Shingles, Zostavax vaccination and risk of developing dementia: a nested case–control study—results from the UK Biobank cohort
ObjectivesTo investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.DesignNested case–control study.SettingsData were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linka...
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| Published in | BMJ open Vol. 11; no. 10; p. e045871 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
British Medical Journal Publishing Group
08.10.2021
BMJ Publishing Group LTD BMJ Publishing Group |
| Series | Original research |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2044-6055 2044-6055 |
| DOI | 10.1136/bmjopen-2020-045871 |
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| Abstract | ObjectivesTo investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.DesignNested case–control study.SettingsData were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records.ParticipantsThe analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk.ResultsThere was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993).ConclusionA history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia. |
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| AbstractList | ObjectivesTo investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.DesignNested case–control study.SettingsData were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records.ParticipantsThe analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk.ResultsThere was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993).ConclusionA history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia. To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.OBJECTIVESTo investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.Nested case-control study.DESIGNNested case-control study.Data were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records.SETTINGSData were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records.The analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk.PARTICIPANTSThe analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk.There was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993).RESULTSThere was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993).A history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia.CONCLUSIONA history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia. Objectives To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.Design Nested case–control study.Settings Data were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records.Participants The analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk.Results There was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993).Conclusion A history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia. To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia. Nested case-control study. Data were drawn from the UK Biobank cohort study with a total of 228 223 participants with Hospital Episodes Statistics and primary care linkage health records. The analyses included 2378 incident dementia cases and 225 845 controls. Inclusion criteria for incident cases were a dementia diagnosis 3 years or more after the first assessment date derived from all sources including International Classification of Diseases (ICD)-10, ICD-9, self-report and primary care linkage records. Subjects with no dementia code from all sources were coded as controls. Both shingles and Zostavax vaccination were investigated for their association with dementia risk. There was a small but non-significant increase in the risk of dementia in subjects with shingles diagnosed 3 years or more prior to dementia diagnosis (OR: 1.088 with 95% CI: 0.978 to 1.211). In those subjects who had had Zostavax vaccination, the risk of dementia significantly decreased (OR: 0.808 with 95% CI: 0.657 to 0.993). A history of shingles was not associated with an increased risk of dementia. In subjects who were eligible for the immunisation and vaccinated with Zostavax, we saw reduced risk of developing dementia. |
| Author | Dobson, Curtis Cant, Rachel Burns, Alistair Muir, Kenneth Itzhaki, Ruth Mekli, Krisztina Lophatananon, Artitaya |
| AuthorAffiliation | 1 Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK 4 The Oxford Institute of Population Ageing , University of Oxford , Oxford , UK 3 Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK 2 Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK |
| AuthorAffiliation_xml | – name: 1 Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK – name: 2 Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK – name: 3 Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health , The University of Manchester , Manchester , UK – name: 4 The Oxford Institute of Population Ageing , University of Oxford , Oxford , UK |
| Author_xml | – sequence: 1 givenname: Artitaya orcidid: 0000-0003-0550-4657 surname: Lophatananon fullname: Lophatananon, Artitaya organization: Division of Population Health, Health Services Research and Primary Care,School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 2 givenname: Krisztina surname: Mekli fullname: Mekli, Krisztina organization: Division of Population Health, Health Services Research and Primary Care,School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 3 givenname: Rachel surname: Cant fullname: Cant, Rachel organization: Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 4 givenname: Alistair surname: Burns fullname: Burns, Alistair organization: Division of Neuroscience & Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 5 givenname: Curtis surname: Dobson fullname: Dobson, Curtis organization: Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK – sequence: 6 givenname: Ruth surname: Itzhaki fullname: Itzhaki, Ruth organization: The Oxford Institute of Population Ageing, University of Oxford, Oxford, UK – sequence: 7 givenname: Kenneth orcidid: 0000-0001-6429-988X surname: Muir fullname: Muir, Kenneth email: kenneth.muir@manchester.ac.uk organization: Division of Population Health, Health Services Research and Primary Care,School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK |
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| Cites_doi | 10.1371/journal.pone.0096779 10.1093/aje/kwx246 10.1002/psb.1688 10.1007/s10654-019-00499-1 10.1016/j.jalz.2019.07.014 10.4088/JCP.16m11312 10.1007/s004150050078 10.1016/S0140-6736(20)30367-6 10.1002/jmv.1890330403 10.1016/S0140-6736(96)10149-5 10.1016/0002-9343(62)90179-1 10.1056/NEJMc2008597 10.1007/s13365-020-00830-7 10.1007/s00415-002-0874-2 10.2147/CLEP.S282475 10.1002/jmv.23397 10.1016/S1473-3099(03)00857-0 10.1136/bmjopen-2018-023502 10.1371/journal.pone.0188490 10.1186/s13195-017-0241-2 10.1177/15333175211006504 10.1016/s0140-6736(96)10149-5 |
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| References | Thomas, Hall (R14) 2004; 4 Wetzel, Asholt, Herrmann (R17) 2002; 249 Westman, Berglund, Widén (R5) 2014; 9 Wilkinson, Schnier, Bush (R8) 2019; 34 Curran, Hunjan, El Ghachi (R13) 2019; 9 Grahn, Bauer, Silver (R18) 2013; 54 Helms, Kremer, Merdji (R23) 2020; 382 Stowe, Peek, Cutchin (R4) 2012; 84 Dowden (R7) 2018; 29 Choi, Park, Lim (R11) 2021; 36 Itzhaki, Lin, Shang (R3) 1997; 349 Ludvigsson, Appelros, Askling (R10) 2021; 13 Hokkanen, Launes, Poutiainen (R16) 1997; 244 Calvin, Wilkinson, Starr (R12) 2019; 15 Bubak, Beseler, Como (R6) 2020; 26 Jamieson, Maitland, Wilcock (R2) 1991; 33 Chen, Wu, Huang (R20) 2018; 79 Tsai, Cheng, Sheu (R19) 2017; 12 Fry, Littlejohns, Sudlow (R26) 2017; 186 McManus, Heneka (R24) 2017; 9 Livingston, Huntley, Sommerlad (R1) 2020; 396 Verreault, Laurin, Lindsay (R22) 2001; 165 Appelbaum, Kreps, Sunshine (R15) 1962; 32 Itzhaki, Dobson (R21) 2002; 167 2024102817410846000_11.10.e045871.14 2024102817410846000_11.10.e045871.1 2024102817410846000_11.10.e045871.15 2024102817410846000_11.10.e045871.8 2024102817410846000_11.10.e045871.9 Bubak (2024102817410846000_11.10.e045871.6) 2020; 26 Dowden (2024102817410846000_11.10.e045871.7) 2018; 29 2024102817410846000_11.10.e045871.4 Calvin (2024102817410846000_11.10.e045871.12) 2019; 15 2024102817410846000_11.10.e045871.2 2024102817410846000_11.10.e045871.3 Curran (2024102817410846000_11.10.e045871.13) 2019; 9 2024102817410846000_11.10.e045871.25 Wetzel (2024102817410846000_11.10.e045871.17) 2002; 249 Chen (2024102817410846000_11.10.e045871.20) 2018; 79 2024102817410846000_11.10.e045871.26 Ludvigsson (2024102817410846000_11.10.e045871.10) 2021; 13 Hokkanen (2024102817410846000_11.10.e045871.16) 1997; 244 Itzhaki (2024102817410846000_11.10.e045871.21) 2002; 167 Choi (2024102817410846000_11.10.e045871.11) 2021; 36 Westman (2024102817410846000_11.10.e045871.5) 2014; 9 Tsai (2024102817410846000_11.10.e045871.19) 2017; 12 Verreault (2024102817410846000_11.10.e045871.22) 2001; 165 McManus (2024102817410846000_11.10.e045871.24) 2017; 9 Helms (2024102817410846000_11.10.e045871.23) 2020; 382 Grahn (2024102817410846000_11.10.e045871.18) 2013; 54 |
| References_xml | – volume: 9 year: 2014 ident: R5 article-title: Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer’s disease publication-title: PLoS One doi: 10.1371/journal.pone.0096779 – volume: 186 start-page: 1026 year: 2017 ident: R26 article-title: Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population publication-title: Am J Epidemiol doi: 10.1093/aje/kwx246 – volume: 29 start-page: 23 year: 2018 ident: R7 article-title: Is the UK shingles vaccination programme fit for the future? publication-title: Prescriber doi: 10.1002/psb.1688 – volume: 34 start-page: 557 year: 2019 ident: R8 article-title: Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data publication-title: Eur J Epidemiol doi: 10.1007/s10654-019-00499-1 – volume: 15 start-page: 1546 year: 2019 ident: R12 article-title: Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people publication-title: Alzheimer's & Dementia doi: 10.1016/j.jalz.2019.07.014 – volume: 36 year: 2021 ident: R11 article-title: Herpes zoster does not increase the risk of neurodegenerative dementia: a case-control study publication-title: American Journal of Alzheimer’s Disease and Other Dementias – volume: 79 year: 2018 ident: R20 article-title: Herpes zoster and dementia: a nationwide population-based cohort study publication-title: J Clin Psychiatry doi: 10.4088/JCP.16m11312 – volume: 165 start-page: 1495 year: 2001 ident: R22 article-title: Past exposure to vaccines and subsequent risk of Alzheimer's disease publication-title: CMAJ – volume: 244 start-page: 239 year: 1997 ident: R16 article-title: Subcortical type cognitive impairment in herpes zoster encephalitis publication-title: J Neurol doi: 10.1007/s004150050078 – volume: 396 start-page: 413 year: 2020 ident: R1 article-title: Dementia prevention, intervention, and care: 2020 report of the Lancet Commission publication-title: Lancet doi: 10.1016/S0140-6736(20)30367-6 – volume: 33 start-page: 224 year: 1991 ident: R2 article-title: Latent herpes simplex virus type 1 in normal and Alzheimer’s disease brains publication-title: J Med Virol doi: 10.1002/jmv.1890330403 – volume: 349 start-page: 241 year: 1997 ident: R3 article-title: Herpes simplex virus type 1 in brain and risk of Alzheimer’s disease publication-title: The Lancet doi: 10.1016/S0140-6736(96)10149-5 – volume: 32 start-page: 25 year: 1962 ident: R15 article-title: Herpes zoster encephalitis publication-title: Am J Med doi: 10.1016/0002-9343(62)90179-1 – volume: 382 start-page: 2268 year: 2020 ident: R23 article-title: Neurologic features in severe SARS-CoV-2 infection publication-title: N Engl J Med Overseas Ed doi: 10.1056/NEJMc2008597 – volume: 26 start-page: 422 year: 2020 ident: R6 article-title: Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic publication-title: J Neurovirol doi: 10.1007/s13365-020-00830-7 – volume: 249 start-page: 1612 year: 2002 ident: R17 article-title: Good cognitive outcome of patients with herpes zoster encephalitis: a follow-up study publication-title: J Neurol doi: 10.1007/s00415-002-0874-2 – volume: 54 start-page: 86 year: 2013 ident: R18 article-title: Diagnostic ophthalmology publication-title: Can Vet J – volume: 167 start-page: 13 year: 2002 ident: R21 article-title: Alzheimer's disease and herpes publication-title: CMAJ – volume: 13 start-page: 21 year: 2021 ident: R10 article-title: Adaptation of the Charlson comorbidity index for register-based research in Sweden publication-title: Clinical epidemiology doi: 10.2147/CLEP.S282475 – volume: 84 start-page: 1797 year: 2012 ident: R4 article-title: Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age publication-title: J Med Virol doi: 10.1002/jmv.23397 – volume: 4 start-page: 26 year: 2004 ident: R14 article-title: What does epidemiology tell us about risk factors for herpes zoster? publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(03)00857-0 – volume: 9 year: 2019 ident: R13 article-title: Herpes zoster related healthcare burden and costs in immunocompromised (IC) and IC-free populations in England: an observational retrospective database analysis publication-title: BMJ Open doi: 10.1136/bmjopen-2018-023502 – volume: 12 year: 2017 ident: R19 article-title: Increased risk of dementia following herpes zoster ophthalmicus publication-title: PLoS One doi: 10.1371/journal.pone.0188490 – volume: 9 start-page: 14 year: 2017 ident: R24 article-title: Role of neuroinflammation in neurodegeneration: new insights publication-title: Alzheimers Res Ther doi: 10.1186/s13195-017-0241-2 – volume: 36 year: 2021 ident: 2024102817410846000_11.10.e045871.11 article-title: Herpes zoster does not increase the risk of neurodegenerative dementia: a case-control study publication-title: American Journal of Alzheimer’s Disease and Other Dementias doi: 10.1177/15333175211006504 – ident: 2024102817410846000_11.10.e045871.3 doi: 10.1016/s0140-6736(96)10149-5 – ident: 2024102817410846000_11.10.e045871.15 doi: 10.1016/0002-9343(62)90179-1 – volume: 382 start-page: 2268 year: 2020 ident: 2024102817410846000_11.10.e045871.23 article-title: Neurologic features in severe SARS-CoV-2 infection publication-title: N Engl J Med Overseas Ed doi: 10.1056/NEJMc2008597 – ident: 2024102817410846000_11.10.e045871.26 doi: 10.1093/aje/kwx246 – volume: 165 start-page: 1495 year: 2001 ident: 2024102817410846000_11.10.e045871.22 article-title: Past exposure to vaccines and subsequent risk of Alzheimer's disease publication-title: CMAJ – ident: 2024102817410846000_11.10.e045871.1 doi: 10.1016/S0140-6736(20)30367-6 – volume: 13 start-page: 21 year: 2021 ident: 2024102817410846000_11.10.e045871.10 article-title: Adaptation of the Charlson comorbidity index for register-based research in Sweden publication-title: Clinical epidemiology doi: 10.2147/CLEP.S282475 – volume: 15 start-page: 1546 year: 2019 ident: 2024102817410846000_11.10.e045871.12 article-title: Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people publication-title: Alzheimer's & Dementia doi: 10.1016/j.jalz.2019.07.014 – volume: 26 start-page: 422 year: 2020 ident: 2024102817410846000_11.10.e045871.6 article-title: Acute zoster plasma contains elevated amyloid, correlating with Aβ42 and amylin levels, and is amyloidogenic publication-title: J Neurovirol doi: 10.1007/s13365-020-00830-7 – volume: 12 year: 2017 ident: 2024102817410846000_11.10.e045871.19 article-title: Increased risk of dementia following herpes zoster ophthalmicus publication-title: PLoS One doi: 10.1371/journal.pone.0188490 – ident: 2024102817410846000_11.10.e045871.14 doi: 10.1016/S1473-3099(03)00857-0 – volume: 79 year: 2018 ident: 2024102817410846000_11.10.e045871.20 article-title: Herpes zoster and dementia: a nationwide population-based cohort study publication-title: J Clin Psychiatry doi: 10.4088/JCP.16m11312 – volume: 9 year: 2014 ident: 2024102817410846000_11.10.e045871.5 article-title: Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer’s disease publication-title: PLoS One doi: 10.1371/journal.pone.0096779 – volume: 9 start-page: 14 year: 2017 ident: 2024102817410846000_11.10.e045871.24 article-title: Role of neuroinflammation in neurodegeneration: new insights publication-title: Alzheimers Res Ther doi: 10.1186/s13195-017-0241-2 – volume: 54 start-page: 86 year: 2013 ident: 2024102817410846000_11.10.e045871.18 article-title: Diagnostic ophthalmology publication-title: Can Vet J – ident: 2024102817410846000_11.10.e045871.8 doi: 10.1007/s10654-019-00499-1 – volume: 29 start-page: 23 year: 2018 ident: 2024102817410846000_11.10.e045871.7 article-title: Is the UK shingles vaccination programme fit for the future? 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| Snippet | ObjectivesTo investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.DesignNested case–control... To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia. Nested case-control study. Data were drawn from... To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.OBJECTIVESTo investigate the association between... Objectives To investigate the association between shingles and dementia, and between Zostavax vaccination and dementia.Design Nested case–control... |
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| SubjectTerms | Age Alzheimer's disease Biobanks Biological Specimen Banks Brain research Case-Control Studies Chicken pox Codes Cohort Studies Cytomegalovirus Datasets Dementia Dementia - epidemiology Epidemiology Herpes viruses Herpes Zoster Herpes Zoster Vaccine Humans Immunization Investigations Primary care public health United Kingdom - epidemiology Vaccination Vaccines |
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| Title | Shingles, Zostavax vaccination and risk of developing dementia: a nested case–control study—results from the UK Biobank cohort |
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