Comparison of Linear Quadratic Regulator and Model Predictive Control Based Algorithms in Continuous Production

The integration of Industry 4.0 into manufacturing processes necessitates the automation of complex, large-scale operations within cyber-physical systems (CPSs). Pharmaceutical manufacturing, in particular, requires a transition from traditional batch processing to continuous manufacturing to achiev...

Full description

Saved in:
Bibliographic Details
Published inBulletin of the Polytechnic Institute of Iași. Electrical Engineering, Power Engineering, Electronics Section Vol. 69; no. 2; pp. 9 - 34
Main Authors Chindruş, Amelia, Copoţ, Dana, Căruntu, Constantin-Florin
Format Journal Article
LanguageEnglish
Published Iasi Sciendo 01.06.2023
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Subjects
Online AccessGet full text
ISSN2537-2726
1223-8139
2537-2726
DOI10.2478/bipie-2023-0007

Cover

Abstract The integration of Industry 4.0 into manufacturing processes necessitates the automation of complex, large-scale operations within cyber-physical systems (CPSs). Pharmaceutical manufacturing, in particular, requires a transition from traditional batch processing to continuous manufacturing to achieve seamless integration with CPSs. This paper explores the comparison between two control strategies for pharmaceutical tablet production: the linear quadratic regulator (LQR) method and an established model predictive control (MPC) algorithm. The LQR method focuses on providing optimal stability and robustness for the plant’s operations, particularly through centralized management of key process units in the dry granulation process. A detailed plant model is utilized to test the performance of the LQR controller, with results benchmarked against those obtained using the MPC algorithm.
AbstractList The integration of Industry 4.0 into manufacturing processes necessitates the automation of complex, large-scale operations within cyber-physical systems (CPSs). Pharmaceutical manufacturing, in particular, requires a transition from traditional batch processing to continuous manufacturing to achieve seamless integration with CPSs. This paper explores the comparison between two control strategies for pharmaceutical tablet production: the linear quadratic regulator (LQR) method and an established model predictive control (MPC) algorithm. The LQR method focuses on providing optimal stability and robustness for the plant’s operations, particularly through centralized management of key process units in the dry granulation process. A detailed plant model is utilized to test the performance of the LQR controller, with results benchmarked against those obtained using the MPC algorithm.
Author Chindruş, Amelia
Copoţ, Dana
Căruntu, Constantin-Florin
Author_xml – sequence: 1
  givenname: Amelia
  surname: Chindruş
  fullname: Chindruş, Amelia
  email: amelia.vatamanu@student.tuiasi.ro
  organization: “Gheorghe Asachi” Technical University of Iași, Romania, Faculty of Automatic Control and Computer Engineering
– sequence: 2
  givenname: Dana
  surname: Copoţ
  fullname: Copoţ, Dana
  organization: Ghent University of Ghent, Belgium, Faculty of Engineering and Architecture
– sequence: 3
  givenname: Constantin-Florin
  surname: Căruntu
  fullname: Căruntu, Constantin-Florin
  organization: “Gheorghe Asachi” Technical University of Iași, Romania, Faculty of Automatic Control and Computer Engineering
BookMark eNp1kE1LAzEQhoNU8PPsNeB5bZLdzW7wVItfUPEDPS9jMqmRbVKTXaX_3m0r6MXTvDDvMwPPARn54JGQE87ORFHV41e3dJgJJvKMMVbtkH1R5lUmKiFHf_IeOU7JvbJCKl7LQuyTMA2LJUSXgqfB0pnzCJE-9mAidE7TJ5z3LXQhUvCG3gWDLX2IaJzu3CfSafBdDC29gISGTtp5iK57WyTq_GbnfB_6NBDB9AMR_BHZtdAmPP6Zh-Tl6vJ5epPN7q9vp5NZprlgKqstCA6gjeEy11yWFdMoLLBSAQqd2xKUrsFiLbkouGRKKVS14lYaXtkiPySn27vLGD56TF3zHvroh5dNzktV5oOAamiNty0dQ0oRbbOMbgFx1XDWrMU2G7HNWmyzFjsQ51viC9oOo8F57FdD-D3_DymVUPk3yeiDRw
Cites_doi 10.3390/pr1020067
10.1007/s12247-015-9215-8
10.1007/s10916-018-0921-x
10.1016/j.ejpb.2021.01.003
10.1007/s11276-021-02579-1
10.1016/j.ifacol.2021.10.316
10.3390/pr11041258
10.1016/j.ces.2012.06.024
10.1016/j.ijpharm.2012.09.009
10.1109/ETFA54631.2023.10275494
10.1109/TENCON.2000.893707
10.1109/MIE.2013.2290138
10.1109/ICSTCC55426.2022.9931791
10.1016/j.comnet.2018.03.024
10.1016/B978-0-12-814295-0.00001-0
10.1016/j.ijpharm.2020.119427
10.1109/TII.2017.2759178
10.1201/9781420085310
10.1109/TAC.2014.2305951
10.1016/j.compchemeng.2017.02.030
10.1115/1.3627325
10.3182/20120823-5-NL-3013.00040
10.1007/s12247-017-9276-y
10.1109/AQTR.2014.6857843
ContentType Journal Article
Copyright 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
DOI 10.2478/bipie-2023-0007
DatabaseName CrossRef
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
ProQuest Central Korea
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
DatabaseTitleList
CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
EISSN 2537-2726
EndPage 34
ExternalDocumentID 10_2478_bipie_2023_0007
10_2478_bipie_2023_00076929
GroupedDBID ALMA_UNASSIGNED_HOLDINGS
AAYXX
CITATION
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
ID FETCH-LOGICAL-c1209-8fa21aacdd163c16570ce2fa059ae2c3f5a9c8afe86124160999e9891f6d17f43
IEDL.DBID BENPR
ISSN 2537-2726
1223-8139
IngestDate Sun Oct 19 01:26:31 EDT 2025
Wed Oct 01 04:28:06 EDT 2025
Sat Sep 06 16:59:29 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
http://creativecommons.org/licenses/by-nc-nd/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c1209-8fa21aacdd163c16570ce2fa059ae2c3f5a9c8afe86124160999e9891f6d17f43
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://www.proquest.com/docview/3159539187?pq-origsite=%requestingapplication%&accountid=15518
PQID 3159539187
PQPubID 6770815
PageCount 26
ParticipantIDs proquest_journals_3159539187
crossref_primary_10_2478_bipie_2023_0007
walterdegruyter_journals_10_2478_bipie_2023_00076929
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-06-01
PublicationDateYYYYMMDD 2023-06-01
PublicationDate_xml – month: 06
  year: 2023
  text: 2023-06-01
  day: 01
PublicationDecade 2020
PublicationPlace Iasi
PublicationPlace_xml – name: Iasi
PublicationTitle Bulletin of the Polytechnic Institute of Iași. Electrical Engineering, Power Engineering, Electronics Section
PublicationYear 2023
Publisher Sciendo
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Publisher_xml – name: Sciendo
– name: De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
References 2024083018402360625_j_bipie-2023-0007_ref_004
2024083018402360625_j_bipie-2023-0007_ref_026
2024083018402360625_j_bipie-2023-0007_ref_005
2024083018402360625_j_bipie-2023-0007_ref_027
2024083018402360625_j_bipie-2023-0007_ref_006
2024083018402360625_j_bipie-2023-0007_ref_028
2024083018402360625_j_bipie-2023-0007_ref_007
2024083018402360625_j_bipie-2023-0007_ref_029
2024083018402360625_j_bipie-2023-0007_ref_008
2024083018402360625_j_bipie-2023-0007_ref_009
2024083018402360625_j_bipie-2023-0007_ref_020
2024083018402360625_j_bipie-2023-0007_ref_021
2024083018402360625_j_bipie-2023-0007_ref_022
2024083018402360625_j_bipie-2023-0007_ref_001
2024083018402360625_j_bipie-2023-0007_ref_023
2024083018402360625_j_bipie-2023-0007_ref_002
2024083018402360625_j_bipie-2023-0007_ref_024
2024083018402360625_j_bipie-2023-0007_ref_003
2024083018402360625_j_bipie-2023-0007_ref_025
2024083018402360625_j_bipie-2023-0007_ref_015
2024083018402360625_j_bipie-2023-0007_ref_016
2024083018402360625_j_bipie-2023-0007_ref_017
2024083018402360625_j_bipie-2023-0007_ref_018
2024083018402360625_j_bipie-2023-0007_ref_019
2024083018402360625_j_bipie-2023-0007_ref_030
2024083018402360625_j_bipie-2023-0007_ref_031
2024083018402360625_j_bipie-2023-0007_ref_010
2024083018402360625_j_bipie-2023-0007_ref_032
2024083018402360625_j_bipie-2023-0007_ref_011
2024083018402360625_j_bipie-2023-0007_ref_033
2024083018402360625_j_bipie-2023-0007_ref_012
2024083018402360625_j_bipie-2023-0007_ref_034
2024083018402360625_j_bipie-2023-0007_ref_013
2024083018402360625_j_bipie-2023-0007_ref_014
References_xml – ident: 2024083018402360625_j_bipie-2023-0007_ref_015
– ident: 2024083018402360625_j_bipie-2023-0007_ref_026
  doi: 10.3390/pr1020067
– ident: 2024083018402360625_j_bipie-2023-0007_ref_023
  doi: 10.1007/s12247-015-9215-8
– ident: 2024083018402360625_j_bipie-2023-0007_ref_007
– ident: 2024083018402360625_j_bipie-2023-0007_ref_012
  doi: 10.1007/s10916-018-0921-x
– ident: 2024083018402360625_j_bipie-2023-0007_ref_020
  doi: 10.1016/j.ejpb.2021.01.003
– ident: 2024083018402360625_j_bipie-2023-0007_ref_021
  doi: 10.1007/s11276-021-02579-1
– ident: 2024083018402360625_j_bipie-2023-0007_ref_024
  doi: 10.1016/j.ifacol.2021.10.316
– ident: 2024083018402360625_j_bipie-2023-0007_ref_003
– ident: 2024083018402360625_j_bipie-2023-0007_ref_009
  doi: 10.3390/pr11041258
– ident: 2024083018402360625_j_bipie-2023-0007_ref_028
  doi: 10.1016/j.ces.2012.06.024
– ident: 2024083018402360625_j_bipie-2023-0007_ref_029
  doi: 10.1016/j.ijpharm.2012.09.009
– ident: 2024083018402360625_j_bipie-2023-0007_ref_018
– ident: 2024083018402360625_j_bipie-2023-0007_ref_010
  doi: 10.1109/ETFA54631.2023.10275494
– ident: 2024083018402360625_j_bipie-2023-0007_ref_027
  doi: 10.1109/TENCON.2000.893707
– ident: 2024083018402360625_j_bipie-2023-0007_ref_031
  doi: 10.1109/MIE.2013.2290138
– ident: 2024083018402360625_j_bipie-2023-0007_ref_008
  doi: 10.1109/ICSTCC55426.2022.9931791
– ident: 2024083018402360625_j_bipie-2023-0007_ref_014
  doi: 10.1016/j.comnet.2018.03.024
– ident: 2024083018402360625_j_bipie-2023-0007_ref_011
  doi: 10.1016/B978-0-12-814295-0.00001-0
– ident: 2024083018402360625_j_bipie-2023-0007_ref_005
  doi: 10.1016/j.ijpharm.2020.119427
– ident: 2024083018402360625_j_bipie-2023-0007_ref_030
  doi: 10.1109/TII.2017.2759178
– ident: 2024083018402360625_j_bipie-2023-0007_ref_004
  doi: 10.1201/9781420085310
– ident: 2024083018402360625_j_bipie-2023-0007_ref_006
– ident: 2024083018402360625_j_bipie-2023-0007_ref_016
  doi: 10.1109/TAC.2014.2305951
– ident: 2024083018402360625_j_bipie-2023-0007_ref_001
– ident: 2024083018402360625_j_bipie-2023-0007_ref_033
  doi: 10.1016/j.compchemeng.2017.02.030
– ident: 2024083018402360625_j_bipie-2023-0007_ref_002
– ident: 2024083018402360625_j_bipie-2023-0007_ref_022
  doi: 10.1115/1.3627325
– ident: 2024083018402360625_j_bipie-2023-0007_ref_025
– ident: 2024083018402360625_j_bipie-2023-0007_ref_013
  doi: 10.3182/20120823-5-NL-3013.00040
– ident: 2024083018402360625_j_bipie-2023-0007_ref_017
  doi: 10.1007/s12247-017-9276-y
– ident: 2024083018402360625_j_bipie-2023-0007_ref_032
– ident: 2024083018402360625_j_bipie-2023-0007_ref_019
  doi: 10.1109/AQTR.2014.6857843
– ident: 2024083018402360625_j_bipie-2023-0007_ref_034
SSID ssib046918642
ssib051457368
ssib059940547
ssib058464613
ssib059239658
Score 2.223371
Snippet The integration of Industry 4.0 into manufacturing processes necessitates the automation of complex, large-scale operations within cyber-physical systems...
SourceID proquest
crossref
walterdegruyter
SourceType Aggregation Database
Index Database
Publisher
StartPage 9
SubjectTerms continuous manufacturing
Cyber-physical system
Industry 4.0
linear quadratic regulator
model predictive control
Title Comparison of Linear Quadratic Regulator and Model Predictive Control Based Algorithms in Continuous Production
URI https://www.degruyter.com/doi/10.2478/bipie-2023-0007
https://www.proquest.com/docview/3159539187
Volume 69
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 2537-2726
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssib058464613
  issn: 2537-2726
  databaseCode: BENPR
  dateStart: 20210101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVJWN
  databaseName: Sciendo
  customDbUrl:
  eissn: 2537-2726
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssib046918642
  issn: 2537-2726
  databaseCode: 9WM
  dateStart: 20210320
  isFulltext: true
  titleUrlDefault: https://content.sciendo.com/
  providerName: Sciendo
– providerCode: PRVAZK
  databaseName: Walter De Gruyter: Open Access Journals
  customDbUrl:
  eissn: 2537-2726
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssib046918642
  issn: 2537-2726
  databaseCode: AHGSO
  dateStart: 20210320
  isFulltext: true
  titleUrlDefault: https://www.degruyterbrill.com
  providerName: Walter de Gruyter
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PT9swFLZKe9kFDW2IsoJ82GGXiCaxY_swIahACImqq4bGLXL8AypB0rWN0P77veckFCaxcxIfvjy_77Of_T5CvrrCWqMh-_nEi4jZMY-UsAZ-SGaBv2VqwvWxm2l2dcuu7_hdj0y7uzB4rLLLiSFR28rgHvlJCrzLUxVLcbr8HaFrFFZXOwsN3Vor2O-hxdgOGSTYGatPBucX09m8izBYC8YyYy-EDmqBi3QruJGN2SuC4yB_XndH4UqBwAmuZTHwaiRBPzX9ghIm5EmxWC5chIbkeFlbvKW6rX7dfQ6VcOvuV_WfTVd5DYR2-ZHstkqUnjWhs0d6rvxEqsmLLyGtPIWVKswE-qPWFiPF0HljXV-tqC4tRSO1RzpbYbEH0yadNAff6Tlwo6Vnj_eA4ObhaU0XZXi2KOuqXsMXoc0shMRncnt58XNyFbWeDJHBW7aR9DqJtTbWgpAzMR6cMS7xGqDRLjGp51oZqb2TIJ1A7KEAdUqq2Gc2Fp6l-6RfVqU7IHTMCp6MvVSF5syKTCtnIaAyA6gXoOKG5FsHX75sWm_ksGRBpPOAdI5IY_VcDMmogzdv5-A630bMkLB_IN--9c6IGcjGw_-P-oV8aH41bsmMSH-zqt0RKJRNcQyJ9tfNcRt8fwHbLeGT
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1NT9wwELUoHNoLKmqrLqWtD63US8QmsWP7gCrYgpYCK4pA4pY6_tiuRJPt7kaIP9ff1hknYQGJ3jgn8WHmxfPG45lHyCdXWGs07H4-8SJits8jJawBh2QW4rdMTWgfOxllwwv2_ZJfrpC_XS8MXqvs9sSwUdvK4Bn5dgpxl6cqluLr9E-EqlFYXe0kNHQrrWB3woixtrHjyN1cQwo33zn8Bv7-nCQH--eDYdSqDEQG-0Yj6XUSa22sBWpiYrwKYlziNfAO7RKTeq6Vkdo7CWQA6AtSKqekin1mY-FZCus-I2ssZQqSv7W9_dHpWYdoyD1jmbFbAgHshIt0SfAx-rM7AZUD3bo7jYUrBYQqqKTFEMcjCXytmU-UMCG3i8l04iIUQMfmcHE_tC758vp1qLxbN57VN4uu0hsC6MFLst4yX7rbQHWDrLjyFakGtzqItPIUMmMwKf1Ra4vINPTMjVFfrJpRXVqKwm1X9HSGxSXcpumguWhP9yAWW7p7NQaPLX79ntNJGZ5Nyrqq5_BFGGsLEHxNLp7EO2_IalmV7i2hfVbwpO-lKjRnVmRaOQsAzgxYvQDW2CNfOvPl02bURw4pElo6D5bO0dJYrRc9stWZN2__-Xm-RGiPsAcmX771yIoZ0NTN_6_6kTwfnp8c58eHo6N35EXjdjwO2iKri1nt3gM7WhQfWghS8vOpUf8PQTsdUg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDI5gSIgLAgHiTQ4cuFRb26RpjmMwxvstcavSPKAStFO3CvHvcdKVCQQXzmly-OzYn-vYRmhfp0pJAdbPBIZ5RHWox5mSIJBIgf-OQ-nKxy6vosEjOXuiTzOo3dTCOLuvXLayPVTGPVUmLG6n2TDTnp31beug2Syas43YaQvNdQcn99eNCkGw58cR-fLYQAcoC6eMmnIODIWwusnPbyd_909T0rn47tLXSj-X1ce4SZc6L9RfQosT-oi7tbyX0YzOV1DR-xomiAuDIbwE9cW3lVBWvBLf1fPmixKLXGE7_ewV35Q2Q2NtHe7Vr9XxITg0hbuvz0WZjV_eRjjL3VqWV0U1gh2uNyzIcRU99o8fegNvMkjBk7Y01ouNCHwhpFLAvqRvX7tIHRgBcAgdyNBQwWUsjI6B7wBDs6xR85j7JlI-MyRcQ628yPU6wh2S0qBjYp4KShSLBNcKtCCSlAcpUK8NdNDAlwzrfhkJxBkW6cQhnVikbcqbbaDtBt5kcnFGSQj0ioYgRFgmPyCffvXHiRFwvc3_bdtD8zdH_eTi9Op8Cy3U2mB_tWyj1ris9A4wj3G6O9G2T_aG1Ok
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+Linear+Quadratic+Regulator+and+Model+Predictive+Control+Based+Algorithms+in+Continuous+Production&rft.jtitle=Bulletin+of+the+Polytechnic+Institute+of+Ia%C8%99i.+Electrical+Engineering%2C+Power+Engineering%2C+Electronics+Section&rft.au=Chindru%C5%9F%2C+Amelia&rft.au=Copo%C5%A3%2C+Dana&rft.au=C%C4%83runtu%2C+Constantin-Florin&rft.date=2023-06-01&rft.issn=2537-2726&rft.eissn=2537-2726&rft.volume=69&rft.issue=2&rft.spage=9&rft.epage=34&rft_id=info:doi/10.2478%2Fbipie-2023-0007&rft.externalDBID=n%2Fa&rft.externalDocID=10_2478_bipie_2023_0007
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2537-2726&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2537-2726&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2537-2726&client=summon