Pulmonary Arterial Hypertension is Normalized Following Six Years of Inhaled Iloprost Treatment in a Patient with Systemic Sclerosis

Pulmonary arterial hypertension is a critical manifestation of systemic sclerosis (SSc) and is a main cause of death. Several treatment modalities for SSc have been identified, with effects that improve quality of life and mortality rates. However, whether these drugs can also normalize pulmonary ar...

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Published inJournal of rheumatic diseases Vol. 24; no. 2; pp. 114 - 118
Main Authors Yoon, So-Young, Yoo, Eun-Soo, Yoo, Eun-Jung, Jung, Ju-Yang, Kim, Hyoun-Ah, Suh, Chang-Hee
Format Journal Article
LanguageEnglish
Published 대한류마티스학회 01.04.2017
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ISSN2093-940X
2233-4718
2233-4718
DOI10.4078/jrd.2017.24.2.114

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Abstract Pulmonary arterial hypertension is a critical manifestation of systemic sclerosis (SSc) and is a main cause of death. Several treatment modalities for SSc have been identified, with effects that improve quality of life and mortality rates. However, whether these drugs can also normalize pulmonary arterial pressure, remains unclear. Here, we report the case of a woman with diffuse SSc with pulmonary arterial hypertension, who had a functional status equivalent to the New York Heart Association class III. The patient was treated with inhaled iloprost. After six years of inhaled iloprost therapy, echocardiography showed that pulmonary arterial pressure normalized, accompanied by improvement in functional capacity. Inhaled iloprost might not only normalize pulmonary arterial pressure, but also improve the functional status of patients with SSc with pulmonary arterial hypertension. (J Rheum Dis 2017;24:114-118) KCI Citation Count: 0
AbstractList Pulmonary arterial hypertension is a critical manifestation of systemic sclerosis (SSc) and is a main cause of death. Several treatment modalities for SSc have been identified, with effects that improve quality of life and mortality rates. However, whether these drugs can also normalize pulmonary arterial pressure, remains unclear. Here, we report the case of a woman with diffuse SSc with pulmonary arterial hypertension, who had a functional status equivalent to the New York Heart Association class III. The patient was treated with inhaled iloprost. After six years of inhaled iloprost therapy, echocardiography showed that pulmonary arterial pressure normalized, accompanied by improvement in functional capacity. Inhaled iloprost might not only normalize pulmonary arterial pressure, but also improve the functional status of patients with SSc with pulmonary arterial hypertension. (J Rheum Dis 2017;24:114-118) KCI Citation Count: 0
Author Kim, Hyoun-Ah
Jung, Ju-Yang
Yoo, Eun-Soo
Yoon, So-Young
Suh, Chang-Hee
Yoo, Eun-Jung
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Cites_doi 10.1056/NEJMoa020204
10.1093/rheumatology/36.2.239
10.1253/circj.CJ-11-0473
10.1378/chest.10-0260
10.2147/VHRM.S3223
10.1093/rheumatology/keu450
10.1097/BOR.0b013e3283307dc8
10.1002/acr.22307
10.1056/NEJMoa012212
10.7326/0003-4819-132-6-200003210-00002
10.1002/art.30541
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References Humbert (10.4078/jrd.2017.24.2.114_ref7) 2011; 63
Krug (10.4078/jrd.2017.24.2.114_ref11) 2009; 5
Miyamichi-Yamamoto (10.4078/jrd.2017.24.2.114_ref5) 2011; 75
Olschewski (10.4078/jrd.2017.24.2.114_ref3) 2002; 347
Denton (10.4078/jrd.2017.24.2.114_ref4) 1997; 36
Chung (10.4078/jrd.2017.24.2.114_ref6) 2010; 138
Badesch (10.4078/jrd.2017.24.2.114_ref10) 2000; 132
Rubin (10.4078/jrd.2017.24.2.114_ref9) 2002; 346
Pope (10.4078/jrd.2017.24.2.114_ref1) 2005; 32
Mathai (10.4078/jrd.2017.24.2.114_ref2) 2009; 21
Gopal (10.4078/jrd.2017.24.2.114_ref8) 2014; 66
Hachulla (10.4078/jrd.2017.24.2.114_ref12) 2015; 54
References_xml – volume: 347
  start-page: 322
  year: 2002
  ident: 10.4078/jrd.2017.24.2.114_ref3
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa020204
– volume: 36
  start-page: 239
  year: 1997
  ident: 10.4078/jrd.2017.24.2.114_ref4
  publication-title: Br J Rheumatol
  doi: 10.1093/rheumatology/36.2.239
– volume: 75
  start-page: 2668
  year: 2011
  ident: 10.4078/jrd.2017.24.2.114_ref5
  publication-title: Circ J
  doi: 10.1253/circj.CJ-11-0473
– volume: 138
  start-page: 1383
  year: 2010
  ident: 10.4078/jrd.2017.24.2.114_ref6
  publication-title: Chest
  doi: 10.1378/chest.10-0260
– volume: 5
  start-page: 465
  year: 2009
  ident: 10.4078/jrd.2017.24.2.114_ref11
  publication-title: Vasc Health Risk Manag
  doi: 10.2147/VHRM.S3223
– volume: 54
  start-page: 1262
  year: 2015
  ident: 10.4078/jrd.2017.24.2.114_ref12
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/keu450
– volume: 21
  start-page: 642
  year: 2009
  ident: 10.4078/jrd.2017.24.2.114_ref2
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/BOR.0b013e3283307dc8
– volume: 32
  start-page: 1273
  year: 2005
  ident: 10.4078/jrd.2017.24.2.114_ref1
  publication-title: J Rheumatol
– volume: 66
  start-page: 1386
  year: 2014
  ident: 10.4078/jrd.2017.24.2.114_ref8
  publication-title: Arthritis Care Res (Hoboken)
  doi: 10.1002/acr.22307
– volume: 346
  start-page: 896
  year: 2002
  ident: 10.4078/jrd.2017.24.2.114_ref9
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa012212
– volume: 132
  start-page: 425
  year: 2000
  ident: 10.4078/jrd.2017.24.2.114_ref10
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-132-6-200003210-00002
– volume: 63
  start-page: 3522
  year: 2011
  ident: 10.4078/jrd.2017.24.2.114_ref7
  publication-title: Arthritis Rheum
  doi: 10.1002/art.30541
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Title Pulmonary Arterial Hypertension is Normalized Following Six Years of Inhaled Iloprost Treatment in a Patient with Systemic Sclerosis
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