Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids
Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may co...
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| Published in | Journal of investigative medicine Vol. 65; no. 7; pp. 1021 - 1027 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.10.2017
Sage Publications Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1081-5589 1708-8267 1708-8267 |
| DOI | 10.1136/jim-2017-000535 |
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| Abstract | Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders. |
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| AbstractList | Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders. Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders.Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders. |
| Author | Pahlavani, Mandana Koboziev, Iurii Moustaid-Moussa, Naima Jayarathne, Shasika Filgueiras, Luciano R Ramalho, Theresa LeMieux, Monique J Ramalingam, Latha |
| AuthorAffiliation | 3 Department of Nutrition and Food Science, Texas Woman’s University, Denton, Texas, USA 2 Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil 1 Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA |
| AuthorAffiliation_xml | – name: 2 Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil – name: 1 Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA – name: 3 Department of Nutrition and Food Science, Texas Woman’s University, Denton, Texas, USA |
| Author_xml | – sequence: 1 givenname: Mandana surname: Pahlavani fullname: Pahlavani, Mandana email: naima.moustaid-moussa@ttu.edu organization: Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA – sequence: 2 givenname: Theresa surname: Ramalho fullname: Ramalho, Theresa email: naima.moustaid-moussa@ttu.edu organization: Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil – sequence: 3 givenname: Iurii surname: Koboziev fullname: Koboziev, Iurii email: naima.moustaid-moussa@ttu.edu organization: Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA – sequence: 4 givenname: Monique J surname: LeMieux fullname: LeMieux, Monique J email: naima.moustaid-moussa@ttu.edu organization: Department of Nutrition and Food Science, Texas Woman’s University, Denton, Texas, USA – sequence: 5 givenname: Shasika surname: Jayarathne fullname: Jayarathne, Shasika email: naima.moustaid-moussa@ttu.edu organization: Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA – sequence: 6 givenname: Latha surname: Ramalingam fullname: Ramalingam, Latha email: naima.moustaid-moussa@ttu.edu organization: Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA – sequence: 7 givenname: Luciano R surname: Filgueiras fullname: Filgueiras, Luciano R email: naima.moustaid-moussa@ttu.edu organization: Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil – sequence: 8 givenname: Naima orcidid: 0000-0002-7508-8030 surname: Moustaid-Moussa fullname: Moustaid-Moussa, Naima email: naima.moustaid-moussa@ttu.edu organization: Department of Nutritional Sciences and Obesity Research Cluster, Texas Tech University, Lubbock, Texas, USA |
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| Copyright | American Federation for Medical Research (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. 2017 American Federation for Medical Research Copyright: 2017 © American Federation for Medical Research (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
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| Keywords | inflammation obesity polyunsaturated fatty acids |
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| Snippet | Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and... |
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| SubjectTerms | Adipose Tissue - pathology Animals Body fat Fatty Acids, Omega-3 - therapeutic use Glucose Humans Inflammation - drug therapy Inflammation - pathology Insulin - metabolism Insulin Resistance Kinases Obesity Obesity - drug therapy Obesity - metabolism Obesity - pathology Polyunsaturated fatty acids |
| Title | Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids |
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