Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers

Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived hepatocellular carcinoma (HCC). Here, we report an elevation of MDSC in other hepatobiliary malignancies including non-viral HCC, neuroendocrine tumo...

Full description

Saved in:
Bibliographic Details
Published inbioRxiv
Main Authors Bayik, Defne, Lauko, Adam, Roversi, Gustavo A, Serbinowski, Emily, Acevedo-Moreno, Lou-Anne, Lanigan, Christopher, Orujov, Mushfig, Lo, Alice, Tyler, Alban, Silver, Daniel J, Brown, J Mark, Allende, Daniela S, Aucejo, Federico N, Lathia, Justin D
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.12.2019
Cold Spring Harbor Laboratory
Edition1.2
Subjects
Antigen-presenting cells
CD11b antigen
Cholangiocarcinoma
Colorectal carcinoma
Genomes
Hepatocellular carcinoma
Histocompatibility antigen HLA
Immunoregulation
Immunotherapy
Liver
Lymphocytes T
Metastases
Metastasis
Neuroendocrine tumors
Pathology
Peripheral blood
Suppressor cells
Tumors
immunosuppression
cholangiocarcinoma
Myeloid-derived suppressor cells
hepatocellular carcinoma
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/554600

Cover

Abstract Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived hepatocellular carcinoma (HCC). Here, we report an elevation of MDSC in other hepatobiliary malignancies including non-viral HCC, neuroendocrine tumors (NET), colorectal carcinoma with liver metastases (CRLM), but not cholangiocarcinoma (CCA). Investigation of myeloid cell infiltration in HCC, NET and intrahepatic CCA tumors further established that the frequency of antigen-presenting cells was limited compared to benign lesions suggesting that primary and metastatic hepatobiliary cancers have distinct peripheral and tumoral myeloid signatures. Bioinformatics analysis of the Cancer Genome Atlas demonstrated that a high MDSC score in HCC patients predicted poor disease outcome. Mechanistic studies indicated that the oncometabolite D-2-hydroxyglutarate resulting from isocitrate dehydrogenase 1 mutation could be a limiting factor of MDSC accumulation in CCA patients. Given our observation that MDSCs are increased in non-CCA malignant liver cancers, they may comprise suitable targets for effective immunotherapy approaches.
AbstractList Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived hepatocellular carcinoma (HCC). Here, we report an elevation of MDSC in other hepatobiliary malignancies including non-viral HCC, neuroendocrine tumors (NET), colorectal carcinoma with liver metastases (CRLM), but not cholangiocarcinoma (CCA). Investigation of myeloid cell infiltration in HCC, NET and intrahepatic CCA tumors further established that the frequency of antigen-presenting cells was limited compared to benign lesions suggesting that primary and metastatic hepatobiliary cancers have distinct peripheral and tumoral myeloid signatures. Bioinformatics analysis of the Cancer Genome Atlas demonstrated that a high MDSC score in HCC patients predicted poor disease outcome. Mechanistic studies indicated that the oncometabolite D-2-hydroxyglutarate resulting from isocitrate dehydrogenase 1 mutation could be a limiting factor of MDSC accumulation in CCA patients. Given our observation that MDSCs are increased in non-CCA malignant liver cancers, they may comprise suitable targets for effective immunotherapy approaches.
Author Tyler, Alban
Roversi, Gustavo A
Serbinowski, Emily
Aucejo, Federico N
Brown, J Mark
Lo, Alice
Allende, Daniela S
Lauko, Adam
Acevedo-Moreno, Lou-Anne
Lathia, Justin D
Orujov, Mushfig
Bayik, Defne
Silver, Daniel J
Lanigan, Christopher
Author_xml – sequence: 1
  givenname: Defne
  surname: Bayik
  fullname: Bayik, Defne
– sequence: 2
  givenname: Adam
  surname: Lauko
  fullname: Lauko, Adam
– sequence: 3
  givenname: Gustavo
  surname: Roversi
  middlename: A
  fullname: Roversi, Gustavo A
– sequence: 4
  givenname: Emily
  surname: Serbinowski
  fullname: Serbinowski, Emily
– sequence: 5
  givenname: Lou-Anne
  surname: Acevedo-Moreno
  fullname: Acevedo-Moreno, Lou-Anne
– sequence: 6
  givenname: Christopher
  surname: Lanigan
  fullname: Lanigan, Christopher
– sequence: 7
  givenname: Mushfig
  surname: Orujov
  fullname: Orujov, Mushfig
– sequence: 8
  givenname: Alice
  surname: Lo
  fullname: Lo, Alice
– sequence: 9
  givenname: Alban
  surname: Tyler
  fullname: Tyler, Alban
– sequence: 10
  givenname: Daniel
  surname: Silver
  middlename: J
  fullname: Silver, Daniel J
– sequence: 11
  givenname: J
  surname: Brown
  middlename: Mark
  fullname: Brown, J Mark
– sequence: 12
  givenname: Daniela
  surname: Allende
  middlename: S
  fullname: Allende, Daniela S
– sequence: 13
  givenname: Federico
  surname: Aucejo
  middlename: N
  fullname: Aucejo, Federico N
– sequence: 14
  givenname: Justin
  surname: Lathia
  middlename: D
  fullname: Lathia, Justin D
BookMark eNpNkEtLAzEUhYNUsGr9B0LAhavRPOaRLKX4goKb7oc7mUybkknGZKa2_94pI8XVvXA-Dh_nGs2cdxqhO0qeKCX0OcvSnJALNGe5ZIlgJJv9-6_QIsYdIYTJnPIinaPDcustuI3xCoIyzreAu6Cjdn3EgGsTe-NUj9ujtt7USa2D2esax6E7YdEHrLS1OJqNg34IGivfdhBGpPfY91sd8FZ30PvKWAPhiBU4pUO8RZcN2KgXf_cGrd9e18uPZPX1_rl8WSXVKJxUWomUpKmiWgrBtchBcsabDKiUhBOSF3VFZEUFkxQaUKSQUqaVaEgjGRT8Bj1OtYPr4PgD1pZdMO0oUlJSniYrp8lG8n4iK-PDwezP3Dl_mPIu-O9Bx77c-SG40b1kVHAuR4Wc_wLo_Hdt
Cites_doi 10.1101/gad.294991.116
10.1007/s00262-013-1447-1
10.1016/j.intimp.2011.01.003
10.1177/1073274817729245
10.1172/jci.insight.122264
10.1158/0008-5472.CAN-12-3381
10.1158/2159-8290.CD-13-0083
10.5009/gnl15568
10.1093/pcmedi/pby005
10.1111/j.1365-3083.2012.02725.x
10.1080/2162402X.2017.1331807
10.1001/archsurg.2011.186
10.1016/j.it.2016.01.004
10.1172/jci.insight.130748
10.1158/0008-5472.CAN-09-3690
10.1002/stem.2393
10.1634/theoncologist.2011-0386
10.1038/s41598-019-45346-1
10.1158/0008-5472.CAN-12-4124
10.1007/s00262-008-0523-4
10.1038/s41467-017-00530-7
10.1016/S0065-230X(10)07003-X
10.1097/CJI.0b013e318242169f
10.1007/s13277-016-4916-2
10.1158/1078-0432.CCR-13-2649
10.3748/wjg.v23.i15.2763
10.1016/j.cellimm.2008.08.007
10.1007/s10753-012-9496-8
10.1016/j.canlet.2015.10.040
10.1002/hep.23054
10.1055/s-2006-939841
10.1111/imm.12036
10.1189/jlb.0311177
10.1038/nri2506
10.1016/j.jim.2012.04.004
10.4161/21624011.2014.954829
10.3389/fimmu.2018.00398
10.1038/ncomms14979
ContentType Paper
Copyright 2019. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2019, Posted by Cold Spring Harbor Laboratory
Copyright_xml – notice: 2019. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2019, Posted by Cold Spring Harbor Laboratory
DBID 8FE
8FH
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
FX.
UNPAY
DOI 10.1101/554600
DatabaseName ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
bioRxiv
Unpaywall
DatabaseTitle Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Biological Science Collection
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
DatabaseTitleList Publicly Available Content Database
Database_xml – sequence: 1
  dbid: FX.
  name: bioRxiv
  url: https://www.biorxiv.org/
  sourceTypes: Open Access Repository
– sequence: 2
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2692-8205
Edition 1.2
ExternalDocumentID 10.1101/554600
554600v2
Genre Working Paper/Pre-Print
GroupedDBID 8FE
8FH
ABUWG
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M7P
NQS
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PROAC
RHI
FX.
UNPAY
ID FETCH-LOGICAL-b820-bec84044c1e9883e86a9323f5a199030067db09b18291afac079994b8f0f92a73
IEDL.DBID FX.
ISSN 2692-8205
IngestDate Sun Oct 26 02:12:03 EDT 2025
Tue Jan 07 18:54:17 EST 2025
Fri Jul 25 09:13:55 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Keywords immunosuppression
cholangiocarcinoma
Myeloid-derived suppressor cells
hepatocellular carcinoma
Language English
License This pre-print is available under a Creative Commons License (Attribution-NonCommercial-NoDerivs 4.0 International), CC BY-NC-ND 4.0, as described at http://creativecommons.org/licenses/by-nc-nd/4.0
cc-by-nc-nd
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-b820-bec84044c1e9883e86a9323f5a199030067db09b18291afac079994b8f0f92a73
Notes SourceType-Working Papers-1
ObjectType-Working Paper/Pre-Print-1
content type line 50
ORCID 0000-0002-3355-8911
0000-0003-2288-2561
0000-0003-3168-7290
0000-0001-9868-8269
0000-0002-4740-8869
0000-0001-8793-2254
0000-0003-2708-7487
OpenAccessLink https://www.biorxiv.org/content/10.1101/554600
PQID 2183398296
PQPubID 2050091
PageCount 34
ParticipantIDs unpaywall_primary_10_1101_554600
biorxiv_primary_554600
proquest_journals_2183398296
PublicationCentury 2000
PublicationDate 20191211
PublicationDateYYYYMMDD 2019-12-11
PublicationDate_xml – month: 12
  year: 2019
  text: 20191211
  day: 11
PublicationDecade 2010
PublicationPlace Cold Spring Harbor
PublicationPlace_xml – name: Cold Spring Harbor
PublicationTitle bioRxiv
PublicationYear 2019
Publisher Cold Spring Harbor Laboratory Press
Cold Spring Harbor Laboratory
Publisher_xml – name: Cold Spring Harbor Laboratory Press
– name: Cold Spring Harbor Laboratory
References Alban (554600v2.35) 2018; 3
Hoechst (554600v2.15) 2009; 50
Ananthakrishnan, Gogineni, Saeian (554600v2.3) 2006; 23
Aktas, Kucuksezer, Bilgic, Erten, Deniz (554600v2.33) 2009; 254
Chiu (554600v2.40) 2017; 8
Wang, Till, Gao (554600v2.43) 2017; 6
Mougiakakos, Choudhury, Lladser, Kiessling, Johansson (554600v2.20) 2010; 107
Gabrilovich, Nagaraj (554600v2.7) 2009; 9
Amankulor (554600v2.26) 2017; 31
Borger (554600v2.24) 2014; 20
Youn, Collazo, Shalova, Biswas, Gabrilovich (554600v2.37) 2012; 91
Kalathil, Lugade, Miller, Iyer, Thanavala (554600v2.13) 2013; 73
Unruh (554600v2.27) 2019; 9
Draghiciu, Lubbers, Nijman, Daemen (554600v2.11) 2015; 4
Borger (554600v2.22) 2012; 17
Cairns, Mak (554600v2.23) 2013; 3
Gedaly (554600v2.4) 2011; 146
Kumar, Patel, Tcyganov, Gabrilovich (554600v2.8) 2016; 37
Hartling (554600v2.31) 2012; 76
Wang, An, Xie, Yao, Feng (554600v2.16) 2016; 37
Arihara (554600v2.14) 2013; 62
Yu (554600v2.29) 2012; 35
Ouzounova (554600v2.19) 2017; 8
Fleming (554600v2.12) 2018; 9
Peereboom (554600v2.44) 2019; 4
Ramachandran (554600v2.10) 2016; 371
(554600v2.1) 2018
Montero, Diaz-Montero, Kyriakopoulos, Bronte, Mandruzzato (554600v2.9) 2012; 35
Otvos (554600v2.42) 2016; 34
Fletcher (554600v2.36) 1986; 104
Massarweh, El-Serag (554600v2.5) 2017; 24
Mohsen (554600v2.32) 2017; 23
Greten, Manns, Korangy (554600v2.18) 2011; 11
Thomas, Lipsky (554600v2.39) 1994; 153
Karin (554600v2.6) 2018; 1
Lindau, Gielen, Kroesen, Wesseling, Adema (554600v2.21) 2013; 138
Kotsakis (554600v2.28) 2012; 381
Youn, Nagaraj, Collazo, Gabrilovich (554600v2.38) 2008; 181
Blechacz (554600v2.25) 2017; 11
Vincent (554600v2.41) 2010; 70
Diaz-Montero (554600v2.34) 2009; 58
Kohanbash (554600v2.17) 2013; 73
Gomaa, Khan, Toledano, Waked, Taylor-Robinson (554600v2.2) 2008; 14
Xu (554600v2.30) 2006; 177
References_xml – volume: 31
  start-page: 774
  year: 2017
  end-page: 786
  ident: 554600v2.26
  article-title: Mutant IDH1 regulates the tumor-associated immune system in gliomas
  publication-title: Genes Dev
  doi: 10.1101/gad.294991.116
– volume: 62
  start-page: 1421
  year: 2013
  end-page: 1430
  ident: 554600v2.14
  article-title: Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-013-1447-1
– volume: 11
  start-page: 802
  year: 2011
  end-page: 807
  ident: 554600v2.18
  article-title: Myeloid derived suppressor cells in human diseases
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2011.01.003
– volume: 24
  year: 2017
  ident: 554600v2.5
  article-title: Epidemiology of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
  publication-title: Cancer Control
  doi: 10.1177/1073274817729245
– volume: 3
  year: 2018
  ident: 554600v2.35
  article-title: Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.122264
– volume: 73
  start-page: 2435
  year: 2013
  end-page: 2444
  ident: 554600v2.13
  article-title: Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-12-3381
– volume: 3
  start-page: 730
  year: 2013
  end-page: 741
  ident: 554600v2.23
  article-title: Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-13-0083
– volume: 11
  start-page: 13
  year: 2017
  end-page: 26
  ident: 554600v2.25
  article-title: Cholangiocarcinoma: Current Knowledge and New Developments
  publication-title: Gut Liver
  doi: 10.5009/gnl15568
– volume: 104
  start-page: 66
  year: 1986
  end-page: 73
  ident: 554600v2.36
  article-title: Carcinoembryonic antigen
  publication-title: Ann Intern Med
– volume: 181
  start-page: 5791
  year: 2008
  end-page: 5802
  ident: 554600v2.38
  article-title: Subsets of myeloid-derived suppressor cells in tumor-bearing mice
  publication-title: J Immunol
– volume: 1
  start-page: 21
  year: 2018
  end-page: 28
  ident: 554600v2.6
  article-title: New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance
  publication-title: Precis Clin Med
  doi: 10.1093/pcmedi/pby005
– volume: 76
  start-page: 294
  year: 2012
  end-page: 305
  ident: 554600v2.31
  article-title: CD4(+) and CD8(+) regulatory T cells (Tregs) are elevated and display an active phenotype in patients with chronic HCV mono-infection and HIV/HCV co-infection
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2012.02725.x
– volume: 6
  start-page: e1331807
  year: 2017
  ident: 554600v2.43
  article-title: Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2017.1331807
– volume: 153
  start-page: 4016
  year: 1994
  end-page: 4028
  ident: 554600v2.39
  article-title: Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells
  publication-title: J Immunol
– volume: 146
  start-page: 953
  year: 2011
  end-page: 958
  ident: 554600v2.4
  article-title: Liver transplantation for the treatment of liver metastases from neuroendocrine tumors: an analysis of the UNOS database
  publication-title: Arch Surg
  doi: 10.1001/archsurg.2011.186
– volume: 37
  start-page: 208
  year: 2016
  end-page: 220
  ident: 554600v2.8
  article-title: The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2016.01.004
– volume: 4
  year: 2019
  ident: 554600v2.44
  article-title: Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.130748
– volume: 177
  start-page: 739
  year: 2006
  end-page: 747
  ident: 554600v2.30
  article-title: Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
  publication-title: J Immunol
– volume: 70
  start-page: 3052
  year: 2010
  end-page: 3061
  ident: 554600v2.41
  article-title: 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-09-3690
– volume: 34
  start-page: 2026
  year: 2016
  end-page: 2039
  ident: 554600v2.42
  article-title: Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion
  publication-title: Stem Cells
  doi: 10.1002/stem.2393
– volume: 17
  start-page: 72
  year: 2012
  end-page: 79
  ident: 554600v2.22
  article-title: Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
  publication-title: Oncologist
  doi: 10.1634/theoncologist.2011-0386
– volume: 9
  start-page: 8946
  year: 2019
  ident: 554600v2.27
  article-title: Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-45346-1
– volume: 73
  start-page: 6413
  year: 2013
  end-page: 6423
  ident: 554600v2.17
  article-title: GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-alpha
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-12-4124
– volume: 58
  start-page: 49
  year: 2009
  end-page: 59
  ident: 554600v2.34
  article-title: Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s00262-008-0523-4
– volume: 8
  start-page: 517
  year: 2017
  ident: 554600v2.40
  article-title: Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-00530-7
– volume: 107
  start-page: 57
  year: 2010
  end-page: 117
  ident: 554600v2.20
  article-title: Regulatory T cells in cancer
  publication-title: Adv Cancer Res
  doi: 10.1016/S0065-230X(10)07003-X
– volume: 35
  start-page: 107
  year: 2012
  end-page: 115
  ident: 554600v2.9
  article-title: Myeloid-derived suppressor cells in cancer patients: a clinical perspective
  publication-title: J Immunother
  doi: 10.1097/CJI.0b013e318242169f
– volume: 37
  start-page: 10427
  year: 2016
  end-page: 10433
  ident: 554600v2.16
  article-title: The clinical and prognostic significance of CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy
  publication-title: Tumour Biol
  doi: 10.1007/s13277-016-4916-2
– volume: 20
  start-page: 1884
  year: 2014
  end-page: 1890
  ident: 554600v2.24
  article-title: Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-13-2649
– volume: 23
  start-page: 2763
  year: 2017
  end-page: 2770
  ident: 554600v2.32
  article-title: Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v23.i15.2763
– volume: 254
  start-page: 149
  year: 2009
  end-page: 154
  ident: 554600v2.33
  article-title: Relationship between CD107a expression and cytotoxic activity
  publication-title: Cell Immunol
  doi: 10.1016/j.cellimm.2008.08.007
– volume: 35
  start-page: 1773
  year: 2012
  end-page: 1780
  ident: 554600v2.29
  article-title: CD4(+)CD25 (+)CD127 (low/-) T cells: a more specific Treg population in human peripheral blood
  publication-title: Inflammation
  doi: 10.1007/s10753-012-9496-8
– volume: 371
  start-page: 117
  year: 2016
  end-page: 124
  ident: 554600v2.10
  article-title: Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.10.040
– volume: 50
  start-page: 799
  year: 2009
  end-page: 807
  ident: 554600v2.15
  article-title: Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
  publication-title: Hepatology
  doi: 10.1002/hep.23054
– volume: 23
  start-page: 47
  year: 2006
  end-page: 63
  ident: 554600v2.3
  article-title: Epidemiology of primary and secondary liver cancers
  publication-title: Semin Intervent Radiol
  doi: 10.1055/s-2006-939841
– volume: 138
  start-page: 105
  year: 2013
  end-page: 115
  ident: 554600v2.21
  article-title: The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells
  publication-title: Immunology
  doi: 10.1111/imm.12036
– volume: 91
  start-page: 167
  year: 2012
  end-page: 181
  ident: 554600v2.37
  article-title: Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0311177
– volume: 9
  start-page: 162
  year: 2009
  end-page: 174
  ident: 554600v2.7
  article-title: Myeloid-derived suppressor cells as regulators of the immune system
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2506
– year: 2018
  ident: 554600v2.1
  publication-title: Cancer Stat Facts: Liver and Intrahepatic Bile Duct Cancer
– volume: 381
  start-page: 14
  year: 2012
  end-page: 22
  ident: 554600v2.28
  article-title: Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples
  publication-title: J Immunol Methods
  doi: 10.1016/j.jim.2012.04.004
– volume: 4
  start-page: e954829
  year: 2015
  ident: 554600v2.11
  article-title: Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy
  publication-title: Oncoimmunology
  doi: 10.4161/21624011.2014.954829
– volume: 9
  start-page: 398
  year: 2018
  ident: 554600v2.12
  article-title: Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00398
– volume: 8
  start-page: 14979
  year: 2017
  ident: 554600v2.19
  article-title: Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
  publication-title: Nat Commun
  doi: 10.1038/ncomms14979
– volume: 14
  start-page: 4300
  year: 2008
  end-page: 4308
  ident: 554600v2.2
  article-title: Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis
  publication-title: World J Gastroenterol
SSID ssj0002961374
Score 1.5814412
SecondaryResourceType preprint
Snippet Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived...
SourceID unpaywall
biorxiv
proquest
SourceType Open Access Repository
Aggregation Database
SubjectTerms Antigen-presenting cells
CD11b antigen
Cholangiocarcinoma
Colorectal carcinoma
Genomes
Hepatocellular carcinoma
Histocompatibility antigen HLA
Immunoregulation
Immunotherapy
Liver
Lymphocytes T
Metastases
Metastasis
Neuroendocrine tumors
Pathology
Peripheral blood
Suppressor cells
Tumors
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9xADLZgV4jeWlrEUlrNgeuITCaPmUNVqQiEKrFCiErcVp5H2khLErKPsv--nmyybS_8gBkpHtuf7dj-AM7RIwovHS-skDzxquDG-Iyn2rvIED6nOswO306zmx_J98f0cQ-mwyxMaKscfGLnqF1tQ438IkC51CrW2dfmmQfWqPB3daDQwJ5awX3pVoztwzgOm7FGMP52Nb2731Vd6LiQ3WrmONPkCuIo7QmHSDUvQsdWGHU7MGXdvpTr_6LOw1XV4OY3zuf_AND1WxjfYePbd7DnqyM42DJIbt7Dy2XITaufJUFSa8uqfkLWbCeKFgyZCxZc2SV72vh5XTruSOHW3rHFquk6YOuWhdI9C20c3YpPNjSls2XNuuks9osQi8y-nJfYbpgNatIuPsDD9dXD5Q3vyRS4oa_k9FSUyiWJFV4rJb3KkCI3WaQoCI9kAC1nIm0o3dACC7RRTqFjYlQRFTrGXB7DqKorfwIstxoj47TKMQQv0sSWjF6qQskiUTqfwHEvv1mz3Zgx2wp2AmeDOGe9pSxmf991Amwn4t3JLkeJRH_D6es3fIQ3FM909A5CnMFo2a78J4oZluZzrwh_AAOMwpI
  priority: 102
  providerName: ProQuest
– databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV09T8MwELWgHdgAAaIIkAfWNHGdD3tECFQhUTFQqUyVPyGiTaI0Bcqv55y6CFhYWCPHsezLvXf2uzNCF8IIQQzVgVWEBrFhNpDSpEHCjY4k4HPCXe7w3SgdjuPbSTLZQsNNLoyTVcq8rN_z1_Yc3wm2wfuG_lloXNlfiNgJD8kgJCR0Kqso6rvN6n6l7Tbqpgmw8g7qjkf3l4_-OiEwPN8SeK7v6wen3FkWlVi9idnsG7zc7KJ8M7C1quSlv2xkX338qtn4HyPfQ917UZl6H22Z4gC9X7nYtnjKAdJqlRflXOBqnZG0wAJr5wEK1eD5yszKXAcaDPbVaLxYVq2Ctqyx2_rHTgbSlgjFG1E7bkrcZnfhZ0A8cBv5LBf1CitnZvXiED3cXD9cDQN_GUMggSQEsNQQCsaxIoYzRg1LBTA_ahNBAM-oAz0tIy4hXOFEWKGiDKhnLJmNLB-IjB6hTlEW5hjhTHERSc1ZJhz5oXKgwGlQZhm1MeNZDx35OZtW64ob0_VU9dDpZsGm_k9bTB3Foxy-mvYQ_lrErzfbGCcivoeTv5ucok5TL80ZUI1Gnnsr-gSXT9tw
  priority: 102
  providerName: Unpaywall
Title Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers
URI https://www.proquest.com/docview/2183398296
https://www.biorxiv.org/content/10.1101/554600
https://www.biorxiv.org/content/biorxiv/early/2019/12/11/554600.full.pdf
UnpaywallVersion acceptedVersion
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1dS8MwFA2yIfrm13A6Rx58rTZLP5JHHRtDcAzZYD6VpE210LWl3eb6771pu6kPPhbaFG5ye85Jz81F6F4oIYiigRH6hBqWYqEhpXIMm6vAlIDPNte1w69TZ7KwXpb2shGKRWOrlFGa76Jt9R9fG7bh61snt0ketanKBInedgHXtYVrvHw47KkMOICTazUthH5uB27bjPmHR55skkyUXyKOf0HK-Ay1ZyJT-Tk6UskFOq57QpaXaDfUajP5iABkcj9K0pXAWV0jVGCBA52Tib_Gq1LFaRQYASyhrQpwsckqT2uaY70Zj7Uxozq0E-9t5nid4qreCn8CBkEiR3Ek8hL7euLz4grNx6P5cGI07REMCbBtQPBBnFmWTxRnjCrmCOBiNLQFAYShGoYCaXIJAoITEQrfdIEMWpKFZsgHwqUd1ErSRF0j7PpcmDLgzBWajlA58CGNKQsZDS3G3S7qNPHzsvoMDK8ObBf19uH0mrVfeJp0UQ5vdboIH0J8eLJSHSZpRrj5b-hbdArcpGrVQEgPtdb5Rt0B_q9lH7WfR9PZW7-afLhaTGdP79_sPbRX
linkProvider Cold Spring Harbor Laboratory Press
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1NT9wwEB1RVojeSlvULZT60B4t4jgf9gFVKh9aCqxQtZW4RXbstJGWJCS7QH5c_1vH2WRLL73xA2Ilk_GbN_bMPIBPyirFLDc0SxmngRUZ1dpGNJTWeBrjcyhd7_DVNJr8CL7dhDcb8HvohXFllQMmdkBtytSdkR-6UM6l8GX0pbqjTjXK3a4OEhqql1YwR92Isb6x48K2D5jCNUfnJ_i_P_v-2enseEJ7lQGqMfpR_AbMcYIgZVYKwa2IFFIanoWKIVBzh-ZGe1IjD5dMZSr1YuRUgRaZl0lfxRyXfQGjgAcSc7_R19Pp9ff1IQ--LePdJGg_kog8vhf2-ka4Ew5dgZjrrNvSeVk_5vf_kNztZVGp9kHN50_i3dkrGF2rytY7sGGL17C1Eqxs38DjsUuFi585RsA6zYvyVpFq1cDUEEWMA4wiXZDb1s7L3FCD_n1vDWmWVVdwW9bE3RQQVzXSTRQlQw08WZSkawYjvzBAIsrk81zVLUmdV9bNW5g9h1V3YbMoC_sOSJxK5WkjRawcV-LaTxFjuMgEzwIh4zHs9vZLqtWAjmRl2DHsD-ZM-o3ZJH_daAxkbeL1k11K5LF-hff_X-EjbE9mV5fJ5fn0Yg9eIpXqlCUY24fNRb20H5CuLPRB7xQEkmd2wz_CKf0E
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3JTsMwELVYxHJjFYUCPnBNseu0sc9AVVb1UKTeIju2IVKbRElb2r9nnKQFDnyAJ9LY4_dm8saD0I00UlLDtGcjyjzfcOspZbpeRxhNFOBzR7je4de3bv_dfxp1RnXpoqhllSpO80U8L__jO8E23L5VcBN660RVhLRcbbqVabuJtgMAeJd19UatdXGlLQClAr-eJfSzDkhubfwPodybJZlcfsnx-Be29A7Q9kBmJj9EGyY5QjvVcMjlMVrcubQz-YgBbfIoTtKJxFnVLFRgibULziSa4snSjNNYexrO0txoXMyyUtya5thV5bFTaJSvd-KV3hxPU1w2XuFPACOI6Hgcy3yJI3cC8uIEDXsPw7u-V89J8BTgtwe7AFma70fUCM6Z4V0JpIzZjqQANczhkVZEKMgkBJVWRiQAVugrbokVbRmwU7SVpIk5QziIhCRKCx5Ix0uYakcQz4xbzqzPRdBAp7X_wqx6DCOsHNtAzZU7wzoIitCxLybgq90GwmsXr1eW6QehtYXz_0xfo93BfS98eXx7vkD7wFfK8Q2UNtHWNJ-ZS-AEU3VV7v83WMG27A
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV09T8MwELWgHdgAAaIIkAfWNHGdD3tECFQhUTFQqUyVPyGiTaI0Bcqv55y6CFhYWCPHsezLvXf2uzNCF8IIQQzVgVWEBrFhNpDSpEHCjY4k4HPCXe7w3SgdjuPbSTLZQsNNLoyTVcq8rN_z1_Yc3wm2wfuG_lloXNlfiNgJD8kgJCR0Kqso6rvN6n6l7Tbqpgmw8g7qjkf3l4_-OiEwPN8SeK7v6wen3FkWlVi9idnsG7zc7KJ8M7C1quSlv2xkX338qtn4HyPfQ917UZl6H22Z4gC9X7nYtnjKAdJqlRflXOBqnZG0wAJr5wEK1eD5yszKXAcaDPbVaLxYVq2Ctqyx2_rHTgbSlgjFG1E7bkrcZnfhZ0A8cBv5LBf1CitnZvXiED3cXD9cDQN_GUMggSQEsNQQCsaxIoYzRg1LBTA_ahNBAM-oAz0tIy4hXOFEWKGiDKhnLJmNLB-IjB6hTlEW5hjhTHERSc1ZJhz5oXKgwGlQZhm1MeNZDx35OZtW64ob0_VU9dDpZsGm_k9bTB3Foxy-mvYQ_lrErzfbGCcivoeTv5ucok5TL80ZUI1Gnnsr-gSXT9tw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cholangiocarcinoma+presents+a+distinct+myeloid-derived+suppressor+cell+signature+compared+to+other+hepatobiliary+cancers&rft.jtitle=bioRxiv&rft.au=Bayik%2C+Defne&rft.au=Lauko%2C+Adam+J.&rft.au=Roversi%2C+Gustavo+A.&rft.au=Serbinowski%2C+Emily&rft.date=2019-12-11&rft.pub=Cold+Spring+Harbor+Laboratory&rft.eissn=2692-8205&rft_id=info:doi/10.1101%2F554600&rft.externalDocID=554600v2
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2692-8205&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2692-8205&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2692-8205&client=summon