Test-retest reproducibility of extrastriatal binding with 123 I-FP-CIT SPECT in healthy male subjects

I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, n...

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Published inPsychiatry research. Neuroimaging Vol. 258; pp. 10 - 15
Main Authors Matsuoka, Kiwamu, Yasuno, Fumihiko, Shinkai, Takayuki, Miyasaka, Toshiteru, Takahashi, Masato, Kiuchi, Kuniaki, Kosaka, Jun, Inoue, Makoto, Kichikawa, Kimihiko, Hasegawa, Masatoshi, Kishimoto, Toshifumi
Format Journal Article
LanguageEnglish
Published Netherlands 30.12.2016
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Online AccessGet full text
ISSN0925-4927
1872-7506
DOI10.1016/j.pscychresns.2016.10.007

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Abstract I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices).
AbstractList I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices).
Author Hasegawa, Masatoshi
Takahashi, Masato
Yasuno, Fumihiko
Kosaka, Jun
Inoue, Makoto
Miyasaka, Toshiteru
Kiuchi, Kuniaki
Matsuoka, Kiwamu
Shinkai, Takayuki
Kishimoto, Toshifumi
Kichikawa, Kimihiko
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Keywords I-FP-CIT
Midbrain
Serotonin transporter
Reproducibility
SPECT
Cortex
Language English
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Snippet I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it...
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crossref
SourceType Index Database
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StartPage 10
SubjectTerms Adult
Cerebellum - diagnostic imaging
Cerebellum - metabolism
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dopamine Plasma Membrane Transport Proteins - metabolism
Healthy Volunteers
Humans
Image Processing, Computer-Assisted
Iodine Radioisotopes
Male
Mesencephalon - diagnostic imaging
Mesencephalon - metabolism
Middle Aged
Radiopharmaceuticals - metabolism
Reproducibility of Results
Serotonin Plasma Membrane Transport Proteins - metabolism
Tomography, Emission-Computed, Single-Photon - methods
Tropanes
Title Test-retest reproducibility of extrastriatal binding with 123 I-FP-CIT SPECT in healthy male subjects
URI https://www.ncbi.nlm.nih.gov/pubmed/27814458
Volume 258
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