Associations between spirometric impairments and microvascular complications in type 2 diabetes: a cross-sectional study

• Published in: BMJ open Vol. 13; no. 10; p. e075209
• Main Authors: Hayfron-Benjamin, Charles F, Agyemang, Charles, van den Born, Bert-Jan H, Amoah, Albert G B, Amissah-Arthur, Kwesi Nyan, Musah, Latif, Abaidoo, Benjamin, Awula, Pelagia, Awuviri, Henry Wedoi, Abbey, Joseph Agyapong, Fummey, Deladem A, Ackam, Joana N, Asante, Gloria Odom, Hashimoto, Simone, Maitland-van der Zee, Anke H
• Format: Journal Article
• Language: English
• Published: London British Medical Journal Publishing Group 30.10.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Asthma; Body mass index; Cardiology; Cardiovascular disease; Chronic obstructive pulmonary disease; Creatinine; Cross-sectional studies; Diabetes; Diabetic nephropathy; diabetic nephropathy & vascular disease; Diabetic neuropathy; Diabetic retinopathy; Heart; Hypertension; Insulin; Lung diseases; Medical records; pulmonary disease, chronic obstructive; Regression analysis; Respiratory Medicine; Sociodemographics; Spirometry; Standard scores; Variables
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2023-075209

ObjectiveEvidence shows that the conventional cardiometabolic risk factors do not fully explain the burden of microvascular complications in type 2 diabetes (T2D). One potential factor is the impact of pulmonary dysfunction on systemic microvascular injury. We assessed the associations between spirometric impairments and systemic microvascular complications in T2D.DesignCross-sectional study.SettingNational Diabetes Management and Research Centre in Ghana.ParticipantsThe study included 464 Ghanaians aged ≥35 years with established diagnosis of T2D without primary myocardial disease or previous/current heart failure. Participants were excluded if they had primary lung disease including asthma or chronic obstructive pulmonary disease.Primary and secondary outcome measuresThe associations of spirometric measures (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio) with microvascular complications (nephropathy (albumin-creatinine ratio ≥30 mg/g), neuropathy (vibration perception threshold ≥25 V and/or Diabetic Neuropathy Symptom score >1) and retinopathy (based on retinal photography)) were assessed using multivariable logistic regression models with adjustments for age, sex, diabetes duration, glycated haemoglobin concentration, suboptimal blood pressure control, smoking pack years and body mass index.ResultsIn age and sex-adjusted models, lower Z-score FEV1 was associated with higher odds of nephropathy (OR 1.55, 95% CI 1.19–2.02, p=0.001) and neuropathy (1.27 (1.01–1.65), 0.038) but not retinopathy (1.22 (0.87–1.70), 0.246). Similar observations were made for the associations of lower Z-score FVC with nephropathy (1.54 (1.19–2.01), 0.001), neuropathy (1.25 (1.01–1.54), 0.037) and retinopathy (1.19 (0.85–1.68), 0.318). In the fully adjusted model, the associations remained significant for only lower Z-score FEV1 with nephropathy (1.43 (1.09–1.87), 0.011) and neuropathy (1.34 (1.04–1.73), 0.024) and for lower Z-score FVC with nephropathy (1.45 (1.11–1.91), 0.007) and neuropathy (1.32 (1.03–1.69), 0.029). Lower Z-score FEV1/FVC ratio was not significantly associated with microvascular complications in age and sex and fully adjusted models.ConclusionOur study shows positive but varying strengths of associations between pulmonary dysfunction and microvascular complications in different circulations. Future studies could explore the mechanisms linking pulmonary dysfunction to microvascular complications in T2D.