Plasma Membrane Shaping by the BAR Domain Superfamily Proteins for Endocytosis and Extracellular Vesicles

The plasma membrane has protrusions and invaginations. The protrusions are filopodia, lamellipodia, and so on, and the invaginations are clathrin-coated pits, caveolae, and so on. The specific shape of these membrane protrusions and invaginations are made by the actin cytoskeleton and the fine molds...

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Bibliographic Details
Published inSeibutsu Butsuri Vol. 65; no. 1; pp. 4 - 8
Main Author SUETSUGU, Shiro
Format Journal Article
LanguageEnglish
Japanese
Published The Biophysical Society of Japan General Incorporated Association 2025
Subjects
actin cytoskeleton
BAR domain
endocytic vesicles
extracellular vesicles
plasma membrane
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ISSN0582-4052
1347-4219
DOI10.2142/biophys.65.4

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Summary:The plasma membrane has protrusions and invaginations. The protrusions are filopodia, lamellipodia, and so on, and the invaginations are clathrin-coated pits, caveolae, and so on. The specific shape of these membrane protrusions and invaginations are made by the actin cytoskeleton and the fine molds of the membrane, which are BAR domain superfamily proteins of ~70 members. The invaginations are cleaved off into intracellular vesicles for endocytosis. Because of the similar molecular architectures, the protrusions are cleaved off into extracellular vesicles in a reminiscent manner as the cleavage of the invagination into the endocytic vesicles.
ISSN:0582-4052
1347-4219
DOI:10.2142/biophys.65.4