Feasibility of free‐breathing 19 F MRI image acquisition to characterize ventilation defects in CF and healthy volunteers at wash‐in
To explore the feasibility of measuring ventilation defect percentage (VDP) using F MRI during free-breathing wash-in of fluorinated gas mixture with postacquisition denoising and to compare these results with those obtained through traditional Cartesian breath-hold acquisitions. Eight adults with c...
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| Published in | Magnetic resonance in medicine Vol. 90; no. 1; pp. 79 - 89 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.07.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0740-3194 1522-2594 1522-2594 |
| DOI | 10.1002/mrm.29630 |
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| Abstract | To explore the feasibility of measuring ventilation defect percentage (VDP) using
F MRI during free-breathing wash-in of fluorinated gas mixture with postacquisition denoising and to compare these results with those obtained through traditional Cartesian breath-hold acquisitions.
Eight adults with cystic fibrosis and 5 healthy volunteers completed a single MR session on a Siemens 3T Prisma.
H Ultrashort-TE MRI sequences were used for registration and masking, and ventilation images with
F MRI were obtained while the subjects breathed a normoxic mixture of 79% perfluoropropane and 21% oxygen (O
).
F MRI was performed during breath holds and while free breathing with one overlapping spiral scan at breath hold for VDP value comparison. The
F spiral data were denoised using a low-rank matrix recovery approach.
VDP measured using
F VIBE and
F spiral images were highly correlated (r = 0.84) at 10 wash-in breaths. Second-breath VDPs were also highly correlated (r = 0.88). Denoising greatly increased SNR (pre-denoising spiral SNR, 2.46 ± 0.21; post-denoising spiral SNR, 33.91 ± 6.12; and breath-hold SNR, 17.52 ± 2.08).
Free-breathing
F lung MRI VDP analysis was feasible and highly correlated with breath-hold measurements. Free-breathing methods are expected to increase patient comfort and extend ventilation MRI use to patients who are unable to perform breath holds, including younger subjects and those with more severe lung disease. |
|---|---|
| AbstractList | To explore the feasibility of measuring ventilation defect percentage (VDP) using
F MRI during free-breathing wash-in of fluorinated gas mixture with postacquisition denoising and to compare these results with those obtained through traditional Cartesian breath-hold acquisitions.
Eight adults with cystic fibrosis and 5 healthy volunteers completed a single MR session on a Siemens 3T Prisma.
H Ultrashort-TE MRI sequences were used for registration and masking, and ventilation images with
F MRI were obtained while the subjects breathed a normoxic mixture of 79% perfluoropropane and 21% oxygen (O
).
F MRI was performed during breath holds and while free breathing with one overlapping spiral scan at breath hold for VDP value comparison. The
F spiral data were denoised using a low-rank matrix recovery approach.
VDP measured using
F VIBE and
F spiral images were highly correlated (r = 0.84) at 10 wash-in breaths. Second-breath VDPs were also highly correlated (r = 0.88). Denoising greatly increased SNR (pre-denoising spiral SNR, 2.46 ± 0.21; post-denoising spiral SNR, 33.91 ± 6.12; and breath-hold SNR, 17.52 ± 2.08).
Free-breathing
F lung MRI VDP analysis was feasible and highly correlated with breath-hold measurements. Free-breathing methods are expected to increase patient comfort and extend ventilation MRI use to patients who are unable to perform breath holds, including younger subjects and those with more severe lung disease. Click here for author‐reader discussions To explore the feasibility of measuring ventilation defect percentage (VDP) using 19 F MRI during free-breathing wash-in of fluorinated gas mixture with postacquisition denoising and to compare these results with those obtained through traditional Cartesian breath-hold acquisitions.PURPOSETo explore the feasibility of measuring ventilation defect percentage (VDP) using 19 F MRI during free-breathing wash-in of fluorinated gas mixture with postacquisition denoising and to compare these results with those obtained through traditional Cartesian breath-hold acquisitions.Eight adults with cystic fibrosis and 5 healthy volunteers completed a single MR session on a Siemens 3T Prisma. 1 H Ultrashort-TE MRI sequences were used for registration and masking, and ventilation images with 19 F MRI were obtained while the subjects breathed a normoxic mixture of 79% perfluoropropane and 21% oxygen (O2 ). 19 F MRI was performed during breath holds and while free breathing with one overlapping spiral scan at breath hold for VDP value comparison. The 19 F spiral data were denoised using a low-rank matrix recovery approach.METHODSEight adults with cystic fibrosis and 5 healthy volunteers completed a single MR session on a Siemens 3T Prisma. 1 H Ultrashort-TE MRI sequences were used for registration and masking, and ventilation images with 19 F MRI were obtained while the subjects breathed a normoxic mixture of 79% perfluoropropane and 21% oxygen (O2 ). 19 F MRI was performed during breath holds and while free breathing with one overlapping spiral scan at breath hold for VDP value comparison. The 19 F spiral data were denoised using a low-rank matrix recovery approach.VDP measured using 19 F VIBE and 19 F spiral images were highly correlated (r = 0.84) at 10 wash-in breaths. Second-breath VDPs were also highly correlated (r = 0.88). Denoising greatly increased SNR (pre-denoising spiral SNR, 2.46 ± 0.21; post-denoising spiral SNR, 33.91 ± 6.12; and breath-hold SNR, 17.52 ± 2.08).RESULTSVDP measured using 19 F VIBE and 19 F spiral images were highly correlated (r = 0.84) at 10 wash-in breaths. Second-breath VDPs were also highly correlated (r = 0.88). Denoising greatly increased SNR (pre-denoising spiral SNR, 2.46 ± 0.21; post-denoising spiral SNR, 33.91 ± 6.12; and breath-hold SNR, 17.52 ± 2.08).Free-breathing 19 F lung MRI VDP analysis was feasible and highly correlated with breath-hold measurements. Free-breathing methods are expected to increase patient comfort and extend ventilation MRI use to patients who are unable to perform breath holds, including younger subjects and those with more severe lung disease.CONCLUSIONFree-breathing 19 F lung MRI VDP analysis was feasible and highly correlated with breath-hold measurements. Free-breathing methods are expected to increase patient comfort and extend ventilation MRI use to patients who are unable to perform breath holds, including younger subjects and those with more severe lung disease. |
| Author | Huynh, Khoi Minh Powell, Margret Z. Ceppe, Agathe S. Chung, Sang Hun Chen, Yong Donaldson, Scott H. Goralski, Jennifer L. Yap, Pew‐Thian Lee, Yueh Z. |
| Author_xml | – sequence: 1 givenname: Sang Hun orcidid: 0000-0002-0605-9420 surname: Chung fullname: Chung, Sang Hun organization: Department of Biomedical Engineering University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 2 givenname: Khoi Minh surname: Huynh fullname: Huynh, Khoi Minh organization: Department of Biomedical Engineering University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 3 givenname: Jennifer L. surname: Goralski fullname: Goralski, Jennifer L. organization: Division of Pulmonary and Critical Care Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA, Marsico Lung Institute/UNC Cystic Fibrosis Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA, Division of Pediatric Pulmonology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 4 givenname: Yong surname: Chen fullname: Chen, Yong organization: Department of Radiology Case Western Reserve University Cleveland Ohio USA – sequence: 5 givenname: Pew‐Thian surname: Yap fullname: Yap, Pew‐Thian organization: Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 6 givenname: Agathe S. surname: Ceppe fullname: Ceppe, Agathe S. organization: Division of Pulmonary and Critical Care Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA, Marsico Lung Institute/UNC Cystic Fibrosis Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 7 givenname: Margret Z. surname: Powell fullname: Powell, Margret Z. organization: Marsico Lung Institute/UNC Cystic Fibrosis Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 8 givenname: Scott H. surname: Donaldson fullname: Donaldson, Scott H. organization: Division of Pulmonary and Critical Care Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA, Marsico Lung Institute/UNC Cystic Fibrosis Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – sequence: 9 givenname: Yueh Z. orcidid: 0000-0003-1846-7680 surname: Lee fullname: Lee, Yueh Z. organization: Division of Pulmonary and Critical Care Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA, Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA |
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for author‐reader discussions To explore the feasibility of measuring ventilation defect percentage (VDP) using F MRI during free-breathing wash-in of fluorinated gas mixture with... To explore the feasibility of measuring ventilation defect percentage (VDP) using 19 F MRI during free-breathing wash-in of fluorinated gas mixture with... |
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| SubjectTerms | Adult Cystic Fibrosis - diagnostic imaging Feasibility Studies Healthy Volunteers Humans Lung Magnetic Resonance Imaging - methods Oxygen Respiration Respiration Disorders |
| Title | Feasibility of free‐breathing 19 F MRI image acquisition to characterize ventilation defects in CF and healthy volunteers at wash‐in |
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