Evaluation of Mild Childhood Asthma with Bronchial Hyperreactivity, the Number of Eosinophil and Serum Eosinophil Cationic Protein as a Marker of Disease Activity
To evaluate 13 mild childhood asthmatics (aged [mean±SD] 11.3±3.5 yr), bronchial hyperreactivity, the number of eosinophil and serum eosinophil cationic protein were measured. All were considered mild in severity based on the symptoms according to the classification of the Japanese Society of Pediat...
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| Published in | Japanese Journal of Pediatric Pulmonology Vol. 7; no. 2; pp. 88 - 95 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Pediatric Pulmonology
1996
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0918-3876 2185-3754 |
| DOI | 10.5701/jjpp.7.88 |
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| Abstract | To evaluate 13 mild childhood asthmatics (aged [mean±SD] 11.3±3.5 yr), bronchial hyperreactivity, the number of eosinophil and serum eosinophil cationic protein were measured. All were considered mild in severity based on the symptoms according to the classification of the Japanese Society of Pediatric Allergy and Clinical Immunology . The average number of peripheral eosinophil was 677±394/mm3 (ranged from 195 to 1616). The ECP mean concentration was 32.46±15.18μg/l (ranged from 4.35 to 54.35). The ECP levels of 12 out of 13 subjects proved to be above normal. The geometrical mean of PC20 methacholine was 490.9μg/ml ranged from 92.7 to 16117.1μg/ml. The ECP levels and PC20 methacholine covered a wide range although all of these childhood asthmatics were considered mild clinically. These observations suggest that the childhood anthmatics considered mild according to symptoms may still have bronchial hyperreactivity possibly due to persistent allergic inflammation. |
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| AbstractList | To evaluate 13 mild childhood asthmatics (aged [mean±SD] 11.3±3.5 yr), bronchial hyperreactivity, the number of eosinophil and serum eosinophil cationic protein were measured. All were considered mild in severity based on the symptoms according to the classification of the Japanese Society of Pediatric Allergy and Clinical Immunology . The average number of peripheral eosinophil was 677±394/mm3 (ranged from 195 to 1616). The ECP mean concentration was 32.46±15.18μg/l (ranged from 4.35 to 54.35). The ECP levels of 12 out of 13 subjects proved to be above normal. The geometrical mean of PC20 methacholine was 490.9μg/ml ranged from 92.7 to 16117.1μg/ml. The ECP levels and PC20 methacholine covered a wide range although all of these childhood asthmatics were considered mild clinically. These observations suggest that the childhood anthmatics considered mild according to symptoms may still have bronchial hyperreactivity possibly due to persistent allergic inflammation. |
| Author | Suehiro, Yutaka Shinomiya, Keisuke Kamesaki, Saori Owa, Kenji |
| Author_xml | – sequence: 1 fullname: Suehiro, Yutaka organization: Department of Pediatrics, Saiseikai Nakatsu Hospital – sequence: 1 fullname: Owa, Kenji organization: Department of Pediatrics, Saiseikai Nakatsu Hospital – sequence: 1 fullname: Kamesaki, Saori organization: Department of Pediatrics, Saiseikai Nakatsu Hospital – sequence: 1 fullname: Shinomiya, Keisuke organization: Department of Pediatrics, Saiseikai Nakatsu Hospital |
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| References | 1) Mochizuki, H., Shigeta, M., Kato, M. et al.: Age-related Changes in Bronchial Hyperreactivity to Methacholine in Asthmatic Children. Am J Respir Crit Care Med 152: 906-910, 1995. 12) 飯倉洋治, 石津博子, 八木剛一・他: 小児気管支喘息患者における血清中Eosinophil Cationic Protein (ECP) 濃度測定の臨床的意義の検討. 小児科臨床, 46: 2949-2958, 1993. 15) 望月博之, 三橋将人, 徳山研一・他: 小児の気道過敏性と年齢-メサコリン吸入試験を用いての検討-. アレルギー, 34: 837-842, 1985. 7) Kay, A.: Asthma and inflammation. J Allergy Clin Immunol 87: 893-910, 1991. 10) 三好麻里, 桜井隆, 児玉壮一: 血清中Eosinophil Cationic Proteiln濃度測定結果と気管支喘息患者の各臨床因子との関連について.アレルギー, 40: 1391-1398, 1991. 11) 三好麻里, 桜井隆, 児玉壮一: 気管支喘息発作準備段階における血清中Eosinophil Cationic Protein濃度, Major Basic Protein濃度の検討.アレルギー, 41: 1672-1678, 1992. 3) 牧野荘平, 小林節雄, 宮本昭正・他: 気管支喘息および過敏性肺臓炎における吸入試験の標準法.アレルギー, 31: 1074-1076, 1982. 4) Peterson, C., Enander, I., and Nystrand, J.: Radioimmunoassay of human ECP by an improved method; Establishment of normal levels in serum and turnover in vivo. Clin Exp Allergy 21: 561-567, 1991. 13) 栗原和幸, 山田節, 斉藤博久・他: 血液中の Eosinophil Cationic Protein (ECP) 測定に関する基礎的条件の検討. アレルギー, 41: 512-518, 1992. 2) 古庄巻史, 西間三馨, 赤坂徹・他: 小児気管支喘息の発作の程度, 重症度, 予後判定基準検討委員会報告. 日本小児アレルギー学会誌, 10: 114-119, 1996. 8) Busse, W., Banks-Schlegel, S. and Larsen, C.: Childhood-versus Adult-Onset Asthma. Am J Respir Crit Care Med 151: 1635-1639, 1995. 5) Wardlaw, A. J., Dunnette, S., Gleich, G. J. et al.: Eosinophil and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma. Am Rev Respir Dis 137: 62-69, 1988. 14) Ferguson, A., Vaughan, R., Brown, H. et al.: Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma. J Allergy Clin Immunol 95: 23-28, 1995. 9) 長谷川昌弘, 藤沢隆夫, 駒田幹彦・他: 気管支喘息におけるEosillophil Cationic Protein血清中濃度測定の臨床的意義. アレルギー, 40: 173-180, 1991. 6) Adelroth, E., Rosenhall, L., Johansson, S. et al.: Inflammatory Cells and Eosinophilic Activity in Asthmatics Investigated by Bronchoalveolar Lavage. Am Rev Respir Dis 142: 91-99, 1990. |
| References_xml | – reference: 7) Kay, A.: Asthma and inflammation. J Allergy Clin Immunol 87: 893-910, 1991. – reference: 6) Adelroth, E., Rosenhall, L., Johansson, S. et al.: Inflammatory Cells and Eosinophilic Activity in Asthmatics Investigated by Bronchoalveolar Lavage. Am Rev Respir Dis 142: 91-99, 1990. – reference: 8) Busse, W., Banks-Schlegel, S. and Larsen, C.: Childhood-versus Adult-Onset Asthma. Am J Respir Crit Care Med 151: 1635-1639, 1995. – reference: 11) 三好麻里, 桜井隆, 児玉壮一: 気管支喘息発作準備段階における血清中Eosinophil Cationic Protein濃度, Major Basic Protein濃度の検討.アレルギー, 41: 1672-1678, 1992. – reference: 2) 古庄巻史, 西間三馨, 赤坂徹・他: 小児気管支喘息の発作の程度, 重症度, 予後判定基準検討委員会報告. 日本小児アレルギー学会誌, 10: 114-119, 1996. – reference: 14) Ferguson, A., Vaughan, R., Brown, H. et al.: Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma. J Allergy Clin Immunol 95: 23-28, 1995. – reference: 15) 望月博之, 三橋将人, 徳山研一・他: 小児の気道過敏性と年齢-メサコリン吸入試験を用いての検討-. アレルギー, 34: 837-842, 1985. – reference: 3) 牧野荘平, 小林節雄, 宮本昭正・他: 気管支喘息および過敏性肺臓炎における吸入試験の標準法.アレルギー, 31: 1074-1076, 1982. – reference: 10) 三好麻里, 桜井隆, 児玉壮一: 血清中Eosinophil Cationic Proteiln濃度測定結果と気管支喘息患者の各臨床因子との関連について.アレルギー, 40: 1391-1398, 1991. – reference: 4) Peterson, C., Enander, I., and Nystrand, J.: Radioimmunoassay of human ECP by an improved method; Establishment of normal levels in serum and turnover in vivo. Clin Exp Allergy 21: 561-567, 1991. – reference: 13) 栗原和幸, 山田節, 斉藤博久・他: 血液中の Eosinophil Cationic Protein (ECP) 測定に関する基礎的条件の検討. アレルギー, 41: 512-518, 1992. – reference: 12) 飯倉洋治, 石津博子, 八木剛一・他: 小児気管支喘息患者における血清中Eosinophil Cationic Protein (ECP) 濃度測定の臨床的意義の検討. 小児科臨床, 46: 2949-2958, 1993. – reference: 5) Wardlaw, A. J., Dunnette, S., Gleich, G. J. et al.: Eosinophil and Mast Cells in Bronchoalveolar Lavage in Subjects with Mild Asthma. Am Rev Respir Dis 137: 62-69, 1988. – reference: 9) 長谷川昌弘, 藤沢隆夫, 駒田幹彦・他: 気管支喘息におけるEosillophil Cationic Protein血清中濃度測定の臨床的意義. アレルギー, 40: 173-180, 1991. – reference: 1) Mochizuki, H., Shigeta, M., Kato, M. et al.: Age-related Changes in Bronchial Hyperreactivity to Methacholine in Asthmatic Children. Am J Respir Crit Care Med 152: 906-910, 1995. |
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| SubjectTerms | bronchial hyperreactivity (PC20) eosinophil mild childhood asthma serum eosinophil cationic protein (ECP) |
| Title | Evaluation of Mild Childhood Asthma with Bronchial Hyperreactivity, the Number of Eosinophil and Serum Eosinophil Cationic Protein as a Marker of Disease Activity |
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