Preliminary report: modulation of parasympathetic nervous system tone influences oesophageal pain hypersensitivity
Objectives Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences...
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| Published in | Gut Vol. 64; no. 4; pp. 611 - 617 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.04.2015
BMJ Publishing Group LTD |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0017-5749 1468-3288 1468-3288 |
| DOI | 10.1136/gutjnl-2013-306698 |
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| Abstract | Objectives Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain. Design Prior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion. Results Study 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs −0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (−0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046). Conclusions The development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. |
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| AbstractList | Objectives Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain. Design Prior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion. Results Study 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs −0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (−0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046). Conclusions The development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain. Prior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion. Study 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs -0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (-0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046). The development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain.OBJECTIVESAutonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain.Prior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion.DESIGNPrior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion.Study 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs -0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (-0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046).RESULTSStudy 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs -0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (-0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046).The development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity.CONCLUSIONSThe development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. ObjectivesAutonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain.DesignPrior to, and following, a 30-min distal oesophageal infusion of 0.15M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion.ResultsStudy 1: Deep breathing increased cardiac vagal tone (2.1 plus or minus 2.3 vs -0.3 plus or minus 2.3, p=0.0006) with concomitant withdrawal of skin conductance response (-0.6 plus or minus 4.9 vs 3 plus or minus 4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046).ConclusionsThe development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. ObjectivesAutonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain.DesignPrior to, and following, a 30-min distal oesophageal infusion of 0.15 M hydrochloric acid, pain thresholds to electrical stimulation were determined in the proximal non-acid exposed oesophagus in healthy subjects. Validated sympathetic (skin conductance response) and parasympathetic (cardiac vagal tone) parameters were measured at baseline and continuously thereafter. In study 1, 55 subjects were randomised in a pragmatic blinded crossover design to receive deep breathing or un-paced breathing during acid infusion. In study 2, 32 subjects were randomised in a blinded, crossover design to receive intravenous atropine or placebo (saline) with deep breathing during acid infusion.ResultsStudy 1: Deep breathing increased cardiac vagal tone (2.1±2.3 vs −0.3±2.3, p=0.0006) with concomitant withdrawal of skin conductance response (−0.6±4.9 vs 3±4.8, p=0.03) in comparison with un-paced breathing. Deep breathing prevented the development of acid-induced oesophageal hypersensitivity in comparison with sham breathing (p=0.0001). Study 2: Atropine, in comparison with placebo, blocked the attenuating effect of deep breathing on the development of acid-induced oesophageal hypersensitivity (p=0.046).ConclusionsThe development of oesophageal hyperalgesia is prevented by physiologically increasing parasympathetic tone. This effect is pharmacologically blocked with atropine, providing evidence that the PNS influences the development of oesophageal pain hypersensitivity. |
| Author | Botha, Claude Nilsson, Matias Brock, Christina Farmer, Adam D Knowles, Charles H Drewes, Asbjørn Mohr Gavrila, Ana D Aziz, Qasim |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24870622$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1523/JNEUROSCI.2543-11.2012 10.1017/CBO9780511546396 10.1007/s10484-006-9028-0 10.1111/j.1365-2982.2006.00890.x 10.1111/nmo.12245 10.1152/japplphysiol.00128.2013 10.1161/01.CIR.93.5.1043 10.1212/01.wnl.0000266671.61599.a0 10.1016/j.brs.2012.04.006 10.1111/j.1365-2036.2011.04955.x 10.1016/S0140-6736(00)02758-6 10.1111/j.1474-8673.1992.tb00368.x 10.1016/j.pain.2009.10.001 10.1016/0006-8993(88)91075-X 10.1136/adc.2007.123661 10.1053/j.gastro.2003.11.047 10.1016/0006-8993(81)90690-9 10.1007/s00702-007-0755-z 10.1097/PSY.0b013e3181f5c021 10.1016/j.pain.2013.05.016 10.1111/j.1365-2982.2012.01929.x 10.1161/01.CIR.98.14.1394 10.1002/0470854596 10.1586/egh.10.88 10.1016/j.cgh.2012.10.031 10.1016/j.pain.2009.02.022 10.1111/j.1600-0447.1983.tb09716.x 10.1136/gutjnl-2011-300253 10.1111/nmo.12076 10.1016/S0006-8993(99)01521-8 10.1038/35013070 10.1016/j.hrtlng.2005.10.005 10.1136/gutjnl-2013-304676 10.1136/gutjnl-2012-302550 10.1016/S0006-8993(03)02277-7 10.1038/nrn894 10.1152/jn.00079.2001 |
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| Keywords | Abdominal Pain Visceral Hypersensitivity Visceral Nociception Visceral Sensitivity |
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| References | Julu (R21) 1992; 12 Craig (R4) 2002; 3 Zhang, Chandler, Foreman (R33) 2003; 969 Zigmond, Snaith (R15) 1983; 67 Farmer, Coen, Kano (R2) 2013; 154 Kraus, Hosl, Kiess (R37) 2007; 114 Matteoli, Gomez-Pinilla, Nemethova (R32) 2014; 63 Palsson, Whitehead (R12) 2013; 11 Friesner, Curry, Moddeman (R29) 2006; 35 Borovikova, Ivanova, Zhang (R31) 2000; 405 Paine, Kishor, Worthen (R19) 2009; 144 Bonaz, Picq, Sinniger (R14) 2013; 25 Sharma, Paine, Rhodes (R9) 2012; 24 Hassett, Radvanski, Vaschillo (R28) 2007; 32 Willert, Woolf, Hobson (R10) 2004; 126 Nishikawa, Koyama, Yoshida (R35) 1999; 833 Higashimoto, Baldwin, Gold (R5) 2008; 93 Holschneider, Bradesi, Mayer (R11) 2011; 5 Matteoli, Boeckxstaens (R6) 2013; 62 (R22) 1996; 93 Montano, Cogliati, Porta (R39) 1998; 98 Farmer, Coen, Kano (R3) 2014; 26 Thijs, Wieling, van den Aardweg (R23) 2007; 69 Chua, Ng, Sharma (R8) 2012; 35 Chandler, Zhang, Qin (R34) 2002; 87 Thies, Foreman (R30) 1981; 207 Randich, Aicher (R36) 1988; 445 Willert, Delaney, Kelly (R25) 2007; 19 Wilder-Smith (R27) 2011; 60 Busch, Zeman, Heckel (R38) 2013; 6 Zautra, Fasman, Davis (R13) 2010; 149 Brooks, Kong, Lee (R26) 2012; 32 Sarkar, Aziz, Woolf (R7) 2000; 356 Little, Julu, Hansen (R20) 1999; 276 Lucas, Lewis, Sikken (R24) 2013; 115 Sharma, Van Oudenhove, Paine (R16) 2010; 72 Holschneider, Bradesi, Mayer 2011; 5 Lucas, Lewis, Sikken 2013; 115 Thijs, Wieling, van den Aardweg 2007; 69 Craig 2002; 3 Zautra, Fasman, Davis 2010; 149 Kraus, Hosl, Kiess 2007; 114 Chua, Ng, Sharma 2012; 35 1996; 93 Montano, Cogliati, Porta 1998; 98 Sharma, Van Oudenhove, Paine 2010; 72 Busch, Zeman, Heckel 2013; 6 Farmer, Coen, Kano 2013; 154 Thies, Foreman 1981; 207 Wilder-Smith 2011; 60 Palsson, Whitehead 2013; 11 Little, Julu, Hansen 1999; 276 Hassett, Radvanski, Vaschillo 2007; 32 Sharma, Paine, Rhodes 2012; 24 Zigmond, Snaith 1983; 67 Zhang, Chandler, Foreman 2003; 969 Willert, Woolf, Hobson 2004; 126 Matteoli, Boeckxstaens 2013; 62 Sarkar, Aziz, Woolf 2000; 356 Bonaz, Picq, Sinniger 2013; 25 Chandler, Zhang, Qin 2002; 87 Randich, Aicher 1988; 445 Willert, Delaney, Kelly 2007; 19 Brooks, Kong, Lee 2012; 32 Julu 1992; 12 Friesner, Curry, Moddeman 2006; 35 Nishikawa, Koyama, Yoshida 1999; 833 Farmer, Coen, Kano 2014; 26 Paine, Kishor, Worthen 2009; 144 Higashimoto, Baldwin, Gold 2008; 93 Borovikova, Ivanova, Zhang 2000; 405 Matteoli, Gomez-Pinilla, Nemethova 2014; 63 Matteoli (key-10.1136/gutjnl-2013-306698-32) 2014; 63 Sharma (key-10.1136/gutjnl-2013-306698-9) 2012; 24 Little (key-10.1136/gutjnl-2013-306698-20) 1999; 276 Matteoli (key-10.1136/gutjnl-2013-306698-6) 2013; 62 Cacioppo (key-10.1136/gutjnl-2013-306698-18) 2007 Nishikawa (key-10.1136/gutjnl-2013-306698-35) 1999; 833 Hassett (key-10.1136/gutjnl-2013-306698-28) 2007; 32 Farmer (key-10.1136/gutjnl-2013-306698-2) 2013; 154 Chua (key-10.1136/gutjnl-2013-306698-8) 2012; 35 Palsson (key-10.1136/gutjnl-2013-306698-12) 2013; 11 Paine (key-10.1136/gutjnl-2013-306698-19) 2009; 144 Lucas (key-10.1136/gutjnl-2013-306698-24) 2013; 115 Brooks (key-10.1136/gutjnl-2013-306698-26) 2012; 32 Bonaz (key-10.1136/gutjnl-2013-306698-14) 2013; 25 Sharma (key-10.1136/gutjnl-2013-306698-16) 2010; 72 Spielberger (key-10.1136/gutjnl-2013-306698-17) 1983 Holschneider (key-10.1136/gutjnl-2013-306698-11) 2011; 5 Wilder-Smith (key-10.1136/gutjnl-2013-306698-27) 2011; 60 Thijs (key-10.1136/gutjnl-2013-306698-23) 2007; 69 Montano (key-10.1136/gutjnl-2013-306698-39) 1998; 98 Drossman (key-10.1136/gutjnl-2013-306698-1) 2006 Kraus (key-10.1136/gutjnl-2013-306698-37) 2007; 114 Busch (key-10.1136/gutjnl-2013-306698-38) 2013; 6 (key-10.1136/gutjnl-2013-306698-22) 1996; 93 Thies (key-10.1136/gutjnl-2013-306698-30) 1981; 207 Chandler (key-10.1136/gutjnl-2013-306698-34) 2002; 87 Farmer (key-10.1136/gutjnl-2013-306698-3) 2014; 26 Senn (key-10.1136/gutjnl-2013-306698-40) 2002 Higashimoto (key-10.1136/gutjnl-2013-306698-5) 2008; 93 Zigmond (key-10.1136/gutjnl-2013-306698-15) 1983; 67 Sarkar (key-10.1136/gutjnl-2013-306698-7) 2000; 356 Friesner (key-10.1136/gutjnl-2013-306698-29) 2006; 35 Craig (key-10.1136/gutjnl-2013-306698-4) 2002; 3 Zautra (key-10.1136/gutjnl-2013-306698-13) 2010; 149 Willert (key-10.1136/gutjnl-2013-306698-25) 2007; 19 Randich (key-10.1136/gutjnl-2013-306698-36) 1988; 445 Willert (key-10.1136/gutjnl-2013-306698-10) 2004; 126 Borovikova (key-10.1136/gutjnl-2013-306698-31) 2000; 405 Julu (key-10.1136/gutjnl-2013-306698-21) 1992; 12 Zhang (key-10.1136/gutjnl-2013-306698-33) 2003; 969 |
| References_xml | – volume: 87 start-page: 1290 year: 2002 ident: R34 article-title: Spinal inhibitory effects of cardiopulmonary afferent inputs in monkeys: neuronal processing in high cervical segments publication-title: J Neurophysiol – volume: 276 start-page: H758 year: 1999 ident: R20 article-title: Real-time measurement of cardiac vagal tone in conscious dogs publication-title: Am J Physiol – volume: 63 start-page: 938 year: 2014 ident: R32 article-title: A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen publication-title: Gut – volume: 126 start-page: 683 year: 2004 ident: R10 article-title: The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor publication-title: Gastroenterology – volume: 833 start-page: 108 year: 1999 ident: R35 article-title: Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis publication-title: Brain Res – volume: 98 start-page: 1394 year: 1998 ident: R39 article-title: Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity publication-title: Circulation – volume: 114 start-page: 1485 year: 2007 ident: R37 article-title: BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation publication-title: J Neural Transm – volume: 115 start-page: 202 year: 2013 ident: R24 article-title: Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial publication-title: J Appl Physiol – volume: 12 start-page: 109 year: 1992 ident: R21 article-title: A linear scale for measuring vagal tone in man publication-title: J Auton Pharmacol – volume: 35 start-page: 269 year: 2006 ident: R29 article-title: Comparison of two pain-management strategies during chest tube removal: relaxation exercise with opioids and opioids alone publication-title: Heart Lung – volume: 26 start-page: 139 year: 2014 ident: R3 article-title: Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters publication-title: Neurogastroenterol Motil – volume: 62 start-page: 1214 year: 2013 ident: R6 article-title: The vagal innervation of the gut and immune homeostasis publication-title: Gut – volume: 67 start-page: 361 year: 1983 ident: R15 article-title: The hospital anxiety and depression scale publication-title: Acta Psychiatr Scand – volume: 19 start-page: 270 year: 2007 ident: R25 article-title: Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification—evidence of central sensitization publication-title: Neurogastroenterol Motil – volume: 35 start-page: 319 year: 2012 ident: R8 article-title: Randomised clinical trial: pregabalin attenuates the development of acid-induced oesophageal hypersensitivity in healthy volunteers—a placebo-controlled study publication-title: Aliment Pharmacol Ther – volume: 207 start-page: 178 year: 1981 ident: R30 article-title: Descending inhibition of spinal neurons in the cardiopulmonary region by electrical stimulation of vagal afferent nerves publication-title: Brain Res – volume: 144 start-page: 236 year: 2009 ident: R19 article-title: Exploring relationships for visceral and somatic pain with autonomic control and personality publication-title: Pain – volume: 405 start-page: 458 year: 2000 ident: R31 article-title: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin publication-title: Nature – volume: 93 start-page: 1043 year: 1996 ident: R22 article-title: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology publication-title: Circulation – volume: 60 start-page: 1589 year: 2011 ident: R27 article-title: The balancing act: endogenous modulation of pain in functional gastrointestinal disorders publication-title: Gut – volume: 154 start-page: 2266 year: 2013 ident: R2 article-title: Psychophysiological responses to pain identify reproducible human clusters publication-title: Pain – volume: 24 start-page: e285 year: 2012 ident: R9 article-title: The autonomic response to human esophageal acidification and the development of hyperalgesia publication-title: Neurogastroenterol Motil – volume: 32 start-page: 6231 year: 2012 ident: R26 article-title: Stimulus site and modality dependence of functional activity within the human spinal cord publication-title: J Neurosci – volume: 3 start-page: 655 year: 2002 ident: R4 article-title: How do you feel? Interoception: the sense of the physiological condition of the body publication-title: Nat Rev Neurosci – volume: 149 start-page: 12 year: 2010 ident: R13 article-title: The effects of slow breathing on affective responses to pain stimuli: an experimental study publication-title: Pain – volume: 6 start-page: 202 year: 2013 ident: R38 article-title: The effect of transcutaneous vagus nerve stimulation on pain perception—an experimental study publication-title: Brain Stimul – volume: 93 start-page: 390 year: 2008 ident: R5 article-title: Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance publication-title: Arch Dis Child – volume: 5 start-page: 43 year: 2011 ident: R11 article-title: The role of experimental models in developing new treatments for irritable bowel syndrome publication-title: Expert Rev Gastroenterol Hepatol – volume: 11 start-page: 208 year: 2013 ident: R12 article-title: Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist publication-title: Clin Gastroenterol Hepatol – volume: 445 start-page: 68 year: 1988 ident: R36 article-title: Medullary substrates mediating antinociception produced by electrical stimulation of the vagus publication-title: Brain Res – volume: 356 start-page: 1154 year: 2000 ident: R7 article-title: Contribution of central sensitisation to the development of non-cardiac chest pain publication-title: Lancet – volume: 72 start-page: 802 year: 2010 ident: R16 article-title: Anxiety increases acid-induced esophageal hyperalgesia publication-title: Psychosom Med – volume: 969 start-page: 53 year: 2003 ident: R33 article-title: Cardiopulmonary sympathetic and vagal afferents excite C1-C2 propriospinal cells in rats publication-title: Brain Res – volume: 69 start-page: 582 year: 2007 ident: R23 article-title: Respiratory countermaneuvers in autonomic failure publication-title: Neurology – volume: 32 start-page: 1 year: 2007 ident: R28 article-title: A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia publication-title: Appl Psychophysiol Biofeedback – volume: 25 start-page: 208 year: 2013 ident: R14 article-title: Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway publication-title: Neurogastroenterol Motil – volume: 6 start-page: 202 year: 2013 article-title: The effect of transcutaneous vagus nerve stimulation on pain perception—an experimental study publication-title: Brain Stimul – volume: 3 start-page: 655 year: 2002 article-title: How do you feel? Interoception: the sense of the physiological condition of the body publication-title: Nat Rev Neurosci – volume: 72 start-page: 802 year: 2010 article-title: Anxiety increases acid-induced esophageal hyperalgesia publication-title: Psychosom Med – volume: 87 start-page: 1290 year: 2002 article-title: Spinal inhibitory effects of cardiopulmonary afferent inputs in monkeys: neuronal processing in high cervical segments publication-title: J Neurophysiol – volume: 115 start-page: 202 year: 2013 article-title: Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial publication-title: J Appl Physiol – volume: 19 start-page: 270 year: 2007 article-title: Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification—evidence of central sensitization publication-title: Neurogastroenterol Motil – volume: 445 start-page: 68 year: 1988 article-title: Medullary substrates mediating antinociception produced by electrical stimulation of the vagus publication-title: Brain Res – volume: 32 start-page: 6231 year: 2012 article-title: Stimulus site and modality dependence of functional activity within the human spinal cord publication-title: J Neurosci – volume: 154 start-page: 2266 year: 2013 article-title: Psychophysiological responses to pain identify reproducible human clusters publication-title: Pain – volume: 67 start-page: 361 year: 1983 article-title: The hospital anxiety and depression scale publication-title: Acta Psychiatr Scand – volume: 5 start-page: 43 year: 2011 article-title: The role of experimental models in developing new treatments for irritable bowel syndrome publication-title: Expert Rev Gastroenterol Hepatol – volume: 25 start-page: 208 year: 2013 article-title: Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway publication-title: Neurogastroenterol Motil – volume: 126 start-page: 683 year: 2004 article-title: The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor publication-title: Gastroenterology – volume: 356 start-page: 1154 year: 2000 article-title: Contribution of central sensitisation to the development of non-cardiac chest pain publication-title: Lancet – volume: 11 start-page: 208 year: 2013 article-title: Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist publication-title: Clin Gastroenterol Hepatol – volume: 969 start-page: 53 year: 2003 article-title: Cardiopulmonary sympathetic and vagal afferents excite C1-C2 propriospinal cells in rats publication-title: Brain Res – volume: 149 start-page: 12 year: 2010 article-title: The effects of slow breathing on affective responses to pain stimuli: an experimental study publication-title: Pain – volume: 60 start-page: 1589 year: 2011 article-title: The balancing act: endogenous modulation of pain in functional gastrointestinal disorders publication-title: Gut – volume: 276 start-page: H758 year: 1999 article-title: Real-time measurement of cardiac vagal tone in conscious dogs publication-title: Am J Physiol – volume: 24 start-page: e285 year: 2012 article-title: The autonomic response to human esophageal acidification and the development of hyperalgesia publication-title: Neurogastroenterol Motil – volume: 35 start-page: 319 year: 2012 article-title: Randomised clinical trial: pregabalin attenuates the development of acid-induced oesophageal hypersensitivity in healthy volunteers—a placebo-controlled study publication-title: Aliment Pharmacol Ther – volume: 93 start-page: 1043 year: 1996 article-title: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology publication-title: Circulation – volume: 32 start-page: 1 year: 2007 article-title: A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia publication-title: Appl Psychophysiol Biofeedback – volume: 114 start-page: 1485 year: 2007 article-title: BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation publication-title: J Neural Transm – volume: 144 start-page: 236 year: 2009 article-title: Exploring relationships for visceral and somatic pain with autonomic control and personality publication-title: Pain – volume: 26 start-page: 139 year: 2014 article-title: Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters publication-title: Neurogastroenterol Motil – volume: 833 start-page: 108 year: 1999 article-title: Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis publication-title: Brain Res – volume: 69 start-page: 582 year: 2007 article-title: Respiratory countermaneuvers in autonomic failure publication-title: Neurology – volume: 62 start-page: 1214 year: 2013 article-title: The vagal innervation of the gut and immune homeostasis publication-title: Gut – volume: 63 start-page: 938 year: 2014 article-title: A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen publication-title: Gut – volume: 93 start-page: 390 year: 2008 article-title: Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance publication-title: Arch Dis Child – volume: 98 start-page: 1394 year: 1998 article-title: Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity publication-title: Circulation – volume: 207 start-page: 178 year: 1981 article-title: Descending inhibition of spinal neurons in the cardiopulmonary region by electrical stimulation of vagal afferent nerves publication-title: Brain Res – volume: 405 start-page: 458 year: 2000 article-title: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin publication-title: Nature – volume: 12 start-page: 109 year: 1992 article-title: A linear scale for measuring vagal tone in man publication-title: J Auton Pharmacol – volume: 35 start-page: 269 year: 2006 article-title: Comparison of two pain-management strategies during chest tube removal: relaxation exercise with opioids and opioids alone publication-title: Heart Lung – volume: 32 start-page: 6231 year: 2012 ident: key-10.1136/gutjnl-2013-306698-26 article-title: Stimulus site and modality dependence of functional activity within the human spinal cord publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2543-11.2012 – volume-title: Handbook of psychophysiology year: 2007 ident: key-10.1136/gutjnl-2013-306698-18 doi: 10.1017/CBO9780511546396 – volume: 32 start-page: 1 year: 2007 ident: key-10.1136/gutjnl-2013-306698-28 article-title: A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia publication-title: Appl Psychophysiol Biofeedback doi: 10.1007/s10484-006-9028-0 – volume: 19 start-page: 270 year: 2007 ident: key-10.1136/gutjnl-2013-306698-25 article-title: Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification—evidence of central sensitization publication-title: Neurogastroenterol Motil doi: 10.1111/j.1365-2982.2006.00890.x – volume: 26 start-page: 139 year: 2014 ident: key-10.1136/gutjnl-2013-306698-3 article-title: Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters publication-title: Neurogastroenterol Motil doi: 10.1111/nmo.12245 – volume: 115 start-page: 202 year: 2013 ident: key-10.1136/gutjnl-2013-306698-24 article-title: Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00128.2013 – volume: 93 start-page: 1043 year: 1996 ident: key-10.1136/gutjnl-2013-306698-22 article-title: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology publication-title: Circulation doi: 10.1161/01.CIR.93.5.1043 – volume: 69 start-page: 582 year: 2007 ident: key-10.1136/gutjnl-2013-306698-23 article-title: Respiratory countermaneuvers in autonomic failure publication-title: Neurology doi: 10.1212/01.wnl.0000266671.61599.a0 – volume: 6 start-page: 202 year: 2013 ident: key-10.1136/gutjnl-2013-306698-38 article-title: The effect of transcutaneous vagus nerve stimulation on pain perception—an experimental study publication-title: Brain Stimul doi: 10.1016/j.brs.2012.04.006 – volume: 35 start-page: 319 year: 2012 ident: key-10.1136/gutjnl-2013-306698-8 article-title: Randomised clinical trial: pregabalin attenuates the development of acid-induced oesophageal hypersensitivity in healthy volunteers—a placebo-controlled study publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2011.04955.x – volume: 356 start-page: 1154 year: 2000 ident: key-10.1136/gutjnl-2013-306698-7 article-title: Contribution of central sensitisation to the development of non-cardiac chest pain publication-title: Lancet doi: 10.1016/S0140-6736(00)02758-6 – volume: 12 start-page: 109 year: 1992 ident: key-10.1136/gutjnl-2013-306698-21 article-title: A linear scale for measuring vagal tone in man publication-title: J Auton Pharmacol doi: 10.1111/j.1474-8673.1992.tb00368.x – volume-title: Rome III: the functional gastrointestinal disorders year: 2006 ident: key-10.1136/gutjnl-2013-306698-1 – volume: 149 start-page: 12 year: 2010 ident: key-10.1136/gutjnl-2013-306698-13 article-title: The effects of slow breathing on affective responses to pain stimuli: an experimental study publication-title: Pain doi: 10.1016/j.pain.2009.10.001 – volume-title: Manual for the state/trait anxiety inventory (form Y): (self evaluation questionnaire) year: 1983 ident: key-10.1136/gutjnl-2013-306698-17 – volume: 445 start-page: 68 year: 1988 ident: key-10.1136/gutjnl-2013-306698-36 article-title: Medullary substrates mediating antinociception produced by electrical stimulation of the vagus publication-title: Brain Res doi: 10.1016/0006-8993(88)91075-X – volume: 93 start-page: 390 year: 2008 ident: key-10.1136/gutjnl-2013-306698-5 article-title: Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance publication-title: Arch Dis Child doi: 10.1136/adc.2007.123661 – volume: 126 start-page: 683 year: 2004 ident: key-10.1136/gutjnl-2013-306698-10 article-title: The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor publication-title: Gastroenterology doi: 10.1053/j.gastro.2003.11.047 – volume: 207 start-page: 178 year: 1981 ident: key-10.1136/gutjnl-2013-306698-30 article-title: Descending inhibition of spinal neurons in the cardiopulmonary region by electrical stimulation of vagal afferent nerves publication-title: Brain Res doi: 10.1016/0006-8993(81)90690-9 – volume: 114 start-page: 1485 year: 2007 ident: key-10.1136/gutjnl-2013-306698-37 article-title: BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation publication-title: J Neural Transm doi: 10.1007/s00702-007-0755-z – volume: 72 start-page: 802 year: 2010 ident: key-10.1136/gutjnl-2013-306698-16 article-title: Anxiety increases acid-induced esophageal hyperalgesia publication-title: Psychosom Med doi: 10.1097/PSY.0b013e3181f5c021 – volume: 154 start-page: 2266 year: 2013 ident: key-10.1136/gutjnl-2013-306698-2 article-title: Psychophysiological responses to pain identify reproducible human clusters publication-title: Pain doi: 10.1016/j.pain.2013.05.016 – volume: 24 start-page: e285 year: 2012 ident: key-10.1136/gutjnl-2013-306698-9 article-title: The autonomic response to human esophageal acidification and the development of hyperalgesia publication-title: Neurogastroenterol Motil doi: 10.1111/j.1365-2982.2012.01929.x – volume: 98 start-page: 1394 year: 1998 ident: key-10.1136/gutjnl-2013-306698-39 article-title: Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity publication-title: Circulation doi: 10.1161/01.CIR.98.14.1394 – volume-title: Cross-over trials in clinical research year: 2002 ident: key-10.1136/gutjnl-2013-306698-40 doi: 10.1002/0470854596 – volume: 5 start-page: 43 year: 2011 ident: key-10.1136/gutjnl-2013-306698-11 article-title: The role of experimental models in developing new treatments for irritable bowel syndrome publication-title: Expert Rev Gastroenterol Hepatol doi: 10.1586/egh.10.88 – volume: 11 start-page: 208 year: 2013 ident: key-10.1136/gutjnl-2013-306698-12 article-title: Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2012.10.031 – volume: 144 start-page: 236 year: 2009 ident: key-10.1136/gutjnl-2013-306698-19 article-title: Exploring relationships for visceral and somatic pain with autonomic control and personality publication-title: Pain doi: 10.1016/j.pain.2009.02.022 – volume: 67 start-page: 361 year: 1983 ident: key-10.1136/gutjnl-2013-306698-15 article-title: The hospital anxiety and depression scale publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.1983.tb09716.x – volume: 60 start-page: 1589 year: 2011 ident: key-10.1136/gutjnl-2013-306698-27 article-title: The balancing act: endogenous modulation of pain in functional gastrointestinal disorders publication-title: Gut doi: 10.1136/gutjnl-2011-300253 – volume: 25 start-page: 208 year: 2013 ident: key-10.1136/gutjnl-2013-306698-14 article-title: Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway publication-title: Neurogastroenterol Motil doi: 10.1111/nmo.12076 – volume: 833 start-page: 108 year: 1999 ident: key-10.1136/gutjnl-2013-306698-35 article-title: Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis publication-title: Brain Res doi: 10.1016/S0006-8993(99)01521-8 – volume: 405 start-page: 458 year: 2000 ident: key-10.1136/gutjnl-2013-306698-31 article-title: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin publication-title: Nature doi: 10.1038/35013070 – volume: 35 start-page: 269 year: 2006 ident: key-10.1136/gutjnl-2013-306698-29 article-title: Comparison of two pain-management strategies during chest tube removal: relaxation exercise with opioids and opioids alone publication-title: Heart Lung doi: 10.1016/j.hrtlng.2005.10.005 – volume: 63 start-page: 938 year: 2014 ident: key-10.1136/gutjnl-2013-306698-32 article-title: A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen publication-title: Gut doi: 10.1136/gutjnl-2013-304676 – volume: 62 start-page: 1214 year: 2013 ident: key-10.1136/gutjnl-2013-306698-6 article-title: The vagal innervation of the gut and immune homeostasis publication-title: Gut doi: 10.1136/gutjnl-2012-302550 – volume: 969 start-page: 53 year: 2003 ident: key-10.1136/gutjnl-2013-306698-33 article-title: Cardiopulmonary sympathetic and vagal afferents excite C1-C2 propriospinal cells in rats publication-title: Brain Res doi: 10.1016/S0006-8993(03)02277-7 – volume: 276 start-page: H758 year: 1999 ident: key-10.1136/gutjnl-2013-306698-20 article-title: Real-time measurement of cardiac vagal tone in conscious dogs publication-title: Am J Physiol – volume: 3 start-page: 655 year: 2002 ident: key-10.1136/gutjnl-2013-306698-4 article-title: How do you feel? Interoception: the sense of the physiological condition of the body publication-title: Nat Rev Neurosci doi: 10.1038/nrn894 – volume: 87 start-page: 1290 year: 2002 ident: key-10.1136/gutjnl-2013-306698-34 article-title: Spinal inhibitory effects of cardiopulmonary afferent inputs in monkeys: neuronal processing in high cervical segments publication-title: J Neurophysiol doi: 10.1152/jn.00079.2001 |
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| Snippet | Objectives Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic... Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system... ObjectivesAutonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic... |
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| SubjectTerms | Abdominal Pain Acidification Adolescent Adult Anxiety Atropine Autonomic nervous system Catheters Conductance Cross-Over Studies Electrical stimuli Electrodes Esophagus Female Heart Hospitals Humans Hydrochloric acid Hypersensitivity Male Middle Aged Nervous system Neurogastroenterology Pain Pain - physiopathology Pain Measurement Pain perception Parasympathetic nervous system Parasympathetic Nervous System - physiology Physiology Placebos Respiration Skin Skin conductance response Vagus nerve Visceral Hypersensitivity Visceral Nociception Visceral Sensitivity Young Adult |
| Title | Preliminary report: modulation of parasympathetic nervous system tone influences oesophageal pain hypersensitivity |
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