery for malignant craniofacial tumors from January 1st, 2009 to January 1st, 2019 at a University Hospital in Argentina. Only patients who required reconstruction of the resulting defect with a free flap were included. Twenty-four patients required reconstruction with FF; 14 were male (58.3%) and mean age was 54.9 years. Sarcoma was the most frequent tumor histology. Free flaps used were the following: anterolateral thigh, rectus abdominis, radial, latissimus dorsi, iliac crest and fibular. Complications occurred in 6 cases and no deaths were reported in the study group. Free flaps are considered one of the preferable choices of treatment for large skull base defects. In spite of the complexity of the technique and the learning curve required, free flaps have shown to be safe, with a low rate of serious complications. For these patients, the surgical resolution should be performed by a multidisciplinary team. La resección de los tumores malignos de la base de cráneo anterior y media requieren no solo un amplio conocimiento anatómico, sino también experiencia en las posibles opciones reconstructivas factibles para resolver el defecto generado. La importancia anatómica y funcional de la región, la complejidad de los defectos a reconstruir y las posibles complicaciones que pueden desarrollar representan un verdadero desafío para el equipo quirúrgico. El objetivo del presente trabajo es exponer las posibles opciones reconstructivas microquirúrgicas, su utilidad y las complicaciones postoperatorias en pacientes con tumores malignos que comprometen la base de cráneo. Se realizó un estudio observacional retrospectivo de todos los pacientes operados de tumores malignos craneofaciales en el período comprendido entre el primero de enero de 2009 al primero de enero de 2019 en un hospital universitario de Argentina. Se incluyeron solo aquellos pacientes en los que fue necesario reconstruir el defecto a través de un colgajo libre (CL). Veinticuatro pacientes requirieron reconstrucción con CL. Catorce fueron varones (n=14 [58,3%]) y la media de edad fue de 54,9 años. La variedad tumoral histológica más frecuente fue el sarcoma. Los tipos de CL utilizados fueron los siguientes: anterolateral de muslo, recto anterior del abdomen, radial, dorsal ancho, cresta iliaca y fibular fueron los CL utilizados. Se reportó una tasa global de complicaciones del n=6 (25%). Un solo paciente presentó isquemia del colgajo. No hubo mortalidad asociada. Los CL representan una de las primeras opciones en el tratamiento en defectos grandes de la base de cráneo. A pesar de la complejidad de la técnica y la curva de aprendizaje necesaria, los CL han demostrado ser seguros con bajas tasas de complicaciones graves. La resolución quirúrgica de estos pacientes se debe realizar por un equipo multidisciplinario.
AbstractList Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexity of the defects requiring reconstruction and the potential complications that can occur, represent a true challenge for the surgical team. The goal of this study is to describe the microsurgical reconstructive techniques available, their usefulness and postoperative complications, in patients with malignant tumors involving the skull base. This observational, retrospective study, included all patients who underwent surgery for malignant craniofacial tumors from January 1st, 2009 to January 1st, 2019 at a University Hospital in Argentina. Only patients who required reconstruction of the resulting defect with a free flap were included. Twenty-four patients required reconstruction with FF; 14 were male (58.3%) and mean age was 54.9 years. Sarcoma was the most frequent tumor histology. Free flaps used were the following: anterolateral thigh, rectus abdominis, radial, latissimus dorsi, iliac crest and fibular. Complications occurred in 6 cases and no deaths were reported in the study group. Free flaps are considered one of the preferable choices of treatment for large skull base defects. In spite of the complexity of the technique and the learning curve required, free flaps have shown to be safe, with a low rate of serious complications. For these patients, the surgical resolution should be performed by a multidisciplinary team.
Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexity of the defects requiring reconstruction and the potential complications that can occur, represent a true challenge for the surgical team. The goal of this study is to describe the microsurgical reconstructive techniques available, their usefulness and postoperative complications, in patients with malignant tumors involving the skull base. This observational, retrospective study, included all patients who underwent surgery for malignant craniofacial tumors from January 1st, 2009 to January 1st, 2019 at a University Hospital in Argentina. Only patients who required reconstruction of the resulting defect with a free flap were included. Twenty-four patients required reconstruction with FF; 14 were male (58.3%) and mean age was 54.9 years. Sarcoma was the most frequent tumor histology. Free flaps used were the following: anterolateral thigh, rectus abdominis, radial, latissimus dorsi, iliac crest and fibular. Complications occurred in 6 cases and no deaths were reported in the study group. Free flaps are considered one of the preferable choices of treatment for large skull base defects. In spite of the complexity of the technique and the learning curve required, free flaps have shown to be safe, with a low rate of serious complications. For these patients, the surgical resolution should be performed by a multidisciplinary team. La resección de los tumores malignos de la base de cráneo anterior y media requieren no solo un amplio conocimiento anatómico, sino también experiencia en las posibles opciones reconstructivas factibles para resolver el defecto generado. La importancia anatómica y funcional de la región, la complejidad de los defectos a reconstruir y las posibles complicaciones que pueden desarrollar representan un verdadero desafío para el equipo quirúrgico. El objetivo del presente trabajo es exponer las posibles opciones reconstructivas microquirúrgicas, su utilidad y las complicaciones postoperatorias en pacientes con tumores malignos que comprometen la base de cráneo. Se realizó un estudio observacional retrospectivo de todos los pacientes operados de tumores malignos craneofaciales en el período comprendido entre el primero de enero de 2009 al primero de enero de 2019 en un hospital universitario de Argentina. Se incluyeron solo aquellos pacientes en los que fue necesario reconstruir el defecto a través de un colgajo libre (CL). Veinticuatro pacientes requirieron reconstrucción con CL. Catorce fueron varones (n=14 [58,3%]) y la media de edad fue de 54,9 años. La variedad tumoral histológica más frecuente fue el sarcoma. Los tipos de CL utilizados fueron los siguientes: anterolateral de muslo, recto anterior del abdomen, radial, dorsal ancho, cresta iliaca y fibular fueron los CL utilizados. Se reportó una tasa global de complicaciones del n=6 (25%). Un solo paciente presentó isquemia del colgajo. No hubo mortalidad asociada. Los CL representan una de las primeras opciones en el tratamiento en defectos grandes de la base de cráneo. A pesar de la complejidad de la técnica y la curva de aprendizaje necesaria, los CL han demostrado ser seguros con bajas tasas de complicaciones graves. La resolución quirúrgica de estos pacientes se debe realizar por un equipo multidisciplinario.
Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexity of the defects requiring reconstruction and the potential complications that can occur, represent a true challenge for the surgical team. The goal of this study is to describe the microsurgical reconstructive techniques available, their usefulness and postoperative complications, in patients with malignant tumors involving the skull base.INTRODUCTIONResection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience regarding the possible reconstructive options to resolve the resulting defects. The anatomical and functional relevance of the region, the complexity of the defects requiring reconstruction and the potential complications that can occur, represent a true challenge for the surgical team. The goal of this study is to describe the microsurgical reconstructive techniques available, their usefulness and postoperative complications, in patients with malignant tumors involving the skull base.This observational, retrospective study, included all patients who underwent surgery for malignant craniofacial tumors from January 1st, 2009 to January 1st, 2019 at a University Hospital in Argentina. Only patients who required reconstruction of the resulting defect with a free flap were included.MATERIALS AND METHODThis observational, retrospective study, included all patients who underwent surgery for malignant craniofacial tumors from January 1st, 2009 to January 1st, 2019 at a University Hospital in Argentina. Only patients who required reconstruction of the resulting defect with a free flap were included.Twenty-four patients required reconstruction with FF; 14 were male (58.3%) and mean age was 54.9 years. Sarcoma was the most frequent tumor histology. Free flaps used were the following: anterolateral thigh, rectus abdominis, radial, latissimus dorsi, iliac crest and fibular. Complications occurred in 6 cases and no deaths were reported in the study group.RESULTSTwenty-four patients required reconstruction with FF; 14 were male (58.3%) and mean age was 54.9 years. Sarcoma was the most frequent tumor histology. Free flaps used were the following: anterolateral thigh, rectus abdominis, radial, latissimus dorsi, iliac crest and fibular. Complications occurred in 6 cases and no deaths were reported in the study group.Free flaps are considered one of the preferable choices of treatment for large skull base defects. In spite of the complexity of the technique and the learning curve required, free flaps have shown to be safe, with a low rate of serious complications. For these patients, the surgical resolution should be performed by a multidisciplinary team.CONCLUSIONFree flaps are considered one of the preferable choices of treatment for large skull base defects. In spite of the complexity of the technique and the learning curve required, free flaps have shown to be safe, with a low rate of serious complications. For these patients, the surgical resolution should be performed by a multidisciplinary team.
Author Padilla-Lichtenberger, Fernando
Ajler, Pablo
Boccalatte, Luis
Larrañaga, Juan
Figari, Marcelo
Plou, Pedro
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Cites_doi 10.1097/00006534-199612000-00005
10.1097/00006534-199705010-00013
10.1001/archopht.1941.00870080015001
10.1002/hed.10147
10.1016/j.jcms.2016.10.017
10.1002/cncr.28108
10.1097/00006534-198606000-00005
10.1097/01.PRS.0000160691.63029.74
10.1016/j.otohns.2009.02.025
10.1097/SCS.0000000000000858
10.1002/hed.20166
10.1055/s-0032-1329618
10.1001/archotol.1993.01880240054007
10.1002/hed.2880120502
10.1002/hed.2880160403
10.1055/s-0039-1677881
10.1002/(SICI)1097-0347(199609/10)18:5<412::AID-HED4>3.0.CO;2-8
10.1097/SAP.0b013e3181715707
10.1055/s-2006-932503
10.1002/cncr.11630
10.1097/01.sap.0000218490.16921.c2
10.1007/s10143-009-0222-4
10.1055/s-0031-1286119
10.1016/S0194-5998(99)70172-5
10.1002/cncr.25390
10.1001/archotol.1994.01880350017004
10.1001/archotol.128.2.161
10.1016/j.bjps.2016.06.008
10.1002/(SICI)1097-0347(199901)21:1<12::AID-HED2>3.0.CO;2-#
10.1177/014556131809700712
10.1097/PRS.0000000000003917
10.1016/0002-9610(63)90387-8
10.1016/S0094-1298(20)32722-X
10.1002/hed.2880160103
10.1055/s-0037-1606556
10.1055/s-0037-1607273
10.1001/archotol.125.3.295
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Issue 1
Keywords Cirugía de la base del cráneo
Colgajo libre
Malignant tumors
Skull base surgery
Free flap
Tumores malignos
Reconstrucción de la base del cráneo
Skull base reconstruction
Language English
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References Irish, Gullane, Gentili, Freeman, Boyd, Brown (bib0310) 1994; 16
Paprottka, Krezdorn, Ipaktchi, Radtke, Vogt (bib0290) 2016; 69
Chiu, Kraus, Bui, Mehrara, Disa, Bilsky (bib0220) 2008; 60
Urken, Catalano, Sen, Post, Futran, Biller (bib0235) 1993; 119
Browne, Burke (bib0265) 1999; 121
Catalano, Hecht, Biller, Lawson, Post, Sachdev (bib0245) 1994; 120
Ganly, Patel, Singh, Kraus, Cantu, Fliss (bib0370) 2011; 117
Yeo, Kim, Park, Lim, Kim, Lee (bib0285) 2014; 25
Shestak (bib0230) 1994; 21
Allen, Isaacson, Kutz, Purcell, Roland (bib0375) 2012; 73
Hanasono, Sacks, Goel, Ayad, Skoracki (bib0275) 2009; 140
Wang, Vincent, Sokoya, Kohlert, Kadakia, Ducic (bib0345) 2019; 33
Ansa, Goodman, Ward, Kono, Owonikoko, Higgins (bib0205) 2013; 119
Forner, Williams, Makki, Trites, Taylor, Hart (bib0390) 2018; 97
Brown (bib0300) 1996; 18
Marchetti, Gessaroli, Cipriani, Contedini, Frattarelli, Staffa (bib0270) 2002; 110
Arnaoutakis, Kadakia, Abraham, Lee, Ducic (bib0320) 2017; 31
Dias, Sá, Kligerman, Lopes, Wance, Paiva (bib0330) 1999; 21
Heth, Funk, Karnell, McCulloch, Traynelis, Nerad (bib0250) 2002; 24
Jackson, Adham, Marsh (bib0225) 1986; 77
Kraus, Shah, Arbit, Galicich, Strong (bib0240) 1994; 16
Peng, Mao, Yu, Guo, Huang, Zhang (bib0340) 2005; 115
Ketcham, Wilkins, Vanburen, Smith (bib0215) 1963; 106
Amin, Rifaat, Civantos, Weed, Abu-Sedira, Bassiouny (bib0335) 2006; 22
O’Connell, Teng, Mendez, Futran (bib0260) 2011; 4
Dandy (bib0210) 1941; 25
Granick, Ramasastry, Newton, Solomon, Hanna, Kaltman (bib0295) 1990; 12
Ganly, Patel, Singh, Kraus, Bridger, Cantu (bib0365) 2005; 27
Largo, Selber, Garvey, Chang, Hanasono, Yu (bib0380) 2018; 141
Malata, Tehrani, Kumiponjera, Hardy, Moffat (bib0280) 2006; 57
Futran, Wadsworth, Villaret, Farwell (bib0305) 2002; 128
Blackwell (bib0385) 1999; 125
Herr, Lin (bib0325) 2013; 74
Neligan, Mulholland, Irish, Gullane, Boyd, Gentili (bib0315) 1996; 98
Raza, Conway, Li, Attenello, Boahene, Subramanian (bib0360) 2010; 33
Cherubino, Turri-Zanoni, Battaglia, Giudice, Pellegatta, Tamborini (bib0200) 2017; 45
Foster, Anthony, Singer, Kaplan, Pogrel, Mathes (bib0350) 1997; 99
Kwon, Iloreta, Miles, Inman (bib0255) 2017; 31
Patel, Singh, Polluri, Bridger, Cantu, Cheesman (bib0355) 2003; 98
Dandy (10.1016/j.neucie.2022.11.005_bib0210) 1941; 25
Amin (10.1016/j.neucie.2022.11.005_bib0335) 2006; 22
Foster (10.1016/j.neucie.2022.11.005_bib0350) 1997; 99
Heth (10.1016/j.neucie.2022.11.005_bib0250) 2002; 24
Blackwell (10.1016/j.neucie.2022.11.005_bib0385) 1999; 125
Irish (10.1016/j.neucie.2022.11.005_bib0310) 1994; 16
Herr (10.1016/j.neucie.2022.11.005_bib0325) 2013; 74
Yeo (10.1016/j.neucie.2022.11.005_bib0285) 2014; 25
Ansa (10.1016/j.neucie.2022.11.005_bib0205) 2013; 119
Browne (10.1016/j.neucie.2022.11.005_bib0265) 1999; 121
Malata (10.1016/j.neucie.2022.11.005_bib0280) 2006; 57
Largo (10.1016/j.neucie.2022.11.005_bib0380) 2018; 141
Kraus (10.1016/j.neucie.2022.11.005_bib0240) 1994; 16
Brown (10.1016/j.neucie.2022.11.005_bib0300) 1996; 18
Ganly (10.1016/j.neucie.2022.11.005_bib0370) 2011; 117
Paprottka (10.1016/j.neucie.2022.11.005_bib0290) 2016; 69
Granick (10.1016/j.neucie.2022.11.005_bib0295) 1990; 12
Futran (10.1016/j.neucie.2022.11.005_bib0305) 2002; 128
Forner (10.1016/j.neucie.2022.11.005_bib0390) 2018; 97
Jackson (10.1016/j.neucie.2022.11.005_bib0225) 1986; 77
Catalano (10.1016/j.neucie.2022.11.005_bib0245) 1994; 120
Ketcham (10.1016/j.neucie.2022.11.005_bib0215) 1963; 106
Dias (10.1016/j.neucie.2022.11.005_bib0330) 1999; 21
Hanasono (10.1016/j.neucie.2022.11.005_bib0275) 2009; 140
Cherubino (10.1016/j.neucie.2022.11.005_bib0200) 2017; 45
Chiu (10.1016/j.neucie.2022.11.005_bib0220) 2008; 60
Peng (10.1016/j.neucie.2022.11.005_bib0340) 2005; 115
Patel (10.1016/j.neucie.2022.11.005_bib0355) 2003; 98
Wang (10.1016/j.neucie.2022.11.005_bib0345) 2019; 33
Ganly (10.1016/j.neucie.2022.11.005_bib0365) 2005; 27
Urken (10.1016/j.neucie.2022.11.005_bib0235) 1993; 119
Allen (10.1016/j.neucie.2022.11.005_bib0375) 2012; 73
Marchetti (10.1016/j.neucie.2022.11.005_bib0270) 2002; 110
Shestak (10.1016/j.neucie.2022.11.005_bib0230) 1994; 21
O’Connell (10.1016/j.neucie.2022.11.005_bib0260) 2011; 4
Raza (10.1016/j.neucie.2022.11.005_bib0360) 2010; 33
Kwon (10.1016/j.neucie.2022.11.005_bib0255) 2017; 31
Neligan (10.1016/j.neucie.2022.11.005_bib0315) 1996; 98
Arnaoutakis (10.1016/j.neucie.2022.11.005_bib0320) 2017; 31
References_xml – volume: 115
  start-page: 1562
  year: 2005
  end-page: 1569
  ident: bib0340
  article-title: Maxillary reconstruction with the free fibula flap
  publication-title: Plast Reconstr Surg
– volume: 128
  start-page: 161
  year: 2002
  end-page: 166
  ident: bib0305
  article-title: Midface reconstruction with the fibula free flap
  publication-title: Arch Otolaryngol Head Neck Surg
– volume: 45
  start-page: 87
  year: 2017
  end-page: 92
  ident: bib0200
  article-title: Chimeric anterolateral thigh free flap for reconstruction of complex cranio-orbito-facial defects after skull base cancers resection
  publication-title: J Craniomaxillofac Surg
– volume: 98
  start-page: 1179
  year: 2003
  end-page: 1187
  ident: bib0355
  article-title: Craniofacial surgery for malignant skull base tumors: report of an international collaborative study
  publication-title: Cancer
– volume: 33
  start-page: 63
  year: 2010
  end-page: 70
  ident: bib0360
  article-title: A modified frontal-nasal-orbital approach to midline lesions of the anterior cranial fossa and skull base: technical note with case illustrations
  publication-title: Neurosurg Rev
– volume: 74
  start-page: 81
  year: 2013
  end-page: 91
  ident: bib0325
  article-title: Microvascular free flaps in skull base reconstruction
  publication-title: Adv Otorhinolaryngol
– volume: 120
  start-page: 1203
  year: 1994
  end-page: 1208
  ident: bib0245
  article-title: Craniofacial resection. An analysis of 73 cases
  publication-title: Arch Otolaryngol Head Neck Surg
– volume: 25
  start-page: 1376
  year: 2014
  end-page: 1378
  ident: bib0285
  article-title: Successful reconstruction of irradiated anterior skull base defect using the dual flap technique involving local pericranial flap and radial forearm free flap
  publication-title: J Craniofac Surg
– volume: 12
  start-page: 377
  year: 1990
  end-page: 385
  ident: bib0295
  article-title: Reconstruction of complex maxillectomy defects with the scapular-free flap
  publication-title: Head Neck
– volume: 121
  start-page: 203
  year: 1999
  end-page: 209
  ident: bib0265
  article-title: Benefits of routine maxillectomy and orbital reconstruction with the rectus abdominis free flap
  publication-title: Otolaryngol Head Neck Surg
– volume: 140
  start-page: 855
  year: 2009
  end-page: 860
  ident: bib0275
  article-title: The anterolateral thigh free flap for skull base reconstruction
  publication-title: Otolaryngol Head Neck Surg
– volume: 57
  start-page: 169
  year: 2006
  end-page: 176
  ident: bib0280
  article-title: Use of anterolateral thigh and lateral arm fasciocutaneous free flaps in lateral skull base reconstruction
  publication-title: Ann Plast Surg
– volume: 60
  start-page: 514
  year: 2008
  end-page: 520
  ident: bib0220
  article-title: Anterior and middle cranial fossa skull base reconstruction using microvascular free tissue techniques: surgical complications and functional outcomes
  publication-title: Ann Plast Surg
– volume: 119
  start-page: 2602
  year: 2013
  end-page: 2610
  ident: bib0205
  article-title: Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009
  publication-title: Cancer
– volume: 73
  start-page: 401
  year: 2012
  end-page: 404
  ident: bib0375
  article-title: The association of meningitis with postoperative cerebrospinal fluid fistula
  publication-title: J Neurol Surg B: Skull Base
– volume: 21
  start-page: 107
  year: 1994
  end-page: 111
  ident: bib0230
  article-title: Soft-tissue reconstruction of craniofacial defects
  publication-title: Clin Plast Surg
– volume: 18
  start-page: 412
  year: 1996
  end-page: 421
  ident: bib0300
  article-title: Deep circumflex iliac artery free flap with internal oblique muscle as a new method of immediate reconstruction of maxillectomy defect
  publication-title: Head Neck
– volume: 99
  start-page: 1555
  year: 1997
  end-page: 1565
  ident: bib0350
  article-title: Reconstruction of complex midfacial defects
  publication-title: Plast Reconstr Surg
– volume: 16
  start-page: 3
  year: 1994
  end-page: 10
  ident: bib0310
  article-title: Tumors of the skull base: outcome and survival analysis of 77 cases
  publication-title: Head Neck
– volume: 25
  start-page: 191
  year: 1941
  end-page: 216
  ident: bib0210
  article-title: Results following the transcranial operative attack on orbital tumors
  publication-title: Arch Ophthalmol
– volume: 31
  start-page: 189
  year: 2017
  end-page: 196
  ident: bib0255
  article-title: Open anterior skull base reconstruction: a contemporary review
  publication-title: Semin Plast Surg
– volume: 141
  start-page: 20e
  year: 2018
  end-page: 27e
  ident: bib0380
  article-title: Outcome analysis of free flap salvage in outpatients presenting with microvascular compromise
  publication-title: Plast Reconstr Surg
– volume: 110
  start-page: 1303
  year: 2002
  end-page: 1309
  ident: bib0270
  article-title: Use of “perforator flaps” in skull base reconstruction after tumor resection
  publication-title: Plast Reconstr Surg
– volume: 33
  start-page: 72
  year: 2019
  end-page: 77
  ident: bib0345
  article-title: Free-flap reconstruction of skull base and orbital defects
  publication-title: Semin Plast Surg
– volume: 22
  start-page: 97
  year: 2006
  end-page: 104
  ident: bib0335
  article-title: Free anterolateral thigh flap for reconstruction of major craniofacial defects
  publication-title: J Reconstr Microsurg
– volume: 106
  start-page: 698
  year: 1963
  end-page: 703
  ident: bib0215
  article-title: A combined intracranial facial approach to the paranasal sinuses
  publication-title: Am J Surg
– volume: 16
  start-page: 307
  year: 1994
  end-page: 312
  ident: bib0240
  article-title: Complications of craniofacial resection for tumors involving the anterior skull base
  publication-title: Head Neck
– volume: 24
  start-page: 901
  year: 2002
  end-page: 911
  ident: bib0250
  article-title: Free tissue transfer and local flap complications in anterior and anterolateral skull base surgery
  publication-title: Head Neck
– volume: 119
  start-page: 1318
  year: 1993
  end-page: 1325
  ident: bib0235
  article-title: Free tissue transfer for skull base reconstruction analysis of complications and a classification scheme for defining skull base defects
  publication-title: Arch Otolaryngol Head Neck Surg
– volume: 69
  start-page: 1266
  year: 2016
  end-page: 1274
  ident: bib0290
  article-title: Plastic reconstructive surgery techniques for defect coverage of extended skull base defects
  publication-title: J Plast Reconstr Aesthet Surg
– volume: 125
  start-page: 295
  year: 1999
  end-page: 299
  ident: bib0385
  article-title: Unsurpassed reliability of free flaps for head and neck reconstruction
  publication-title: Arch Otolaryngol Head Neck Surg
– volume: 97
  start-page: 213
  year: 2018
  end-page: 216
  ident: bib0390
  article-title: Late free flap failure in head and neck reconstruction: a systematic review
  publication-title: Ear Nose Throat J
– volume: 77
  start-page: 905
  year: 1986
  end-page: 910
  ident: bib0225
  article-title: Use of the galeal frontalis myofascial flap in craniofacial surgery
  publication-title: Plast Reconstr Surg
– volume: 117
  start-page: 563
  year: 2011
  end-page: 571
  ident: bib0370
  article-title: Craniofacial resection for malignant tumors involving the skull base in the elderly: an international collaborative study
  publication-title: Cancer
– volume: 4
  start-page: 179
  year: 2011
  end-page: 188
  ident: bib0260
  article-title: Microvascular free tissue transfer in the reconstruction of scalp and lateral temporal bone defects
  publication-title: Craniomaxillofac Trauma Reconstr
– volume: 27
  start-page: 445
  year: 2005
  end-page: 451
  ident: bib0365
  article-title: Complications of craniofacial resection for malignant tumors of the skull base: report of an International Collaborative Study
  publication-title: Head Neck
– volume: 98
  start-page: 1159
  year: 1996
  end-page: 1166
  ident: bib0315
  article-title: Flap selection in cranial base reconstruction
  publication-title: Plast Reconstr Surg
– volume: 31
  start-page: 197
  year: 2017
  end-page: 202
  ident: bib0320
  article-title: Locoregional and microvascular free tissue reconstruction of the lateral skull base
  publication-title: Semin Plast Surg
– volume: 21
  start-page: 12
  year: 1999
  end-page: 20
  ident: bib0330
  article-title: Complications of anterior craniofacial resection
  publication-title: Head Neck
– volume: 98
  start-page: 1159
  year: 1996
  ident: 10.1016/j.neucie.2022.11.005_bib0315
  article-title: Flap selection in cranial base reconstruction
  publication-title: Plast Reconstr Surg
  doi: 10.1097/00006534-199612000-00005
– volume: 99
  start-page: 1555
  year: 1997
  ident: 10.1016/j.neucie.2022.11.005_bib0350
  article-title: Reconstruction of complex midfacial defects
  publication-title: Plast Reconstr Surg
  doi: 10.1097/00006534-199705010-00013
– volume: 25
  start-page: 191
  year: 1941
  ident: 10.1016/j.neucie.2022.11.005_bib0210
  article-title: Results following the transcranial operative attack on orbital tumors
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1941.00870080015001
– volume: 24
  start-page: 901
  year: 2002
  ident: 10.1016/j.neucie.2022.11.005_bib0250
  article-title: Free tissue transfer and local flap complications in anterior and anterolateral skull base surgery
  publication-title: Head Neck
  doi: 10.1002/hed.10147
– volume: 45
  start-page: 87
  year: 2017
  ident: 10.1016/j.neucie.2022.11.005_bib0200
  article-title: Chimeric anterolateral thigh free flap for reconstruction of complex cranio-orbito-facial defects after skull base cancers resection
  publication-title: J Craniomaxillofac Surg
  doi: 10.1016/j.jcms.2016.10.017
– volume: 119
  start-page: 2602
  year: 2013
  ident: 10.1016/j.neucie.2022.11.005_bib0205
  article-title: Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009
  publication-title: Cancer
  doi: 10.1002/cncr.28108
– volume: 77
  start-page: 905
  year: 1986
  ident: 10.1016/j.neucie.2022.11.005_bib0225
  article-title: Use of the galeal frontalis myofascial flap in craniofacial surgery
  publication-title: Plast Reconstr Surg
  doi: 10.1097/00006534-198606000-00005
– volume: 115
  start-page: 1562
  year: 2005
  ident: 10.1016/j.neucie.2022.11.005_bib0340
  article-title: Maxillary reconstruction with the free fibula flap
  publication-title: Plast Reconstr Surg
  doi: 10.1097/01.PRS.0000160691.63029.74
– volume: 140
  start-page: 855
  year: 2009
  ident: 10.1016/j.neucie.2022.11.005_bib0275
  article-title: The anterolateral thigh free flap for skull base reconstruction
  publication-title: Otolaryngol Head Neck Surg
  doi: 10.1016/j.otohns.2009.02.025
– volume: 25
  start-page: 1376
  year: 2014
  ident: 10.1016/j.neucie.2022.11.005_bib0285
  article-title: Successful reconstruction of irradiated anterior skull base defect using the dual flap technique involving local pericranial flap and radial forearm free flap
  publication-title: J Craniofac Surg
  doi: 10.1097/SCS.0000000000000858
– volume: 27
  start-page: 445
  year: 2005
  ident: 10.1016/j.neucie.2022.11.005_bib0365
  article-title: Complications of craniofacial resection for malignant tumors of the skull base: report of an International Collaborative Study
  publication-title: Head Neck
  doi: 10.1002/hed.20166
– volume: 73
  start-page: 401
  year: 2012
  ident: 10.1016/j.neucie.2022.11.005_bib0375
  article-title: The association of meningitis with postoperative cerebrospinal fluid fistula
  publication-title: J Neurol Surg B: Skull Base
  doi: 10.1055/s-0032-1329618
– volume: 119
  start-page: 1318
  year: 1993
  ident: 10.1016/j.neucie.2022.11.005_bib0235
  article-title: Free tissue transfer for skull base reconstruction analysis of complications and a classification scheme for defining skull base defects
  publication-title: Arch Otolaryngol Head Neck Surg
  doi: 10.1001/archotol.1993.01880240054007
– volume: 12
  start-page: 377
  year: 1990
  ident: 10.1016/j.neucie.2022.11.005_bib0295
  article-title: Reconstruction of complex maxillectomy defects with the scapular-free flap
  publication-title: Head Neck
  doi: 10.1002/hed.2880120502
– volume: 16
  start-page: 307
  year: 1994
  ident: 10.1016/j.neucie.2022.11.005_bib0240
  article-title: Complications of craniofacial resection for tumors involving the anterior skull base
  publication-title: Head Neck
  doi: 10.1002/hed.2880160403
– volume: 33
  start-page: 72
  year: 2019
  ident: 10.1016/j.neucie.2022.11.005_bib0345
  article-title: Free-flap reconstruction of skull base and orbital defects
  publication-title: Semin Plast Surg
  doi: 10.1055/s-0039-1677881
– volume: 18
  start-page: 412
  year: 1996
  ident: 10.1016/j.neucie.2022.11.005_bib0300
  article-title: Deep circumflex iliac artery free flap with internal oblique muscle as a new method of immediate reconstruction of maxillectomy defect
  publication-title: Head Neck
  doi: 10.1002/(SICI)1097-0347(199609/10)18:5<412::AID-HED4>3.0.CO;2-8
– volume: 60
  start-page: 514
  year: 2008
  ident: 10.1016/j.neucie.2022.11.005_bib0220
  article-title: Anterior and middle cranial fossa skull base reconstruction using microvascular free tissue techniques: surgical complications and functional outcomes
  publication-title: Ann Plast Surg
  doi: 10.1097/SAP.0b013e3181715707
– volume: 74
  start-page: 81
  year: 2013
  ident: 10.1016/j.neucie.2022.11.005_bib0325
  article-title: Microvascular free flaps in skull base reconstruction
  publication-title: Adv Otorhinolaryngol
– volume: 22
  start-page: 97
  year: 2006
  ident: 10.1016/j.neucie.2022.11.005_bib0335
  article-title: Free anterolateral thigh flap for reconstruction of major craniofacial defects
  publication-title: J Reconstr Microsurg
  doi: 10.1055/s-2006-932503
– volume: 98
  start-page: 1179
  year: 2003
  ident: 10.1016/j.neucie.2022.11.005_bib0355
  article-title: Craniofacial surgery for malignant skull base tumors: report of an international collaborative study
  publication-title: Cancer
  doi: 10.1002/cncr.11630
– volume: 57
  start-page: 169
  year: 2006
  ident: 10.1016/j.neucie.2022.11.005_bib0280
  article-title: Use of anterolateral thigh and lateral arm fasciocutaneous free flaps in lateral skull base reconstruction
  publication-title: Ann Plast Surg
  doi: 10.1097/01.sap.0000218490.16921.c2
– volume: 33
  start-page: 63
  year: 2010
  ident: 10.1016/j.neucie.2022.11.005_bib0360
  article-title: A modified frontal-nasal-orbital approach to midline lesions of the anterior cranial fossa and skull base: technical note with case illustrations
  publication-title: Neurosurg Rev
  doi: 10.1007/s10143-009-0222-4
– volume: 4
  start-page: 179
  year: 2011
  ident: 10.1016/j.neucie.2022.11.005_bib0260
  article-title: Microvascular free tissue transfer in the reconstruction of scalp and lateral temporal bone defects
  publication-title: Craniomaxillofac Trauma Reconstr
  doi: 10.1055/s-0031-1286119
– volume: 121
  start-page: 203
  year: 1999
  ident: 10.1016/j.neucie.2022.11.005_bib0265
  article-title: Benefits of routine maxillectomy and orbital reconstruction with the rectus abdominis free flap
  publication-title: Otolaryngol Head Neck Surg
  doi: 10.1016/S0194-5998(99)70172-5
– volume: 117
  start-page: 563
  year: 2011
  ident: 10.1016/j.neucie.2022.11.005_bib0370
  article-title: Craniofacial resection for malignant tumors involving the skull base in the elderly: an international collaborative study
  publication-title: Cancer
  doi: 10.1002/cncr.25390
– volume: 110
  start-page: 1303
  year: 2002
  ident: 10.1016/j.neucie.2022.11.005_bib0270
  article-title: Use of “perforator flaps” in skull base reconstruction after tumor resection
  publication-title: Plast Reconstr Surg
– volume: 120
  start-page: 1203
  year: 1994
  ident: 10.1016/j.neucie.2022.11.005_bib0245
  article-title: Craniofacial resection. An analysis of 73 cases
  publication-title: Arch Otolaryngol Head Neck Surg
  doi: 10.1001/archotol.1994.01880350017004
– volume: 128
  start-page: 161
  year: 2002
  ident: 10.1016/j.neucie.2022.11.005_bib0305
  article-title: Midface reconstruction with the fibula free flap
  publication-title: Arch Otolaryngol Head Neck Surg
  doi: 10.1001/archotol.128.2.161
– volume: 69
  start-page: 1266
  year: 2016
  ident: 10.1016/j.neucie.2022.11.005_bib0290
  article-title: Plastic reconstructive surgery techniques for defect coverage of extended skull base defects
  publication-title: J Plast Reconstr Aesthet Surg
  doi: 10.1016/j.bjps.2016.06.008
– volume: 21
  start-page: 12
  year: 1999
  ident: 10.1016/j.neucie.2022.11.005_bib0330
  article-title: Complications of anterior craniofacial resection
  publication-title: Head Neck
  doi: 10.1002/(SICI)1097-0347(199901)21:1<12::AID-HED2>3.0.CO;2-#
– volume: 97
  start-page: 213
  year: 2018
  ident: 10.1016/j.neucie.2022.11.005_bib0390
  article-title: Late free flap failure in head and neck reconstruction: a systematic review
  publication-title: Ear Nose Throat J
  doi: 10.1177/014556131809700712
– volume: 141
  start-page: 20e
  year: 2018
  ident: 10.1016/j.neucie.2022.11.005_bib0380
  article-title: Outcome analysis of free flap salvage in outpatients presenting with microvascular compromise
  publication-title: Plast Reconstr Surg
  doi: 10.1097/PRS.0000000000003917
– volume: 106
  start-page: 698
  year: 1963
  ident: 10.1016/j.neucie.2022.11.005_bib0215
  article-title: A combined intracranial facial approach to the paranasal sinuses
  publication-title: Am J Surg
  doi: 10.1016/0002-9610(63)90387-8
– volume: 21
  start-page: 107
  year: 1994
  ident: 10.1016/j.neucie.2022.11.005_bib0230
  article-title: Soft-tissue reconstruction of craniofacial defects
  publication-title: Clin Plast Surg
  doi: 10.1016/S0094-1298(20)32722-X
– volume: 16
  start-page: 3
  year: 1994
  ident: 10.1016/j.neucie.2022.11.005_bib0310
  article-title: Tumors of the skull base: outcome and survival analysis of 77 cases
  publication-title: Head Neck
  doi: 10.1002/hed.2880160103
– volume: 31
  start-page: 197
  year: 2017
  ident: 10.1016/j.neucie.2022.11.005_bib0320
  article-title: Locoregional and microvascular free tissue reconstruction of the lateral skull base
  publication-title: Semin Plast Surg
  doi: 10.1055/s-0037-1606556
– volume: 31
  start-page: 189
  year: 2017
  ident: 10.1016/j.neucie.2022.11.005_bib0255
  article-title: Open anterior skull base reconstruction: a contemporary review
  publication-title: Semin Plast Surg
  doi: 10.1055/s-0037-1607273
– volume: 125
  start-page: 295
  year: 1999
  ident: 10.1016/j.neucie.2022.11.005_bib0385
  article-title: Unsurpassed reliability of free flaps for head and neck reconstruction
  publication-title: Arch Otolaryngol Head Neck Surg
  doi: 10.1001/archotol.125.3.295
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Snippet Resection of malignant tumors located in the anterior and middle fossae of the skull base requires thorough anatomical knowledge, as well as experience...
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SubjectTerms Cirugía de la base del cráneo
Colgajo libre
Female
Free flap
Free Tissue Flaps - surgery
Humans
Male
Malignant tumors
Middle Aged
Plastic Surgery Procedures
Reconstrucción de la base del cráneo
Retrospective Studies
Skull Base - surgery
Skull base reconstruction
Treatment Outcome
Tumores malignos
Title Microsurgical free flaps for skull base reconstruction following tumor resection: Available techniques and complications
URI https://dx.doi.org/10.1016/j.neucie.2022.11.005
https://www.ncbi.nlm.nih.gov/pubmed/36623890
https://www.proquest.com/docview/2763334210
Volume 34
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