The Lipid-regulating Effects of Atorvastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia

• Published in: Current medical science Vol. 24; no. 2; pp. 138 - 139
• Main Author: 涂玲 刘晓晴 李仁立 黄葵 姚汉华 范巧
• Format: Journal Article
• Language: English
• Published: China Department of Integration, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China 2004
• Subjects: Aged; Anticholesteremic Agents - therapeutic use; Atorvastatin; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Female; Heptanoic Acids - therapeutic use; Humans; Hyperlipidemias - complications; Hyperlipidemias - drug therapy; Male; Middle Aged; Pyrroles - therapeutic use; Triglycerides - blood; 老年性2型糖尿病; 阿托伐他汀; 高密度脂蛋白; 高血脂症; Atorvastatin diabetes hyperlipidemia
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/BF02885412

To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88±0.72 mmol/L to 2.65±0.32 mmol/L; HDL-C was increased from 0.85±0.31 mmol/L to 1.28±0.29 mmol/L；LDL-C was declined from 3.71±2.98 mmol/L to 2.10±1.22 mmol/L, sLDL-A was increased from (42.49±8.1)% to (53.27±7.5)% LDL-B was decreased from (57.91±8.1)% to (46.73±7.5%) (P＜0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia.