Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles - Yan, Helen H N; Siu, Hoi Cheong; Ho, Siu Lun; Yue, Sarah S K; Gao, Yang; Tsui, Wai Yin; Chan, Dessy; Chan, April S; Wong, Jason W H; Man, Alice H Y; Lee, Bernard C H; Chan, Annie S Y; et al. (Gut, 2020)
Keywords: Adenomatous polyposis coli; Adenomatous Polyposis Coli Protein - genetics; Age; Biobanks; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein Receptors, Type I - genetics; Cancer; Cell Adhesion Molecules - genetics; Cell culture; Colon; colon carcinogenesis; Colorectal cancer; colorectal cancer genes; Colorectal carcinoma; Colorectal Neoplasms - genetics; CRISPR; CRISPR-Cas Systems; Early-onset colon cancer; Gene expression; Gene Expression Profiling; Gene Fusion; Genetic engineering; Genetic Profile; Genomes; Humans; Leukemia; Lymphatic system; Models, Genetic; Mutants; Mutation; organoid models; Organoids; Organoids - pathology; Patients; Phenotypes; Proofreading; R-spondin fusion; Receptor Protein-Tyrosine Kinases - genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics; RNF43; serrated neoplasia; Smad4 protein; Smad4 Protein - genetics; Thrombospondins - genetics; Tissue Banks; Transcription; Tumors; Ubiquitin-Protein Ligases - genetics; Up-Regulation; Whole Exome Sequencing; Wnt protein; RNF43; Early-onset colon cancer; colon carcinogenesis; colorectal cancer; organoid models; R-spondin fusion; serrated neoplasia; colorectal cancer genes; gene expression