Test-retest reproducibility of extrastriatal binding with 123 I-FP-CIT SPECT in healthy male subjects
I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ( I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, n...
Saved in:
Published in | Psychiatry research. Neuroimaging Vol. 258; pp. 10 - 15 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
30.12.2016
|
Subjects | |
Online Access | Get full text |
ISSN | 0925-4927 1872-7506 |
DOI | 10.1016/j.pscychresns.2016.10.007 |
Cover
Abstract | I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (
I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the
I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of
I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two
I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of
I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that
I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that
I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices). |
---|---|
AbstractList | I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (
I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it can also quantify extrastriatal serotonin transporter (SERT) expressions. While FP-CIT uptake in extrastriatal regions has been quantified, no information exists on the reproducibility of the
I-FP-CIT specific uptake ratio (SUR) in extrastriatal regions. We investigated test-retest reproducibility of
I-FP-CIT binding in the striatum, the midbrain, and cortical regions in eight healthy male subjects. All subjects underwent two
I-FP-CIT SPECT scans, and SUR was calculated using the cerebellum as the reference. We found good test-retest reproducibility of
I-FP-CIT SUR in the midbrain, and in the lateral frontal/temporal cortex and combined cortical regions. The overall variability and intraclass correlation of SUR were, respectively, 4.9-7.8% and 0.90-0.96 in striatal regions, 8.6% and 0.79 in the midbrain, and 3.6-9.1% and 0.84-0.95 in the lateral frontal/temporal cortex and combined cortical regions. Our results provide evidence that
I-FP-CIT SPECT is a valid technique for analyzing striatal DAT, as well as extrastriatal SERT in areas such as the SERT-enriched midbrain. In addition, our data suggest that
I-FP-CIT could be used for analyzing SERT in regions with relatively low SERT expression (e.g., temporal or frontal cortices). |
Author | Hasegawa, Masatoshi Takahashi, Masato Yasuno, Fumihiko Kosaka, Jun Inoue, Makoto Miyasaka, Toshiteru Kiuchi, Kuniaki Matsuoka, Kiwamu Shinkai, Takayuki Kishimoto, Toshifumi Kichikawa, Kimihiko |
Author_xml | – sequence: 1 givenname: Kiwamu surname: Matsuoka fullname: Matsuoka, Kiwamu – sequence: 2 givenname: Fumihiko surname: Yasuno fullname: Yasuno, Fumihiko – sequence: 3 givenname: Takayuki surname: Shinkai fullname: Shinkai, Takayuki – sequence: 4 givenname: Toshiteru surname: Miyasaka fullname: Miyasaka, Toshiteru – sequence: 5 givenname: Masato surname: Takahashi fullname: Takahashi, Masato – sequence: 6 givenname: Kuniaki surname: Kiuchi fullname: Kiuchi, Kuniaki – sequence: 7 givenname: Jun surname: Kosaka fullname: Kosaka, Jun – sequence: 8 givenname: Makoto surname: Inoue fullname: Inoue, Makoto – sequence: 9 givenname: Kimihiko surname: Kichikawa fullname: Kichikawa, Kimihiko – sequence: 10 givenname: Masatoshi surname: Hasegawa fullname: Hasegawa, Masatoshi – sequence: 11 givenname: Toshifumi surname: Kishimoto fullname: Kishimoto, Toshifumi |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27814458$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkNtKxDAURYOMOBf9BYkfkJpbb08iw4wODDhg30vSJjal05Ykg_bvbRkV8cmnA_vssw97LcGs7VoFwB3BAcEkuq-D3hVDUVnlWhfQURr1AOP4AixIElMUhziagQVOaYh4SuM5WDpXY0xZErErMKdxQjgPkwVQmXIeWeXHAa3qbVeeCiNNY_wAOw3Vh7fCeWuEFw2Upi1N-wbfja8goQzu0PaA1rsMvh426wyaFlZKNL4a4FE0CrqTrFXh3TW41KJx6uZrrkC23WTrZ7R_edqtH_eoIDRNkBAJlkzqJJWMcMGkLJXWGHMeY0bLVNN4LMlkGTFc0kjQspBc8phQLUlI2ArcnmP7kzyqMu-tOQo75N91R0N6NhS2c84q_WMhOJ_Q5nX-C20-oZ1W09cVePhzWxgvvOnakZBp_pHwCWflhlU |
CitedBy_id | crossref_primary_10_1007_s00259_020_05085_2 crossref_primary_10_1186_s13550_017_0338_4 crossref_primary_10_1007_s12149_020_01561_9 crossref_primary_10_1007_s00259_019_04324_5 crossref_primary_10_2967_jnumed_123_266276 crossref_primary_10_1038_s41598_021_02385_x |
Cites_doi | 10.1007/s002590050346 10.1016/j.nucmedbio.2004.10.001 10.1007/s00259-008-0979-7 10.1016/S0969-8051(97)00081-4 10.1002/(SICI)1098-2396(199704)25:4<345::AID-SYN5>3.0.CO;2-A 10.1002/syn.890130402 10.1002/syn.1084 10.2967/jnumed.115.153734 10.1016/j.neuroimage.2012.07.001 10.1007/s00259-006-0155-x 10.1016/S2215-0366(15)00232-1 10.1006/nimg.2002.1120 10.1007/s00259-014-2785-8 10.2967/jnumed.111.102277 10.1016/j.euroneuro.2014.05.005 10.5665/sleep.5000 10.1046/j.1471-4159.1994.62020549.x 10.2967/jnumed.109.065656 10.1016/0969-8051(95)00029-W 10.1007/BF02984583 10.1016/0006-8993(89)90511-8 10.1002/syn.20813 10.1016/S1474-4422(07)70057-1 10.1002/syn.890160203 10.1021/ar500233s 10.1002/mds.23179 |
ContentType | Journal Article |
Copyright | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
Copyright_xml | – notice: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM |
DOI | 10.1016/j.pscychresns.2016.10.007 |
DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1872-7506 |
EndPage | 15 |
ExternalDocumentID | 27814458 10_1016_j_pscychresns_2016_10_007 |
Genre | Journal Article |
GroupedDBID | --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM 9JO AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO AAYXX ABBQC ABCQJ ABFNM ABIVO ABMAC ABMZM ABOYX ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACXNI ADBBV ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AEVXI AFJKZ AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIIUN AIKHN AITUG AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CITATION CS3 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HMK HMO HMQ HVGLF HZ~ IHE J1W KOM M29 M2V M39 M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SEL SES SEW SNS SSB SSH SSN SSY SSZ T5K WUQ Z5R ZGI ~G- ~HD AACTN AFCTW CGR CUY CVF ECM EIF NPM RIG |
ID | FETCH-LOGICAL-c1298-aa80b3bf89b314a3bbdeff00447032d9f270073bd630d26a2dcb4b4712fb1513 |
ISSN | 0925-4927 |
IngestDate | Tue Apr 08 05:56:59 EDT 2025 Wed Oct 01 01:55:46 EDT 2025 Thu Apr 24 22:56:22 EDT 2025 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | I-FP-CIT Midbrain Serotonin transporter Reproducibility SPECT Cortex |
Language | English |
License | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c1298-aa80b3bf89b314a3bbdeff00447032d9f270073bd630d26a2dcb4b4712fb1513 |
PMID | 27814458 |
PageCount | 6 |
ParticipantIDs | pubmed_primary_27814458 crossref_primary_10_1016_j_pscychresns_2016_10_007 crossref_citationtrail_10_1016_j_pscychresns_2016_10_007 |
ProviderPackageCode | CITATION AAYXX |
PublicationCentury | 2000 |
PublicationDate | 2016-Dec-30 |
PublicationDateYYYYMMDD | 2016-12-30 |
PublicationDate_xml | – month: 12 year: 2016 text: 2016-Dec-30 day: 30 |
PublicationDecade | 2010 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Psychiatry research. Neuroimaging |
PublicationTitleAlternate | Psychiatry Res Neuroimaging |
PublicationYear | 2016 |
References | Kish (10.1016/j.pscychresns.2016.10.007_bib13) 2005; 32 Joutsa (10.1016/j.pscychresns.2016.10.007_bib12) 2015; 56 Lundkvist (10.1016/j.pscychresns.2016.10.007_bib17) 1995; 22 Günther (10.1016/j.pscychresns.2016.10.007_bib9) 1997; 24 Hesse (10.1016/j.pscychresns.2016.10.007_bib10) 2009; 36 Tsuchida (10.1016/j.pscychresns.2016.10.007_bib28) 2004; 18 Scheffel (10.1016/j.pscychresns.2016.10.007_bib22) 1997; 25 Savli (10.1016/j.pscychresns.2016.10.007_bib21) 2012; 63 Booij (10.1016/j.pscychresns.2016.10.007_bib5) 1998; 39 Koopman (10.1016/j.pscychresns.2016.10.007_bib15) 2012; 53 Van de Bittner (10.1016/j.pscychresns.2016.10.007_bib29) 2014; 47 Staley (10.1016/j.pscychresns.2016.10.007_bib26) 1994; 62 Narendran (10.1016/j.pscychresns.2016.10.007_bib19) 2011; 65 Farde (10.1016/j.pscychresns.2016.10.007_bib7) 1994; 16 Fleiss (10.1016/j.pscychresns.2016.10.007_bib8) 1986 Booij (10.1016/j.pscychresns.2016.10.007_bib4) 2007; 48 Varrone (10.1016/j.pscychresns.2016.10.007_bib30) 2010; 51 Tossici-Bolt (10.1016/j.pscychresns.2016.10.007_bib27) 2006; 33 Koch (10.1016/j.pscychresns.2016.10.007_bib14) 2014; 41 Arnaldi (10.1016/j.pscychresns.2016.10.007_bib2) 2015; 38 Roselli (10.1016/j.pscychresns.2016.10.007_bib20) 2010; 25 Spies (10.1016/j.pscychresns.2016.10.007_bib24) 2015; 2 Booij (10.1016/j.pscychresns.2016.10.007_bib6) 1998; 25 Laruelle (10.1016/j.pscychresns.2016.10.007_bib16) 1993; 13 Bäckström (10.1016/j.pscychresns.2016.10.007_bib3) 1989; 486 Staley (10.1016/j.pscychresns.2016.10.007_bib25) 2001; 41 Vingerhoets (10.1016/j.pscychresns.2016.10.007_bib31) 1994; 35 Abi-Dargham (10.1016/j.pscychresns.2016.10.007_bib1) 1996; 37 Seibyl (10.1016/j.pscychresns.2016.10.007_bib23) 1996; 37 McKeith (10.1016/j.pscychresns.2016.10.007_bib18) 2007; 6 Hesse (10.1016/j.pscychresns.2016.10.007_bib11) 2014; 24 Yasuno (10.1016/j.pscychresns.2016.10.007_bib32) 2002; 16 |
References_xml | – volume: 39 start-page: 1879 year: 1998 ident: 10.1016/j.pscychresns.2016.10.007_bib5 article-title: Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease publication-title: J. Nucl. Med. – volume: 25 start-page: 1666 year: 1998 ident: 10.1016/j.pscychresns.2016.10.007_bib6 article-title: Iodine-123 labelled nor-beta-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats publication-title: Eur. J. Nucl. Med. doi: 10.1007/s002590050346 – volume: 32 start-page: 123 year: 2005 ident: 10.1016/j.pscychresns.2016.10.007_bib13 article-title: Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2004.10.001 – volume: 36 start-page: 428 year: 2009 ident: 10.1016/j.pscychresns.2016.10.007_bib10 article-title: Monoamine transporter availability in Parkinson's disease patients with or without depression publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-008-0979-7 – volume: 24 start-page: 629 year: 1997 ident: 10.1016/j.pscychresns.2016.10.007_bib9 article-title: [125I] beta-CIT-FE and [125I] beta-CIT-FP are superior to [125I] beta-CIT for dopamine transporter visualization: autoradiographic evaluation in the human brain publication-title: Nucl. Med. Biol. doi: 10.1016/S0969-8051(97)00081-4 – volume: 25 start-page: 345 year: 1997 ident: 10.1016/j.pscychresns.2016.10.007_bib22 article-title: N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter publication-title: Synapse doi: 10.1002/(SICI)1098-2396(199704)25:4<345::AID-SYN5>3.0.CO;2-A – volume: 13 start-page: 295 year: 1993 ident: 10.1016/j.pscychresns.2016.10.007_bib16 article-title: SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates publication-title: Synapse doi: 10.1002/syn.890130402 – volume: 41 start-page: 275 year: 2001 ident: 10.1016/j.pscychresns.2016.10.007_bib25 article-title: Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers publication-title: Synapse doi: 10.1002/syn.1084 – volume: 56 start-page: 1036 year: 2015 ident: 10.1016/j.pscychresns.2016.10.007_bib12 article-title: Dorsal-to-ventral shift in midbrain dopaminergic projections and increased thalamic/raphe serotonergic function in early Parkinson disease publication-title: J. Nucl. Med. doi: 10.2967/jnumed.115.153734 – volume: 63 start-page: 447 year: 2012 ident: 10.1016/j.pscychresns.2016.10.007_bib21 article-title: Normative database of the serotonergic system in healthy subjects using multi-tracer PET publication-title: NeuroImage doi: 10.1016/j.neuroimage.2012.07.001 – volume: 33 start-page: 1491 year: 2006 ident: 10.1016/j.pscychresns.2016.10.007_bib27 article-title: Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-006-0155-x – volume: 37 start-page: 222 year: 1996 ident: 10.1016/j.pscychresns.2016.10.007_bib23 article-title: Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters publication-title: J. Nucl. Med. – volume: 2 start-page: 743 year: 2015 ident: 10.1016/j.pscychresns.2016.10.007_bib24 article-title: The serotonin transporter in psychiatric disorders: insights from PET imaging publication-title: Lancet Psychiatry doi: 10.1016/S2215-0366(15)00232-1 – volume: 16 start-page: 577 year: 2002 ident: 10.1016/j.pscychresns.2016.10.007_bib32 article-title: Template-based method for multiple volumes of interest of human brain PET images publication-title: NeuroImage doi: 10.1006/nimg.2002.1120 – volume: 35 start-page: 18 year: 1994 ident: 10.1016/j.pscychresns.2016.10.007_bib31 article-title: Reproducibility of fluorine-18-6-fluorodopa positron emission tomography in normal human subjects publication-title: J. Nucl. Med. – volume: 41 start-page: 1938 year: 2014 ident: 10.1016/j.pscychresns.2016.10.007_bib14 article-title: Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-014-2785-8 – volume: 53 start-page: 1087 year: 2012 ident: 10.1016/j.pscychresns.2016.10.007_bib15 article-title: Assessing the optimal time point for the measurement of extrastriatal serotonin transporter binding with 123I-FP-CIT SPECT in healthy, male subjects publication-title: J. Nucl. Med. doi: 10.2967/jnumed.111.102277 – volume: 24 start-page: 1240 year: 2014 ident: 10.1016/j.pscychresns.2016.10.007_bib11 article-title: Association of central serotonin transporter availability and body mass index in healthy Europeans publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2014.05.005 – volume: 38 start-page: 1505 year: 2015 ident: 10.1016/j.pscychresns.2016.10.007_bib2 article-title: The role of the serotonergic system in REM sleep behavior disorder publication-title: Sleep doi: 10.5665/sleep.5000 – volume: 62 start-page: 549 year: 1994 ident: 10.1016/j.pscychresns.2016.10.007_bib26 article-title: Visualizing dopamine and serotonin transporters in the human brain with the potent cocaine analogue [125I]RTI-55: in vitro binding and autoradiographic characterization publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.1994.62020549.x – volume: 51 start-page: 1331 year: 2010 ident: 10.1016/j.pscychresns.2016.10.007_bib30 article-title: Molecular imaging of the dopamine transporter publication-title: J. Nucl. Med. doi: 10.2967/jnumed.109.065656 – volume: 22 start-page: 905 year: 1995 ident: 10.1016/j.pscychresns.2016.10.007_bib17 article-title: [O-methyl-11C]beta-CIT-FP, a potential radioligand for quantitation of the dopamine transporter: preparation, autoradiography, metabolite studies, and positron emission tomography examinations publication-title: Nucl. Med. Biol. doi: 10.1016/0969-8051(95)00029-W – volume: 18 start-page: 609 year: 2004 ident: 10.1016/j.pscychresns.2016.10.007_bib28 article-title: Reproducibility of dopamine transporter density measured with 123I-FPCIT SPECT in normal control and Parkinson's disease patients publication-title: Ann. Nucl. Med. doi: 10.1007/BF02984583 – volume: 37 start-page: 1129 year: 1996 ident: 10.1016/j.pscychresns.2016.10.007_bib1 article-title: SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT publication-title: J. Nucl. Med. – volume: 48 start-page: 359 year: 2007 ident: 10.1016/j.pscychresns.2016.10.007_bib4 article-title: Quantification of striatal dopamine transporters with 123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects publication-title: J. Nucl. Med. – volume: 486 start-page: 261 year: 1989 ident: 10.1016/j.pscychresns.2016.10.007_bib3 article-title: High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue publication-title: Brain Res. doi: 10.1016/0006-8993(89)90511-8 – year: 1986 ident: 10.1016/j.pscychresns.2016.10.007_bib8 – volume: 65 start-page: 35 year: 2011 ident: 10.1016/j.pscychresns.2016.10.007_bib19 article-title: Positron emission tomography imaging of dopamine D2/3 receptors in the human cortex with [11C]FLB 457: reproducibility studies publication-title: Synapse doi: 10.1002/syn.20813 – volume: 6 start-page: 305 year: 2007 ident: 10.1016/j.pscychresns.2016.10.007_bib18 article-title: Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(07)70057-1 – volume: 16 start-page: 93 year: 1994 ident: 10.1016/j.pscychresns.2016.10.007_bib7 article-title: PET study of [11C]beta-CIT binding to monoamine transporters in the monkey and human brain publication-title: Synapse doi: 10.1002/syn.890160203 – volume: 47 start-page: 3127 year: 2014 ident: 10.1016/j.pscychresns.2016.10.007_bib29 article-title: A philosophy for CNS radiotracer design publication-title: Acc. Chem. Res. doi: 10.1021/ar500233s – volume: 25 start-page: 1853 year: 2010 ident: 10.1016/j.pscychresns.2016.10.007_bib20 article-title: Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study publication-title: Mov. Disord. doi: 10.1002/mds.23179 |
SSID | ssj0023863 |
Score | 2.1580791 |
Snippet | I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (
I-FP-CIT) is used to assess striatal dopamine transporter (DAT) expression, but it... |
SourceID | pubmed crossref |
SourceType | Index Database Enrichment Source |
StartPage | 10 |
SubjectTerms | Adult Cerebellum - diagnostic imaging Cerebellum - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Healthy Volunteers Humans Image Processing, Computer-Assisted Iodine Radioisotopes Male Mesencephalon - diagnostic imaging Mesencephalon - metabolism Middle Aged Radiopharmaceuticals - metabolism Reproducibility of Results Serotonin Plasma Membrane Transport Proteins - metabolism Tomography, Emission-Computed, Single-Photon - methods Tropanes |
Title | Test-retest reproducibility of extrastriatal binding with 123 I-FP-CIT SPECT in healthy male subjects |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27814458 |
Volume | 258 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1872-7506 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023863 issn: 0925-4927 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1872-7506 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023863 issn: 0925-4927 databaseCode: ACRLP dateStart: 19950531 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1872-7506 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023863 issn: 0925-4927 databaseCode: AIKHN dateStart: 19950531 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection 2013 customDbUrl: eissn: 1872-7506 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0023863 issn: 0925-4927 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEF5MAqGX0vSZtglb6E1IWCtpJR2LiUkKKYaqkJvY1QMrrqVgSRT30F_SH9vZh9Zy2tI0F2EWdrA8n2dmZ7-ZQeg9jUkWZMSzKS-JDQYP7KDLAtvnpR_C_8kNQ1GNfPWJXnzxP14H15PJzxFrqe-4k33_Y13JQ7QKa6BXUSX7H5o1QmEBPoN-4Qkahuf9dAwm3d6I1Gknkv-yeatiu8p7c7C7GybncoiKR16pAhaZeQVPYl3a84U9u0ysz4vzWSISH6oocmutwWtYbc9FjqYdh68Lw422dJegpWPJ_h7VWo472iW4u7ZvVqrerPrG1r0xL6zt5bhva96vq2W1akySZwnnYjUdO2Ertu1XlRFXbVnLlLikacXVx6YfJyxcOeZH373ozCMBLMSqJcBghIlq4K7NqGa6Koesyj1_M_Uq63Dj3LYZvDq8dC26r7vUkWS9cOffhjv9O27PkBEHnttNOhKVClGwnspWBYckpFTMx3B-GAIRxDpqTt_wOkfo3Y49-JdvtRf97J1jZDyTPEGP9UEEf1CoOkaTon6Kjq401eIZKkbgwnfAhZsS74ELa3BhAS4M4MIDuLAEF65qrMGFBbjwAK7nKJmfJ7MLW8_ksDOIDCObsWjKPV5GMfdcn3mc50VZCloAuA6Sx6UgMoQez6k3zQllJM-4zyECIiWH4NJ7gQ7qpi5eIRyG0zKIWUxAoJ8HlFM4Qbl55PogMufFCYqGnyrNdL96MTbla_pPhZ0gYrbeqqYt99n0UunDbCGiHZwfRK8fIu4NerQD_1t00G364hTi146fSRj9Anj4oFo |
linkProvider | Elsevier |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Test-retest+reproducibility+of+extrastriatal+binding+with+123+I-FP-CIT+SPECT+in+healthy+male+subjects&rft.jtitle=Psychiatry+research.+Neuroimaging&rft.au=Matsuoka%2C+Kiwamu&rft.au=Yasuno%2C+Fumihiko&rft.au=Shinkai%2C+Takayuki&rft.au=Miyasaka%2C+Toshiteru&rft.date=2016-12-30&rft.issn=0925-4927&rft.volume=258&rft.spage=10&rft.epage=15&rft_id=info:doi/10.1016%2Fj.pscychresns.2016.10.007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_pscychresns_2016_10_007 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0925-4927&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0925-4927&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0925-4927&client=summon |