Decompressive craniectomy in acute cerebral ischemia in rats
Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the hypothesis that craniectomy may also be beneficial in smaller MCA infarction we evaluated the effects of craniectomy on infarction size in small...
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| Published in | Neuroscience letters Vol. 370; no. 2; pp. 85 - 90 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ireland Ltd
01.11.2004
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-3940 1872-7972 |
| DOI | 10.1016/j.neulet.2004.07.092 |
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| Abstract | Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the hypothesis that craniectomy may also be beneficial in smaller MCA infarction we evaluated the effects of craniectomy on infarction size in small thromboembolic cerebral infarction in rats.
Therefore, thromboembolic cerebral ischemia was induced in 40 rats by endovascular injection of autologous, fibrin-rich emboli. Twenty-one animals with a diffusion-weighted MR imaging (DWI)-derived infarction size of 50–100
mm
3 (involving one- to two-third of the MCA territory) at 1
h after injection were randomly assigned to two groups. Eleven animals of group 1 immediately underwent craniectomy, ten animals of group 2 (controls) were not treated. Serial DWI was performed at 4 and 24
h. Infarction size was assessed by TTC-staining at 48
h after emboli injection.
As result, prior to treatment, at 1
h after emboli injection, infarction size in groups 1 and 2 was 65.9 ± 16.0
mm
3 and 67.9 ± 17.8
mm
3, respectively. At 4 and 24
h, infarction size in group 1 was 73.5 ± 22.1
mm
3 and 85.2 ± 24.7
mm
3, and 76.3 ± 21.0
mm
3 and 83.4 ± 22.9
mm
3 in group 2, respectively. TTC-derived infarction size was 84.0 ± 23.3
mm
3 and 82.7 ± 21.5
mm
3, respectively. There was no significant difference between the two groups (
P > 0.79).
In conclusion, our results demonstrate that for small thromboembolic MCA infarction early craniectomy is not beneficial. |
|---|---|
| AbstractList | Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the hypothesis that craniectomy may also be beneficial in smaller MCA infarction we evaluated the effects of craniectomy on infarction size in small thromboembolic cerebral infarction in rats.
Therefore, thromboembolic cerebral ischemia was induced in 40 rats by endovascular injection of autologous, fibrin-rich emboli. Twenty-one animals with a diffusion-weighted MR imaging (DWI)-derived infarction size of 50–100
mm
3 (involving one- to two-third of the MCA territory) at 1
h after injection were randomly assigned to two groups. Eleven animals of group 1 immediately underwent craniectomy, ten animals of group 2 (controls) were not treated. Serial DWI was performed at 4 and 24
h. Infarction size was assessed by TTC-staining at 48
h after emboli injection.
As result, prior to treatment, at 1
h after emboli injection, infarction size in groups 1 and 2 was 65.9 ± 16.0
mm
3 and 67.9 ± 17.8
mm
3, respectively. At 4 and 24
h, infarction size in group 1 was 73.5 ± 22.1
mm
3 and 85.2 ± 24.7
mm
3, and 76.3 ± 21.0
mm
3 and 83.4 ± 22.9
mm
3 in group 2, respectively. TTC-derived infarction size was 84.0 ± 23.3
mm
3 and 82.7 ± 21.5
mm
3, respectively. There was no significant difference between the two groups (
P > 0.79).
In conclusion, our results demonstrate that for small thromboembolic MCA infarction early craniectomy is not beneficial. |
| Author | Schwab, Stefan Engelhorn, Tobias Busch, Elmar Forsting, Michael Schabitz, Wolf-Ruediger Doerfler, Arnd Heiland, Sabine |
| Author_xml | – sequence: 1 givenname: Tobias surname: Engelhorn fullname: Engelhorn, Tobias email: tobias.engelhorn@uni-essen.de organization: Department of Neuroradiology, University of Essen, School of Medicine, Hufelandstrasse 55, D-45122 Essen, Germany – sequence: 2 givenname: Sabine surname: Heiland fullname: Heiland, Sabine organization: Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany – sequence: 3 givenname: Wolf-Ruediger surname: Schabitz fullname: Schabitz, Wolf-Ruediger organization: Department of Neurology, University of Heidelberg, Heidelberg, Germany – sequence: 4 givenname: Stefan surname: Schwab fullname: Schwab, Stefan organization: Department of Neurology, University of Heidelberg, Heidelberg, Germany – sequence: 5 givenname: Elmar surname: Busch fullname: Busch, Elmar organization: Department of Neurology, University of Essen, Essen, Germany – sequence: 6 givenname: Michael surname: Forsting fullname: Forsting, Michael organization: Department of Neuroradiology, University of Essen, School of Medicine, Hufelandstrasse 55, D-45122 Essen, Germany – sequence: 7 givenname: Arnd surname: Doerfler fullname: Doerfler, Arnd organization: Department of Neuroradiology, University of Essen, School of Medicine, Hufelandstrasse 55, D-45122 Essen, Germany |
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| Cites_doi | 10.1056/NEJM199512143332401 10.1161/01.STR.17.3.472 10.1016/S0304-3940(03)00441-5 10.1161/01.STR.24.1.117 10.1001/jama.274.13.1017 10.3171/jns.1992.77.2.0169 10.1161/01.STR.30.7.1456 10.1097/00004424-200211000-00003 10.1161/hs0202.102374 10.1161/01.STR.26.2.259 10.1227/00006123-199207000-00014 10.1055/s-1999-9889 10.1161/01.STR.20.1.84 10.1097/00006123-199706000-00010 10.1161/01.STR.1.3.158 10.3171/jns.2002.96.5.0933 10.1212/WNL.42.1.235 10.3171/jns.1996.85.5.0853 10.1161/01.STR.17.6.1304 10.1161/01.STR.29.9.1783 10.1007/s001010050763 10.1161/01.STR.29.9.1888 10.1016/S0006-8993(96)01343-1 10.1212/WNL.54.3.689 10.1001/archneur.1996.00550040037012 |
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| Keywords | Thromboembolic stroke MCA occlusion Decompressive craniectomy Rat |
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Neurol. doi: 10.1001/archneur.1996.00550040037012 |
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| Snippet | Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the... |
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| SubjectTerms | Decompressive craniectomy MCA occlusion Rat Thromboembolic stroke |
| Title | Decompressive craniectomy in acute cerebral ischemia in rats |
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