Serum homocysteine and risk of dementia in Japan
ObjectiveTo examine the association between serum total homocysteine levels (tHcy) and dementia risk.MethodsA total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimat...
Saved in:
| Published in | Journal of neurology, neurosurgery and psychiatry Vol. 91; no. 5; pp. 540 - 546 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BMJ Publishing Group Ltd
01.05.2020
BMJ Publishing Group LTD BMJ Publishing Group |
| Series | Original research |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3050 1468-330X 1468-330X |
| DOI | 10.1136/jnnp-2019-322366 |
Cover
| Abstract | ObjectiveTo examine the association between serum total homocysteine levels (tHcy) and dementia risk.MethodsA total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia.ResultsDuring the follow-up, 372 subjects developed all-cause dementia; 247 had Alzheimer’s disease (AD) and 98 had vascular dementia (VaD). Compared with the lowest tHcy quintile (≤6.4 µmol/L), the multivariable-adjusted HRs (95% CI) of the highest quintile (≥11.5 µmol/L) were 2.28 (1.51–3.43) for all-cause dementia, 1.96 (1.19–3.24) for AD and 2.51 (1.14–5.51) for VaD. In restricted cubic splines, the risk of all-cause dementia steadily increased between approximately 8–15 µmol/L and plateaued thereafter, with a similar non-linear shape observed for AD and VaD (all p for non-linearity ≤0.02). In stratified analyses by the most recognised genetic polymorphism affecting tHcy concentrations (methylenetetrahydrofolate reductase C677T), the positive association of tHcy with all-cause dementia persisted in both non-carriers and carriers of the risk allele, and even tended to be stronger in the former (p for heterogeneity=0.07).ConclusionHigh serum tHcy levels are associated with an elevated risk of dementia, AD and VaD in a non-linear manner, such that an exposure-response association is present only within a relatively high range of tHcy levels. Non-genetic factors affecting serum tHcy concentrations may play important roles in tHcy-dementia associations irrespective of the genetic susceptibility for raised tHcy. |
|---|---|
| AbstractList | ObjectiveTo examine the association between serum total homocysteine levels (tHcy) and dementia risk.MethodsA total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia.ResultsDuring the follow-up, 372 subjects developed all-cause dementia; 247 had Alzheimer’s disease (AD) and 98 had vascular dementia (VaD). Compared with the lowest tHcy quintile (≤6.4 µmol/L), the multivariable-adjusted HRs (95% CI) of the highest quintile (≥11.5 µmol/L) were 2.28 (1.51–3.43) for all-cause dementia, 1.96 (1.19–3.24) for AD and 2.51 (1.14–5.51) for VaD. In restricted cubic splines, the risk of all-cause dementia steadily increased between approximately 8–15 µmol/L and plateaued thereafter, with a similar non-linear shape observed for AD and VaD (all p for non-linearity ≤0.02). In stratified analyses by the most recognised genetic polymorphism affecting tHcy concentrations (methylenetetrahydrofolate reductase C677T), the positive association of tHcy with all-cause dementia persisted in both non-carriers and carriers of the risk allele, and even tended to be stronger in the former (p for heterogeneity=0.07).ConclusionHigh serum tHcy levels are associated with an elevated risk of dementia, AD and VaD in a non-linear manner, such that an exposure-response association is present only within a relatively high range of tHcy levels. Non-genetic factors affecting serum tHcy concentrations may play important roles in tHcy-dementia associations irrespective of the genetic susceptibility for raised tHcy. To examine the association between serum total homocysteine levels (tHcy) and dementia risk. A total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia. During the follow-up, 372 subjects developed all-cause dementia; 247 had Alzheimer's disease (AD) and 98 had vascular dementia (VaD). Compared with the lowest tHcy quintile (≤6.4 µmol/L), the multivariable-adjusted HRs (95% CI) of the highest quintile (≥11.5 µmol/L) were 2.28 (1.51-3.43) for all-cause dementia, 1.96 (1.19-3.24) for AD and 2.51 (1.14-5.51) for VaD. In restricted cubic splines, the risk of all-cause dementia steadily increased between approximately 8-15 µmol/L and plateaued thereafter, with a similar non-linear shape observed for AD and VaD (all p for non-linearity ≤0.02). In stratified analyses by the most recognised genetic polymorphism affecting tHcy concentrations (methylenetetrahydrofolate reductase C677T), the positive association of tHcy with all-cause dementia persisted in both non-carriers and carriers of the risk allele, and even tended to be stronger in the former (p for heterogeneity=0.07). High serum tHcy levels are associated with an elevated risk of dementia, AD and VaD in a non-linear manner, such that an exposure-response association is present only within a relatively high range of tHcy levels. Non-genetic factors affecting serum tHcy concentrations may play important roles in tHcy-dementia associations irrespective of the genetic susceptibility for raised tHcy. To examine the association between serum total homocysteine levels (tHcy) and dementia risk.OBJECTIVETo examine the association between serum total homocysteine levels (tHcy) and dementia risk.A total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia.METHODSA total of 1588 Japanese adults aged ≥60 years without dementia were prospectively followed from 2002 to 2012. Cox proportional hazards models and restricted cubic splines were used to estimate the HRs of tHcy levels on the risk of dementia.During the follow-up, 372 subjects developed all-cause dementia; 247 had Alzheimer's disease (AD) and 98 had vascular dementia (VaD). Compared with the lowest tHcy quintile (≤6.4 µmol/L), the multivariable-adjusted HRs (95% CI) of the highest quintile (≥11.5 µmol/L) were 2.28 (1.51-3.43) for all-cause dementia, 1.96 (1.19-3.24) for AD and 2.51 (1.14-5.51) for VaD. In restricted cubic splines, the risk of all-cause dementia steadily increased between approximately 8-15 µmol/L and plateaued thereafter, with a similar non-linear shape observed for AD and VaD (all p for non-linearity ≤0.02). In stratified analyses by the most recognised genetic polymorphism affecting tHcy concentrations (methylenetetrahydrofolate reductase C677T), the positive association of tHcy with all-cause dementia persisted in both non-carriers and carriers of the risk allele, and even tended to be stronger in the former (p for heterogeneity=0.07).RESULTSDuring the follow-up, 372 subjects developed all-cause dementia; 247 had Alzheimer's disease (AD) and 98 had vascular dementia (VaD). Compared with the lowest tHcy quintile (≤6.4 µmol/L), the multivariable-adjusted HRs (95% CI) of the highest quintile (≥11.5 µmol/L) were 2.28 (1.51-3.43) for all-cause dementia, 1.96 (1.19-3.24) for AD and 2.51 (1.14-5.51) for VaD. In restricted cubic splines, the risk of all-cause dementia steadily increased between approximately 8-15 µmol/L and plateaued thereafter, with a similar non-linear shape observed for AD and VaD (all p for non-linearity ≤0.02). In stratified analyses by the most recognised genetic polymorphism affecting tHcy concentrations (methylenetetrahydrofolate reductase C677T), the positive association of tHcy with all-cause dementia persisted in both non-carriers and carriers of the risk allele, and even tended to be stronger in the former (p for heterogeneity=0.07).High serum tHcy levels are associated with an elevated risk of dementia, AD and VaD in a non-linear manner, such that an exposure-response association is present only within a relatively high range of tHcy levels. Non-genetic factors affecting serum tHcy concentrations may play important roles in tHcy-dementia associations irrespective of the genetic susceptibility for raised tHcy.CONCLUSIONHigh serum tHcy levels are associated with an elevated risk of dementia, AD and VaD in a non-linear manner, such that an exposure-response association is present only within a relatively high range of tHcy levels. Non-genetic factors affecting serum tHcy concentrations may play important roles in tHcy-dementia associations irrespective of the genetic susceptibility for raised tHcy. |
| Author | Oishi, Emi Kitazono, Takanari Chen, Sanmei Ohara, Tomoyuki Yoshida, Daigo Honda, Takanori Furuta, Yoshihiko Sakata, Satoko Hirakawa, Yoichiro Hata, Jun Shibata, Mao Ninomiya, Toshiharu |
| AuthorAffiliation | 4 Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan 1 Department of Epidemiology and Public Health, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan 3 Center for Cohort Studies, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan 2 Department of Neuropsychiatry, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan |
| AuthorAffiliation_xml | – name: 1 Department of Epidemiology and Public Health, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan – name: 2 Department of Neuropsychiatry, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan – name: 3 Center for Cohort Studies, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan – name: 4 Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan |
| Author_xml | – sequence: 1 givenname: Sanmei orcidid: 0000-0003-0811-1701 surname: Chen fullname: Chen, Sanmei organization: Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 2 givenname: Takanori orcidid: 0000-0002-1011-9879 surname: Honda fullname: Honda, Takanori organization: Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 3 givenname: Tomoyuki surname: Ohara fullname: Ohara, Tomoyuki organization: Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 4 givenname: Jun surname: Hata fullname: Hata, Jun organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 5 givenname: Yoichiro surname: Hirakawa fullname: Hirakawa, Yoichiro organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 6 givenname: Daigo surname: Yoshida fullname: Yoshida, Daigo organization: Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 7 givenname: Mao surname: Shibata fullname: Shibata, Mao organization: Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 8 givenname: Satoko surname: Sakata fullname: Sakata, Satoko organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 9 givenname: Emi surname: Oishi fullname: Oishi, Emi organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 10 givenname: Yoshihiko surname: Furuta fullname: Furuta, Yoshihiko organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 11 givenname: Takanari surname: Kitazono fullname: Kitazono, Takanari organization: Department of Medicine and Clinical Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan – sequence: 12 givenname: Toshiharu surname: Ninomiya fullname: Ninomiya, Toshiharu email: nino@eph.med.kyushu organization: Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32234968$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc1LHTEUxUNR6tO676oMdCPYsfnOZFMoD62K0EUV3IX7ZjKa15nkmcwI_vdmeH5VUJpNFvmdk3Pv2UYbPniL0GeCDwhh8vvS-1VJMdElo5RJ-QHNCJdVyRi-3EAzjCktGRZ4C22ntMTTqfRHtDXRXMtqhvAfG8e-uA59qO_SYJ23BfimiC79LUJbNLa3fnBQOF-cwgr8J7TZQpfs7sO9gy6ODs_nx-XZ718n859n5UJINpRMca71AgSRoMA20BDLuWiBtNDyVuSwmjdKE6baCpjEoiKqVkxbBULSmu2gH2vf1bjobVPnFBE6s4quh3hnAjjz74t31-Yq3BpFGck_ZYO9B4MYbkabBtO7VNuuA2_DmAxllVCMYqky-vUVugxj9Hm8TGmMpRC8ytSXl4meojwuMwNyDdQxpBRta2o3wODCFNB1hmAztWam1szUmlm3loX4lfDR-x3J_lqy6Jf_Q397pp9mexO_B3LStFs |
| CitedBy_id | crossref_primary_10_1016_j_clnu_2021_05_034 crossref_primary_10_3389_fnagi_2021_665114 crossref_primary_10_14283_jpad_2021_15 crossref_primary_10_14283_jpad_2021_7 crossref_primary_10_26693_jmbs08_01_014 crossref_primary_10_1038_s41598_022_16242_y crossref_primary_10_1016_j_brainresbull_2024_110913 crossref_primary_10_1093_jn_nxaa382 crossref_primary_10_3389_fnagi_2022_863673 crossref_primary_10_3389_fneur_2024_1345832 crossref_primary_10_3389_fnmol_2022_947513 crossref_primary_10_3389_fnagi_2022_868777 crossref_primary_10_3389_fnagi_2024_1475571 crossref_primary_10_1007_s00394_024_03449_0 crossref_primary_10_1093_mr_roac106 crossref_primary_10_3390_nu14173535 crossref_primary_10_3390_nu16162759 crossref_primary_10_1177_0891988720988914 crossref_primary_10_1080_20473869_2024_2410534 |
| Cites_doi | 10.1212/WNL.34.7.939 10.1038/ng0595-111 10.1038/ng1934 10.1002/ana.24145 10.1016/j.neurobiolaging.2008.02.020 10.1001/jamapsychiatry.2019.1694 10.3233/JAD-141101 10.1212/01.WNL.0000129504.60409.88 10.1159/000437098 10.1212/WNL.0000000000003932 10.1111/j.1468-1331.2009.02590.x 10.1016/j.jalz.2010.08.234 10.3233/JAD-150458 10.1002/sim.4780080504 10.1136/jnnp-2018-318212 10.1159/000047739 10.3233/JAD-171042 10.1146/annurev-nutr-071715-050947 10.1053/j.ajkd.2010.02.344 10.1373/clinchem.2006.082149 10.1161/01.CIR.99.9.1230 10.1136/bmj.316.7135.894 10.1016/j.neurobiolaging.2009.02.024 10.1001/jama.288.16.2015 10.1210/jc.2018-01782 10.1136/jnnp.2011.242446 10.1212/WNL.43.2.250 10.1016/S1474-4422(03)00438-1 10.1161/CIRCULATIONAHA.113.002424 10.1073/pnas.94.11.5923 10.1016/j.nutres.2015.10.003 10.1001/archneur.55.11.1449 10.1002/sim.2848 10.1056/NEJMoa011613 10.1093/ajcn/82.3.636 10.1111/j.1750-3639.2008.00169.x 10.1093/brain/awt206 10.1212/WNL.0b013e3181f88162 10.1016/j.brainres.2004.05.106 10.1212/WNL.0000000000000168 |
| ContentType | Journal Article |
| Copyright | Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2020 |
| Copyright_xml | – notice: Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2020 |
| DBID | 9YT ACMMV AAYXX CITATION NPM 3V. 7RV 7X7 7XB 88E 88G 88I 8AF 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR BTHHO CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 M0S M1P M2M M2P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM |
| DOI | 10.1136/jnnp-2019-322366 |
| DatabaseName | BMJ Open Access Journals BMJ Journals:Open Access CrossRef PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central BMJ Journals ProQuest One ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection Medical Database Psychology Database Science Database Nursing & Allied Health Premium ProQuest One Academic ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition BMJ Journals ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest One Psychology PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: ACMMV name: BMJ Journals:Open Access url: https://journals.bmj.com/ sourceTypes: Publisher – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1468-330X |
| EndPage | 546 |
| ExternalDocumentID | PMC7231445 32234968 10_1136_jnnp_2019_322366 jnnp |
| Genre | Journal Article |
| GeographicLocations | Japan |
| GeographicLocations_xml | – name: Japan |
| GrantInformation_xml | – fundername: Grants-in-Aid for Scientific Research (A), Ministry of Education, Culture, Sports, Science and Technology of Japan grantid: JP16H02692 – fundername: Grants-in-Aid for Scientific Research (B), Ministry of Education, Culture, Sports, Science and Technology of Japan grantid: JP16H05850; JP17H04126; JP18H02737 – fundername: Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan grantid: H29-Junkankitou-Ippan-003; H30-Shokuhin-[Sitei]-005 – fundername: Grants-in-Aid for Scientific Research (C), Ministry of Education, Culture, Sports, Science and Technology of Japan grantid: JP17K01853; JP17K09113; JP17K09114; JP18K07565; JP18K09412; JP19K07890 – fundername: Grants-in-Aid for Early-Career Scientists, Ministry of Education, Culture, Sports, Science and Technology of Japan grantid: JP18K17382; JP18K17925; JP19K19474 – fundername: Japan Agency for Medical Research and Development grantid: JP19dk0207025; JP19ek0210080; JP19ek0210082; JP19ek0210083; JP19fk0108075; JP19km0405202 funderid: http://dx.doi.org/10.13039/100009619 – fundername: ; grantid: H29-Junkankitou-Ippan-003; H30-Shokuhin-[Sitei]-005 – fundername: ; grantid: JP19dk0207025; JP19ek0210080; JP19ek0210082; JP19ek0210083; JP19fk0108075; JP19km0405202 – fundername: ; grantid: JP16H02692 – fundername: ; grantid: JP18K17382; JP18K17925; JP19K19474 – fundername: ; grantid: JP16H05850; JP17H04126; JP18H02737 – fundername: ; grantid: JP17K01853; JP17K09113; JP17K09114; JP18K07565; JP18K09412; JP19K07890 |
| GroupedDBID | --- .55 .GJ .VT 0R~ 18M 29L 2WC 354 39C 3O- 4.4 40O 41~ 53G 5GY 5RE 5VS 7RV 7X7 7~S 88E 88I 8AF 8FI 8FJ 8R4 8R5 9YT AAHLL AAKAS AAOJX AAUVZ AAWJN AAWTL ABAAH ABIVO ABJNI ABKDF ABMQD ABOCM ABUWG ABVAJ ACGFO ACGFS ACGOD ACGTL ACHTP ACMFJ ACMMV ACOAB ACOFX ACQSR ACTZY ADBBV ADCEG ADFRT ADUGQ ADZCM AEKJL AENEX AFKRA AFWFF AGQPQ AHMBA AHNKE AHQMW AI. AJYBZ AKKEP ALIPV ALMA_UNASSIGNED_HOLDINGS AZFZN AZQEC BAWUL BENPR BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI C45 CAG CCPQU COF CS3 CXRWF DIK DU5 DWQXO E3Z EBS EJD EX3 F5P FEDTE FYUFA GNUQQ GX1 H13 HAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IEA IHR INH INR IOF IPO IPY ITC J5H KQ8 L7B M1P M2M M2P N9A NAPCQ NTWIH NXWIF O9- OK1 OMB OMG OVD P2P PCD PHGZT PQQKQ PROAC PSQYO PSYQQ Q2X R53 RHI RMJ RPM RV8 SJN TEORI TR2 UKHRP UPT UYXKK V24 VH1 VM9 VVN W8F WH7 WOW X7M YFH YQT YQY ZGI AAYXX ACQHZ ADGHP AERUA CITATION PHGZM 3V. NPM PKN RHF YCJ 7XB 8FK K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-b563t-374499ba516a7aedad1e445fa1faf4f536694d79137f8a3605817c739e7a562c3 |
| IEDL.DBID | 9YT |
| ISSN | 0022-3050 1468-330X |
| IngestDate | Thu Aug 21 14:10:29 EDT 2025 Fri Sep 05 03:29:11 EDT 2025 Fri Jul 25 22:30:30 EDT 2025 Wed Feb 19 02:31:04 EST 2025 Thu Apr 24 23:00:20 EDT 2025 Tue Jul 01 01:21:51 EDT 2025 Thu Apr 24 22:50:40 EDT 2025 Thu Apr 24 22:50:15 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| License | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b563t-374499ba516a7aedad1e445fa1faf4f536694d79137f8a3605817c739e7a562c3 |
| Notes | Original research ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-1011-9879 0000-0003-0811-1701 |
| OpenAccessLink | http://dx.doi.org/10.1136/jnnp-2019-322366 |
| PMID | 32234968 |
| PQID | 2390065548 |
| PQPubID | 2041879 |
| PageCount | 7 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7231445 proquest_miscellaneous_2385732067 proquest_journals_2390065548 pubmed_primary_32234968 crossref_citationtrail_10_1136_jnnp_2019_322366 crossref_primary_10_1136_jnnp_2019_322366 bmj_primary_10_1136_jnnp_2019_322366 bmj_journals_10_1136_jnnp_2019_322366 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-05-01 |
| PublicationDateYYYYMMDD | 2020-05-01 |
| PublicationDate_xml | – month: 05 year: 2020 text: 2020-05-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London – name: BMA House, Tavistock Square, London, WC1H 9JR |
| PublicationSeriesTitle | Original research |
| PublicationTitle | Journal of neurology, neurosurgery and psychiatry |
| PublicationTitleAbbrev | J Neurol Neurosurg Psychiatry |
| PublicationTitleAlternate | J Neurol Neurosurg Psychiatry |
| PublicationYear | 2020 |
| Publisher | BMJ Publishing Group Ltd BMJ Publishing Group LTD BMJ Publishing Group |
| Publisher_xml | – name: BMJ Publishing Group Ltd – name: BMJ Publishing Group LTD – name: BMJ Publishing Group |
| References | Hooshmand, Refsum, Smith (R13) 2019 Hou, Feng, Zhang (R40) 2019; 90 Clarke, Smith, Jobst (R1) 1998; 55 Smith, Refsum, Bottiglieri (R6) 2018; 62 Shimizu, Kiyohara, Kato (R34) 2002; 13 Hata, Ninomiya, Hirakawa (R18) 2013; 128 Fujimi, Sasaki, Noda (R23) 2008; 18 Ravaglia, Forti, Maioli (R8) 2005; 82 (R33) 2002; 288 Seshadri, Beiser, Selhub (R7) 2002; 346 Inaishi, Hirakawa, Horikoshi (R25) 2019; 104 Govindarajulu, Spiegelman, Thurston (R27) 2007; 26 Wen, Yang, Liu (R37) 2004; 1022 Kloppenborg, Geerlings, Visseren (R29) 2014; 82 Wald, Kasturiratne, Simmonds (R28) 2011; 7 Ford, Flicker, Alfonso (R9) 2012; 83 Miwa, Tanaka, Okazaki (R12) 2016; 49 Morris (R4) 2003; 2 Román, Tatemichi, Erkinjuntti (R22) 1993; 43 Zylberstein, Lissner, Björkelund (R14) 2011; 32 McKhann, Drachman, Folstein (R21) 1984; 34 Kivipelto, Annerbo, Hultdin (R11) 2009; 16 Horio, Imai, Yasuda (R24) 2010; 56 Li, Praticò (R36) 2014; 43 Smith, Refsum (R32) 2016; 36 Luchsinger, Tang, Shea (R15) 2004; 62 Frosst, Blom, Milos (R31) 1995; 10 Hooshmand, Polvikoski, Kivipelto (R39) 2013; 136 Ikeda, Ikeda, Minota (R3) 1999; 99 Rastas, Pirttilä, Mattila (R16) 2010; 31 Bathum, Petersen, Christiansen (R17) 2007; 53 Lai, Kan (R35) 2015; 67 Bertram, McQueen, Mullin (R30) 2007; 39 Hooshmand, Solomon, Kåreholt (R10) 2010; 75 Lipton, Kim, Choi (R2) 1997; 94 Li, Chu, Barrero (R38) 2014; 75 Ohara, Hata, Yoshida (R19) 2017; 88 (R5) 1998; 316 Durrleman, Simon (R26) 1989; 8 Spence (R41) 2016; 36 Smith, Refsum 2016; 36 Luchsinger, Tang, Shea 2004; 62 Smith, Refsum, Bottiglieri 2018; 62 Hooshmand, Refsum, Smith 2019 Fujimi, Sasaki, Noda 2008; 18 Ikeda, Ikeda, Minota 1999; 99 Wen, Yang, Liu 2004; 1022 Hata, Ninomiya, Hirakawa 2013; 128 Román, Tatemichi, Erkinjuntti 1993; 43 1998; 316 Kivipelto, Annerbo, Hultdin 2009; 16 Horio, Imai, Yasuda 2010; 56 Rastas, Pirttilä, Mattila 2010; 31 Shimizu, Kiyohara, Kato 2002; 13 Hooshmand, Polvikoski, Kivipelto 2013; 136 Ohara, Hata, Yoshida 2017; 88 Kloppenborg, Geerlings, Visseren 2014; 82 Inaishi, Hirakawa, Horikoshi 2019; 104 Morris 2003; 2 Li, Praticò 2014; 43 Bathum, Petersen, Christiansen 2007; 53 Spence 2016; 36 Zylberstein, Lissner, Björkelund 2011; 32 Li, Chu, Barrero 2014; 75 Durrleman, Simon 1989; 8 Hou, Feng, Zhang 2019; 90 Seshadri, Beiser, Selhub 2002; 346 Lipton, Kim, Choi 1997; 94 Govindarajulu, Spiegelman, Thurston 2007; 26 2002; 288 Clarke, Smith, Jobst 1998; 55 McKhann, Drachman, Folstein 1984; 34 Lai, Kan 2015; 67 Miwa, Tanaka, Okazaki 2016; 49 Bertram, McQueen, Mullin 2007; 39 Frosst, Blom, Milos 1995; 10 Ravaglia, Forti, Maioli 2005; 82 Wald, Kasturiratne, Simmonds 2011; 7 Hooshmand, Solomon, Kåreholt 2010; 75 Ford, Flicker, Alfonso 2012; 83 2024111108100630000_91.5.540.6 2024111108100630000_91.5.540.5 2024111108100630000_91.5.540.4 2024111108100630000_91.5.540.3 2024111108100630000_91.5.540.9 2024111108100630000_91.5.540.7 Miwa (2024111108100630000_91.5.540.12) 2016; 49 2024111108100630000_91.5.540.34 2024111108100630000_91.5.540.35 2024111108100630000_91.5.540.14 Ravaglia (2024111108100630000_91.5.540.8) 2005; 82 2024111108100630000_91.5.540.15 2024111108100630000_91.5.540.37 2024111108100630000_91.5.540.30 2024111108100630000_91.5.540.31 2024111108100630000_91.5.540.10 2024111108100630000_91.5.540.11 2024111108100630000_91.5.540.33 Smith (2024111108100630000_91.5.540.32) 2016; 36 2024111108100630000_91.5.540.17 2024111108100630000_91.5.540.39 2024111108100630000_91.5.540.18 Hooshmand (2024111108100630000_91.5.540.13) 2019 Ohara (2024111108100630000_91.5.540.19) 2017; 88 Rastas (2024111108100630000_91.5.540.16) 2010; 31 2024111108100630000_91.5.540.40 Inaishi (2024111108100630000_91.5.540.25) 2019; 104 Li (2024111108100630000_91.5.540.38) 2014; 75 2024111108100630000_91.5.540.23 2024111108100630000_91.5.540.24 2024111108100630000_91.5.540.26 Li (2024111108100630000_91.5.540.36) 2014; 43 2024111108100630000_91.5.540.41 2024111108100630000_91.5.540.20 2024111108100630000_91.5.540.21 2024111108100630000_91.5.540.22 2024111108100630000_91.5.540.2 2024111108100630000_91.5.540.27 2024111108100630000_91.5.540.1 2024111108100630000_91.5.540.28 2024111108100630000_91.5.540.29 |
| References_xml | – volume: 34 start-page: 939 year: 1984 ident: R21 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services Task force on Alzheimer's disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 10 start-page: 111 year: 1995 ident: R31 article-title: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase publication-title: Nat Genet doi: 10.1038/ng0595-111 – volume: 39 start-page: 17 year: 2007 ident: R30 article-title: Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database publication-title: Nat Genet doi: 10.1038/ng1934 – volume: 75 start-page: 851 year: 2014 ident: R38 article-title: Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles publication-title: Ann Neurol doi: 10.1002/ana.24145 – volume: 31 start-page: 1 year: 2010 ident: R16 article-title: Vascular risk factors and dementia in the general population aged >85 years publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.02.020 – year: 2019 ident: R13 article-title: Association of methionine to homocysteine status with brain magnetic resonance imaging measures and risk of dementia publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2019.1694 – volume: 43 start-page: 29 year: 2014 ident: R36 article-title: High levels of homocysteine results in cerebral amyloid angiopathy in mice publication-title: J Alzheimer’s Dis doi: 10.3233/JAD-141101 – volume: 62 start-page: 1972 year: 2004 ident: R15 article-title: Plasma homocysteine levels and risk of Alzheimer disease publication-title: Neurology doi: 10.1212/01.WNL.0000129504.60409.88 – volume: 67 start-page: 1 year: 2015 ident: R35 article-title: Homocysteine-induced endothelial dysfunction publication-title: Ann Nutr Metab doi: 10.1159/000437098 – volume: 88 start-page: 1925 year: 2017 ident: R19 article-title: Trends in dementia prevalence, incidence, and survival rate in a Japanese community publication-title: Neurology doi: 10.1212/WNL.0000000000003932 – volume: 16 start-page: 808 year: 2009 ident: R11 article-title: Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2009.02590.x – volume: 7 start-page: 412 year: 2011 ident: R28 article-title: Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2010.08.234 – volume: 49 start-page: 503 year: 2016 ident: R12 article-title: Increased total homocysteine levels predict the risk of incident dementia independent of cerebral small-vessel diseases and vascular risk factors publication-title: J Alzheimers Dis doi: 10.3233/JAD-150458 – volume: 8 start-page: 551 year: 1989 ident: R26 article-title: Flexible regression models with cubic splines publication-title: Stat Med doi: 10.1002/sim.4780080504 – volume: 90 start-page: 373 year: 2019 ident: R40 article-title: Models for predicting risk of dementia: a systematic review publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2018-318212 – volume: 13 start-page: 9 year: 2002 ident: R34 article-title: Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study publication-title: Cerebrovasc Dis doi: 10.1159/000047739 – volume: 62 start-page: 561 year: 2018 ident: R6 article-title: Homocysteine and dementia: an international consensus statement publication-title: J Alzheimers Dis doi: 10.3233/JAD-171042 – volume: 36 start-page: 211 year: 2016 ident: R32 article-title: Homocysteine, B vitamins, and cognitive impairment publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071715-050947 – volume: 56 start-page: 32 year: 2010 ident: R24 article-title: Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2010.02.344 – volume: 53 start-page: 971 year: 2007 ident: R17 article-title: Genetic and environmental influences on plasma homocysteine: results from a Danish twin study publication-title: Clin Chem doi: 10.1373/clinchem.2006.082149 – volume: 99 start-page: 1230 year: 1999 ident: R3 article-title: Homocysteine increases nitric oxide synthesis in cytokine-stimulated vascular smooth muscle cells publication-title: Circulation doi: 10.1161/01.CIR.99.9.1230 – volume: 316 start-page: 894 year: 1998 ident: R5 article-title: Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials publication-title: BMJ doi: 10.1136/bmj.316.7135.894 – volume: 32 start-page: 380 year: 2011 ident: R14 article-title: Midlife homocysteine and late-life dementia in women. A prospective population study publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2009.02.024 – volume: 288 start-page: 2015 year: 2002 ident: R33 article-title: Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis publication-title: JAMA doi: 10.1001/jama.288.16.2015 – volume: 104 start-page: 3213 year: 2019 ident: R25 article-title: Association between genetic risk and development of type 2 diabetes in a general Japanese population: the Hisayama study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2018-01782 – volume: 83 start-page: 70 year: 2012 ident: R9 article-title: Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2011.242446 – volume: 43 start-page: 250 year: 1993 ident: R22 article-title: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International workshop publication-title: Neurology doi: 10.1212/WNL.43.2.250 – volume: 2 start-page: 425 year: 2003 ident: R4 article-title: Homocysteine and Alzheimer's disease publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00438-1 – volume: 128 start-page: 1198 year: 2013 ident: R18 article-title: Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama study (1961-2009) publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.002424 – volume: 94 start-page: 5923 year: 1997 ident: R2 article-title: Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.11.5923 – volume: 36 start-page: 109 year: 2016 ident: R41 article-title: Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke publication-title: Nutr Res doi: 10.1016/j.nutres.2015.10.003 – volume: 55 start-page: 1449 year: 1998 ident: R1 article-title: Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease publication-title: Arch Neurol doi: 10.1001/archneur.55.11.1449 – volume: 26 start-page: 3735 year: 2007 ident: R27 article-title: Comparing smoothing techniques in COX models for exposure-response relationships publication-title: Stat Med doi: 10.1002/sim.2848 – volume: 346 start-page: 476 year: 2002 ident: R7 article-title: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease publication-title: N Engl J Med doi: 10.1056/NEJMoa011613 – volume: 82 start-page: 636 year: 2005 ident: R8 article-title: Homocysteine and folate as risk factors for dementia and Alzheimer disease publication-title: Am J Clin Nutr doi: 10.1093/ajcn/82.3.636 – volume: 18 start-page: 317 year: 2008 ident: R23 article-title: Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study publication-title: Brain Pathol doi: 10.1111/j.1750-3639.2008.00169.x – volume: 136 start-page: 2707 year: 2013 ident: R39 article-title: Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study publication-title: Brain doi: 10.1093/brain/awt206 – volume: 75 start-page: 1408 year: 2010 ident: R10 article-title: Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study publication-title: Neurology doi: 10.1212/WNL.0b013e3181f88162 – volume: 1022 start-page: 30 year: 2004 ident: R37 article-title: Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein publication-title: Brain Res doi: 10.1016/j.brainres.2004.05.106 – volume: 82 start-page: 777 year: 2014 ident: R29 article-title: Homocysteine and progression of generalized small-vessel disease: the SMART-MR study publication-title: Neurology doi: 10.1212/WNL.0000000000000168 – volume: 31 start-page: 1 year: 2010 article-title: Vascular risk factors and dementia in the general population aged >85 years publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.02.020 – volume: 288 start-page: 2015 year: 2002 article-title: Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis publication-title: JAMA doi: 10.1001/jama.288.16.2015 – volume: 83 start-page: 70 year: 2012 article-title: Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2011.242446 – volume: 316 start-page: 894 year: 1998 article-title: Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials publication-title: BMJ doi: 10.1136/bmj.316.7135.894 – volume: 39 start-page: 17 year: 2007 article-title: Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database publication-title: Nat Genet doi: 10.1038/ng1934 – volume: 2 start-page: 425 year: 2003 article-title: Homocysteine and Alzheimer's disease publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00438-1 – volume: 36 start-page: 109 year: 2016 article-title: Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke publication-title: Nutr Res doi: 10.1016/j.nutres.2015.10.003 – year: 2019 article-title: Association of methionine to homocysteine status with brain magnetic resonance imaging measures and risk of dementia publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2019.1694 – volume: 18 start-page: 317 year: 2008 article-title: Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study publication-title: Brain Pathol doi: 10.1111/j.1750-3639.2008.00169.x – volume: 94 start-page: 5923 year: 1997 article-title: Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.94.11.5923 – volume: 62 start-page: 561 year: 2018 article-title: Homocysteine and dementia: an international consensus statement publication-title: J Alzheimers Dis doi: 10.3233/JAD-171042 – volume: 32 start-page: 380 year: 2011 article-title: Midlife homocysteine and late-life dementia in women. A prospective population study publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2009.02.024 – volume: 128 start-page: 1198 year: 2013 article-title: Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama study (1961-2009) publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.113.002424 – volume: 56 start-page: 32 year: 2010 article-title: Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2010.02.344 – volume: 99 start-page: 1230 year: 1999 article-title: Homocysteine increases nitric oxide synthesis in cytokine-stimulated vascular smooth muscle cells publication-title: Circulation doi: 10.1161/01.CIR.99.9.1230 – volume: 49 start-page: 503 year: 2016 article-title: Increased total homocysteine levels predict the risk of incident dementia independent of cerebral small-vessel diseases and vascular risk factors publication-title: J Alzheimers Dis doi: 10.3233/JAD-150458 – volume: 75 start-page: 851 year: 2014 article-title: Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles publication-title: Ann Neurol doi: 10.1002/ana.24145 – volume: 67 start-page: 1 year: 2015 article-title: Homocysteine-induced endothelial dysfunction publication-title: Ann Nutr Metab doi: 10.1159/000437098 – volume: 10 start-page: 111 year: 1995 article-title: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase publication-title: Nat Genet doi: 10.1038/ng0595-111 – volume: 55 start-page: 1449 year: 1998 article-title: Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease publication-title: Arch Neurol doi: 10.1001/archneur.55.11.1449 – volume: 34 start-page: 939 year: 1984 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services Task force on Alzheimer's disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 16 start-page: 808 year: 2009 article-title: Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study publication-title: Eur J Neurol doi: 10.1111/j.1468-1331.2009.02590.x – volume: 62 start-page: 1972 year: 2004 article-title: Plasma homocysteine levels and risk of Alzheimer disease publication-title: Neurology doi: 10.1212/01.WNL.0000129504.60409.88 – volume: 26 start-page: 3735 year: 2007 article-title: Comparing smoothing techniques in COX models for exposure-response relationships publication-title: Stat Med doi: 10.1002/sim.2848 – volume: 53 start-page: 971 year: 2007 article-title: Genetic and environmental influences on plasma homocysteine: results from a Danish twin study publication-title: Clin Chem doi: 10.1373/clinchem.2006.082149 – volume: 346 start-page: 476 year: 2002 article-title: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease publication-title: N Engl J Med doi: 10.1056/NEJMoa011613 – volume: 7 start-page: 412 year: 2011 article-title: Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2010.08.234 – volume: 104 start-page: 3213 year: 2019 article-title: Association between genetic risk and development of type 2 diabetes in a general Japanese population: the Hisayama study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2018-01782 – volume: 90 start-page: 373 year: 2019 article-title: Models for predicting risk of dementia: a systematic review publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2018-318212 – volume: 8 start-page: 551 year: 1989 article-title: Flexible regression models with cubic splines publication-title: Stat Med doi: 10.1002/sim.4780080504 – volume: 13 start-page: 9 year: 2002 article-title: Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction. The Hisayama study publication-title: Cerebrovasc Dis doi: 10.1159/000047739 – volume: 36 start-page: 211 year: 2016 article-title: Homocysteine, B vitamins, and cognitive impairment publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071715-050947 – volume: 82 start-page: 636 year: 2005 article-title: Homocysteine and folate as risk factors for dementia and Alzheimer disease publication-title: Am J Clin Nutr doi: 10.1093/ajcn/82.3.636 – volume: 43 start-page: 29 year: 2014 article-title: High levels of homocysteine results in cerebral amyloid angiopathy in mice publication-title: J Alzheimer’s Dis doi: 10.3233/JAD-141101 – volume: 136 start-page: 2707 year: 2013 article-title: Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study publication-title: Brain doi: 10.1093/brain/awt206 – volume: 75 start-page: 1408 year: 2010 article-title: Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study publication-title: Neurology doi: 10.1212/WNL.0b013e3181f88162 – volume: 88 start-page: 1925 year: 2017 article-title: Trends in dementia prevalence, incidence, and survival rate in a Japanese community publication-title: Neurology doi: 10.1212/WNL.0000000000003932 – volume: 1022 start-page: 30 year: 2004 article-title: Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein publication-title: Brain Res doi: 10.1016/j.brainres.2004.05.106 – volume: 82 start-page: 777 year: 2014 article-title: Homocysteine and progression of generalized small-vessel disease: the SMART-MR study publication-title: Neurology doi: 10.1212/WNL.0000000000000168 – volume: 43 start-page: 250 year: 1993 article-title: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International workshop publication-title: Neurology doi: 10.1212/WNL.43.2.250 – year: 2019 ident: 2024111108100630000_91.5.540.13 article-title: Association of methionine to homocysteine status with brain magnetic resonance imaging measures and risk of dementia publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2019.1694 – ident: 2024111108100630000_91.5.540.39 doi: 10.1093/brain/awt206 – ident: 2024111108100630000_91.5.540.28 doi: 10.1016/j.jalz.2010.08.234 – ident: 2024111108100630000_91.5.540.4 doi: 10.1016/S1474-4422(03)00438-1 – ident: 2024111108100630000_91.5.540.11 doi: 10.1111/j.1468-1331.2009.02590.x – ident: 2024111108100630000_91.5.540.15 doi: 10.1212/01.WNL.0000129504.60409.88 – volume: 88 start-page: 1925 year: 2017 ident: 2024111108100630000_91.5.540.19 article-title: Trends in dementia prevalence, incidence, and survival rate in a Japanese community publication-title: Neurology doi: 10.1212/WNL.0000000000003932 – ident: 2024111108100630000_91.5.540.2 doi: 10.1073/pnas.94.11.5923 – ident: 2024111108100630000_91.5.540.18 doi: 10.1161/CIRCULATIONAHA.113.002424 – ident: 2024111108100630000_91.5.540.30 doi: 10.1038/ng1934 – ident: 2024111108100630000_91.5.540.24 doi: 10.1053/j.ajkd.2010.02.344 – ident: 2024111108100630000_91.5.540.40 doi: 10.1136/jnnp-2018-318212 – ident: 2024111108100630000_91.5.540.9 doi: 10.1136/jnnp.2011.242446 – ident: 2024111108100630000_91.5.540.14 doi: 10.1016/j.neurobiolaging.2009.02.024 – ident: 2024111108100630000_91.5.540.41 doi: 10.1016/j.nutres.2015.10.003 – ident: 2024111108100630000_91.5.540.7 doi: 10.1056/NEJMoa011613 – ident: 2024111108100630000_91.5.540.35 doi: 10.1159/000437098 – ident: 2024111108100630000_91.5.540.23 doi: 10.1111/j.1750-3639.2008.00169.x – ident: 2024111108100630000_91.5.540.3 doi: 10.1161/01.CIR.99.9.1230 – ident: 2024111108100630000_91.5.540.22 doi: 10.1212/WNL.43.2.250 – ident: 2024111108100630000_91.5.540.27 doi: 10.1002/sim.2848 – volume: 75 start-page: 851 year: 2014 ident: 2024111108100630000_91.5.540.38 article-title: Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles publication-title: Ann Neurol doi: 10.1002/ana.24145 – ident: 2024111108100630000_91.5.540.17 doi: 10.1373/clinchem.2006.082149 – volume: 82 start-page: 636 year: 2005 ident: 2024111108100630000_91.5.540.8 article-title: Homocysteine and folate as risk factors for dementia and Alzheimer disease publication-title: Am J Clin Nutr doi: 10.1093/ajcn/82.3.636 – volume: 31 start-page: 1 year: 2010 ident: 2024111108100630000_91.5.540.16 article-title: Vascular risk factors and dementia in the general population aged >85 years publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2008.02.020 – ident: 2024111108100630000_91.5.540.34 doi: 10.1159/000047739 – volume: 104 start-page: 3213 year: 2019 ident: 2024111108100630000_91.5.540.25 article-title: Association between genetic risk and development of type 2 diabetes in a general Japanese population: the Hisayama study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2018-01782 – ident: 2024111108100630000_91.5.540.6 doi: 10.3233/JAD-171042 – volume: 49 start-page: 503 year: 2016 ident: 2024111108100630000_91.5.540.12 article-title: Increased total homocysteine levels predict the risk of incident dementia independent of cerebral small-vessel diseases and vascular risk factors publication-title: J Alzheimers Dis doi: 10.3233/JAD-150458 – ident: 2024111108100630000_91.5.540.5 doi: 10.1136/bmj.316.7135.894 – ident: 2024111108100630000_91.5.540.10 doi: 10.1212/WNL.0b013e3181f88162 – ident: 2024111108100630000_91.5.540.1 doi: 10.1001/archneur.55.11.1449 – ident: 2024111108100630000_91.5.540.26 doi: 10.1002/sim.4780080504 – ident: 2024111108100630000_91.5.540.33 doi: 10.1001/jama.288.16.2015 – ident: 2024111108100630000_91.5.540.21 doi: 10.1212/WNL.34.7.939 – ident: 2024111108100630000_91.5.540.37 doi: 10.1016/j.brainres.2004.05.106 – volume: 36 start-page: 211 year: 2016 ident: 2024111108100630000_91.5.540.32 article-title: Homocysteine, B vitamins, and cognitive impairment publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071715-050947 – volume: 43 start-page: 29 year: 2014 ident: 2024111108100630000_91.5.540.36 article-title: High levels of homocysteine results in cerebral amyloid angiopathy in mice publication-title: J Alzheimer’s Dis doi: 10.3233/JAD-141101 – ident: 2024111108100630000_91.5.540.20 – ident: 2024111108100630000_91.5.540.31 doi: 10.1038/ng0595-111 – ident: 2024111108100630000_91.5.540.29 doi: 10.1212/WNL.0000000000000168 |
| SSID | ssj0000089 |
| Score | 2.442824 |
| Snippet | ObjectiveTo examine the association between serum total homocysteine levels (tHcy) and dementia risk.MethodsA total of 1588 Japanese adults aged ≥60 years... To examine the association between serum total homocysteine levels (tHcy) and dementia risk. A total of 1588 Japanese adults aged ≥60 years without dementia... To examine the association between serum total homocysteine levels (tHcy) and dementia risk.OBJECTIVETo examine the association between serum total... |
| SourceID | pubmedcentral proquest pubmed crossref bmj |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 540 |
| SubjectTerms | Blood pressure Dementia Diabetes Epidemiology Homocysteine Hypertension Medical imaging Neuropsychiatry Polymorphism Population Psychiatrists Studies Surveillance Trends Vitamin B Womens health |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LT8MwDI54SIgL4s14KUhw4FCtXV7NCSEEmibBCaTdqrRJxBBLB9v-P3bXFQbSuDZO2tpObMfWZ0IuwaT6OMl15LCHO9hrGaW20FHqBbqn1hYVbsHjk-y-8F5f9OsLt3FdVjk_E6uD2pYF3pG3OxCcg7kEB_tm9BFh1yjMrtYtNFbJegKuCmq16qsf7m-qG7TwWMTzNCWT7bcQRqAhiY5AoxliJK7mw7dF4_TH4_xdOPnDEj1sk63ahaS3M5nvkBUXdsnGY50k3yMx7P_pkL6Ww7JAnGZ4SE2wFKvIaemprW4EB4YOAu2BrQz75OXh_vmuG9WNEaJcSDaBQ4FDoJIbkUijjLPGJo5z4U3ijedewP9obpVOmPKpYZj5TFShmHbKgHAKdkDWQhncEaEgIg0mSXRir7jlecri1FlpWCEZY520Ra6AL1mt2OOsihmYzJB_GfIvm_GvRS6RbjSDyFhC1p4zOCtqEHLshfG-ZMZ1M-P_1U_nMvv-4m_FaZGLZhg2EWZGTHDlFGlSoRgi2bfI4UzEzctwaa4lzFYLwm8IEKB7cSQMXiugbgXOM8jlePlnnZDNDgbxVRXlKVmbfE7dGXg6k_y8UucvuVb2fA priority: 102 providerName: ProQuest |
| Title | Serum homocysteine and risk of dementia in Japan |
| URI | https://jnnp.bmj.com/content/91/5/540.full https://www.ncbi.nlm.nih.gov/pubmed/32234968 https://www.proquest.com/docview/2390065548 https://www.proquest.com/docview/2385732067 https://pubmed.ncbi.nlm.nih.gov/PMC7231445 |
| Volume | 91 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1468-330X dateEnd: 20250330 omitProxy: true ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: 7X7 dateStart: 19440701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1468-330X dateEnd: 20250330 omitProxy: true ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: BENPR dateStart: 19440701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS-QwEB_8APFF7tt63pID7-Eeim3z_aiiiLAihx57TyVtElxxU9Hd_99Jt1tdPbx7amkmaTu_pDPTGX4B2EOT6rO80qmLe7ijvRapsrVOlefRPbW2bnkLhufi9IqdjfjoiSbnRQY_p2L_JoQ7xDLXKc49KsQqrBeyULF8S_-5fObqKt0zg2c8W6Qk_zLCJmzEE6ZbftVqcrNsk145mi_rJZ8ZoJN3sNV5juRgDvV7WHHhA2wMu9z4R8hw2c8m5LqZNHWkZ8aLxARLYvE4aTyx7Y_AsSHjQM7QRIZPcHVyfHl0mnb7IaQVF3SK3wKG8UlleC6MNM4amzvGuDe5N555jq-mmZU6p9IrQ2PCM5e1pNpJg5jU9DOshSa4bSCIjEZLxIvMS2ZZpWimnBWG1oJSWqgEfqBeym4-P5RtqEBFGVVZRlWWc1UmsBfl7ubMGG-I7S8UXNYd93jcAuP2jR4_-x7_Hn13gdnTExdUR_cKA7IEvvfNuHZiQsQE18yijOKSRgL7BL7MIe5vtpghCcgl8HuByMu93BLG1y0_t0SfGXHZ-T_dfIXNIsbwbRHlLqxN72fuGzo602oAq3IkB-08H8D6wdFw-BuPh8fnF78eAerB884 |
| linkProvider | BMJ Publishing Group Ltd |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB61RQIuiGfZUsBI7YFDtEns2PEBIQRU28f21Ep7C07sqFuxztLuCvGn-I3M5NUuSMup1_gRZx6esWfyDcAemtQyjHIdOKrhjvZaBqktdJCWCbmn1hY1bsH4VI7OxdEkmWzA7-5fGEqr7PbEeqO2VUF35MMYD-doLtHB_jj_EVDVKIqudiU0GrE4dr9-4pHt-sPhF-TvfhwffD37PAraqgJBnki-QI0S6OXnJomkUcZZYyMnRFKaqDSlKBMupRZW6YirMjWcwoaRKhTXThn8soLjvJtwT_BQEFa_mqhb7naqe3TyMAm7sCiXw0vv5yiRkQ5QgzhhMm7ms8tVY_iPh_t3ouYty3fwGB61Liv71MjYE9hw_incH7dB-WcQ4n6znLGLalYVhAuND5nxllHWOqtKZusbyKlhU8-O0Db753B-JyR7AVu-8u4lMBQJjSYwicNSCSvylIeps9LwQnLO43QA-0iXrFWk66w-o3CZEf0yol_W0G8Ae9Rv3kByrOk27AicFS3oOdXe-L5mxPt-xP9n3-14drPiG0EdwLu-GZWWIjHGu2pJfdJEcULOH8B2w-L-ZTS10BJHqxXm9x0IEHy1xU8vamBwhc468mVn_bLewoPR2fgkOzk8PX4FD2O6QKgzOHdha3G1dK_Ry1rkb2rRZvDtrnXpD8_YMp0 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB61Raq4IMqrCy0YqT1wiDaJHTs5oKqirPqgFQcq7S04sa1uxToL3RXir_HrmMmrXZCWU6_xI848PGPP5BuAPTSpLoyKLLBUwx3ttQxSU2ZB6hJyT40pa9yC8wt5fClOx8l4DX53_8JQWmW3J9YbtalKuiMfxng4R3OJDvbQtWkRn49GB7PvAVWQokhrV06jEZEz--snHt9u3p8cIa_343j08cuH46CtMBAUieRz1C6BHn-hk0hqpa3RJrJCJE5HTjvhEi5lJozKIq5cqjmFECNVKp5ZpfErS47zrsMDxQWndDI1Vndc7zTrkcrDJOxCpFwOr72foXRGWYDaxAmfcb2YXi8bxn-83b-TNu9YwdFjeNS6r-ywkbctWLP-CWyetwH6pxDi3rOYsqtqWpWEEY0PmfaGUQY7qxwz9W3kRLOJZ6dop_0zuLwXkj2HDV95uw0MxSNDc5jEoVPCiCLlYWqN1LyUnPM4HcA-0iVvleomr88rXOZEv5zolzf0G8Ae9Zs18Bwrug07AudlC4BOdTi-rRjxrh_x_9l3Op7drvhWaAfwtm9GBaaojPa2WlCfNFGcUPQH8KJhcf8ymlpkEkerJeb3HQgcfLnFT65qkHCFjjvy5eXqZb2BTdSi_NPJxdkreBjTXUKdzLkDG_MfC7uLDte8eF1LNoOv961KfwBoaTbY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serum+homocysteine+and+risk+of+dementia+in+Japan&rft.jtitle=Journal+of+neurology%2C+neurosurgery+and+psychiatry&rft.au=Chen%2C+Sanmei&rft.au=Honda%2C+Takanori&rft.au=Ohara%2C+Tomoyuki&rft.au=Hata%2C+Jun&rft.date=2020-05-01&rft.pub=BMJ+Publishing+Group+LTD&rft.issn=0022-3050&rft.eissn=1468-330X&rft.volume=91&rft.issue=5&rft.spage=540&rft.epage=546&rft_id=info:doi/10.1136%2Fjnnp-2019-322366&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3050&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3050&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3050&client=summon |