传统的荧光原位杂交与单核苷酸多态性微阵列技术在 植入前遗传学诊断中的比较

【目的】 对染色体易位携带者的植入前遗传学诊断(PGD),随机的采用传统荧光原位杂交技术结合卵裂球活检并新鲜周期移植的策略,或单核苷酸多态性微阵列技术结合滋养外胚层活检并冷冻周期移植的策略,对两种策略的诊断结果及妊娠结局进行比较,以选择最佳的诊断策略?【方法】 回顾性的分析了2012年4月至2014年6月,染色体易位携带者行PGD的183个周期资料,其中91个FISH-PGD周期采用D3卵裂球活检并新鲜周期移植的策略,记为FISH组?92个SNP-PGD周期采用滋养外胚层活检并冷冻周期移植的策略,记为SNP组?将两组方法的诊断结果及妊娠结局进行比较?【结果】 SNP组的无胚胎移植周期低于FIS...

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Published inZhongshan da xue xue bao. Zhongshan daxue xuebao yixue kexue ban = Journal of Sun Yat-sen University. Yi xue ke xue ban Vol. 36
Format Journal Article
LanguageChinese
Published Editorial Office of Journal of Sun Yat-sen University 01.01.2015
Subjects
单核苷酸多态性微阵列技术
染色体易位
植入前遗传学诊断
荧光原位杂交
Online AccessGet full text
ISSN1672-3554

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Abstract 【目的】 对染色体易位携带者的植入前遗传学诊断(PGD),随机的采用传统荧光原位杂交技术结合卵裂球活检并新鲜周期移植的策略,或单核苷酸多态性微阵列技术结合滋养外胚层活检并冷冻周期移植的策略,对两种策略的诊断结果及妊娠结局进行比较,以选择最佳的诊断策略?【方法】 回顾性的分析了2012年4月至2014年6月,染色体易位携带者行PGD的183个周期资料,其中91个FISH-PGD周期采用D3卵裂球活检并新鲜周期移植的策略,记为FISH组?92个SNP-PGD周期采用滋养外胚层活检并冷冻周期移植的策略,记为SNP组?将两组方法的诊断结果及妊娠结局进行比较?【结果】 SNP组的无胚胎移植周期低于FISH组,差异有统计学意义;诊断正常率SNP组为33.8%,高于FISH组,两者间差异有统计学意义;移植周期临床妊娠率方面,SNP组高于FISH组而早期流产/胎停率则低于FISH组?【结论】 SNP-PGD的滋养外胚层活检结合冷冻周期移植的策略有助于获得更好的临床妊娠结局?
AbstractList 【目的】 对染色体易位携带者的植入前遗传学诊断(PGD),随机的采用传统荧光原位杂交技术结合卵裂球活检并新鲜周期移植的策略,或单核苷酸多态性微阵列技术结合滋养外胚层活检并冷冻周期移植的策略,对两种策略的诊断结果及妊娠结局进行比较,以选择最佳的诊断策略?【方法】 回顾性的分析了2012年4月至2014年6月,染色体易位携带者行PGD的183个周期资料,其中91个FISH-PGD周期采用D3卵裂球活检并新鲜周期移植的策略,记为FISH组?92个SNP-PGD周期采用滋养外胚层活检并冷冻周期移植的策略,记为SNP组?将两组方法的诊断结果及妊娠结局进行比较?【结果】 SNP组的无胚胎移植周期低于FISH组,差异有统计学意义;诊断正常率SNP组为33.8%,高于FISH组,两者间差异有统计学意义;移植周期临床妊娠率方面,SNP组高于FISH组而早期流产/胎停率则低于FISH组?【结论】 SNP-PGD的滋养外胚层活检结合冷冻周期移植的策略有助于获得更好的临床妊娠结局?
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Snippet 【目的】 对染色体易位携带者的植入前遗传学诊断(PGD),随机的采用传统荧光原位杂交技术结合卵裂球活检并新鲜周期移植的策略,或单核苷酸多态性微阵列技术结合滋养外胚层活检...
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SubjectTerms 单核苷酸多态性微阵列技术
染色体易位
植入前遗传学诊断
荧光原位杂交
Title 传统的荧光原位杂交与单核苷酸多态性微阵列技术在 植入前遗传学诊断中的比较
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