A Case of False-negative Malaria Rapid Diagnostic Test Induced by Treatment with Doxycycline
Rapid diagnostic tests (RDTs) for malaria using antibodies against pan-Plasmodium antigen lactate dehydrogenase (pLDH) are commonly used for malaria diagnosis. The level of malaria parasitemia determined by peripheral blood smears (PBS) correlates with the pLDH concentration in most cases. We report...
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| Published in | Laboratory Medicine Online Vol. 9; no. 3; pp. 194 - 196 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
대한진단검사의학회
01.07.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2093-6338 2093-6338 |
| DOI | 10.3343/lmo.2019.9.3.194 |
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| Abstract | Rapid diagnostic tests (RDTs) for malaria using antibodies against pan-Plasmodium antigen lactate dehydrogenase (pLDH) are commonly used for malaria diagnosis. The level of malaria parasitemia determined by peripheral blood smears (PBS) correlates with the pLDH concentration in most cases. We report a case of malaria recurrence associated with false-negative RDT results. A 22-year-old male patient was admitted to the Armed Forces Capital Hospital with fever and chills, and was diagnosed with malaria infection. Four days after antimalarial treatment, these symptoms recurred. After admitting to our hospital, doxycycline was administered for 4 days. Even after administration of doxycycline, the malaria parasites in blood smears remained positive, but RDT showed negative results. Therefore, for patients receiving doxycycline, serial blood smear testing should be performed to exclude false-negative malaria RDT results. KCI Citation Count: 0 |
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| AbstractList | Rapid diagnostic tests (RDTs) for malaria using antibodies against pan-Plasmodium antigen lactate dehydrogenase (pLDH) are commonly used for malaria diagnosis. The level of malaria parasitemia determined by peripheral blood smears (PBS) correlates with the pLDH concentration in most cases. We report a case of malaria recurrence associated with false-negative RDT results. A 22-year-old male patient was admitted to the Armed Forces Capital Hospital with fever and chills, and was diagnosed with malaria infection. Four days after antimalarial treatment, these symptoms recurred. After admitting to our hospital, doxycycline was administered for 4 days. Even after administration of doxycycline, the malaria parasites in blood smears remained positive, but RDT showed negative results. Therefore, for patients receiving doxycycline, serial blood smear testing should be performed to exclude false-negative malaria RDT results. KCI Citation Count: 0 |
| Author | Lim, Jae-Hyung Baek, Eun Jung |
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| References | Gaillard (10.3343/lmo.2019.9.3.194_ref9) 2015; 14 Piper (10.3343/lmo.2019.9.3.194_ref7) 1999; 60 Miller (10.3343/lmo.2019.9.3.194_ref11) 2001; 113 Kim (10.3343/lmo.2019.9.3.194_ref3) 2018; 33 Dalrymple (10.3343/lmo.2019.9.3.194_ref4) 2018; 17 Jang (10.3343/lmo.2019.9.3.194_ref1) 2013; 12 Grandesso (10.3343/lmo.2019.9.3.194_ref5) 2016; 15 Pasricha (10.3343/lmo.2019.9.3.194_ref10) 2013; 88 Fogg (10.3343/lmo.2019.9.3.194_ref6) 2008; 102 World Health Organization (10.3343/lmo.2019.9.3.194_ref8) 2015 Gillet (10.3343/lmo.2019.9.3.194_ref2) 2011; 10 |
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| Title | A Case of False-negative Malaria Rapid Diagnostic Test Induced by Treatment with Doxycycline |
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