Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB115 alleles - Saper, Vivian E; Ombrello, Michael J; Tremoulet, Adriana H; Montero-Martin, Gonzalo; Prahalad, Sampath; Canna, Scott; Shimizu, Chisato; Deutsch, Gail; Tan, Serena Y; Remmers, Elaine F; Monos, Dimitri; Hahn, Timothy; et al. (Annals of the rheumatic diseases, 2022)
Keywords: Adult; adult-onset; Alleles; Antigens; Antirheumatic Agents - adverse effects; Arthritis; biological therapy; Case-Control Studies; Cell activation; Children; Classification; Cytokines; Drb1 protein; Drug Hypersensitivity Syndrome - genetics; Drug Hypersensitivity Syndrome - immunology; Drug Tolerance - genetics; Eosinophilia; Female; Gene frequency; Haplotypes; Histocompatibility antigen HLA; HLA-DRB1 Chains - genetics; HLA-DRB1 Chains - immunology; Humans; Hypersensitivity (delayed); Hypersensitivity, Delayed - genetics; Hypersensitivity, Delayed - immunology; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 6; Interleukin-1 - antagonists & inhibitors; Interleukin-6 - antagonists & inhibitors; juvenile; Kawasaki disease; Laboratories; Lung diseases; Lymphocytes; Macrophages; Male; Mucocutaneous lymph node syndrome; Mucocutaneous Lymph Node Syndrome - drug therapy; Mucocutaneous Lymph Node Syndrome - genetics; Patients; Peptides; pharmacogenetics; Retrospective Studies; Steroids; Still's disease; Still's Disease, Adult-Onset - drug therapy; Still's Disease, Adult-Onset - genetics; Still's Disease, Adult-Onset - immunology; Tissue typing; Treatment; Vigilance; Still's disease; adult-onset; juvenile; arthritis; biological therapy; pharmacogenetics